检索结果-南通市图书馆

First determination of the highly genotoxic fungal contaminant altertoxin II in a naturally infested apple sample

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging Contaminants 2020年第1期6卷 82-86页

作者： Hannes Puntscher Doris marko Benedikt Warth Department of Food Chemistry and Toxicology Faculty of ChemistryUniversity of ViennaWahringer Str.381090ViennaAustria

Altertoxin II is an epoxide-holding perylene quinone and secondary metabolite produced by Alternaria *** genotoxic potential and the high concentrations determined in laboratory fungal cultures resulted in an increased scientific interest in this emerging ***,no natural occurrence in food has been reported to date to the best of our ***,we unambiguously identified altertoxin II in a naturally infected,unprocessed *** a validated LC-MS/MS method,fruit peel spots(approx.1 mm in diameter),typically associated with Alternaria infestation,were tested for 17 mycotoxins produced by this *** concentrations of tentoxin were determined 24 h after harvest,and the dibenzopyrones alternariol,alternariol monomethyl ether(AME)and AME-3-sulfate after six months of ***,these contamination patterns can be considered unlikely to be of toxicological concern for ***,an inconspicuous peel lesion(0.5×1 cm)separately sampled from a stored apple,exhibited considerably high concentrations of 14 Alternaria toxins,including dibenzopyrones,their barely studied modified forms(glucosides and sulfates),as well as genotoxic perylene quinones including altertoxin *** the toxicological potential of this compound,contaminations in such infected fruit parts should not be underestimated,*** the case of exposure through the consumption of fresh smoothies or fruit juices.

关键词： Alternaria alternata Emerging contaminants Genotoxicity Food safety Plant pathology Liquid chromatography tandem mass spectrometry

Analysis of shock wave unsteadiness using space and time correlations applied to shadowgraph flow visualization data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Aerodynamics 2019年第1期1卷 14-38页

作者： S.marko P.M.Ligrani Propulsion Research Center Department of Mechanical and Aerospace EngineeringUniversity of Alabama in Huntsville5000 Technology DriveOlin B.King Technology Hall S236HuntsvilleAL 35899USA

Unsteady flow characteristics of a normal shock wave,a lambda foot,and a separated turbulent boundary layer are investigated within a unique test section with supersonic inlet *** supersonic wind tunnel facility,containing this test section,provides a Mach number of approximately 1.54 at the test section *** shadowgraph flow visualization data are employed to visualize shock wave structure within the test *** data are analyzed to determine shock wave unsteadiness characteristics,including grayscale spectral energy variations with frequency,as well as time and space correlations,which give coherence and time lag properties associated with perturbations associated with different flow *** illustrate the complexity and unsteadiness of shock-wave-boundary-layerinteractions,including event frequencies from grayscale spectral energy distributions determined using a Lagrangian approach applied to shock wave location,and by grayscale spectral energy distributions determined using ensemble-averaging applied to multiple closely-located stationary pixel ***-correlation function results and two-point correlation functions(in the form of magnitude squared coherence)quantify the time-scales of periodic events,as well as the coherence of flow perturbations associated with different locations,over a range of *** time lag data provide information on the originating location of perturbation events,as well as the propagation direction and event sequence associated with different flow *** insight into spatial variations of time lag and flow coherence is provided by application of magnitude squared coherence analysis to multiple locations,relative to a single location associated with the normal shock wave.

关键词： Shock wave Supersonic flow Time correlation Spatial correlation Autocorrelation Two-point correlation Frequency spectra Magnitude squared coherence Time lag Lagrangian flow analysis Unsteady flow analysis

Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第11期12卷 1942-1956页

作者： marko Grahovac marko Kumric Marino Vilovic Dinko Martinovic Ante Kreso Tina Ticinovic Kurir Josip Vrdoljak Karlo Prizmic Joško Božić Department of Pharmacology University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

