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Clinical and prognostic implications of atrial fibrillation in patients undergoing transcatheter aortic valve implantation

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World Journal of Cardiology 2012年第1期4卷 8-14页

作者： Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose maría Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón Division of Interventional Cardiology University Hospital La Paz Unit of Echocardiography University Hospital La Paz Department of Cardiology University Hospital La Paz Vascular Surgery University Hospital La Paz Department of Cardiac Anaesthesia University Hospital La Paz Cardiac Surgery University Hospital La Paz Department of Cardiology Hospital Infanta Sofia Department of Cardiology Hospital de la Cruz Roja

AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups.

关键词： Aortic stenosis Transcatheter aortic valve implantation Stroke Atrial fibrillation

Erratum to:Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第4期24卷 371-372页

作者： Dulce maría Moreno-García Armando Zepeda-Bastida Juan Ocampo-López Brisa Rodope Alarcón-Sánchez Osiris Germán Idelfonso-García Sandra Rosas-Madrigal Diana Ivette Aparicio-Bautista Julio Isael Pérez-Carreón Saúl Villa-Treviño Jaime Arellanes-Robledo Laboratory of Liver Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Institute of Agricultural Sciences Autonomous University of Hidalgo State-ICAP-UAEHHidalgo43600Mexico Department of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPNCDMX07360Mexico Laboratory of Cardiovascular Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Proteomics Unit National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Directorate of Cátedras National Council of Science and Technology-CONACYTCDMX03940Mexico

Following an Assessment by the Autonomous University of Hidalgo State and the National Institute of Genomic Medicine,this erratum corrects the authorship of this article by adding Dulce maria MORENO-garcia as the first *** published article(Zepeda-Bastida et al.,2021)has now been updated with the corrected authorship,author contributions,and acknowledgments,which may be seen in this erratum.

关键词： larval adding corrected

A Comparative Analysis between the Spanish and Portuguese Seismic Codes: Application to a Border RC Primary School

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Journal of Mechanics Engineering and Automation 2020年第3期10卷 87-97页

作者： maría-Victoria Requena-garcia-Cruz Antonio Morales-Esteban maría-Luisa Segovia-Verjel Emilio Romero-Sánchez Jaime De-Miguel-Rodríguezand João Manuel Carvalho Estêvão Department of Building Structures and Geotechnical Engineering University of SevilleAv.Reina Mercedes 2Seville 41012Spain Department of Civil Engineering ISEUniversity of AlgarveFaro 8005-139Portugal

The Iberian Peninsula is close to the Eurasia-Africa plate boundary resulting in a considerable seismic *** fact,the southwestern Iberian Peninsula is affected by far away earthquakes of long-return period with large-very large magnitude.A project named PERSISTAH(Projetos de Escolas Resilientes aos SISmos no Território do Algarve e de Huelva,in Portuguese)aims to cooperatively assess the seismic vulnerability of primary schools located in the Algarve(Portugal)and Huelva(Spain).Primary schools have been selected due to the considerable amount of similar buildings and their seismic *** Portugal,the Decreto Lei 235/83(RSAEEP)is mandatory while in Spain,the mandatory code is the Seismic Building Code(NCSE-02).In both countries,the Eurocode-8(EC-8)is *** the fact that both regions would be equally affected by an earthquake,both seismic codes are significantly *** research compares the seismic action of Ayamonte(Huelva)and Vila Real de Santo António(Portugal).Both towns are very close and located at both sides of the ***,they share the same *** analysis has been applied considering a reinforced concrete(RC)primary school building located in *** do so,the performance-based method has been *** seismic action and the damage levels are compared and *** results have shown considerable differences in the seismic actions designation,in the performance point values and in the damage *** values considered in the Portuguese code are significantly more *** agreement between codes should be made for border regions.

