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Development of Non-ABO Red Blood Cell Alloantibodies in Patient Undergoing Allogeneic Haematopoietic Stem Cell Transplant

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Case Reports in Clinical Medicine 2024年第5期13卷 162-170页

作者： ahmed Alsuhaibani Khalid Batarfi ahmed Alharbi Haya Alwasel Abdullah Alenazi Abdulmohsen Alotaibi Jalal Hassan Rayyan Alotaibi Hajer Aziz Nourah Alharethi Sara Alobaidi maram Alonayzan Sanad Alharthi Majd Alanazi Sarah Alotaibi ahmed Shareefi Bandar Alqahtani Department of Laboratory and Pathology King Abdulaziz Medical City of National Guard Riyadh Saudi Arabia

Alloantibodies that are non ABO Alloimmunization to protein antigens happens only after exposure, in contrast to ABO isohaemagglutinins, which are present naturally, even in the absence of prior exposure. It is recognized that while non-ABO RBC antibodies are less common than ABO antibodies, they generate essentially the same issues that lead to unfavorable clinical results. If non-ABO alloantibodies are identified early on, these issues related complications may be avoided This call for an in-depth understanding of the recipient and donor’s ABO-Rh grouping, antibody screening, and the phenotype of certain antigens. Equally important, the temporal association time between transplantation and hemolysis can help identify the underlying mechanism of hemolysis and direct appropriate management. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-ABO-incompatible HSCT and the temporal link between HSCT and anemia. Finding the cause of post-HSCT anemia is essential for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-ABO-incompatible HSCT and the temporal link between HSCT and anemia. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia. In this case report review, we would like to highlight the vital role of transfusion medicine services and stem cell clinical teams in paying particular attention to the clinical significance of non-ABO alloantibodies involved to avoid causing overt hemolysis of incompatible donor RBCs or delayed erythropoiesis. Considering the fact that some of the Haematopoietic stem cell transplant centers do not give an attention to the other non-ABO RBC antigens.

关键词： Haematopoietic Stem Cell Transplant (HSCT) Non-ABO Red Blood Cell Antibodies Alloantibodies

An Improved Evolutionary Algorithm for Data Mining and Knowledge Discovery

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Computers, Materials & Continua 2022年第4期71卷 1233-1247页

作者： Mesfer Al Duhayyim Radwa Marzouk Fahd N.Al-Wesabi maram Alrajhi Manar ahmed Hamza Abu Sarwar Zamani Department of Natural and Applied Sciences College of Community-AflajPrince Sattam bin Abdulaziz UniversitySaudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversitySaudi Arabia Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt Department of Computer Science Faculty of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Information Systems Faculty of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlkharjSaudi Arabia

Recent advancements in computer technologies for data processing,collection,and storage have offered several chances to improve the abilities in production,services,communication,and researches.Data mining(DM)is an interdisciplinary field commonly used to extract useful patterns from the data.At the same time,educational data mining(EDM)is a kind of DM concept,which finds use in educational sector.Recently,artificial intelligence(AI)techniques can be used for mining a large amount of data.At the same time,in DM,the feature selection process becomes necessary to generate subset of features and can be solved by the use of metaheuristic optimization algorithms.With this motivation,this paper presents an improved evolutionary algorithm based feature subsets election with neuro-fuzzy classification(IEAFSS-NFC)for data mining in the education sector.The presented IEAFSS-NFC model involves data pre-processing,feature selection,and classification.Besides,the Chaotic Whale Optimization Algorithm(CWOA)is used for the selection of the highly related feature subsets to accomplish improved classification results.Then,Neuro-Fuzzy Classification(NFC)technique is employed for the classification of education data.The IEAFSS-NFC model is tested against a benchmark Student Performance DataSet from the UCI repository.The simulation outcome has shown that the IEAFSS-NFC model is superior to other methods.

关键词： Educational data mining feature selection whale optimization classification

Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool

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World Journal of Gastroenterology 2018年第34期24卷 3919-3926页

作者： Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen Shehi Elona maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar ahmed Baiomi Danial Shaikh Jasbir Makker Division of Gastroenterology Department of Medicine BronxC are Health system Department of Medicine Bronx Care Health system

AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance colonoscopy.METHODS This is a retrospective single center observational study.We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk.We calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence status.RESULTS The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth quintile.The odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was 3.60.CONCLUSION Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities.