BACKGROUND In recent years,American Diabetes Association started to strongly advocate the Mediterranean diet(MD)over other diets in patients with diabetes mellitus(DM)because of its beneficial effects on glycemic control and cardiovascular(CV)risk *** levels of advanced glycation endproducts(AGEs)emerged as an indicator of CV risk in *** biopsy being invasive,the use of AGE Reader has been shown to reflect tissue AGEs *** To examine the association between adherence to MD and AGEs in patients with DM type *** This cross-sectional study was conducted on 273 patients with DM type II.A survey questionnaire was composed of 3 separate *** first part of the questionnaire included general data and the habits of the *** second part aimed to assess the basic parameters of participants’diseases and associated *** third part of the questionnaire was the Croatian version of the 14-item MD service score(MDSS).AGEs levels and associated CV risk were measured using AGE Reader(DiagnOptics Technologies BV,Groningen,The Netherlands).RESULTS A total of 27(9.9%)patients fulfilled criteria for adherence to MD,with a median score of 8.0(6.0-10.0).Patients with none/limited CV risk had significantly higher percentage of MD adherence in comparison to patients with increased/definite CV risk(15.2%vs 6.9%,P=0.028),as well as better adherence to guidelines for nuts(23.2%vs 12.6%,P=0.023)and legumes(40.4%vs 25.9%,P=0.013)*** number of patients with glycated hemoglobin(HbA1c)ared to patients with HbA1c>7%(14.9%vs 7.3%,P=0.045).Moreover,those patients followed the MDSS guidelines for eggs(33.0%vs 46.8%,P=0.025)and wine(15.6%vs 29.8%,P=0.006)consumption more *** score had significant positive correlation with disease duration(r=0.179,P=0.003)and negative correlation with body mass index(BMI)values(r=-0.159,P=0.008).In the multiple linear regression model,BMI(β±SE,-0.09±0.04,P=0.037

关键词： Mediterranean diet Cardiovascular disease Diabetes mellitus Advanced glycation endproducts Dietary habits Atherosclerosis

Origins of high ductility exhibited by an extruded magnesium alloy Mg-1.8Zn-0.2Ca:Experiments and crystal plasticity modeling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第25期84卷 27-42页

作者： Jie Wang Gaoming Zhu Leyun Wang Evgenii Vasilev Jun-Sang Park Gang Sha Xiaoqin Zeng marko Knezevic National Engineering Research Center of Light Alloy Net Forming Shanghai Jiao Tong UniversityShanghai200240China Department of Mechanical Engineering University of New HampshireDurhamNH03824USA Advanced Photon Source Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai200240China

Low ductility and strength are major bottlenecks against Mg alloys’wide *** this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can be extruded at low temperatures(~250℃)and high speeds(~2 mm/s).After the extrusion,this alloy exhibits a substantially weakened basal texture,relatively small grain size,very high tensile elongation(~30%),and good *** origin of the considerably improved ductility was studied using a combination of three-dimensional atom probe tomography(3D-APT),transmission electron microscopy(TEM),electron backscattered diffraction(EBSD)in conjunction with surface slip trace analysis,in-situ synchrotron X-ray diffraction,and elasto-plastic self-consistent(EPSC)***-segregation of Zn and Ca atoms at a grain boundary is observed and associated with texture weakening and grain boundary mediated plasticity,both improving the *** basal slip and prismatic slip are identified as the dominant deformation systems in the alloy,the ratio between their slip resistances is substantially reduced relative to pure Mg and most other Mg alloys,significantly contributing to the improved ductility of the *** Mg-Zn-Ca alloy exhibiting excellent mechanical properties and low fabrication cost is a promising candidate for industrial productions.

关键词： Mg-Zn-Ca alloy Ductility Deformation mechanisms Crystal plasticity modeling Grain boundary mediated plasticity

Diabetes Prediction Algorithm Using Recursive Ridge Regression L2

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第4期71卷 457-471页

作者： Milos Mravik T.Vetriselvi K.Venkatachalam marko Sarac Nebojsa Bacanin Sasa Adamovic Department of Computer Science Singidunum UniversityBelgrade11000Serbia Department of Computer science and Engineering K.Ramakrishnan College of TechnologyTrichy621112India Department of Applied Cybernetics Faculty of ScienceUniversity of Hradec Králové50003Hradec KrálovéCzech Republic

At present,the prevalence of diabetes is increasing because the human body cannot metabolize the glucose *** prediction of diabetes patients is an important research *** researchers have proposed techniques to predict this disease through data mining and machine learning *** prediction,feature selection is a key concept in ***,the features that are relevant to the disease are used for *** condition improves the prediction *** the right features in the whole feature set is a complicated process,and many researchers are concentrating on it to produce a predictive model with high *** this work,a wrapper-based feature selection method called recursive feature elimination is combined with ridge regression(L2)to form a hybrid L2 regulated feature selection algorithm for overcoming the overfitting problem of data *** is a major problem in feature selection,where the new data are unfit to the model because the training data are *** regression is mainly used to overcome the overfitting *** features are selected by using the proposed feature selection method,and random forest classifier is used to classify the data on the basis of the selected *** work uses the Pima Indians Diabetes data set,and the evaluated results are compared with the existing algorithms to prove the accuracy of the proposed *** accuracy of the proposed algorithm in predicting diabetes is 100%,and its area under the curve is 97%.The proposed algorithm outperforms existing algorithms.

