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Randomized Trial of Ciclosporin with 2-h Monitoring *** with Trough Monitoring in Liver Transplantation:DELTA Study

Journal of Clinical and Translational Hepatology 2023年第4期11卷 839-849页

作者： Bastian N.Ruijter Akin Inderson Aad Pvan den Berg Herold J.Metselaar Jeroen Dubbeld Maarten E.Tushuizen Robert J.Porte Wojciech Polak Danny van der Helm marjolein van Reeven mar Rodriguez-Girondo Bart van Hoek Department of Gastroenterology and Hepatology LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Gastroenterology and Hepatology University Medical Center GroningenGroningenThe Netherlands Department of Gastroenterology and Hepatology Erasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Surgery LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Surgery Section HPB Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Department of Surgery Division of HPB and Transplant SurgeryErasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Biomedical Data Sciences Leiden University Medical CenterLeidenThe Netherlands.

Background and Aims:Previous trials comparing cyclosporine and tacrolimus after liver transplantation(LT)showed conflicting *** used trough monitoring for cyclosporine(C0),leading to less accurate dosing than with 2-h monitoring(C2).Only one larger trial compared C2 with tacrolimus based on trough level(T0)after LT,with similar treated biopsy-proven acute rejection(tBPAR)and graft loss,while a smaller trial had less tBPAR with C2 compared to ***,it is still unclear which calcineurin inhibitor is preferred after *** aimed to demonstrate superior efficacy(tBPAR),tolerability,and safety of C2 or T0 after first ***:Patients after first LT were randomized to C2 or ***,patient-and graft survival,safety and tolerability were the main endpoints,with analysis by Fisher test,Kaplan-Meier survival analysis and log-rank ***:In intention-totreat analysis 84 patients on C2 and 85 on T0 were *** incidence of tBPAR C2 vs.T0 was 17.7%vs.8.4%at 3 months(p=0.104),and 21.9%vs.9.7%at 6 and 12 months(p=0.049).One-year cumulative mortality C2 vs.T0 was 15.5%vs.5.9%(p=0.049)and graft loss 23.8%vs.9.4%(p=0.015).Serum triglyceride and LDL-cholesterol was lower with T0 than with *** of diarrhea in T0 vs,C2 was 64%vs.31%(p≤0.001),with no other differences in safety and ***:In the first year after LT immunosuppression with T0 leads to less tBPAR and better patient-/re-transplant-free survival as compared to C2.

关键词： Adverse effects Ciclosporin Liver transplantation Outcome Randomized controlled trial Rejection Survival Renal function Tacrolimus

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The effect of mixed vaccination rollout strategy:A modelling study

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Infectious Disease Modelling 2023年第2期8卷 318-340页

作者： Nico Stollenwerk Carlo Delfin S.Estadilla Javier mar Joseba Bidaurrazaga van-Dierdonck Oliver Ibarrondo Ruben Blasco-Aguado Maíra Aguiar BCAM-Basque Center for Applied Mathematics BilbaoBasque CountrySpain Dipartimento di Matematica Universita degli Studi di TrentoPovoTrentoItaly Osakidetza Basque Health Service GuipúzcoaBasque CountrySpain Biodonostia Health Research Institute GuipúzcoaBasque CountrySpain Public Health Basque Health DepartmentBilbaoBasque CountrySpain Ikerbasque Basque Foundation for ScienceBilbaoBasque CountrySpain Preventive Medicine and Public Health Department University of the Basque CountryLeioaBasque CountrySpain

Vaccines have measurable efficacy obtained first from vaccine ***,vaccine efficacy(VE)is not a static measure and long-term population studies are needed to evaluate its performance and ***-19 vaccines have been developed in record time and the currently licensed vaccines are extremely effective against severe disease with higher VE after the full immunization *** assess the impact of the initial phase of the COVID-19 vaccination rollout programmes,we used an extended Susceptible-Hospitalized-Asymptomatic/mild-Recovered(SHAR)*** models were proposed to evaluate different vaccine types:vaccine type 1 which protects against severe disease only but fails to block disease transmission,and vaccine type 2 which protects against both severe disease and *** was assumed as reported by the vaccine trials incorporating the difference in efficacy between one and two doses of vaccine *** described the performance of the vaccine in reducing hospitalizations during a momentary scenario in the Basque Country,*** a population in a mixed vaccination setting,our results have shown that reductions in hospitalized COVID-19 cases were observed five months after the vaccination rollout started,from May to June *** in June,a good agreement between modelling simulation and empirical data was well pronounced.

