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Loss of efficacy and safety of the switch from infliximab original to infliximab biosimilar(CT-P13)in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2018年第46期24卷 5288-5296页

作者： maría fernanda guerra veloz Federico Argüelles-Arias Luisa Castro Laria Belén Maldonado Pérez Antonio Benítez Roldan Raúl Perea Amarillo Vicente Merino Bohórquez Miguel Angel Calleja Angel Caunedo Alvarez Angel Vilches Arenas Department of Gastroenterology University Hospital Virgen MacarenaSeville 41007Spain Pharmacy Unit University Hospital Virgen MacarenaSeville 41007Spain Preventive Medicine and Public Health University Hospital Virgen MacarenaSeville 41007Spain

BACKGROUND Infliximab original has changed the natural history of inflammatory bowel diseases(IBD) over the past two decades. However, the recent expiration of its patent has allowed the entry of the first Infliximab biosimilar into the European and Spanish markets. Currently switching drugs data in IBD are limited. AIM To compare the efficacy of infliximab biosimilar, CT-P13, against infliximab original, analyzing the loss of response of both at the 12 mo follow-up in patients with *** An observational study of two cohorts has been conducted. One retrospective cohort that included patients with IBD treated with Infliximab original, and a prospective cohort of patients who were switching from infliximab original to infliximab biosimilar(CT-P13). We had analyzed the overall efficacy and loss of efficacy in patients in remission at the end of one year after treatment with the original drug compared to the results of the year of treatment with the ***98 patients(CD 67, CU 31) were included in both cohorts. The overall efficacy for infliximab original per year of treatment was 71% vs 68.2% for infliximab biosimilar(P = 0.80). The loss of overall efficacy at 12 mo for infliximab original was 6.6% vs 14.5% for infliximab biosimilar(P = 0.806). The loss of efficacy in patients who were in basal remission was 16.3% for infliximab original vs 27.1% for infliximab biosimilar. Adverse events were 9.2% for infliximab original vs 11.2% for infliximab biosimilar. CONCLUSION The overall efficacy and loss of treatment response with infliximab biosimilar(CT-P13) is similar to that observed with infliximab original in patients who were switching at the 12 mo follow-up. There is no difference in the rate of adverse events.

关键词： Crohn’s disease Ulcerative colitis CT-P13 Inflammatory bowel disease Biosimilar agent Infliximab original Efficacy

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Portal vein arterialization in 25 liver transplant recipients:A Latin American single-center experience

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World Journal of Transplantation 2024年第2期14卷 135-147页

作者： Nicolas Andres Cortes-Mejia Diana fernanda Bejarano-Ramirez Juan Jose guerra-Londono Diego Rymel Trivino-Alvarez Raquel Tabares-Mesa Alonso Vera-Torres Division of Anesthesiology Critical Care Medicineand Pain MedicineThe University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Transplant and Hepatobiliary Surgery Department Fundacion Santa Fe de BogotaBogota 110111Colombia General Surgery Department Fundacion Santa Fe de BogotaBogota 110111Colombia

BACKGROUND Portal vein arterialization(PVA)has been used in liver transplantation(LT)to maximize oxygen delivery when arterial circulation is compromised or has been used as an alternative reperfusion technique for complex portal vein thrombosis(PVT).The effect of PVA on portal perfusion and primary graft dysfunction(PGD)has not been *** patients receiving PVA and LT at the Fundacion Santa Fe de Bogota between 2011 and 2022 were *** account for the time-sensitive effects of graft perfusion,patients were classified into two groups:prereperfusion(pre-PVA),if the arterioportal anastomosis was performed before graft revascularization,and postreperfusion(post-PVA),if PVA was performed *** pre-PVA rationale contemplated poor portal hemodynamics,severe vascular steal,or ***-PVA was considered if graft hypoperfusion became *** interventions were attempted before PVA.

