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Kinetics of the reaction of OH radical with ethylfluoroacetate,ethyl 4,4,4-trifluorobutyrate,and butylfluoroacetate

Journal of Environmental Sciences 2025年第5期151卷 273-283页

作者： Pedro l.lugo Vianni Straccia mariano A.Teruel maría B.Blanco laboratorio Universitario de Química y Contaminación del Aire(l.U.Q.C.A) Institute for Research in Physical Chemistry of Córdoba(I.N.F.I.Q.C.)Department of Physical ChemistryFaculty of Chemical SciencesNational University of CórdobaUniversity CityCórdoba 5000Argentina Institute for Atmospheric and Environmental Research University of WuppertalWuppertal DE-42097Germany

Kinetics of the gas-phase reactions of•OH radicals with a series of fluoroesters were studied for the first time at 298±3 K and atmospheric *** rate coefficients were determined by in situ FTIR spectroscopy in nitrogen and GC-FID in air to monitor the decay of reactants and *** following coefficient values(in 10^(−12)cm^(3)/(molecule•sec))were obtained for ethyl fluoroacetate(EFA),ethyl 4,4,4-trifluorobutyrate(ETB),and butyl fluoroacetate(BFA),respectively:k_(1)(EFA+OH)=1.15±0.25 by FTIR and 1.34±0.23 by GC-FID;k_(2)(ETB+OH)=1.61±0.36 by FTIR and 2.02±0.30 by GC-FID;k_(3)(BFA+OH)=2.24±0.37 by *** trends were developed and correlated with the number of CH_(3)and F substituents in the fluoroester,and structure-activity relationships(SARs)calculations were *** addition,the tropospheric lifetimes of EFA,ETB,and BFA upon degradation by OH radicals were calculated to be 9,6,and 5 days,respectively,indicating that these fluorinated compounds could have a possible regional effect from the emission *** small photochemical ozone creation potentials of 9,7,and 19 were estimated for EFA,ETB,and BFA,*** GlobalWarming Potentials(GWPs)for EFA,ETB,and BFA were calculated for different time *** a 20-year time horizon,the GWPs were 1.393,0.063,and 0.062,*** the case of a 100-year time horizon,the GWPs were 0.379,0.017,and 0.017,and for a 500-year time horizon,the GWPs were 0.108,0.005,and 0.005 for EFA,ETB,and BFA.

关键词： CFC replacements sinks in situ FTIR SAR Acidification potentials Greenhouse gases

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz Juan D.navarro-lópez neuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Atmospheric chemistry of trifluorodicarbonyls initiated by Cl atoms:Reactivity trends,mechanism,and acid formation yields

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Journal of Environmental Sciences 2025年第5期151卷 12-25页

作者： Pedro l.lugo Vianni G.Straccia Cynthia B.Rivela mariano A.Teruel maría B.Blanco laboratorio Universitario de Química y Contaminación del Aire(l.U.Q.C.A) Instituto de Investigaciones en Fisicoquímica de Córdoba(I.N.F.I.Q.C.)Dpto.de Fisicoquímica.Facultad de Ciencias QuímicasUniversidad Nacional de Córdoba.Ciudad Universitaria5000 CórdobaArgentina Institute for Atmospheric and Environmental Research University of WuppertalDE-42097 WuppertalGermany

Rate coefficients of the gas-phase reactions of Cl atoms with a series of fluorinated diketones(FDKs):CF_(3)C(O)CH_(2)C(O)CH_(3)(TFP),CF_(3)C(O)CH_(2)C(O)CH_(2)CH_(3)(TFH)and CF_(3)C(O)CH_(2)C(O)CH(CH_(3))2(TFMH),have been measured at(298±2)K and under atmospheric *** experiments were performed using the relative-rate method with a GC-FID detection *** different determinations and references used,the following rate coefficients were obtained(in cm3/(molecule·sec)):k_(4)(TFP+Cl)=(1.75±0.21)×10^(−10),k_(5)(TFH+Cl)=(2.05±0.23)×10^(−10),k_(6)(TFMH+Cl)=(2.71±0.34)×10^(−10).Reactivity trends of FDKs were discussed and Free Energy Relationships analysis was *** expression lgkOH=1.68 lgkCl+5.71 was obtained for the reactivity of the studied FDKs together with similar unsaturated VOCs with Cl and OH radicals Additionally,acetic acid(CH_(3)C(O)OH)and trifluoroacetic acid(CF_(3)C(O)OH)were positively identified and quantified as degradation products using in situ FTIR *** to the identified products,atmospheric chemical mechanisms were *** atmospheric implications of the studied reactions were assessed by the estimation of the tropospheric lifetimes of TFP,TFH,and TFMH concerning their reaction with Cl atoms to be 48,41,and 31 hours,*** relatively short residence in the atmosphere of the fluorocarbons studied will have a local/regional impact with restricted *** warming potential(GWP(20 yr))calculated for the studied fluoro diketones were 0.014,0.003 and 0.001 for TFP,TFH and TFMH,respectively with a negligible contribution to the greenhouse effect.