关键词： Performance-based method seismic code seismic behaviour nonlinear analysis Iberian Peninsula RC building

GOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer

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World Journal of Clinical Oncology 2022年第4期13卷 237-266页

作者： Nuria Rodriguez De Dios Arturo Navarro-martin Cristina Cigarral Rodolfo Chicas-Sett Rafael garcia Virginia garcia Jose Antonio Gonzalez Susana Gonzalo Mauricio Murcia-Mejia Rogelio Robaina Amalia Sotoca Carmen Vallejo German Valtuena Felipe Counago Department of Radiation Oncology Hospital del MarBarcelona 08003Spain Radiation Oncology Research Group Hospital Del Mar Medical Research InstitutionBarcelona 08003Spain Department of Experimental and Health Sciences Pompeu Fabra UniversityBarcelona 08003Spain Department of Radiation Oncology Thoracic Malignancies UnitHospital Duran i Reynals.ICOL´Hospitalet de LLobregat 08908Spain Department of Radiation Oncology Hospital Clinico de SalamancaSalamanca 37007Spain Department of Radiation Oncology ASCIRES Grupo BiomedicoValencia 46004Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario Arnau de VilanovaLleida 25198Spain Department of Radiation Oncology Genesis Care-SpainSevilla 41092Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology Hospital Universitario Sant Joan de ReusReus 43204TarragonaSpain Department of Radiation Oncology Hospital Universitario Ramon y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Clinico Universitario Lozano BlesaZaragoza 50009Spain Department of Radiation Oncology Hospital Universitario QuirónsaludMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Department of Clinical Universidad EuropeaMadrid 28670Spain

Non-small cell lung cancer(NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are treated with radiotherapy(curative-intent or palliative). Technological advancesincluding highly conformal radiotherapy techniques, new immobilization and respiratory control systems, and precision image verification systems-allow clinicians to individualize treatment to maximize tumor control while minimizing treatment-related toxicity. Novel therapeutic regimens such as moderate hypofractionation and advanced techniques such as stereotactic body radiotherapy(SBRT) have reduced the number of radiotherapy sessions. The integration of SBRT into routine clinical practice has radically altered treatment of early-stage disease. SBRT also plays an increasingly important role in oligometastatic disease. The aim of the present guidelines is to review the role of radiotherapy in the treatment of localized, locally-advanced, and metastatic NSCLC. We review the main radiotherapy techniques and clarify the role of radiotherapy in routine clinical practice. These guidelines are based on the best available evidence. The level and grade of evidence supporting each recommendation is provided.

关键词： Radiotherapy Non-small cell lung cancer Guidelines Stereotactic radiation therapy Hypofractionated radiation Oligometastasis

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从现场音乐与录制音乐看流行音乐的市场需求

文化艺术研究 2012年第3期5卷 138-157页

作者： Juan D.Montoro-Pons Manuel Cuadrado-garcia 马绯璠西班牙巴伦西亚大学译林出版社南京210009

最近十年来,随着人们消费习惯的改变,流行音乐市场也发生了很大变化,现场音乐的市场份额不断增加。本文从现场音乐和录制音乐两个方面分析了流行音乐市场需求,采用的数据来自2006—2007年度西班牙"习惯与文化行为调查",通过双变量profi... 详细信息

最近十年来,随着人们消费习惯的改变,流行音乐市场也发生了很大变化,现场音乐的市场份额不断增加。本文从现场音乐和录制音乐两个方面分析了流行音乐市场需求,采用的数据来自2006—2007年度西班牙"习惯与文化行为调查",通过双变量profit模型来分析现场音乐会的上座率和录制音乐的销售情况。通过分析,我们可以大致描述出两个市场中一般消费者和消费频率较高的消费者大致情况。分析结果显示,两种消费者存在一些相似的方面,这主要表现在性别和文化素养对音乐消费的作用;但同时也存在一些十分显著的差别,这主要表现在时间限制、与经济活动的关系和技术利用这三个方面。最后,我们发现,录制音乐消费和现场音乐消费具有一定的互补性,具有直接的因果关系,这可以解释近年来音乐市场组织制度上发生的一些变化。

关键词：现场音乐与录制音乐参与受众文化需求文化素养双变量probit模型

On the Impact of Brazil's Largest Recent Oil Spill on Regional Oceans

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Sustainable marine Structures 2021年第2期3卷 1-14页

作者： Liana de Figueiredo Mendes Patricia Pinheiro Beck Eichler Tatiana Leite Ana Beatriz Alves Bennemann Clara de Souza Melo Andressa Lima Ferreira Khalil Bow Ltaif garcia Luzia Liniane do Nascimento Silva Christofer Paul Barker Helenice Vital Moab Praxedes Gomes Priscila F.M.Lopes Department of Ecology Federal University of Rio Grande do Norte(UFRN)University CampusLagoa Nova59072-970 NatalRNBrazil Graduate Program in Geodynamics and Geophysics(PPGG) Laboratory of Marine Geology and Geophysics and Environmental MonitoringFederal University of Rio Grande do Norte 0JFRN)University CamposLagoa Nova59072-970 NatalRNBrazil ***(California USA) Department of Ecology and Zoology Federal University of Santa CatarinaTrindade88040-900FlorianopolisSCBrazil