关键词： COVID-19 Vaccine efficacy Bayesian approach Herd immunity

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Implementing a DIKW model on a deep mine cooling system

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International Journal of Mining Science and Technology 2019年第2期29卷 319-326页

作者： Jan Gabriel Pretorius marc John Mathews Philip maré marius Kleingeld Johann van Rensburg Centre for Research and Continued Engineering Development North-West University Pretoria 0081 South Africa TEMM International (Pty) Ltd

The South African mining industry has been experiencing increasing economic pressure. Deep mines also suffer from very hot workplaces, which leads to safety risks. These factors place stress on managers to reach their production targets while providing safe workplace conditions. The data information knowledge wisdom(DIKW) model, also known as the wisdom hierarchy, was implemented on a deep mine cooling system. This study aims to show that a simple model such as the DIKW model can assist managers in improving their deep mine cooling system's performance. The study found that the DIKW approach is a suitable approach for use on mine cooling systems to facilitate operational *** the DIKW approach to a case study on a mine cooling system created substantial awareness and facilitated a cooling duty improvement of 55% which relates to an increase of 5.3 MW of refrigeration. The results of this study indicate that the DIKW approach may be a suitable approach to optimise management on deep mines using their existing infrastructure.

关键词： DIKW Cooling system Mining Reporting

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A CLUSTERING ALGORITHM FOR MIXED NUMERIC AND CATEGORICAL DATA

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Journal of Systems Science & Complexity 2003年第4期16卷 562-571页

作者： Ohn mar San van-Nam Huynh Yoshiteru Nakamori School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Tatsunokuchi Ishikawa 923-1292 JapanSchool of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Tatsunokuchi Ishikawa 923-1292 JapanSchool of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Tatsunokuchi Ishikawa 923-1292 Japan

Most of the earlier work on clustering mainly focused on numeric data whose inherent geometric properties can be exploited to naturally define distance functions between data points. However, data mining applications frequently involve many datasets that also consists of mixed numeric and categorical attributes. In this paper we present a clustering algorithm which is based on the k-means algorithm. The algorithm clusters objects with numeric and categorical attributes in a way similar to k-means. The object similarity measure is derived from both numeric and categorical attributes. When applied to numeric data, the algorithm is identical to the k-means. The main result of this paper is to provide a method to update the 'cluster centers' of clustering objects described by mixed numeric and categorical attributes in the clustering process to minimise the clustering cost function. The clustering performance of the algorithm is demonstrated with the two well known data sets, namely credit approval and abalone databases.

关键词：数据挖掘数字数据分类数据聚类算法数据库数据集

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Thermoregulatory function and sexual dimorphism of the throat sack in Helmeted Guineafowl(Numida meleagris)across Africa

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Avian Research 2022年第3期13卷 239-248页

作者： Johann H.van Niekerk Rodrigo Megía-Palma Giovanni Forcina Department of Environmental Sciences College of Agriculture and Environmental SciencesUniversity of South AfricaP.O.Box 392Pretoria0003South Africa Universidad de Alcal a(UAH) Department of Biomedicine and BiotechnologySchool of PharmacyA-2 Highwaykm 33.60028805Alcal a de HenaresMadridSpain Universidad de Alcal a(UAH) Global Change Ecology and Evolution Research Group(GloCEE)Departamento de Ciencias de la Vida28805Alcal a de HenaresMadridSpain CIBIO Centro de Investigaç~ao em Biodiversidade e Recursos Gen eticosInBIO Laborat orio AssociadoCampus de Vair~aoUniversidade do Porto4485-661Vair~aoPortugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de Vair~ao4485-661Vair~aoPortugal

The responses of ground-dwelling birds to heat and cold stress encompass a variety of behavioural,physiological and even morphological ***,the role of glabrous skin in this respect has been marginally addressed so *** Helmeted Guineafowl(Numida meleagris)is a landfowl distributed across Sub-Saharan Africa with eight traditionally recognised extant *** the most prominent morphological traits underlying intraspecific variability are size and pigmentation of the bare throat skin(or sack),which might be related to the different habitats and environmental conditions across its wide *** order to explore the Helmeted Guineafowl range-wide sack variation and pigmentation in relation to thermoregulation and sexual signalling,we collected morphometric and environmental information for *** integrating field data with the inspection of photographic material encompassing seven subspecies and environmental information from their *** data evidenced that sack size was significantly correlated with ambient temperature,thus pointing to a likely involvement of the throat sack in *** the pictorial data from all subspecies were pooled,sack size correlated negatively with biomass,rainfall and humidity,while a positive correlation was found with annual solar *** size correlated positively with monthly temperature variation among the bluethroated subspecies from southern Africa as opposed to the black-throated subspecies ranging north to Zambia and ***,in this latter group the sack was often larger during winter months,possibly to maximise solar radiation ***,sack size was related to sex dimorphism in two *** morphology and colour in the Helmeted Guineafowl likely modulate body temperature by evaporative cooling or heating upon needs,but in some subspecies it is also seemingly related to sexual *** studies are needed to fully understand the mu

