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Selective neuronal PtEN deletion：can we take the brakes off of growth without losing control？

Neural Regeneration Research 2016年第8期11卷 1201-1203页

作者： Erin A.gutilla Oswald Steward Reeve-Irvine Research Center University of California Irvine School of Medicine Irvine CA USA Department of Anatomy & Neurobiology University of California Irvine School of Medicine Irvine CA USA Department of Neurobiology & Behavior University of California Irvine School of Medicine Irvine CA USA : Department of Neurosurgery University of California Irvine School of Medicine Irvine CA USA Center for the Neurobiology of Learning and Memory University of California Irvine School of Medicine Irvine CA USA

the limited ability for injured adult axons to regenerate is a major cause for limited functional recovery after injury to the nervous system,motivating numerous efforts to uncover mechanisms capable of enhancing regeneration *** promising strategy involves deletion or knockdown of the phosphatase and tensin（PtEN） *** genetic deletion of PtEN before,immediately following,or several months after spinal cord injury enables neurons of the corticospinal tract（CSt） to regenerate their axons across the lesion,which is accompanied by enhanced recovery of skilled voluntary motor functions mediated by the *** conditional genetic deletion or knockdown of PtEN in neurons enables axon regeneration,PtEN is a well-known tumor suppressor and mutations of the PtEN gene disrupt brain development leading to neurological abnormalities including macrocephaly,seizures,and early *** long-term consequences of manipulating PtEN in the adult nervous system,as would be done for therapeutic intervention after injury,are only now being ***,we summarize evidence indicating that long-term deletion of PtEN in mature neurons does not cause evident pathology; indeed,cortical neurons that have lived without PtEN for over 1 year appear robust and *** to date provide only a first look at potential negative consequences of PtEN deletion or knockdown,but the absence of any detectable neuropathology supports guarded optimism that interventions to enable axon regeneration after injury are achievable.

关键词： PtEN rotOR spinal cord injury corticospinal tract motor system axon regeneration recovery of function

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