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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： mar.a Norte-Muñoz mar.a Portela-Lomba Paloma Sobrado-calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JoséMcabrera-Maqueda Javier Sierra Manuel Vidal-Sanz mar.a Teresa Moreno-Flores mar.a Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHcII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado mar.a JoséMorillo-Bargues carla Perpiñá-clérigues Francisco García-García Victoria Moreno-Manzano consuelo Guerri mar.a Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSc-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and c–X3–c motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSc-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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challenges and improvement strategies in the hospitalization of chronic multimorbid patients

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World Journal of clinical cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio Garcia cisneros mar.a Jose Garcia Larrosa mar.a del mar callejon gil Ignacio Garcia Delgado mar.a Belen Jimenez martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BAcKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HcU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HcU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HcU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HcU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit chronic multimorbidity Patient-centered care Integrated care Healthcare management

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Powder metallurgy with space holder for porous titanium implants:A review

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Journal of Materials Science & Technology 2021年第17期76卷 129-149页

作者： Alejandra Rodriguez-contreras Miquel Punset JoséA.calero Francisco Javier gil Elisa Ruperez Josémar.a Manero Biomaterials Biomechanics and Tissue Engineering Group(BBT)Department of Materials Science and EngineeringUniversitat Politecnica de Catalunya(UPC)Av.Edurad Maristany 1608019BarcelonaSpain Barcelona Research centre in Multiscale Science and Engineering Technical University of Catalonia(UPC)Av.Eduard Maristany 10-1408019BarcelonaSpain UPc Innovation and Technology center(cIT-UPc).Technical University of catalonia(UPc) C.Jordi Girona 3-108034Barcelona.Spain AMES GROUP SA.carretera Nacional 340 Pol.Ind."Les Fallulles"08620Sant Vicenc dels HortsBarcelonaSpain Bioengineering Institute for Technology Universitat Intemacional de Catalunyac/Josep Trueta s/n08195BarcelonaSpain

One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical *** stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis ***,it can be inhibited by adapting the stiffness of the implant *** the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this *** powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and *** most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography ***,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are ***,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented.

关键词： Powder metallurgy Space holder method Porous titanium structures Medical devices Stress shielding effect Porous materials permeability Interconnected porosity Porous bone substitute materials Open-cell titanium foams Sintering-dissolution technique

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Immunogenicity and mechanisms impairing the response to vaccines in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第40期21卷 11273-11281页

作者： Alicia c marín Javier P Gisbert mar.a chaparro Gastro- enterology Unit Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas28021 MadridSpain

Inflammatory bowel disease(IBD) is an immunological disorder that is usually treated with immunosuppressive therapy,potentially leading to increases in vulnerability to infections. Although many infections can be pre-vented by vaccination,vaccination coverage in these patients in clinical practice is insufficient. Therefore,the seroprotection condition should be verified,even for routine vaccines,such as hepatitis B or pneu-mococcus. Response to vaccines in IBD patients is thought to be impaired due to the immunological alterations generated by the disease and to the immunomodulatory treatments. The immunogenicity of hepatitis B,influenza,and pneumococcal vaccines is impaired in IBD patients,whereas the response to papillomavirus vaccine seems similar to that observed in the healthy population. On the other hand,data on the immunogenicity of tetanus vaccine in IBD patients are conflicting. Studies assessing the response to measles-mumps-rubella,varicella,and herpes zoster vaccines in IBD patients are scarce. The cellular and molecular mechanisms responsible for the impairment of the response to vaccination in IBD patients are poorly understood. Studies aiming to assess the response to vaccines in IBD patients and to identify the mechanisms involved in their immunogenicity are warranted. A better understanding of the immune response,specifically to vaccines,in patients with immune-mediated diseases(such as IBD),is crucial when developing vaccines that trigger more potent immunologic responses.