关键词： National Cancer Institute Colorectal Cancer Risk-Assessment Tool Colorectal cancer Predictors of colorectal cancer Adenomatous polyps Colonoscopy

Multi-Detector Row Computed Tomography Urography (MDCTU) in the Evaluation of Microscopic Hematuria in Adults

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Open Journal of Radiology 2015年第1期5卷 20-27页

作者： Mohamed A. Mahmoud Mustafa Z. Mahmoud Mohammed A. Ali Omer Mohamed E. M. Garalnabi ahmed Abukonna maram A. Fagiri Basic Sciences Department College of Medical Radiological Sciences Sudan University of Science and Technology Khartoum Sudan Radiology and Medical Imaging Department College of Applied Medical Sciences Salman Bin Abdulaziz University Al-Kharj Kingdom of Saudi Arabia Department of Radiologic Technology College of Applied Medical Sciences Qassim University Al-Qassim Kingdom of Saudi Arabia Radiotherapy and Nuclear Medicine Department College of Medical Radiological Sciences Sudan University of Science and Technology Khartoum Sudan

Multi-detector row computed tomography urography (MDCTU) becomes the imaging modality of choice for evaluation of the kidneys and urinary tract. The aim of this study was to discuss and illustrate the role of MDCTU, on a 32-row CT scanner in the evaluation a variety of entities that were frequently associated with microscopic hematuria in adults. This prospective cohort study was performed in the period of August 2013 to October 2014. Fifty positive participants to microscopic hematuria were examined at the radiology department of Alnilin Diagnostic Medical Center and Antalya Medical Center. Computed tomography urography (CTU) scanning was performed using two powerful performances, high speed multi-detector row on 32-row CT scanners (Siemens Healthcare Global, Somatom Emotion Duo Eco). Statistical analysis was done through the standard Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA) version 15 for windows. MDCTU established the correct cause of microscopic hematuria in (44;88%) of participants. In (6;12%) of participants, no cause of hematuria was identified based on the standard of references. The causes of hematuria in (41;82%) participants were diseases in the upper urinary tract, while urinary bladder neoplasms (2;4%) and diverticulum (1;2%) were the causes of hematuria (3;6%) in the lower urinary tract. Thirty two-row MDCTU scanner demonstrated satisfactory results in the investigation of microscopic hematuria, being able to demonstrate a wide spectrum of diseases affecting the urinary tract is the main advantage of the technique.

关键词： Hematuria Imaging Three-Dimensional Multi-Detector Computed Tomography Urologic Diseases

The Viewpoint of Community Pharmacists about Their Professional Role in Dispensing Beauty Products: A Study from Western Region of Saudi Arabia

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Pharmacology & Pharmacy 2021年第3期12卷 63-72页

作者： Ali Mofleh Alshahrani Taghreed Mubarak Alotaibi Nawal Safar Alrabie Bashayer Mohammed Althobaiti Fatimah Nasser Alshelawi maram Abdullah Althobaiti Mona Yaser Alsheikh ahmed Ibrahim Fathelrahman Department of Clinical Pharmacy College of Pharmacy Taif University Taif Kingdom of Saudi Arabia

Background: Community pharmacists play a significant role in dispensing and counseling about medications and pharmaceuticals including beauty and cosmetic products. Aims and Objectives: The current study was conducted to assess the viewpoint of community pharmacists in the Western region of Saudi Arabia about their professional role in dispensing beauty products. Methods: A cross-sectional study was conducted between September and December 2019 using an online questionnaire. Expert professors from college of pharmacy, Taif University validated the questionnaire. Results: Five hundred seventy-seven community pharmacists completed the questionnaire. Most of the participants were male (99%) and aged 23 - 34 years old (71.1%). Slightly less than half (45.58%) of community pharmacists have 6 - 10 years of experience. Most pharmacists (96.9%) communicate directly with customers/ patients and most of them (85.3%) ask and counsel patients about their product. Pharmacists strongly agreed that pharmacists must keep in developing their communication skills with customers/patients. Conclusion: Most of the community pharmacists surveyed in this study reported a good perceived knowledge and attitudes and demonstrated an acceptable level of practices regarding beauty products. Saudi FDA is encouraged to adopt Good Pharmacy Practice standards and guidelines to improve current practice of community pharmacists concerning Beauty Products.

关键词： Community Pharmacies Pharmacists Beauty Products Cosmetics Saudi Arabia