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Swarming Computational Techniques for the Influenza Disease System

Computers, Materials & Continua 2022年第12期73卷 4851-4868页

作者： Sakda Noinang Zulqurnain Sabir Gilder Cieza Altamirano Muhammad Asif Zahoor Raja Manuel Jesús Sànchez-Chero maría-verónica seminario-morales Wajaree Weera Thongchai Botmart Department of Mathematics Statistics and Computer Faculty of ScienceUbon Ratchathani UniversityUbon Ratchathani34190Thailand Department of Mathematics and Statistics Hazara UniversityMansehra21120Pakistan Universidad Nacional Autonoma de Chota Cajamarca06121Peru Future Technology Research Center National Yunlin University of Science and Technology123 University RoadSection 3DouliouYunlin64002Taiwan Universidad Nacional de Frontera SullanaPeru Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand

The current study relates to designing a swarming computational paradigm to solve the influenza disease system(IDS).The nonlinear system’s mathematical form depends upon four classes:susceptible individuals,infected people,recovered individuals and cross-immune *** solutions of the IDS are provided by using the artificial neural networks(ANNs)together with the swarming computational paradigm-based particle swarmoptimization(PSO)and interior-point scheme(IPA)that are the global and local search *** ANNs-PSO-IPA has never been applied to solve the *** a merit function in the sense of mean square error is constructed using the differential form of each class of the IDS and then optimized by the *** correctness and accuracy of the scheme are observed to perform the comparative analysis of the obtained IDS results with the Adams solutions(reference solutions).An absolute error in suitable measures shows the precision of the proposed ANNs procedures and the optimization efficiency of the ***,the reliability and competence of the proposed computing method are enhanced through the statistical performances.

关键词： Disease influenza model reference results particle swarm optimization artificial neural networks interior-point scheme statistical investigations

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Stochastic Computational Heuristic for the Fractional Biological Model Based on Leptospirosis

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Computers, Materials & Continua 2023年第2期74卷 3455-3470页

作者： Zulqurnain Sabir Sánchez-Chero Manuel Muhammad Asif Zahoor Raja Gilder-Cieza–Altamirano maría-verónica seminario-morales Fernández Vásquez JoséArquímedes Purihuamán Leonardo Celso Nazario Thongchai Botmart Wajaree Weera Department of Mathematics and Statistics Hazara UniversityMansehraPakistan Universidad Nacional de Frontera SullanaPiuraPerú Future Technology Research Center National Yunlin University of Science and Technology123 University RoadSection 3Douliou64002YunlinTaiwan Universidad Nacional Autónoma de Chota CajamarcaPerú Universidad Cesar Vallejo TrujilloLa LibertadPerú Universidad Señor de Sipán ChiclayoPerú Department of Mathematics Faculty of ScienceKhon Kaen UniversityKhon Kaen40002Thailand

The purpose of these investigations is to find the numerical outcomes of the fractional kind of biological system based on Leptospirosis by exploiting the strength of artificial neural networks aided by scale conjugate gradient,called *** fractional derivatives have been applied to get more reliable performances of the *** mathematical form of the biological Leptospirosis system is divided into five categories,and the numerical performances of each model class will be provided by using the *** exactness of the ANNs-SCG is performed using the comparison of the reference and obtained *** reference solutions have been obtained by using theAdams numerical *** these investigations,the data selection is performed at 82%for training,while the statics for both testing and authentication is selected as 9%.The procedures based on the recurrence,mean square error,error histograms,regression,state transitions,and correlation will be accomplished to validate the fitness,accuracy,and reliability of the ANNs-SCG scheme.

关键词： Fractional leptospirosis biological model artificial neural networks scale conjugate gradient numerical performances

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Transcriptomic responses to drought stress in the Patagonian southern beech Nothofagus alpina

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Ecological Processes 2024年第2期13卷 192-203页

作者： Rita maria Lopez Laphitz maría verónica Arana Santiago Agustín Varela Leandro Aníbal Becker Carolina Soliani maría marta Azpilicueta Paula marchelli Nicolás Bellora Instituto de Diversidad y Evolución Austral (CENPAT CONICET ) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB INTA CONICET ) Instituto de Tecnologías Nucleares para la Salud (CONICET )