In 2019,an oil spill in Brazil,of unknown origin,severely impacted coastal environs with the worst environmental disaster ever recorded in any tropical coastal region globally severely damaging South Pirangi Reef area in the state of Rio Grande do Norte(RN).Here we discuss acute and chronic impacts including chemical contamination and economic consequences all over the world and show some evidence of the oil spill in this biodiverse ***,the lapse between the moment of the disastei;and the action to manage it,was hampered by a political agenda coinciding with local and global tragedies that redirected public *** almost 2 years have passed still without the offending party identification or culpability;and poor communities may continue to absorb its deleterious impacts for decades without consideration or *** disaster occurred during the Brazilian government's current issues involving extensive environmental mismanagement,resulting in a slow response from an inept *** is with urgent necessity to spotlight this tragedy in this unique and sensitive reef habitat experiencing the ongoing damaging effects that include socio-economic losses not yet addressed.

关键词： Environmental impacts Socioeconomic losses Government Brazilian coast Oil spill Disaster

INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(待续)

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环境与职业医学 2016年第8期33卷 820-825页

作者： maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon mariana F.Fernández Raquel garcia-Esteban Carmen I?iguez David martínez mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer martine Vrijheid 袁亚群金泰廙 Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiologíay Salud Pública(CIBERESP) Department of Analytical Chemistry University of Cordoba ISGlobal Barcelona Centre for International Health Research(CRESIB)Hospital Clínic-Universitat de Barcelona Instituto de Investigación Biosanitaria de Granada(Granada.ibs) University of Granada Foundation for the Promotion of Health and Biomedical Research in the Valencian Region FISABIO/CSISP Universidad de Valencia Hospital del mar Medical Research Institute(IMIM)

[背景]产前暴露于双酚A（BPA）及邻苯二甲酸酯会影响胎儿发育；然而该类研究很少，且得出的结果不一致。[目的]对一个西班牙出生队列中488对母婴进行研究，评估产前暴露于BPA及邻苯二甲酸酯是否与胎儿发育相关。[方法]检测第一和第三孕... 详细信息

[背景]产前暴露于双酚A（BPA）及邻苯二甲酸酯会影响胎儿发育；然而该类研究很少，且得出的结果不一致。[目的]对一个西班牙出生队列中488对母婴进行研究，评估产前暴露于BPA及邻苯二甲酸酯是否与胎儿发育相关。[方法]检测第一和第三孕期两次尿液样本中BPA及8种邻苯二甲酸酯[4种邻苯二甲酸二（2-乙基己基）酯代谢物（DEHPm），邻苯二甲酸单卞酯（MBzP）以及3种低分子量邻苯二甲酸酯代谢物（LMWPm）]。另外，估计股骨长度（FL）、头围（HC）、腹围（AC）、双顶径（BPD）的生长曲线，估计孕期（12—20周，20～34周）的胎儿体重，并测量出生体重、出生长度、出生头围以及胎盘重量。[结果]总体上，结果并不支持孕期暴露于BPA或DEHPm与胎儿发育参数相关。产前MBzP暴露与20～34孕周的FL呈正相关，MBzP浓度每增加一倍，平均FL增加3．7％（95％CI：0．75，6．63％）。MBzP与男婴出生体重呈正相关（48g；95％CI：6，90），但在女婴中没有相关性（-27g；95％CI：-79，25）（交互作用P=0．04）。LMWPm邻苯二甲酸单丁酯（MnBP）与12—20孕周的HC呈负相关[平均HC降低了4．88％（95％CI：-8．36，-1．36％）]。[结论]本研究首次将暴露生物标志重复测量值与胎儿期多种发育参数相结合，发现暴露于BPA或邻苯二甲酸酯与胎儿发育不相关。邻苯二甲酸酯代谢物MBzP与MnBP与部分胎儿发育参数相关，但这些结果还需要重复验证。