关键词： Fluorinated diketones Kinetics SPME-GC-FID FTIR in situ SAR Free energy relationships

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Comprehensive view of suicide:A neuro-immune-endocrine approach

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World Journal of Psychiatry 2025年第2期15卷 1-22页

作者： maría D Ponce-Regalado Enrique Becerril-Villanueva Joséluis Maldonado-García martha C Moreno-lafont Gabriela martínez-Ramírez Salomón Jacinto-Gutiérrez Rodrigo Arreola Karla Sánchez-Huerta Arturo Contis-Montes de Oca Karla maría lópez-martínez Elizabeth Bautista-Rodríguez JoséMiguel Chin-Chan lenin Pavón Gilberto Pérez-Sánchez Departamento de Ciencias de la Salud Centro Universitario de los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620JaliscoMexico laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizCiudad de México 11340Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacánCiudad de México 04510Mexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de México 11350Mexico Facultad de Medicina Facultad de Estudios Superiores IztacalaUniversidad Nacional autónoma de MéxicoTlalnepantla 54090Mexico Subdirección de Investigaciones Clínicas Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizCiudad de México 11340Mexico laboratorio de neurociencias Subdirección de Medicina ExperimentalInstituto Nacional de PediatríaCiudad de México 04530Mexico Sección de Estudios de Posgrado e Investigación Escuela Superior de MedicinaInstituto Politécnico NacionalCiudad de México 11340Mexico Facultad de Biotecnología Universidad Popular Autónoma de PueblaPuebla 72410Mexico Química Clínica Facultad de Ciencias de la SaludUniversidad Autónoma de TlaxcalaTlaxcala 90750Mexico Facultad de Ciencias Químico-Biológicas Universidad Autónoma de CampecheCampeche 24039Mexico

Suicide is defined as the act of a person attempting to take their own life by causing *** is a complex phenomenon that is influenced by a multitude of factors,including psychosocial,cultural,and religious aspects,as well as genetic,biochemical,and environmental *** a biochemical perspective,it is crucial to consider the communication between the endocrine,immune,and nervous systems when studying the etiology of *** pathologies involve the bidirectional communication between the peripheral activity and the central nervous system by the action of molecules such as cytokines,hormones,and *** humoral signals,when present in optimal quantities,are responsible for maintaining physiological homeostasis,including mood *** elevates the cortisol and proinflammatory cytokines levels and alter neurotransmitters balance,thereby increasing the risk of developing a psychiatric disorder and subsequently the risk of suicidal *** review provides an integrative perspective about the neurochemical,immunological,and endocrinological disturbances associated with suicidal behavior,with a particular focus on those alterations that may serve as potential risk markers and/or indicators of the state preceding such a tragic act.

关键词： Suicide neuroimmune endocrine neurotransmitters Hormones Cytokines Hypothalamic-pituitary adrenal axis Early life adversity Inflammation Genetic predisposition Psychiatric disorders

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Prehospital critical care drug-therapy and 30-day mortality in patients with acute respiratory disease

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World Journal of Emergency Medicine 2025年第1期16卷 43-50页

作者： Jesús Jurado-Palomo Joséluis martín-Conty Begoña Polonio-lópez Cristina Rivera Picón Raúl lópez-Izquierdo Carlos del Pozo Vegas Pedro Ángel de Santos Castro Ancor Sanz-García Francisco martín-Rodríguez Technological Innovation Applied to Health Research Group(ITAS) Faculty of Health SciencesCastilla-La Mancha UniversityTalavera de la Reina 45600Spain nuestra Señora del Prado General Hospital Talavera de la Reina 45600Spain Emergency Department Rio Hortega University HospitalValladolid 47012Spain CIBER of Respiratory Diseases(CIBERES) Institute of Health Carlos ⅢMadrid 28029Spain Faculty of Medicine University of ValladolidValladolid 470003Spain Emergency Department University Clinical HospitalValladolid 47003Spain Prehospital Emergency Medical Services(SACYl) Valladolid 47007Spain