Background Deciphering the genetic architecture of drought tolerance could allow the candidate genes identification responding to water stress. In the Andean Patagonian forest, the genus Nothofagus represents an ecologically relevant species to be included in different genomic studies. These studies are scarce in South American ecosystems however represent an important source of genomic data in order to interpret future climate-change environment scenarios of these emblematic forests. Here, we achieved the assemblage of the transcriptome of N. alpina while searching for key genes of activated or suppressed metabolic pathways in response to drought *** De novo transcriptome assembly resulted in 104,030 transcripts. Following confirmation of drought conditions, based on reduction of leaf water potential and stomatal conductance, a differential gene expression analysis resulted in 2720 significantly expressed genes(1601 up-regulated and 1119 down-regulated). Enrichment analysis(over-representation analysis and gene set enrichment analysis) resulted in more than one hundred stress-responsive term ontologies(i.e. biological processes) and pathways. Terms such as response to abscisic acid and pathways such as plant hormone signal transduction or starch and sucrose metabolism were over-represented. Protein–protein interaction assessment resulted in networks with significantly expressed top common hub gene clusters(e.g. planttype cell wall biogenesis among down-regulated or ABA-signalling among up-regulated). These networks evidenced important regulators at gene expression such as transcriptional *** Responses of N. alpina seedlings to drought stress were evidenced by the activation of several genes linked to GO biological processes and KEGG pathways, which were mainly based on over-expression of specific protein kinases, phosphatases, synthases and transcription factors. This suggests an up-regulation of signalling pathways, triggered through pla

关键词： Climate change Differential gene expression Hub genes Patagonia Temperate forest

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A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing Sugar Release

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Journal of Renewable Materials 2024年第3期12卷 539-551页

作者： verônica Távilla Ferreira Silva Adriane maria Ferreira Milagres Departamento de Biotecnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving *** goal was to determine the contributions of xylanase(X)and endoglucanase(EG)in the treatment of pulp,specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid(DNS)***,the release of soluble reducing sugars(RSSol)was enhanced after xylanase treatment,while endoglucanase(EG)treatment led to changes in insoluble reducing sugars(RSIns).The maximum synergism was observed for RSIns when a high ratio of endoglucanase to xylanase(320EG:5X/g pulp)was *** relative contribution of endoglucanase to RSins was determined to be 15.6%of the total reducing *** viscosity of pulps treated with xylanase decreased only by 7%,whereas endoglucanase treatment significantly reduced viscosity by 45%.Modifications in the particle size were observed after pulp treatment with the combination of endoglucanase and *** summary,the DNS test is a rapid and effective method for evaluating the efficiency of enzyme treatments on *** measurement of RSIns correlates with changes in pulp viscosity to different extents,providing valuable insights into the effectiveness of enzyme treatments.

关键词： Endoglucanase xylanase cellulose fiber pulp synergism

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Integrative Analysis of Transcriptome and Phenolic Compounds Profile Provides Insights into the Quality of Soursop (Annona muricata L.) Fruit

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1717-1732页

作者： Yolotzin Apatzingán Palomino-Hermosillo Ángel Elpidio Díaz-Jasso Rosendo Balois-morales verónica AlhelíOchoa-Jiménez Pedro Ulises Bautista-Rosales Guillermo Berumen-Varela Unidad de Tecnología de Alimentos-Secretaría de Investigación y Posgrado Universidad Autónoma de Nayarit.Ciudad de la Cultura SNTepic63000NayaritMéxico Programa Académico de Biología Unidad Académica de AgriculturaUniversidad Autónoma de NayaritKm.9.Carretera Tepic-CompostelaXalisco63780NayaritMéxico Estancias Posdoctorales-Consejo Nacional de Humanidades Ciencias y TecnologíasCoordinación de Apoyos a Becarios e InvestigadoresDirección de PosgradoCiudad de México03940México

Soursop(Annona muricata L.)is a tropical fruit highly valued for its uniqueﬂavor,nutritional value,and health-promoting *** ripening process of soursop involves complex changes in gene expression and metabo-lite accumulation,which have been studied using various omics *** analysis has provided insights into the regulation of key genes involved in ripening,while metabolic compound analysis has revealed the presence of numerous bioactive compounds with potential health beneﬁ***,the integration of transcrip-tome and metabolite compound data has not been extensively explored in ***,in this paper,we present a comprehensive analysis of the transcriptome and phenolic compound proﬁles of soursop during *** integration analysis showed that the genes and phenolic compounds were mainly involved in the starch and sucrose metabolism pathways during soursop ***,the phenolic compounds Kaempferol 3-Q-galactoside,Procyanidin C1,Procyanidin trimmer C1,and m-Coumaric,as well as the genes Ubiquitin-like protein 5(UBL5_ARATH),ATP-dependent zinc metalloprotease FTSH8(FTSH8_ORYSJ),Zinc transporter 4(ZIP4_AR-ATH),Thioredoxin-like 3-1(TRL31_ORYSJ),Mitogen-activated protein kinase YODA(YODA_ARATH),R-man-delonitrile lyase-like(MGL_ARATH),26s protease regulatory subunit 6A homolog(PRS6_SOLLC),Cytochrome P45072A13(C7A13ARATH),Cytochrome P45084A1(C84A1_ARATH)and Homoserine O-trans-acetylase(MET2-ORYSJ)were correlated and differentially accumulated and expressed,*** study provides new insights into the molecular mechanisms underlying soursop ripening and may contribute to the development of strategies for improving the nutritional quality and shelf life of this important fruit.