关键词：邻苯二甲酸酯胎儿发育超声测量出生队列中孕期双酚A 邻苯二甲酸二(2-乙基己基)酯产前暴露

INMA-Sabadell队列中孕期双酚A及邻苯二甲酸酯暴露与胎儿发育的超声测量(续完)

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环境与职业医学 2016年第9期33卷 919-921页

作者： maribel Casas Damaskini Valvi Ana Ballesteros-Gomez Mireia Gascon mariana F.Fernández Raquel garcia-Esteban Carmen I?iguez David martínez mario Murcia Nuria Monfort Noelia Luque Soledad Rubio Rosa Ventura Jordi Sunyer martine Vrijheid 袁亚群(翻译) 金泰廙(审校) Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiología y Salud Pública(CIBERESP) Department of Analytical Chemistry University of Cordoba ISGlobal Barcelona Centre for International Health Research(CRESIB)Hospital Clínic-Universitat de Barcelona Instituto de Investigación Biosanitaria de Granada(Granada.ibs) University of Granada Foundation for the Promotion of Health and Biomedical Research in the Valencian Region FISABIO/CSISP Universidad de Valencia Hospital del mar Medical Research Institute(IMIM) 不详

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性（-4．88％；95％CI：-8．36，-1．36），且与EFW增长减低也有... 详细信息

暴露于ΣMWPm与任何胎儿大小或胎儿发育结局（见补充材料，表8）及所评估的出生结局（表2及补充材料表S7）都没有显著相关性。代谢物MnBP与12-20孕周HC增长降低有显著相关性（-4．88％；95％CI：-8．36，-1．36），且与EFW增长减低也有显著相关性（-4．32％；95％CI：-8．33，-0．27）（图3及补充材料表S8）。

关键词：胎儿发育邻苯二甲酸酯超声测量双酚A 中孕期队列相关性出生结局

吡嗪酰胺与利福平联合治疗HIV(-)结核感染的安全性

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结核与肺部疾病杂志 2005年第3期8卷 96-100页

作者： C. Tortajada J. martinez-Lacasa F. Snchez A. Jimnez-Fuentes M. L. De Souza J. F. garcia J. A. martinez J. A. Cayl 马玙 Departmento de Epidemiologia Agenda de Salut Publica de Barcelona Barcelona Departmento de Medicina Interna Hospital Mutua de Terrassa Terrassa Barcelona Departmento de Epidemiologia Agenda de Salut Publica de Barcelona Barcelona Departmento de Medicina Interna Hospital del Mar Barcelona Unitat de Control i Prevencio de Tuberculosis Barcelona Departmento de Medicina Interna Hospital A. Marcide-Profesor Novoa Santos EI Ferrol La Coruna Departmento de Enfermedades Infecciosas Hospital Clinic Universitari Barcelona Spain

背景:西班牙四个城市9 家公共卫生治疗中心。目的:比较2 个月利福平+吡嗪酰胺(2RZ)与6 个月异烟肼(6H)治疗潜伏结核感染(LTBI),评估其效益及安全性。设计:对传染性肺结核病人的HIV(-)接触者进行多中心的前瞻性随机比较研究。结果:352 ... 详细信息

背景:西班牙四个城市9 家公共卫生治疗中心。目的:比较2 个月利福平+吡嗪酰胺(2RZ)与6 个月异烟肼(6H)治疗潜伏结核感染(LTBI),评估其效益及安全性。设计:对传染性肺结核病人的HIV(-)接触者进行多中心的前瞻性随机比较研究。结果:352 例中接受6H 者199 例,2RZ 者153 例;6H 组及2RZ 组治疗完成率各为73%及71%(P=0.73)。因肝毒性反应(AST 或ALT>5 倍正常上限值(ULN))而中断治疗者,2RZ 组为10%,6H 组为2.5%(P=0.007)。2RZ 组肝毒性反应高于期望发生率,因而未到期即终止了研究。停止治疗后肝功能均恢复正常。结论是RZ 方案只应用于不适用其它治疗方案者,且需有强化观察肝功能的条件。

关键词：潜伏结核感染 HIV血清学阴性肝毒性反应异烟肼利福平吡嗪酰胺潜伏结核感染联合治疗吡嗪酰胺安全性利福平前瞻性随机比较研究毒性反应肺结核病人正常上限值