关键词： Ridge regression recursive feature elimination random forest machine learning feature selection

Periodic Solutions in Unbounded Domains for the Boussinesq System

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2010年第5期26卷 837-862页

作者： Elder Jesús VILLAMIZar-ROA María ngeles RODRíGUEZ-BELLIDO marko Antonio ROJAS-MEDar Escuela de Matemáticas Universidad Nacional de Colombia Dpto. Ecuaciones Diferenciales y Análisis Numérico Universidad de Sevilla Aptdo Dpto. de Ciencias Básicas Facultad de Ciencias Universidad del Bío BíoCampus Fernando May

Assuming that the external forces of the system are small enough, the reference temperature being a periodic function, we study the existence, the uniqueness and the regularity of time-periodic solutions for the Boussinesq equations in several classes of unbounded domains of Rn. Our analysis is based on the framework of weak-Lp spaces.

关键词： Boussinesq equations strong periodic solutions unbounded domains

Endoclips vs large or small-volume epinephrine in peptic ulcer recurrent bleeding

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第18期18卷 2219-2224页

作者： Neven Ljubicic Ivan Budimir Alen Biscanin marko Nikolic Vladimir Supanc Davor Hrabar Tajana Pavic Department of Internal Medicine 'Sestre milosrdnice' University Hospital Center10000 ZagrebCroatia

AIM:To compare the recurrent bleeding after endoscopic injection of different epinephrine volumes with hemoclips in patients with bleeding peptic ***:Between January 2005 and December 2009,150 patients with gastric or duodenal bleeding ulcer with major stigmata of hemorrhage and nonbleeding visible vessel in an ulcer bed(Forrest Ⅱa) were included in the *** were randomized to receive a small-volume epinephrine group(15 to 25 mL injection group;Group 1,n = 50),a large-volume epinephrine group(30 to 40 mL injection group;Group 2,n = 50) and a hemoclip group(Group 3,n = 50).The rate of recurrent bleeding,as the primary outcome,was compared between the groups of patients included in the *** outcomes compared between the groups were primary hemostasis rate,permanent hemostasis,need for emergency surgery,30 d mortality,bleeding-related deaths,length of hospital stay and transfusion ***:Initial hemostasis was obtained in all *** rate of early recurrent bleeding was 30%(15/50) in the small-volume epinephrine group(Group 1) and 16%(8/50) in the large-volume epinephrine group(Group 2)(P = 0.09).The rate of recurrent bleeding was 4%(2/50) in the hemoclip group(Group 3);the difference was statistically significant with regard to patients treated with either small-volume or large-volume epinephrine solution(P = 0.0005 and P = 0.045,respectively).Duration of hospital stay was significantly shorter among patients treated with hemoclips than among patients treated with epinephrine whereas there were no differences in transfusion requirement or even 30 d mortality between the ***:Endoclip is superior to both small and large volume injection of epinephrine in the prevention of recurrent bleeding in patients with peptic ulcer.

关键词： Peptic ulcer Hemorrhage Hemoclip Epinephrine Nonvariceal upper gastrointestinal bleeding

Impact of the COVID-19 pandemic on inflammatory bowel disease patients:A review of the current evidence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第25期27卷 3748-3761页

作者： marko Kumric Tina Ticinovic Kurir Dinko Martinovic Piero Marin Zivkovic Josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia

Since the initial coronavirus disease 2019(COVID-19)outbreak in China in December 2019,the infection has now become the biggest medical issue of modern *** major contributors that amplified the impact of the disease and subsequently increased the burden on health care systems were high mortality among patients with multiple co-morbidities and overcapacity of intensive care *** the gastroenterology-related community,particular concern was raised with respect to patients with inflammatory bowel disease(IBD),as those patients are prone to opportunistic infections mainly owing to their immunosuppressive-based ***,we sought to summarize current knowledge regarding COVID-19 infection in patients with ***,it seems that IBD is not a comorbidity that poses an increased risk for COVID-19 acquisition,except in patients treated with ***,outcomes of the infected patients are largely dependent on therapeutic modality by which they are treated,as some worsen the clinical course of COVID-19 infection,whereas others seem to dampen the detrimental effects of ***,we discussed the present and the future impact of COVID-19 pandemic and concomitantly increased health care burden on IBD-management.

关键词： COVID-19 SarS-CoV-2 Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第30期18卷 3945-3954页

作者： Neven Bari Ivan Leroti Lea Smiri-Duvnjak Vedran Tomai marko Duvnjak Division of Gastroenterology and Hepatology Department of Medicine"Sestre milosrdnice" University Hospital Center10000 ZagrebCroatia Vuk Vrhovac University Clinic for Diabetes Endocrinology and Metabolic Diseases10000 ZagrebCroatia

High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology *** methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver *** tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis *** all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative *** present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Liver biopsy Biomarkers Transient elastography Cytokeratin-18 Oxidative stress Insulin resistance Hyaluronic acid