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Review on signal-by-wire and power-by-wire actuation for more electric aircraft

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Chinese Journal of Aeronautics 2017年第3期30卷 857-870页

作者： Jean-Charles mar Jian FU Institut National des Sciences Appliquees Institut Clement Ader (CNRS UMR 5312) Toulouse 31077 France School of Mechanical Engineering and Automation Beihang University Beijing 100083 China

The huge and rapid progress in electric drives offers new opportunities to improve the performances of aircraft at all levels：fuel burn,environmental footprint,safety,integration and production,serviceability,and *** for safety-critical applications like flight-controls,landing gears,and even engines is one of the major consumers of non-propulsive *** actuation with centralized hydraulic power generation and distribution and control of power by throttling has been well established for decades,but offers a limited potential of *** this context,electric drives become more and more attractive to remove the natural drawbacks of conventional actuation and to offer new opportunities for improving *** paper takes the stock,at both the signal and power levels,of the evolution of actuation for safety-critical applications in *** focuses on the recent advances and the remaining challenges to be taken toward full electrical actuation for commercial and military aircraft,helicopters,and *** logically starts by emphasizing the specificity of safety-critical actuation for *** following section addresses in details the evolution of aerospace actuation from mechanically-signaled and hydraulically-supplied to all electric,with special emphasis on research and development programs and on solutions entered into ***,the last section reviews the challenges to be taken to generalize the use of all-electric actuators for future aircraft programs.

关键词： Actuator Aerospace Electrohydrostatic Electromechanical Hydraulic More electric aircraft Power-by-wire Signal-by-wire

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

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World Journal of Gastroenterology 2017年第29期23卷 5266-5281页

作者： mar.a l bacigalupo pablo carabias mar.a f troncoso Facultad de Farmacia y Bioquímica Instituto de Química y Fisicoquímica Biológicas (IQUIFIB) Consejo Nacional de lnvestigaciones Científicas y Técnicas Universidad de Buenos Aires

Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1(Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.

关键词： Galectin-1 Gastric cancer Hepatocellular carcinoma Colorectal carcinoma Pancreatic cancer β1 6-N-acetylglucosaminyltransferase V

Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

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World Journal of Stem Cells 2020年第2期12卷 100-109页

作者： mar.a álvarez-Viejo Unidad de Terapia Celulary Medicina Regenerativa Servicio de Hematologíay Hemoterapia Hospital Universitario Central de Asturias Plataforma de Terapias Avanzadas Instituto de Investigación Sanitaria del Principado de Asturias

Since the introduction of cell therapy as a strategy for the treatment of many diseases,mesenchymal stem cells have emerged as ideal candidates,yet the underlying mechanisms of their beneficial effects are only partially *** the start of the 21st century,a paracrine effect was proposed as a mechanism of tissue repair by these *** addition,a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell *** of these vesicles including exosomes have been isolated from most fluids and cells,as well as from supernatants of in vitro cell *** research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic *** review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy:bone marrow,adipose tissue,and umbilical cord.

关键词： Mesenchymal stem cells Exosomes Cellular therapy

Existence and Uniqueness to a Fully Nonlinear Version of the Loewner–Nirenberg Problem Dedicated to Celebrate the Sixtieth Anniversary of USTC

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Communications in Mathematics and Statistics 2018年第3期6卷 269-288页

作者： mar.a del mar González YanYan Li Luc Nguyen Departamento de Matemáticas Universidad Autónoma de MadridCampus de Cantoblanco28049 MadridSpain Department of Mathematics Hill CenterBusch CampusRutgers University110 Frelinghuysen RoadPiscatawayNJ 08854USA Mathematical Institute and St Edmund Hall University of OxfordAndrew Wiles BuildingRadcliffe Observatory QuarterWoodstock RoadOxford OX26GGUK

We consider the problem of finding on a given Euclidean domainof dimension n≥3 a complete conformally flat metric whose Schouten curvature A satisfies some equations of the form f(λ(−A))=*** generalizes a problem considered by Loewner and Nirenberg for the scalar *** prove the existence and uniqueness of such metric when the boundary δΩ is a smooth bounded hypersurface(of codimension one).When δΩ contains a compact smooth submanifold ∑ of higher codimension with δΩ\∑ being compact,we also give a‘sharp’condition for the divergence to infinity of the conformal factor near ∑ in terms of the codimension.

