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Factors associated with H pylori epidemiology in symptomatic children in Buenos Aires,Argentina

World Journal of Gastroenterology 2006年第33期12卷 5384-5388页

作者： Cinthia Goldman Andrés Barrado mariana Janjetic Norma Balcarce Eduardo Cueto Rua Masaru Oshiro maría l calcagno margarita martinez Sarrasague Julián Fuda Ricardo Weill marcela Zubillaga Guillermo I Perez-Perez José Boccio Radioisotopes laboratory and laboratory of Stable Isotopes Applied to Biology and Medicine Physics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina laboratory of Stable Isotopes Applied to Biology and Medicine Physics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Gastroenterology Unit Hospital de nios "Superiora Sor María Ludovica" La Plata Argentina Health Center Di Matteo San Fernando Buenos Aires Argentina Mathematics Department School of Pharmacy and Biochemistry University of Buenos Aires Buenos Aires Argentina Agrarian Industries Department School of Agronomy University of Morón Buenos Aires Argentina Departments of Medicine and Microbiology New York University School of Medicine New York United States

AIM: To determine prevalence of H pylori infection in symptomatic children in Buenos Aires, Argentina, and to investigate factors associated with H pylori positivity. METHODS: A total of 395 children with upper gastrointestinal symptoms referred to the Gastroente-rology Unit of the Children Hospital “Sor maria ludovica” were evaluated for the presence of H pylori by the 13C-Urea Breath Test (13C-UBT). A questionnaire was applied to the recruited ***: Prevalence of H pylori infection was 40.0%in this population (mean age 9.97 ± 3.1 years). The factors associated with H pylori positivity were number of siblings (P ld, and antecedents of gastritis among family members (P = 0.01). After multivariate analysis, number of siblings [Odds ratio (OR) = 1.39; 95% CI, 1.20-1.61] and contact with pet cats (OR = 1.76; 95% CI, 1.00-3.09) remained as variables associated with H pylori infection. CONClUSION: The prevalence of H pylori infection in children with upper gastrointestinal symptoms in Argentina was similar to that reported in developed countries. Children from families with a higher crowding index and presence of pet cats have a higher risk of being colonized with H pylori.

关键词：流行病学幽门螺杆菌甲酮-钠除草剂阿根庭

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FOlFOXIRI vs FOlFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 332-346页

作者： Angélique Vienot Hortense Chevalier Clément Bolognini Elisabeta Gherga Elodie Klajer Aurélia Meurisse marine Jary Stefano Kim Christelle d’Engremont Thierry Nguyen Fabien calcagno Hamadi Almotlak Francine Fein Meher Nasri Syrine Abdeljaoued Anthony Turpin Christophe Borg Dewi Vernerey Department of Medical Oncology Besançon University HospitalBesançon F-25030France University Bourgogne Franche-Comté INSERMEFS BFCUMR1098Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et GéniqueBesançon F-25000France INSERM CIC-1431 Clinical Investigation Center in BiotherapyBesançon University HospitalBesançon F-25030France Department of Medical Oncology Lille University HospitalLille F-59000France Department of Medical Oncology Nord Franche-ComtéHospitalMontbéliard F-25020France Methodological and Quality of life in Oncology Unit Besançon University HospitalBesançon F-25030France Department of Gastroenterology Besançon University HospitalBesançon F-25030France

BACKGROUND FOlFIRINOX regimen is the first-line reference chemotherapy(l1)in advanced pancreatic ductal adenocarcinoma(aPDAC).FOlFOXIRI,a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil,has demonstrated efficacy and feasibility in colorectal *** To investigate the potential clinical value of FOlFOXIRI in patients with aPDAC in routine clinical *** Analyses were derived from all consecutive aPDAC patients treated in l1 between January 2011 and December 2017 in two French institutions,with either FOlFOXIRI(n=165)or FOlFIRINOX(n=124)*** consisted of irinotecan(165 mg/m2),oxaliplatin(85 mg/m2),leucovorin(200 mg/m2)and 5-fluorouracil(3200 mg/m2 as a 48-h continuous infusion)every 2 ***-six pairs of patients were selected through propensity score matching,and clinical outcomes of the two treatment regimens were *** Median overall survival was 11.1 mo in the FOlFOXIRI and 11.6 mo in the FOlFIRINOX cohorts,*** propensity score matching,survival rates remained similar between the two regimens in terms of overall survival(hazard ratio=1.22;P=0.219)and progression-free survival(hazard ratio=1.27;P=0.120).The objective response rate was 37.1%in the FOlFOXIRI group vs 47.8%in the FOlFIRINOX group(P=0.187).Grade 3/4 toxicities occurred in 28.7%of patients in the FOlFOXIRI cohort vs 19.5%in the FOlFIRINOX cohort(P=0.079).FOlFOXIRI was associated with a higher incidence of grade 3/4 digestive adverse *** growth factors were used after each chemotherapy cycle and the low hematological toxicity rates were below 5%with both *** FOlFOXIRI is feasible in l1 in patients with aPDAC but does not confer any therapeutic benefit as compared with *** low hematological toxicity rates strengthened the relevance of primary prophylaxis with hematopoietic growth factors.

关键词： Advanced pancreatic cancer First-line chemotherapy FOlFOXIRI FOlFIRINOX Propensity score Cohort study

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产后出血病人动脉栓塞后的月经恢复和生育:单中心回顾性观察研究

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国际医学放射学杂志 2009年第2期32卷 207-207页

作者： G.Gaia P.Chabrot l.Cassagnes A.calcagno D.Gallot R.Botchorishvili 陈聪 Department Gynaecology and Obstetrics Polyclinique de l’ Hötel-Dieu CHU

评价动脉栓塞治疗产后出血以后对月经恢复和妊娠的远期影响。该单中心回顾性研究收集了1999--2006年因产后大出血而行动脉栓塞的113例连续病人。栓塞剂使用方面，106例采用可吸收的明胶海绵颗粒．3例采用明胶海绵粉，4例采用惰性微粒。... 详细信息

评价动脉栓塞治疗产后出血以后对月经恢复和妊娠的远期影响。该单中心回顾性研究收集了1999--2006年因产后大出血而行动脉栓塞的113例连续病人。栓塞剂使用方面，106例采用可吸收的明胶海绵颗粒．3例采用明胶海绵粉，4例采用惰性微粒。111／113例（98．1％）病人经动脉栓塞后出血得以成功控制，2例（1．7％）因栓塞不成功而行子宫切除术。

关键词：产后出血动脉栓塞粘连植入胎盘

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