BACKGROUnD: Prehospital medication is a reality, and the role of these therapies must be explored to assess their validity, especially for acute respiratory diseases, which are usually associated with increased morbidity. The aim of this study was to examine the association of prehospital medication use with mortality in patients with acute respiratory ***: A prospective, multicenter, emergency medical service(EMS) delivery cohort study was carried out in adults with unselected respiratory diseases managed by EMS who were transferred to the emergency department. From January 1, 2019, to October 31, 2023, six advanced life support units, thirty-eight basic life support units, and four hospitals in Spain participated in the study. Demographic data, vital signs, use of mechanical ventilation, prehospital respiratory diagnosis, and prehospital medication were collected. The primary outcome was 30-day in-hospital ***: A total of 961 patients were included, with a mortality rate of 17.5%(168 patients). Age, an increasing number of comorbidities, the use of invasive mechanical ventilation(IMV), the use of major analgesics, hypnotics, and bicarbonate were risk factors. In contrast, elevated systolic blood pressure and Glasgow Coma Scale scores were found to be protective factors against mortality. The predictive capacity of the model reached an area under the curve(AUC) of 0.857(95% confidence interval [95% CI] 0.827–0.888).COnClUSIOn: Our data revealed that IMV, major analgesics, hypnotics and bicarbonate administration were associated with elevated mortality. Adding prehospital drug therapy information to demographic variables and vital signs could improve EMS decision-making, allowing a better characterization of patients at risk of clinical worsening.

关键词： Drug-therapy Medication Prehospital Mortality Emergency medical services

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Multiple Chemical Sensitivity: A Sickness of Suffering, not of Dying. Descriptive Study of 33 Cases

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Health 2025年第1期17卷 65-81页

作者： Blanca navas-Soler Aarón Gutiérrez-Pastor Antonio Palazón-Bru Jorge Vallejo-Ortega Álex Méndez-Jover Celia Santano-Pérez Carmen Seguí-Pérez marc Seguí-Pérez Sonia Cascant-Pérez Juan Carlos lópez-Corbalán Míriam Pérez-Cardona Ramón Pérez-Doménech Antonio Hernández-García Patricia lorca-Amorrich Ana Belén llinares-llinares Cristina Valverde-Cámara Rosa maría Bustos-martínez Juan Manuel núñez-Cruz Isidro Hernández-isasi José Juan martínez-Pérez José Manuel Santano-lópez maría Dolores Jover-Ríos Juan Méndez-Mora José Miguel Seguí-Ripoll Internal Medicine Service University Hospital of San Juan de Alicante Alicante Spain Family and Community Medicine Service University Hospital of San Juan de Alicante Alicante Spain Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FisaBIO) University Hospital of San Juan de Alicante Alicante Spain Faculty of Physics University of Alicante Alicante Spain Department of Clinical Medicine Medical School University Miguel Hernandez de Elche Alicante Spain CEU Veterinary School University Cardenal Herrera Alfara del Patriarca Campus Valencia Spain Secondary School Marist Brothers High School Alicante Spain Primary Medicine Hospital Francesc Borgia of Gandia Valencia Spain Faculty of Medicine CEU Cardenal Herrera University Alfara del Patriarca Campus Valencia Spain Faculty of Economics University of Alicante Alicante Spain Department of Internal Medicine Hospital La Vega Baja of Orihuela Alicante Spain

Objective: We describe patients with MCS, the evolution of the Quick Environmental Exposure and Sensitivity Inventory (QEESI) score with a special focus on people whose fillings were removed. Methods: We have conducted a retrospective longitudinal cohort study in patients diagnosed with MCS and attended in the outpatient Internal Medicine department of the University Hospital of San Juan de Alicante, from January 1, 2008 to January 1, 2021. Sociodemographic, clinical, QEESI and treatment-related variables were collected. We performed descriptive and inferential analyses. Mixed linear models were used to analyze the QEESI. Calculations were carried out with an α error of 5%. Results: Thirty-three patients were included (72.7% women, mean age 56.2). MCS was mainly triggered by mercury (n = 20) and food intolerance (n = 22). The mean interval from symptoms onset was 120 months (SD 81.6). 114 QEESIs were analyzed: 82 (n = 17 without amalgams) and 32 (n = 16 with amalgams). In patients without amalgams, severity scores increased across all subscales except the masking index (vs. with amalgams). Mean scores for the group without amalgams (vs. with amalgams) were: chemical intolerance, 62.8 points (vs. 63.4 and 46.7);other intolerances, 52.7 points (vs. 62.8 and 50.3);symptom severity, 63.2 (vs. 76.7 and 63.3);masking index, 3.9 (vs. 3.2 and 2.8);and life impacts, 63.1 (vs. 58.4 and 49.8). Conclusion: The profile of patient with MCS is a middle-aged woman who is a frequent user of healthcare services, presents a long diagnostic delay and has borne a great personal, work and socioeconomic impact. The QEESI is useful for the clinical follow-up of patients, including the optimal treatment response in the case of amalgams. Clinical Significance: People affected by Multiple Chemical Sensitivity deserve the attention, understanding and help of health professionals and family members, to face an invisible illness for those who do not suffer from it. Support is needed and doctors

