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Oxidative stress,the blood-brain barrier and ne.rodegene.ative diseases:The critical bene.icial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares marta martíne. Bernardo Lopez-Torres maría-rosa martíne.-larran aga Xu Wang Arturo Anadon maría-Aranzazu martíne. National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awarene.s of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with ne.rodegene.ative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,vegetables,nuts and oils and are gaining popularity due to recently growing awarene.s of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,gene.ally non-toxic nature,and ease of long-term *** review article examine. the role of oxidative stress in the development of NDs,explores the‘two-sidedne.s’of the blood-brain barrier(BBB)as a protective barrier to the ne.vous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier ne.rodegene.ative diseases Vitamins Carotenoids Flavonoids Polyphenols

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