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Quality Matters:Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 91-103页

作者： Qingyu Chen Ramona Britto Ivan Erill Constance J.Jeffery Arthur Liberzon Michele Magrane Jun-ichi Onami marc robinson-rechavi Jana Sponarova Justin Zobel Karin Verspoor School of Computing and Information Systems University of MelbourneMelbourneVIC 3010Australia European Molecular Biology Laboratory European Bioinformatics Institute(EMBL-EBI)Wellcome Trust Genome CampusCambridge CB101SDUK Department of Biological Sciences University of MarylandBaltimoreMD 21250USA Department of Biological Sciences University of Illinois at ChicagoChicagoIL 60607USA Broad Institute of MIT and Harvard CambridgeMA 02142USA Japan Science and Technology Agency National Bioscience Database CenterTokyo 102-8666Japan National Institute of Health Sciences Tokyo 158-8501Japan Swiss Institute of Bioinformatics CH-1015 LausanneSwitzerland Department of Ecology and Evolution University of LausanneCH-1015 LausanneSwitzerland Nebion AG 8048 ZurichSwitzerland

Introduction Biological databases represent an extraordinary collective volume of *** built up over decades and comprising many millions of contributions from the biomedical research community,biological databases provide worldwide access to a massive number of records(also known as entries)[1].Starting from individual laboratories,genomes are sequenced.

关键词： Impact collective massive

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Novel CABIN score outperforms other prognostic models in predicting in-hospital mortality after salvage transjugular intrahepatic portosystemic shunting

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 34-45页

作者： Jake Krige Eduard Jonas Chanel robinson Steve Beningfield Urda Kotze marc Bernon Sean Burmeister Christo Kloppers Department of Surgical Gastroenterology University of Cape Town Health Sciences FacultyCape Town 7925Western CapeSouth Africa Department of Radiology University of Cape Town Health Sciences FacultyCape Town 7925Western CapeSouth Africa Department of Surgical Gastroenterology University of Cape TownFaculty of Health SciencesCape Town 7925Western CapeSouth Africa

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is now established as the salvage procedure of choice in patients who have uncontrolled or severe recurrent variceal bleeding despite optimal medical and endoscopic *** To analysis compared the performance of eight risk scores to predict in-hospital mortality after salvage TIPS(sTIPS)placement in patients with uncontrolled variceal bleeding after failed medical treatment and endoscopic *** Baseline risk scores for the Acute Physiology and Chronic Health Evaluation(APACHE)II,Bonn TIPS early mortality(BOTEM),Child-Pugh,Emory,FIPS,model for end-stage liver disease(MELD),MELD-Na,and a novel 5 category CABIN score incorporating Creatinine,Albumin,Bilirubin,INR and Na,were calculated before ***(C)statistics for predictive accuracy of inhospital mortality of the eight scores were compared using area under the receiver operating characteristic curve(AUROC)*** Thirty-four patients(29 men,5 women),median age 52 years(range 31-80)received sTIPS for uncontrolled(11)or refractory(23)bleeding between August 1991 and November *** TIPS controlled bleeding in 32(94%)patients with recurrence in ***(29%)patients died in *** scoring systems had a significant association with in-hospital mortality(P*** was 100%in CABIN A patients while mortality was 75%for CABIN B,87.5%for CABIN C,and 83%for CABIN scores>10.

关键词： Transjugular intrahepatic portosystemic shunt Risk score Portal hypertension Variceal bleeding Mortality

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price marc Randall Thompson G robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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Veno-Venous Extra-Corporeal Membrane Oxygenation (ECMO) in a Child with Hemoptysis and Fontan Circulation

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Open Journal of Pediatrics 2020年第2期10卷 280-287页

作者： Claudine Kumba Gauthier Loron Anais Mons Claude marcus Francis Grossenbacher Nathalie Bednarek-Weirauch Vito Giovanni Ruggieri Emre Belli Jean-marc Malinovsky Pierre Mauran Department of Anesthesia and Critical Care CHU Reims Reims France Department of Pediatric Anesthesia and Critical Care HU Necker Enfants Malades University Hospital Assistance Publique Hopitaux de Paris Paris France Department of Pediatric and Neonatal Intensive Care CHU Reims Reims France Department of Radiology CHU Reims Reims France Department of Intensive Care and Emergency Medicine CHU Reims Reims France Department of Thoracic and Cardiovascular Surgery CHU Reims Reims France Department of Pediatric Cardiac Surgery Marie Lannelongue Hospital Le Plessis Robinson France Department of Pediatric Cardiology and Congenital Heart Diseases American Memorial Hospital CHU Reims Reims France

Background: Extracorporeal membrane oxygenation is a rescue life support technique used in life threatening conditions of refractory respiratory and/or cardiac distress. Indication for extracorporeal life support in children depends on age and varies from pulmonary to cardiac pathologies. In some cases, it may be used as a bridge to a therapeutic procedure. We described here the management of respiratory failure due to hemoptysis in a child with a Fontan circulation and veno-venous extracorporeal membrane oxygenation which served as a bridge to angio-embolization. Hemoptysis can be a life threatening condition which can lead to hypovolemic shock and impaired alveolar gas exchange. The latter can result in respiratory failure and consequent asphyxia. When hemoptysis occurs in a patient with a univentricular heart and a Fontan circulation, management of this clinical situation can be challenging due to the particular physiology of the latter. Total cavopulmonary connection is a palliative surgical repair whi

关键词： Extracorporeal Membrane Oxygenation Fontan Circulation Univentricular Heart Tricuspid Atresia Children One Lung Ventilation Mobile ECMO Team Pediatric Anesthesia and Critical Care Angio-Embolization Interventional Radiology Pediatric Cardiology Pediatric Cardiac Surgery Trans-Thoracic Echocardiography Aortic Velocity Time Integral Fluid Responsiveness Goal Directed Fluid and Hemodynamic Therapy

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