关键词： crohn’s disease Inflammatory bowel disease Tumor n

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Glutaminolysis-ammonia-urea cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies

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Journal of clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela Rojas mar.a Rosario García-Lozano Antonio gil-Gómez Manuel Romero-Gómez Javier Ampuero Department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain SeLiver group at the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain center for the Study of Liver and Gastrointestinal Diseases(cIBERehd) Carlos III National Institute of HealthMadridSpain De-partment of Organic and Medicinal chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HSc)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HScs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSc *** mechanisms are plausible antifibrotic targets in NASH,as the activation of HScs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease cirrhosis Fibrosis Glutaminoly-sis Ammonia Urea

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Influence of dissolved organic matter character on mercury incorporation by planktonic organisms: An experimental study using oligotrophic water from Patagonian lakes

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Journal of Environmental Sciences 2013年第10期25卷 1980-1991页

作者： mar.a c.Diéguez claudia P.Queimalios Sergio Ribeiro Guevara mark marvin-DiPasquale carolina Soto crdenas mar.a A.Arribre Laboratorio de Fotobiología INIBIOMA CONICET-UNComahue Laboratorio de Fotobiolog INIBIOMA CONICET-UNComahue Laboratorio de Anlisis por Activación Neutrónica Centro Atómico Bariloche CNEA United States Geological Survey Laboratorio de Anlisis por Activacio Neutrónica Centro Atómico Bariloche CNEA

Ligands present in dissolved organic matter （DOM） form complexes with inorganic divalent mercury （Hg^2＋） affecting its bioavailability in pelagic food webs. This investigation addresses the influence of a natural gradient of DOM present in Patagonian lakes on the bioaccumulation of Hg^2＋（the prevailing mercury species in the water column of these lakes） by the algae cryptomonas erosa and the zooplankters Brachionus calyciflorus and Boeckella antiqua. Hg^2＋ accumulation was studied through laboratory experiments using natural water of four oligotrophic Patagonian lakes amended with^197Hg^2＋. The bioavailability of Hg^2＋ was affected by the concentration and character of DOM. The entrance of Hg^2＋ into pelagic food webs occurs mostly through passive and active accumulation. The incorporation of Hg^2＋ by cryptomonas, up to 27% of the Hg^2＋ amended, was found to be rapid and dominated by passive adsorption, and was greatest when low molecular weight compounds with protein-like or small phenolic signatures prevailed in the DOM. conversely, high molecular weight compounds with a humic or fulvic signature kept Hg^2＋ in the dissolved phase, resulting in the lowest Hg^2＋ accumulation in this algae. In Brachionus and Boeckella the direct incorporation of Hg from the aqueous phase was up to 3% of the Hg^2＋ amended. The dietary incorporation of Hg^2＋ by Boeckella exceeded the direct absorption of this metal in natural water, and was remar.ably similar to the Hg^2＋ adsorbed in their prey. Overall, DOM concentration and character affected the adsorption of Hg^2＋ by algae through competitive binding, while the incorporation of Hg^2＋ into the zooplankton was dominated by trophic or dietary transfer.

关键词： mercury dissolved organic matter plankton mercury incorporation Patagonian lakes Argentina

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Multicenter application of a nursing workload measurement scale in adult hospitalization units

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International Journal of Nursing Sciences 2022年第4期9卷 460-466,I0002页

作者： mar.a Fuensanta Hellín gil marzena Mikla Ana Myriam Seva Llor mar.a Dolores Roldán Valcárcel Francisco Javier Ibáñez-López mar.a JoséLópez Montesinos University of Murcia MurciaSpain Biomedical Research Institute of Murcia(IMIB) MurciaSpain

Objectives:The study aimed to the multicenter application of a nursing workload measurement scale in the internal medicine and surgery adults hospitalization ***:The study design was a multicenter,observational,and descriptive study.A multicenter application of the MIDENF®nursing workload measurement scale was carried out,which consists of 21 items,and covers the four nursing functions(patient care items,teaching,manager,and researcher),in units of hospitalization of adults of internal medicine and surgery of four different *** item contains one or more of the nursing interventions of Nursing Interventions classification(NIc)and has an assigned time,after comparing the real time it takes to perform each intervention with the North American Nursing Diagnosis Association(NANDA)standardized *** study was carried out during nine months of the year 2020,measuring two days each month in the three work shifts(morning,evening,and night)to all patients admitted on the days of measurement in the indicated ***:The descriptive and inferential analysis of 11,756 completed scales,5,695 in general surgery and 6,061 in internal medicine,showed a greater care load for the two units during the morning shift(227,034 min in general surgery,261,835 min in internal medicine),especially in the items of“self-care”,“medication”,“common invasive procedures”,“fluid therapy”,and“patient and family support”,while the managerial function was similar during the three work shifts in the two units studied,getting values between 57,348 and 62,*** the analysis by shift and unit,statistical significance was obtained both for the total workload and the four nursing functions(Pconclusions:It is shown that the use of validated scales with the standardized language of nursing functions,adapted to the units,provides objective information to adjust the nursing staff to the real situation of care in any hospital and unit where it is applied,improving quality