关键词： Fully nonlinear Loewner-Nirenberg problem Singular fully nonlinear Yamabe metrics Conformal invariance

Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： Jose Enrique marTÍN-ALFONSO mar.a Jose marTÍN-ALFONSO Concepción VALENCIA mar.a Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remar.able lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

Immunogenicity and mechanisms impairing the response to vaccines in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第40期21卷 11273-11281页

作者： Alicia C marín Javier P Gisbert mar.a Chaparro Gastro- enterology Unit Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas28021 MadridSpain

Inflammatory bowel disease(IBD) is an immunological disorder that is usually treated with immunosuppressive therapy,potentially leading to increases in vulnerability to infections. Although many infections can be pre-vented by vaccination,vaccination coverage in these patients in clinical practice is insufficient. Therefore,the seroprotection condition should be verified,even for routine vaccines,such as hepatitis B or pneu-mococcus. Response to vaccines in IBD patients is thought to be impaired due to the immunological alterations generated by the disease and to the immunomodulatory treatments. The immunogenicity of hepatitis B,influenza,and pneumococcal vaccines is impaired in IBD patients,whereas the response to papillomavirus vaccine seems similar to that observed in the healthy population. On the other hand,data on the immunogenicity of tetanus vaccine in IBD patients are conflicting. Studies assessing the response to measles-mumps-rubella,varicella,and herpes zoster vaccines in IBD patients are scarce. The cellular and molecular mechanisms responsible for the impairment of the response to vaccination in IBD patients are poorly understood. Studies aiming to assess the response to vaccines in IBD patients and to identify the mechanisms involved in their immunogenicity are warranted. A better understanding of the immune response,specifically to vaccines,in patients with immune-mediated diseases(such as IBD),is crucial when developing vaccines that trigger more potent immunologic responses.

关键词： Crohn’s disease Inflammatory bowel disease Tumor n

Weighted Inequalities for Fractional Type Operators with Some Homogeneous Kernels

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Acta Mathematica Sinica,English Series 2013年第3期29卷 449-460页

作者： mar.a Silvina RIVEROS mar.a URCIUOLO FaMAF-UNC CIEM-CONICET Ciudad Universitaria

In this paper, we study integral operators of the formappropriate weighted BMO and weak type estimates for certain weights satisfying the above inequality. We also give a Coifman type estimate for these operators.

关键词： Fractional operators Calderon-Zygmund operators BMO Muckenhoupt weights

Brain and spinal cord trauma:what we know about the therapeutic potential of insulin growth factor 1 gene therapy

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Neural Regeneration Research 2023年第2期18卷 253-257页

作者： mar.a Jose Bellini Florencia Labombarda Lab de Bioquímica del Envejecimiento INIBIOLP-CONICETFacultad de Ciencias MedicinaUniversidad Nacional de La PlataLa PlataArgentina Laboratory of Neuroendocrine Biochemistry IBYME-CONICETBuenos AiresArgentina Department of Human Biochemistry Faculty of MedicineUniversidad de Buenos AiresBuenos AiresArgentina

Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal co rd injury,several reports have described impairments in cognitive *** group also has contributed significantly to the study of cognitive impairments in a rat model of spinal co rd *** findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes,drugs of abuse,and combined *** are related to changes in brain structures involved in cognition and emotion,such as the *** spinal cord injury decreases neurogenesis,enhances glial reactivity leading to hippocampal neuroinflammation,and trigge rs cognitive *** brain distal abnormalities are recently called te rtiary *** that there is no treatment for Tertiary Damage,insulin growth factor 1 gene therapy emerges as a good *** growth factor 1 gene thera py recove rs neurogenesis and induces the polarization from pro-inflammato ry towards anti-inflammatory microglial phenotypes,which represents a potential strategy to treat the neuroinflammation that supports te rtiary *** growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is *** growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.

关键词： cognitive impairments gene therapy hippocampus insulin growth factor 1 microglial cells neurodegeneration neurogenesis neuroinflammation spinal cord injury traumatic brain injury

Cellular automata model for traffic flow with safe driving conditions

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Chinese Physics B 2014年第5期23卷 216-226页

作者： mar.a Elena Lárraga Luis Alvarez-Icaza Instituto de Ingeniería Universidad Nacional Autónoma de México04510Coyoacán D.F.México

In this paper, a recently introduced cellular automata （CA） model is used for a statistical analysis of the inner micro-scopic structure of synchronized traffic flow. The analysis focuses on the formation and dissolution of clusters or platoons of vehicles, as the mechanism that causes the presence of this synchronized traffic state with a high flow. This platoon formation is one of the most interesting phenomena observed in traffic flows and plays an important role both in manual and automated highway systems （AHS）. Simulation results, obtained from a single-lane system under periodic boundary conditions indicate that in the density region where the synchronized state is observed, most vehicles travel together in pla- toons with approximately the same speed and small spatial distances. The examination of velocity variations and individual vehicle gaps shows that the flow corresponding to the synchronized state is stable, safe and highly correlated. Moreover, results indicate that the observed platoon formation in real traffic is reproduced in simulations by the relation between vehicle headway and velocity that is embedded in the dynamics definition of the CA model.

关键词： traffic flow models synchronized traffic cellular automata platoons formation