关键词： Evaporative cooling Helmeted guineafowl Sexual size dimorphism Sub-Saharan Africa Thermoregulation Throat sack

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Meta-analysis of CO_(2) conversion,energy efficiency,and other performance data of plasma-catalysis reactors with the open access PIONEER database

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Journal of Energy Chemistry 2023年第11期86卷 318-342,I0007页

作者： Antoine Salden Maik Budde Carolina A.Garcia-Soto Omar Biondo Jairo Barauna marzia Faedda Beatrice Musig ChloéFromentin Minh Nguyen-Quang Harry Philpott Golshid Hasrack Domenico Aceto Yuxiang Cai Federico Azzolina Jury Annemie Bogaerts Patrick Da Costa Richard Engeln maría Elena Gálvez Timo Gans Tomas Garcia Vasco Guerra Carlos Henriques Monika Motak maria Victoria Navarro Vasile I.Parvulescu Gerard van Rooij Bogdan Samojeden Ana Sobota Paolo Tosi Xin Tu Olivier Guaitella Department of Physics University of Trento38100 PovoItaly Department of Applied Physics and Science Education Eindhoven University of Technology5600 MB EindhovenThe Netherlands Instituto de Plasmas e Fusão Nuclear Instituto Superior TécnicoUniversidade de Lisboa1049-001 LisboaPortugal LPP CNRSÉcole PolytechniqueSorbonne UniversitéUniversitéParis-SaclayIP-Paris 91128 PalaiseauFrance Department of Organic Chemistry Biochemistry and CatalysisUniversity of BucharestBucharestRomania Research Group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1Wilrijk B-2610Belgium DIFFER 5612AJ EindhovenThe Netherlands Instituto de Carboquímica ICB-CSIC Zaragoza 50018Spain Faculty of Energy and Fuels AGH University of KrakowKrakowPoland Institut Jean le Rond d’Alembert CNRS UMR 7190-Sorbonne UniversitéSaint-Cyr l’Ecole 78210France Laboratoire Catalyse et Spectrochimie(LCS) CNRS-ENSICAEN-Universitéde Caen6 boulevard du Maréchal-Juin14000 CaenFrance CQE Centro de Química EstruturalInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisboaPortugal School of Physical Sciences and National Centre for Plasma Science and Technology Faculty of Science and HealthDublin City UniversityDublinIreland ASML De Run 65015504 DR VeldhovenThe Netherlands Faculty of Science and Engineering Maastricht University6229 GS MaastrichtThe Netherlands CNR Istituto per la Scienza e Tecnologia dei Plasmi(ISTP)Italy Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This paper brings the comparison of performances of CO_(2)conversion by plasma and plasma-assisted catalysis based on the data collected from literature in this field,organised in an open access online *** tool is open to all users to carry out their own analyses,but also to contributors who wish to add their data to the database in order to improve the relevance of the comparisons made,and ultimately to improve the efficiency of CO_(2)conversion by *** creation of this database and database user interface is motivated by the fact that plasma-catalysis is a fast-growing field for all CO_(2)conversion processes,be it methanation,dry reforming of methane,methanolisation,or *** a result of this rapid increase,there is a need for a set of standard procedures to rigorously compare performances of different ***,this is currently not possible because the fundamental mechanisms of plasma-catalysis are still too poorly understood to define these standard *** however,the accumulated data within the CO_(2)plasma-catalysis community has become large enough to warrant so-called“big data”studies more familiar in the fields of medicine and the social *** enable comparisons between multiple data sets and make future research more effective,this work proposes the first database on CO_(2)conversion performances by plasma-catalysis open to the whole *** database has been initiated in the framework of a H_(2)0_(2)0 European project and is called the“PIONEER Data Base”.The database gathers a large amount of CO_(2)conversion performance data such as conversion rate,energy efficiency,and selectivity for numerous plasma sources coupled with or without a *** data set is associated with metadata describing the gas mixture,the plasma source,the nature of the catalyst,and the form of coupling with the *** the database itself,a data extraction tool with direct visualisation features or advance

关键词： Open-access database on plasma-catalysis experiment CO_(2) conversion Plasma-catalysis Carbon capture and utilisation(CCU) Energy efficiency Specific energy input Dielectric barrier discharge Packed bed reactor Methanation Dry reforming of methane