关键词： Liver transplantation Portal vein arterialization Arteriovenous anastomoses Portal hypertension Portal vein thrombosis Spontaneous portosystemic shunts Vascular steal phenomenon Primary graft dysfunction Early allograft dysfunction

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Photodegradation and Removal of Diclofenac by the Green Alga Nannochloropsis oculata

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1519-1533页

作者： Danaé Samara Sánchez-Sandoval Omar González-Ortega mara fernanda Navarro-martínez Juan marcos Castro-Tapia Ramón Fernando García de la Cruz Ruth Elena Soria-guerra Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México

The emerging contaminants(ECs)are organic compounds including *** products are consumed in large quantities,favoring their continuous entrance to the environment and affecting the health of living *** is a non-steroidal anti-inflammatory drug with analgesic properties of prolonged *** is the commonest postoperative analgesic,and it is highly consumed without *** recent years,the capability of microalgae to remove pharmaceuticals in water has been tested as a promising *** this work,the removal efficiency of diclofenac(16µg/mL)by the microalga Nannochloropsis oculata CCAP 186/7 was *** major nutrient concentrations in Bold’s Basal Medium were modified(nitrogen and carbon:50 and 100%of their original concentration)to know their effect in the removal of *** degradation by light was also *** maximum removal capacity of diclofenac in the medium was 68.8%.The percentage of diclofenac adsorbed on the cell wall was between 6 and 12.7%.Around 23.6%of diclofenac was degraded by light after 18 *** did not show growth inhibition due to the presence of *** results obtained point to the promissory application of *** as a bioremediation system for diclofenac removal.

关键词： Adsorption emerging contaminants microalgae pharmaceuticals phycoremediation photodegradation

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Red Onion (Allium Cepa L.) Methanolic Extract Increases Extracellular Nucleotide Hydrolysis in Rat Serum

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Open Journal of Applied Sciences 2020年第12期10卷 864-876页

作者： Janayne Luihan Silva Bruno Quintanilha Faria Vinícius marques Arruda fernanda Cardoso da Silva Joyce Ferreira da Costa guerra Cristina Ribas Fürstenau Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte Brazil Curso de Biotecnologia Universidade Federal de Uberlandia Patos de Minas Brazil Programa de Pós-graduaç o em Biotecnologia Instituto de Biotecnologia Universidade Federal de Uberlandia Patos de Minas Brazil Centro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André Brazil

Ectonucleotidases are enzymes involved in nucleotides metabolism. The amount of circulating nucleotides may modulate distinct pathophysiological processes in the vasculature, including platelet aggregation and vascular tone. Onion (Allium cepa L.) phenolic compounds modulate enzymatic activity. The present study evaluated the total phenolic content of red onion methanolic extract, its antioxidant capacity, and its ability to interfere in nucleotides hydrolyses in rat serum. Total phenolic content was determined with the Folin-Ciocalteau reagent using gallic acid as a standard, while total flavonoid content was obtained through the aluminum chloride colorimetric method with quercetin as a standard. Antioxidant capacity was evaluated from the ability of the extract to scavenge ABTS·+ and DPPH· radicals. ATP, ADP, AMP, and p-Nph-5'-TMP hydrolyses were colorimetrically determined in response to different onion extract concentrations (0, 125, 250, 500, or 1000 μg/mL). Phenolic content of the extract was 54.35 mg GAE 100 g-1 sample, while flavonoid content was 7.22 mg quercetin g-1 sample. The IC50 value for ABTS·+ was 374.13 ± 7.52 μg/mL, while it was 440.29 ± 15.17 μg/mL for DPPH·. Red onion extract increased ADP and p-Nph-5'-TMP hydrolysis. The results confirmed that red onion contains high content of antioxidant, mainly flavonoids, and high antioxidant capacity. Additionally, biochemical studies suggest that the increased ADP breakdown may be important to regulate vascular processes. As it occurs for other enzymes, the antioxidant capacity of onion extract may neutralize reactive oxygen species (ROS) formation and favor ectonucleotidase activity and the hydrolysis of ADP, a major platelet agonist.