关键词： Bioinformatics data integration genes metabolites postharvest storage ripening

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Association of Congenital Heart Defects (CHD) with Factors Related to Maternal Health and Pregnancy in Newborns in Puerto Rico

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Congenital Heart Disease 2024年第1期19卷 19-31页

作者： Yamixa Delgado Caliani Gaytan Naydi Perez Eric Miranda Bryan Colón morales Mónica Santos Biochemistry&Pharmacology Department San Juan Bautista School of MedicineCaguas00726Puerto Rico Hispanic Alliance for Clinical and Translational Research University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico Department of Internal Medicine University of Puerto Rico Medical Sciences CampusSan Juan00936Puerto Rico

Background:Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States,there is a compelling need to investigate the intricate interplay among body mass index(BMI),pregesta-tional,and gestational maternal diabetes,and their potential impact on the occurrence of congenital heart defects(CHD)during neonatal ***:Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico,we conducted a focused analysis on neonates diagnosed with CHD between 2016 and *** assessment encompassed a range of variables,including maternal age,gestational age,BMI,pregestational diabetes,gestational diabetes,hypertension,history of abortion,and presence of ***:A cohort of 673 patients was included in our *** average maternal age was 26 years,within a range of 22 to 32 *** mean gestational age measured 39 weeks,with a median span of 38 to 39 *** the 673 patients,274(41%)mothers gave birth to neonates diagnosed with *** this group,22 cases were linked to pre-gestational diabetes,while 202 were not;20 instances were associated with gestational diabetes,compared to 200 without;and 148 cases exhibited an overweight or obese BMI,whereas 126 displayed a normal ***:We identiﬁed a statistically signiﬁcant correlation between pre-gestational diabetes mellitus and the occurrence of ***,our analysis did not show a statistically signiﬁcant association between maternal BMI and the likelihood of *** results may aid in developing effective strategies to prevent and manage CHD in neonates.

关键词： Congenital heart defects(CHD) obesisty maternal health diabetes body mass index(BMI)

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Effects of fertilization on radial growth of Pinus pinea explored hourly using dendrometers

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Ecological Processes 2024年第1期 25-39页

作者： verónica Loewe-Mu?oz Rodrigo del Río Millar Claudia Delard Rodriguez Mónica Balzarini Chilean Forest Institute (INFOR) Metropolitan Office Centro Nacional de Excelencia Para la Industria de la Madera(CENAMAD) Pontificia Universidad Católica de Chile Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Córdoba Ciudad Universitaria

Background Stone pine(Pinus pinea), a drought-resistant species, has significant socio-economic benefits and increasing interest for the establishment of productive plantations in several countries, especially in a climate change context. Monitoring hourly stem diameter variations contributes to the understanding of the tree-growth response to changes in environmental conditions and management. By monitoring the diameter expansion of tree stems, high-resolution band dendrometers were used to study the development of adult trees growing in a semi-arid coastal environment of central Chile under fertilized and non-fertilized soil conditions through the span of a *** Short cycles( 28 h) occurred at a higher frequency in fertilized trees(16 vs 6). Most of the circadian cycles were regular(24 ± 3 h). The longest cycle duration(59 h) was observed in fertilized trees during spring. In all seasons, each phase of the circadian cycle, especially during the stem diameter increment phase(P3, irreversible growth), started earlier in fertilized than in control trees. P3 duration was significantly longer in fertilized than in control trees in springtime. The maximum shrinkage(P1) was observed in summer for both treatments. Stem diameter increased faster in fer-tilized than in control trees throughout the year, with the highest accumulation occurring in spring and the lowest in autumn. The daily variability pattern showed lower growth under high temperature across *** This study highlights the importance of fertilization in enhancing stone pine diameter growth. This cultural practice should be further explored to contribute to the mitigation of climate change effects in semi-arid environments.