关键词： Hospital Measurement Nursing administration research Workload

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Mercury in an ultraoligotrophic North Patagonian Andean lake (Argentina): concentration patterns in different components of the water column

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Journal of Environmental Sciences 2010年第8期22卷 1171-1178页

作者： mar.a Arribére mar.a c Diéguez Sergio Ribeiro Guevara claudia P Queimalios Vesna Fajon mar.ana Reissig Milena Horvat LAAN-cNEA CAB Av. Bustillo Km 9.5 8400 Bariloche Argentina Laboratorio de Fotobiología INIBIOMA (Universidad Nacional del Comahue-CONICET) Department of Environmental Sciences Jozef Stefan Institute

The deep, ultraoligotrophic piedmont lakes of Northern Patagonia （Argentina） are located in pristine and barely impacted areas, along a wide latitudinal range. Several studies have reported moderate to high total mercury （Hg） concentrations and contrasting methylmercury （cH3Hg＋） production in different lake compartments. Sources of Hg for western Patagonian terrestrial and aquatic ecosystems are still not clear; while point sources can be ruled out and atmospheric deposition is a plausible source, along with contribution from active volcanic areas of the Andes. In this investigation, we reported a noticeably seasonal, spatial （between lake branches）, and vertical （between water column strata） heterogeneity in the total Hg concentrations found in the pelagic zone of Lake Moreno. Sterile water samples taken in a depth profile of the lake showed moderate to high concentrations of cH3Hg＋ in autumn with a decreasing trend with depth. Our results indicated that Hg is largely allocated in the plankton fraction between 10–53 μm; which dominated within the euphotic （epilimnetic） zone of the lake due to the high densities attained by two species of the dinoflagellate Gymnodinium. The 53–200 μm planktonic size fraction （comprising rotifers, ciliates and immature stages of crustaceans） and the 200 μm fraction （calanoid copepods and cladocerans） were found to bear strikingly lower total Hg concentrations, suggesting that the magnification of Hg at the planktonic consumer level is negligible.

关键词： Patagonia deep lakes total mercury plankton

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Alternatives of Small-Scale Biorefineries for the Integrated Production of Xylitol from Sugarcane Bagasse

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Journal of Renewable Materials 2018年第2期6卷 139-151页

作者： Nicolás M.clauser Soledad Gutiérrez mar.a c.Area Fernando E.Felissia mar.a E.Vallejos Materials Institute of Misiones(IMAM) National University of Misiones–National Council of Scientific and Technical Research(UNaM–CONICET)1552 Félix de Azara St.(3300)PosadasMisionesArgentina Faculty of Engineering University of the Republic(UDeLaR)565 Julio Herrera y Reissig St.(11700)MontevideoUruguay

Small-scale biorefinery from sugarcane bagasse offers new possibilities to the sugar and ethanol *** aim of this study was to evaluate the feasibility of a small-scale biorefinery for the production of xylitol from sugarcane *** liquid fraction from the autohydrolysis treatment was selected as the source of sugars for xylitol and two scenarios were analyzed for the residual solid:ethanol or pellet production.A technical-economic analysis of alternatives was *** internal rate of return(IRR)was used to compare the selected *** highest IRR values were obtained when processing 70,000 dry tons per year of *** results showed promising prospects for a small-scale biorefinery with capacities above 20,000 dry tons per year(xylitol and pellets),and above 50,000 dry tons per year(xylitol and ethanol).

关键词： Biorefinery sugarcane bagasse xylitol ethanol pellets

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