关键词： Red Onion Flavonoids Reactive Oxygen Species Ectonucleotidases Vascular Homeostasis

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The Health Education Program Implemented by Nurses Can Improve Blood Pressure Control and Quality of Life in Hypertensive Patients？

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Journal of Health Science 2018年第5期6卷 365-373页

作者： guerra, Grazia maria Lopes, Heno Ferreira Freitas, Elizangela de Oliveira Tsunemi, Miriam H. Giorgi, Dante marcelo Artigas Vieira, margarida Consolim-Colombo, fernanda M. Bortolotto, Luiz Aparecido Hypertension Unit Heart Institute (InCor HC FMUSP) Medical School of Medicine University of Sao Paulo Sao Paulo SP 05403-000 Brazil Sao Camilo University Centers Sao Paulo SP 05022-000 Brazil Cancer Institute of the State of Sao Paulo (ICESP) Sao Paulo 05403-000 Brazil Biostatistics Departament Biosciense Institute UNESP Botucatu SP 18618-689 Brazil Universidade Católica Portuguesa (UCP) Porto 4169-005 Portugal

The relational strategies in group are to improve patient’s BP （blood pressure） control and QoL （quality of life）. Methods： Twenty-one hypertensive patients were randomized into two groups： group A （10 patients, age 67 ± 6 years, BMI （body mass index） 28.3 ± 6 kg/m2） was applied relational strategies, with meetings every 15 days 8 meetings; group B （11 patients, age 58 ± 13 years, BMI 28.2 ± 3 kg/m2） with meetings for group orientation every 40 days 3 meetings. The patients were monitored： at baseline （day 15） and at the end of the study （day 120）, the BP was measured by auscultatory method and the QoL questionnaire （WHOQOL-BREF） was applied, and was submitted to the examination with ABPM （ambulatory blood pressure monitoring）. Results： after 120 days there was a greater （p 〈 0.05） reduction in SBP （systolic blood pressure） in group A （37.8 ± 25 mmHg） than in group B （18 ± 9 mmHg）, but DBP （diastolic blood pressure） decreased similarly in both groups （A, 15 ± 21 vs B, 13 ± 14 mmHg）; the HR （heart rate） reduction was larger （p 〈 0.05） in group A （60.6 ± 8.9 bpm） than in group B （69.7 ± 10.7 bpm）. There was a more significant BMI decrease （p 〈 0.01） in group A （27.8 ± 5 kg/m2） than in group B （28.9 ± 4 kg/m2）. The observed correlations between physical domain and nightime DBP （at day 120） in ABPM were r = -0.712 （negative correlation, p = 0.003）; between psychological domain and SBP sleep time （at day 120） in ABPM were r = -0.527 （negative correlation, p = 0.044）; between environmental domain and daytime Δ HR in ABPM were r = -0.573 （negative correlation, p = 0.007）. Conclusion： the health education program conducted through interpersonal relationships within groups provided better control of SBP and greater reduction in BMI.

关键词： Hypertension nursing health education adherence therapy

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Approach by Health Professionals to the Side Effects of Antihypertensive Therapy： Strategies for Improvement of Adherence

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 340-349页

作者： Grazia maria guerra Heno Ferreira Lopes ELizangela Oliveira Freitast fernanda marciano Consolim-Colombo Patricia Silva Lessa4, Dante marcelo Artigas Giorgi Luiz Aparecido Bortolloto Eduardo Moacyr Krieger Hypertension Unit Heart Institute of Hospital Clinical (InCor-HC FMUSP) School of Medicine University of Sao Paulo Sao Paulo 05403-000 SP Brazil Sao Camilo University Centers Sao Paulo 05022-000 SP Brazil Institute of Cancer of Sao Paulo State Sao Paulo 01246-000 SP Brazil Department of Electronics and Systems (DES-UFPE) Federal University of Pernambuco Recife 50670-901 PE Brazil

The aim was to determine whether complaints about side effects made by stage Ill hypertensive patients undergoing antihypertensive therapy lead to adequate blood pressure control. Forty-eight patients were monitored by a nurse every 15 days over the course of 180 days. At baseline, both groups presented similar SBP （systolic blood pressure）（GA, 196 （5）） mm Hg and GB, 189 （6） mm Hg） and DBP （diastolic blood pressure）（GA, 122 （3） mm Hg and GB, 121 （4） mm Hg）. On day 165, after a progressive decline in blood pressure levels, the two groups differed significantly from each other regarding SBP （GA, -16.9 （24） mm Hg and GB, -40.8 （31） mm Hg）. At the final follow-up, the patients were allocated to two groups： without complaints （GA） and with （GB） complaints about side effects. Complaining about side effects was a decisive factor for immediate nursing intervention and improved control over BP.

关键词： Nursing hypertension patient adherence side effect ambulatory blood pressure monitoring.

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