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Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

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World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stefanolo verónica Segura martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto Puebla maría Paz Temprano Sonia Isabel Niveloni Gabriel de Diego maría E Oregui Edgardo Gustavo Smecuol Mauricio C de marzi Elena F verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina Department of Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant *** To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual *** This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term *** a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or *** endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of *** samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and *** Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol ***,628/640(98.1%)stool samples were *** was undetectable(0.32μg/g)to potentially cause mucosal *** GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in ***-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP *** with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(Pverall GIP stool ***,given the observation of a significantly lower prevale

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

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Long-term monitoring reveals the effect of precipitation and silviculture on Nothofagus regeneration in Northern Patagonia mixed forests

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Ecological Processes 2024年第02期13卷 103-117页

作者： Georgina Sola Camila Mateo Alejandro Dezzotti Paula marchelli Hernán Attis Beltrán Renato Sbrancia Luis Chauchard marcelo González Pe?alba martín Lara verónica El Mujtar Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Asentamiento Universitario San martín de los Andes (AUSMA-UNCo) Instituto de Investigaciones Forestales y Agropecuarias Bariloche (IFAB) Instituto Nacional de Tecnología Agropecuaria (INTA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Departamento de Conservación y Manejo Parque Nacional Lanín- Administración de Parques Nacionales (PNL-APN)

Background Tree regeneration is a key component of resilience because it promotes post-disturbance recovery of forests. Northwestern Patagonia from Argentina is occupied by Nothofagus alpina（Na）, N. obliqua（No）, and N. dombeyi（Nd） forests that grow along an intense precipitation gradient, managed throughout shelterwood silvicultural system by technicians of the Lanin Natural Reserve. The objective of this study was to evaluate the influence of seeding cuttings over the dynamics of Nothofagus mixed forests across landscape（precipitation gradient） based mainly on the composition and abundance of tree regeneration, permanent sampling plots and generalized linear mixed models. In particular, we analysed:（i） the structure of sexual and asexual regeneration during 20 years after harvest（the dynamics of managed forests）, and（ii） the structure of sexual regeneration in primary and managed forests after > 20 years of harvest（the effect of silviculture）.Results Nd was the most abundant species in the regeneration of managed forests during all periods in both sites despite its lower contribution to the adult cohort. During the 10–20 years period after harvest, the humid site exhibited higher regeneration density than the mesic site(120,000 and 6000 ind ha-1, respectively), and it decreased afterwards. The number of established regeneration（> 2 m height） was lower for Na in the mesic site and for No in the humid site(0 and 57 ind ha-1, respectively). However, in comparison to No, Na showed a higher number of sprouted stumps and sprouts per stump, and a higher sprout height in the mesic site. No exhibited higher sprout mortality in the humid site. Finally, the regeneration of primary forests showed lower density and height, and a more balanced composition than that of managed *** The silvicultural effects on the mixed forest regeneration dynamics was strongly influenced by the condition of sites. Therefore, management prescriptions should be adj

关键词： Nothofagus alpina Nothofagus obliqua Nothofagus dombeyi Basal sprouting Shelterwood silvicultural system Ecological resilience

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Geochemical Characterization of Soils in the Playa Lake Environment of Laguna de Encinillas, Chihuahua, Mexico

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Open Journal of Geology 2024年第9期14卷 900-918页

作者： maría Fernanda Ponce-González Alejandro Villalobos-Aragón Vanessa verónica Espejel-García Daphne Espejel-García Facultad de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

Laguna de Encinillas, located in Chihuahua, Mexico, is an ephemeral lake situated within a playa lake sedimentary depositional environment. This region plays a significant role in the aquifer supplying water to Chihuahua City. A surficial soil sampling campaign was conducted in 2017, 2018, and 2021 to assess the potential impact of surface soil composition on groundwater quality. The collected soil samples were analyzed using inductively coupled plasma mass spectrometry (ICP-MS) following microwave-assisted digestion. The analytical results were employed to generate spatial distribution maps of elemental concentrations using QGIS, applying interpolation methods such as inverse distance weighting (IDW) and Kriging. The analysis revealed elevated concentrations of beryllium (Be), calcium (Ca), cadmium (Cd), chromium (Cr), magnesium (Mg), and strontium (Sr) in the eastern part of the study area. In contrast, arsenic (As) and iron (Fe) were more prevalent in the western sector. Notably, high levels of barium (Ba), silver (Ag), cobalt (Co), potassium (K), and scandium (Sc) were identified in the northeastern region. At the same time, nickel (Ni), titanium (Ti), and vanadium (V) were concentrated in the northern portion. Manganese (Mn) was particularly prominent in the southern area. The geogenic source of these elements is likely linked to the volcanic rocks from the surrounding mountain ranges.

关键词： Groundwater Quality Soils El Sauz-Encinillas Aquifer Chihuahua GIS

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