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Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： maría l bacigalupo pablo carabias maría f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

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World Journal of Stem Cells 2020年第2期12卷 100-109页

作者： maría álvarez-Viejo Unidad de Terapia Celulary Medicina Regenerativa Servicio de Hematologíay Hemoterapia Hospital Universitario Central de Asturias Plataforma de Terapias Avanzadas Instituto de Investigación Sanitaria del Principado de Asturias

Since the introduction of cell therapy as a strategy for the treatment of many diseases,mesenchymal stem cells have emerged as ideal candidates,yet the underlying mechanisms of their beneficial effects are only partially *** the start of the 21st century,a paracrine effect was proposed as a mechanism of tissue repair by these *** addition,a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell *** of these vesicles including exosomes have been isolated from most fluids and cells,as well as from supernatants of in vitro cell *** research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic *** review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy:bone marrow,adipose tissue,and umbilical cord.

关键词： Mesenchymal stem cells Exosomes Cellular therapy

How large are the extinct giant insular rodents? New body mass estimations from teeth and bones

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Integrative Zoology 2014年第2期9卷 197-212页

作者： Blanca MONCUNILL-SOLÉ Xavier JORDANA Nekane marÍN-MORATALLA Salvador MOYÀ-SOLÀ Meike kÖHLER Catalan Institute of Paleontology Miquel Crusafont Autonomous University of BarcelonaBellaterraSpain ICREA at Catalan Institute of Paleontology Miquel Crusafont Autonomous University of BarcelonaBellaterraSpain Department of Ecology University of BarcelonaSpain

The island rule entails a modification of the body size of insular mammals,a character related with numerous biological and ecological *** the Miocene to human colonization(Holocene),Mediterranean and Canary Islands were unaltered natural ecosystems,with paleofaunas formed with endemic giant rodents among other *** aim is to create methods to estimate the body masses of fossil island rodents and address the nature of ecological pressures driving the island *** created regression equations based on extant ro-dent data and used these to estimate the body masses of the extinct *** results show strong correlations between teeth,cranial and postcranial measurements and body mass,except for the length of the long bones,the transversal diameter of the distal tibia and the anteroposterior diameter of the proximal tibia,where the equa-tions were less *** use of equations obtained from a more homogeneous group(suborder and family)is preferable when analyzing the area of the first *** new regressions were applied to estimate the body masses of some Mediterranean and Canarian fossil rodents(Canariomys,*** 1.5 kg and *** 1 kg;Hypnomys,*** 230 g and *** 200 g;and Muscardinus cyclopeus 100 g).Our results indi-cate that under absence of predation,resource availability(island area)is the key factor that determines the size of the Canariomys ***,under presence of specialized predators(birds of prey),body size evolution is less pronounced(Hypnomys sp.).

关键词： body mass Canariomys Hypnomys island rule Muscardinus cyclopeus

Existence and Uniqueness to a Fully Nonlinear Version of the Loewner–Nirenberg Problem Dedicated to Celebrate the Sixtieth Anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 269-288页

作者： maría del mar González YanYan Li Luc Nguyen Departamento de Matemáticas Universidad Autónoma de MadridCampus de Cantoblanco28049 MadridSpain Department of Mathematics Hill CenterBusch CampusRutgers University110 Frelinghuysen RoadPiscatawayNJ 08854USA Mathematical Institute and St Edmund Hall University of OxfordAndrew Wiles BuildingRadcliffe Observatory QuarterWoodstock RoadOxford OX26GGUK

We consider the problem of finding on a given Euclidean domainof dimension n≥3 a complete conformally flat metric whose Schouten curvature A satisfies some equations of the form f(λ(−A))=*** generalizes a problem considered by Loewner and Nirenberg for the scalar *** prove the existence and uniqueness of such metric when the boundary δΩ is a smooth bounded hypersurface(of codimension one).When δΩ contains a compact smooth submanifold ∑ of higher codimension with δΩ\∑ being compact,we also give a‘sharp’condition for the divergence to infinity of the conformal factor near ∑ in terms of the codimension.

关键词： Fully nonlinear Loewner-Nirenberg problem Singular fully nonlinear Yamabe metrics Conformal invariance

Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： Jose Enrique marTÍN-ALFONSO maría Jose marTÍN-ALFONSO Concepción VALENCIA maría Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remarkable lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

Brain and spinal cord trauma:what we know about the therapeutic potential of insulin growth factor 1 gene therapy

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Neural Regeneration Research 2023年第2期18卷 253-257页

作者： maría Jose Bellini Florencia Labombarda Lab de Bioquímica del Envejecimiento INIBIOLP-CONICETFacultad de Ciencias MedicinaUniversidad Nacional de La PlataLa PlataArgentina Laboratory of Neuroendocrine Biochemistry IBYME-CONICETBuenos AiresArgentina Department of Human Biochemistry Faculty of MedicineUniversidad de Buenos AiresBuenos AiresArgentina

Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal co rd injury,several reports have described impairments in cognitive *** group also has contributed significantly to the study of cognitive impairments in a rat model of spinal co rd *** findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes,drugs of abuse,and combined *** are related to changes in brain structures involved in cognition and emotion,such as the *** spinal cord injury decreases neurogenesis,enhances glial reactivity leading to hippocampal neuroinflammation,and trigge rs cognitive *** brain distal abnormalities are recently called te rtiary *** that there is no treatment for Tertiary Damage,insulin growth factor 1 gene therapy emerges as a good *** growth factor 1 gene thera py recove rs neurogenesis and induces the polarization from pro-inflammato ry towards anti-inflammatory microglial phenotypes,which represents a potential strategy to treat the neuroinflammation that supports te rtiary *** growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is *** growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.

关键词： cognitive impairments gene therapy hippocampus insulin growth factor 1 microglial cells neurodegeneration neurogenesis neuroinflammation spinal cord injury traumatic brain injury

重症监护室护士限制治疗努力的能力:整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 143-154,I0003页

作者： Elvia R.Lopez-Panza Vanessa C.Pacheco-Roys kelly J.Fernandez-Ahumada Diana C.Díaz-Mass maría Y.Exposito-Concepcion Elizabeth Villarreal-Cantillo Cesar I.Aviles Gonzalez Nursing Department Universidad del NorteBarranquillaColombia Nursing Program Faculty of Health SciencesUniversidad Popular del CesarValleduparColombia Clínica Valledupar ValleduparColombia Hospital Universidad del Norte SoledadColombia Department of Medical Sciences and Public Health University of CagliariCittadella Universitaria di MonserratoCagliariItaly

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对... 详细信息

目的在重症监护病房(IntensiveCareUnit,ICU),护土难免会遇到需要限制治疗努力(limiting therapeutie efort,LTE)的患者,尽管多数护士还缺乏为这些临终患者及其家庭提供支持的准备。本综述旨在描述ICU护士在LTE中需要具备的能力。方法对2010年--2023年发表的文献进行综述。系统检索了5个数据库:Medline、Wiley Online Library、SciELO、ScienceDirect和Web of Science。使用关键评估项目工具西班牙语版(Critical Appraisal Skills Programme in Spanish,CASPe)作为评判性阅读工具。使用牛津循证医学中心(Center for Evidence-Based Medicine.,CEBM)评估工具确定证据级别和推荐强度。结果共纳入25篇文献。ICU护士LTE护理的能力包括对患者的直接护理、以家庭为中心的护理以及护士在团队中的作用。该综述确定了3个类别的能力:作为患者、家庭与跨学科团队之间维护者的能力,在LTE方面的决策能力,在患者生命末期治疗和护理干预的能力。结论ICU护士在LTE方面需要具备相应的能力,这对患者的生活质量死亡尊严以及患者家庭应对悲伤的全面支持至关重要。

关键词：重症监护家庭支持重症监护病房护士的作用安宁疗护专业能力

Weighted Inequalities for Fractional Type Operators with Some Homogeneous kernels

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Acta Mathematica Sinica,English Series 2013年第3期29卷 449-460页

作者： maría Silvina RIVEROS marta URCIUOLO FaMAF-UNC CIEM-CONICET Ciudad Universitaria

In this paper, we study integral operators of the formappropriate weighted BMO and weak type estimates for certain weights satisfying the above inequality. We also give a Coifman type estimate for these operators.

关键词： Fractional operators Calderon-Zygmund operators BMO Muckenhoupt weights

Cellular automata model for traffic flow with safe driving conditions

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Chinese Physics B 2014年第5期23卷 216-226页

作者： maría Elena Lárraga Luis Alvarez-Icaza Instituto de Ingeniería Universidad Nacional Autónoma de México04510Coyoacán D.F.México

In this paper, a recently introduced cellular automata （CA） model is used for a statistical analysis of the inner micro-scopic structure of synchronized traffic flow. The analysis focuses on the formation and dissolution of clusters or platoons of vehicles, as the mechanism that causes the presence of this synchronized traffic state with a high flow. This platoon formation is one of the most interesting phenomena observed in traffic flows and plays an important role both in manual and automated highway systems （AHS）. Simulation results, obtained from a single-lane system under periodic boundary conditions indicate that in the density region where the synchronized state is observed, most vehicles travel together in pla- toons with approximately the same speed and small spatial distances. The examination of velocity variations and individual vehicle gaps shows that the flow corresponding to the synchronized state is stable, safe and highly correlated. Moreover, results indicate that the observed platoon formation in real traffic is reproduced in simulations by the relation between vehicle headway and velocity that is embedded in the dynamics definition of the CA model.

关键词： traffic flow models synchronized traffic cellular automata platoons formation