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Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： mar.a Gracia Luigi-Sierra Almudena Fernández Amparo martínez Dailu Guan Juan Vicente Delgado Javier FernándezÁlvarez Vincenzo Landi Francesc Xavier Such Jordi Jordana mar.a Saura marcel Amills centre for Research in Agricultural Genomics(cRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain Departament de ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,ccL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score

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Oxidative stress,the blood-brain barrier and neurodegenerative diseases:The critical beneficial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares mar.a martínez Bernardo Lopez-Torres mar.a-Rosa martínez-Larran aga Xu Wang Arturo Anadon mar.a-Aranzazu martínez National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awareness of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with neurodegenerative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awareness of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,generally non-toxic nature,and ease of long-term *** review article examines the role of oxidative stress in the development of NDs,explores the‘two-sidedness’of the blood-brain barrier(BBB)as a protective barrier to the nervous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier Neurodegenerative diseases Vitamins carotenoids Flavonoids Polyphenols

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When a general morphology allows many habitat uses

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Integrative Zoology 2016年第6期11卷 483-499页

作者： mar.a J.TULLI Félix B.cRUZ Tiana KOHLSDORF Virginia ABDALA Unidad Ejecutora Lillo(cONIcET)Instituto de Herpetología Fundación Miguel LilloTucumánArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA)cONIcET-UNcOMA BarilocheRío NegroArgentina Departamento de Biologia-FFcLRP Universidade de São PauloRibeirão PretoBrazil Instituto de Biodiversidad Neotropical UNT-CONICETCátedra de Biología GeneralFacultad de Ciencias Naturales e IMLTucumánArgentina

During the last decades the study of functional morphology received more attention incorporating more detailed data corresponding to the internal anatomy that together contribute for a better understanding of the functional basis in *** we focus on 2 lizard families,Tropiduridae and Liolaemidae,and use information related to muscle-tendinous and external morphology traits of hind *** investigate whether the value of the traits analyzed tend to exhibit a reduced phenotypic variation produced by stabilizing selection,and whether species showing specialization in their habitat use will also exhibit special morphological features related to *** a result,we identified that evolution of hind limb traits is mainly explained by the Ornstein-Uhlenbeck model,suggesting stabilizing *** and tropidurids show clear ecomorphological trends in the variables considered,with sand lizards presenting the most specialized morphological *** ecomorphological trends differ between the 2 lineages,and traits of internal morphology tend to be more flexible than those of external morphology,restricting the ability to identify ecomorphs shared between these 2 *** traits of external morphology likely explain such restriction,as ecomorphs have been historically defined in other lizard clades based on variation of external morphology.

关键词： external morphology Lioalemidae muscles tendon Tropiduridae

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Thismia tentaculata(Burmanniaceae tribe Thismieae) from Hong Kong:first record of the genus and tribe from continental china

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Journal of Systematics and Evolution 2009年第6期47卷 605-607页

作者： George W.c.HO Shek Shing mar Richard M.K.SAUNDERS 812 Fu Yuen HouseChuk Yuen South EstateHong KongChina Ying Wa college Hong KongChina Division of Ecology and Biodiversity School of Biological SciencesThe University of Hong Kong

Populations of Thismia tentaculata(Burmanniaceae tribe Thismieae) are described and illustrated from Tai Mo Shan in Hong Kong,southern *** represents the first report of the genus and tribe from continental china.

关键词： Burmanniaceae Hong Kong new record Thismiaceae Thismia tentaculata

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HOP co-chaperones contribute to GA signaling by promoting the accumulation of the F-box protein SNE in Arabidopsis

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Plant communications 2023年第3期4卷 244-257页

作者： Silvina Mangano Alfonso Muñoz Lourdes Fernández-calvino M.mar castellano centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus Montegancedo UPM28223 Pozuelo de Alarcón(Madrid)Spain Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas de Buenos Aires(IIBA CONICET)Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Departamento de Botánica Ecologíay Fisiología VegetalCampus de RabanalesEdificio Severo OchoaUniversidad de Córdoba14071 CórdobaSpain

Gibberellins(GAs)play important roles in multiple developmental processes and in plant response to the *** the GA pathway,a central regulatory step relies on GA-dependent degradation of the DELLA transcriptional ***,the relevance of the stability of other key proteins in this pathway,such as SLY1 and SNE(the F-box proteins involved in DELLA degradation),remains ***,we take advantage of mutants in the HSP70-HSP90 organizing protein(HOP)co-chaperones and reveal that these proteins contribute to the accumulation of SNE in ***,HOP proteins,along with HSP90 and HSP70,interact in vivo with SNE,and SNE accumulation is significantly reduced in the hop ***,greater accumulation of the DELLA protein RGA is observed in these *** agreement with these molecular phenotypes,hop mutants show a hypersensitive response to the GA inhibitor paclobutrazol and display a partial response to the ectopic addition of GA when GA-regulated processes are *** mutants also display different phenotypes associated with alterations in the GA pathway,such as reduced germination rate,delayed bolting,and reduced hypocotyl elongation in response to warm ***,ectopic overexpression of SNE reverts the delay in germination and the thermally dependent hypocotyl elongation defect of the hop1 hop2 hop3 mutant,revealing that SNE accumulation is the key aspect of the hop mutant ***,these data reveal a pivotal role for HOP in SNE accumulation and GA signaling.