关键词： Chemical Sensitivity Electromagnetic Sensitivity Mercury Poisoning Amalgams QEESI

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). However, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of neuroscience and Regenerative Medicine&Department of neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(l-alanine,glycine,l-glutamine,and l-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by n-methyl-D-aspartate *** n-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system n transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through n-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling n-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Effect of alpha-lipoic acid and Silybum marianum supplementation with a Mediterranean diet on metabolic dysfunction-associated steatosis

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World Journal of Hepatology 2025年第1期17卷 86-95页

作者： Ana D Cano Contreras maría Del Rocío Francisco Jose l Vargas Basurto Kevin D Gonzalez-Gomez Mercedes Amieva-Balmori Federico Roesch Dietlen JoséM Remes-Troche Instituto de Investigaciones Médico-Biológicas Universidad VeracruzanaVeracruz 91700Mexico

BACKGROUnD The treatment of metabolic dysfunction-associated steatotic liver disease(MA-SlD)has focused on the control of *** marianum(SM)and alpha-lipoic acid(AlA)have shown antioxidant and adjuvant effects on the control of metabolic *** To evaluate whether the SM-AlA formulation(lUDlEV®),in combination with the Mediterranean diet(MD),could improve MASlD-related liver *** A randomized,double-blind clinical trial was conducted on patients with *** of SM-AlA plus MD(group A)vs placebo plus MD(group B)was compared for 24 *** baseline and weeks 12 and 24,anthropometric measurements,metabolic parameters,and liver function were *** effectiveness was evaluated through transient *** Fifty patients aged 54±10 years were included,and the majority(74%)were *** visceral fat and umbilical circumference were reported in both groups,with significance in group A(P=0.045 and 0.003,respectively).The de-crease in controlled attenuation parameter was gradual and maintained at 12 and 24 weeks in group A(P=0.026),whereas in group B the decrease was greater at week 12 and remained unchanged at week 24(∆controlled attenuation parameter:-27 dB/m).Mild adverse effects were reported in 4 patients in group A(16%)and 4 patients in group B(16%),with no significant differences between groups(P=0.641).COnClUSIOn SM-AlA(lUDlEV®)combined with the MD can promote the improvement of metabolic parameters,reducing visceral fat and hepatic steatosis in Mexican patients with MASlD.

关键词： Steatotic liver disease Silybum marianum Alpha-lipoic acid Mediterranean diet Fatty liver

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In silico analysis of lncRnA-miRnA-mRnA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la Cruz-Ojeda Ester Parras-martínez Raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors laboratory Centre de Recherche des CordeliersParis 75006France Department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUnD Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SnU449 *** To define the long non-codingRnA-microRnA-mRnA(lncRnA-miRnA-mRnA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RnAseq studies using Sorafenib-treated HepG2 and SnU449 *** available software analyses allowed us to establish the lncRnA-miRnA-mRnA regulatory axes following treatment in HepG2 and SnU449 *** HepG2 and SnU449 cells were treated with Sorafenib(10μmol/l)for 24 *** RnA,including small and long RnA,was extracted with a commercial miRneasy *** was carried out for the identification of changes in lncRnA-miRnA-mRnA regulatory *** MAlAT,THAP9-AS1 and SnGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 l4A-AS1,lInC01578,SnHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SnU449 *** axes MAlAT1/hsamir-374b-3p/SMAD7 and MAlAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SnU449 cells to Sorafenib *** Critical lncRnAs acting as sponges of miRnA were identified that regulated mRnA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SnU449 cells.

关键词： Cell culture Hepatocellular carcinoma non-coding RnA RnAseq Sorafenib

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