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Copper-based oxygen carriers supported with alumina/lime for the chemical looping conversion of gaseous fuels

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Journal of Energy Chemistry 2017年第5期26卷 891-901页

作者： Syed K Haider maría Erans Felix Donat Lunbo Duan Stuart A Scott Vasilije Manovic Edward J Anthony Combustion and CCS Centre Cranfield UniversityBedfordshire MK43 0ALUK Key Laboratory of Energy Thermal Conversion and Control Ministry of EducationSchool of Energy and EnvironmentSoutheast UniversityNanjing 210096JiangsuChina Department of Engineering University of CambridgeTrumpington StreetCambridgeUK

Copper（Ⅱ） oxide in varying ratios was combined with either an alumina-based cement（Al300）, or CaO derived from limestone as support material in a mechanical pelletiser. This production method was used to investigate its influence on possible mechanical and chemical improvements for oxygen carriers in chemical looping processes. These materials were tested in a lab-scale fluidised bed with CO or CH;as a reducing gas at 950 °C. As expected, the oxygen carriers containing a greater ratio of support material exhibited an enhanced crushing strength. Oxygen carriers comprised of a 1:3 ratio of support material to active CuO exhibited increased crushing strength by a minimum of 280% compared to pure CuO *** oxygen carriers exhibited a high CO conversion yield and were fully reducible from CuO to Cu. For the initial redox cycle, Al300-supported oxygen carriers showed the highest fuel and oxygen carrier conversion. The general trend observed was a decline in conversion with an increasing number of redox *** the case of CaO-supported oxygen carriers, all but one of the oxygen carriers suffered *** agglomeration was more severe in carriers with higher ratios of CuO. Oxygen carrier Cu25Al75（75 wt% aluminate cement and 25 wt% CuO）, which did not suffer from agglomeration, showed the highest attrition with a loss of approximately 8% of its initial mass over 25 redox cycles. The reducibility of the oxygen carriers was limited with CH;in comparison to CO. CH;conversion were 15%-25% and 50% for Cu25Ca75（25 wt% CuO and 75 wt% CaO） and Cu25Al75, respectively. Cu25Ca75 demonstrated improved conversion, whereas Cu25Al75 exhibited a trending decrease in conversion with increasing redox cycles.

关键词： Chemical-looping Oxygen carrier Copper Carbon capture

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Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection

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Horticulture Research 2020年第1期7卷 1941-1954页

作者： Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap maría JoséDíez Instituto Universitario de Conservación y Mejora de la Agrodiversidad Valenciana.COMAV.Universitat Politècnica de València ValenciaSpain Department of Biochemistry and Molecular Biology Universitat de ValènciaValenciaSpain Boyce Thompson Institute IthacaNYUSA Institute of Plant Breeding Genetics and GenomicsUniversity of GeorgiaGeorgiaGAUSA Department of Horticulture University of GeorgiaGeorgiaGAUSA

A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum *** and Solanum lycopersicum ***,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and *** collection is enriched with *** *** from the Amazonian region that has not been analyzed previously nor used *** collection has been morphologically characterized showing diversity for fruit,flower and vegetative *** genomes were sequenced in the Varitome project and are publicly available(***/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff *** has shown associations for different traits,demonstrating the potential of this collection for this kind of *** have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence *** speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different *** F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate *** data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC *** these resources together make this collection a good candidate for genetic studies.

关键词： germplasm collection traits

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不同软组织密度值对纵隔占位病变鉴别诊断的意义

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放射学实践 1992年第2期7卷 47-53页

作者： J.Gorich S.A.Beyer-enke G.Layer U.Haberkorn G.van Kaick 张良华 Institut fur Radiologie und Pathophysiologie Deutsches KrebsforschungszentrumIm Neuenheimer Feld 2806900 HeidelbergFRG 同济医科大学附属同济医院

CT对纵隔占位病变的定位很确切,密度分辨力能提供进一步鉴别诊断的依据.

关键词：纵隔占位病变软组织密度值诊断

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肺软骨错构瘤的CT表现

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放射学实践 1991年第4期6卷 159-161页

作者： J.G rich S.A.Beyer-enke G.Probst G.Layer G.van Kaick 张良华 Institut für Radiologie und.Pathophysiologie Deutsches Krebsforschungszentrum Heidelberg 同济医科大学附属同济医院

CT诊断肺球形病灶效果明显提高，并可相对确切地良性和恶性病变。

关键词：肺肿瘤肺软骨错构瘤 CT

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