关键词： HSP70-HSP90 organizing protein seed germination thermomorphogenesis RGA protein folding protein stability

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Apaf1 inhibition promotes cell recovery From apoptosis

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Protein & cell 2015年第11期6卷 833-843页

作者： Anna Gortat Monica Sancho Laura Mondragon Angel Messeguer Enrique Perez-Paya mar Orzaez Laboratory of Peptide and Protein chemistry Centro de Investigaci6n Principe Felipe 46012 Valencia Spain Department of chemical and Biomolecular Nanotechnology Instituto Quimica Avanzada de CataluSa (CSIC) 08034 Barcelona Spain Instituto de Biomedicina de Valencia IBV-CSIC 46010 Valencia Spain

The protein apoptoUc protease activating factor I （Apafl） is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release from the mitochondria in the intrinsic pathway of apoptosis. We have developed a vital method that allows fluorescence-activated cell sorting of cells at different stages of the apoptotic pathway and demonstrated that upon pharmacological inhibition of Apafl, cells recover from doxorubicinor hypoxia-induced early apoptosis to normal healthy cell. Inhibiting Apafl not only prevents procaspase-9 activation but delays massive mitochondrial damage allowing cell recovery.

关键词： Apaf1 Apaf1 inhibitors apoptosis,apoptosome autophagy cell recovery

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cyclic heptapeptides with metal binding properties isolated from the fungus cadophora malorum from Antarctic soil

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Natural Products and Bioprospecting 2022年第1期12卷 393-402页

作者： Guidmar c.Donalle mar.a martha martorell Gastón E.Siless Lucas Ruberto Gabriela M.cabrera Facultad de ciencias Exactas y Naturales Departamento de Química OrgánicaUniversidad de Buenos AiresBuenos AiresArgentina Unidad de Microanálisis y Métodos Físicos Aplicados a la Química Orgánica(UMYMFOR) CONICET-Universidad de Buenos AiresBuenos AiresArgentina Instituto Antártico Argentino Instituto NanobiotecCONICET-Universidad de Buenos AiresBuenos AiresArgentina

The Antarctic fungus cadophora malorum produces previously undescribed cyclic heptapeptides(cadophorin A and B)containing an anthranilic acid *** planar structure of these peptides was determined by high-resolution mass spectrometry combined with extensive 1D and 2D NMR *** absolute configuration of the amino acids was determined by marfey’s method,with HPLc analysis of FDVA(Nα-(2,4-dinitro-5-fluorphenyl)-l-valinamide)derivatives making use of a PFP ***,cadophorin 2 possesses both the uncommon d-Ile and d-allo-Ile in its *** peptides have metal binding properties as shown by LcMS with post column addition of metal salt *** results were supported by DFT calculations.

关键词： cyclic peptide cadophora malorum Metal binding

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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks mar.a F Mascardi Adrián Gadano Sebastián marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-consejo Nacional de Investigaciones científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina consejo Nacional de Investigaciones científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease Non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

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Oncology Research 2023年第3期31卷 361-374页

作者： FRANcIScO RAÚL BORZONE mar.a BELÉN GIORELLO LEANDRO marcELO marTINEZ mar.a cEcILIA SANmarTIN LEONARDO FELDMAN FEDERIcO DIMASE EMILIO BATAGELJ GUSTAVO YANNARELLI NORMA ALEJANDRA cHASSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de Regulación Génica y células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de ciencias de la Salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality *** this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MScs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MScs from advanced breast cancer patients(BcPs,infiltrative ductal carcinoma,stage III-B)have an abnormal *** work aims to study some of the metabolic and molecular mechanisms underlying MScs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(SA‑β‑gal)staining of BMderived MScs isolated from 14 BcPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were *** levels of pluripotency,osteogenic,and osteoclastogenic genes(OcT-4,SOX-2,M-cAM,RUNX-2,BMP-2,ccL-2,M-cSF,and IL-6)were also *** results showed that MScs from BcPs had reduced,self-renewal and proliferation *** cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened ***,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere *** also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene *** conclude that these changes could be responsible for the abnormal functional profile that MScs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

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combined cell-based therapy strategies for the treatment of Parkinson's disease:focus on mesenchymal stromal cells

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Neural Regeneration Research 2023年第3期18卷 478-484页

作者： Jannette Rodríguez-Pallares mar.a García-Garrote Juan A.Parga JoséLuis Labandeira-García Laboratory of cellular and Molecular Neurobiology of Parkinson´s Disease Research Center for Molecular Medicine and Chronic Diseases(CiMUS)IDISDepartment of Morphological SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain Networking Research center on Neurodegenerative Diseases(cIBERNED) MadridSpain

Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia *** is an effective and well-tolerated dopamine replacement ***,levodopa provides only symptomatic improvements,without affecting the underlying pathology,and is associated with side effects after long-term ***-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson’s disease *** studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum,release dopamine,integrate into the host neural circuits,and improve motor *** of the limiting factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic *** factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma,growth factor deprivation,hypoxia,and *** factors play an essential role in the survival of grafted ***,direct,timely,and controllable delivery of neurotrophic factors into the brain faces important *** types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal *** this review,we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson’s disease,with a focus on neurotrophic factor-secreting cells,with a particular interest in mesenchymal stromal cells;that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes.

关键词： brain repair cell replacement co-grafts dopaminergic neurons fetal ventral mesencephalic tissue mesenchymal stem cells neural grafting neural transplantation neuroblasts neurotrophic factors

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