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Physiopathology of ischemic stroke and its modulation using memantine.evidence from preclinical stroke

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ne.ral Rege.e.ation Research 2021年第3期16卷 433-439页

作者： Hilda martíne.-Coria Isabel Arrieta-Cruz maría-esther Cruz Héctor e.López-Valdés División de Investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Laboratorio experimental de enfermedades ne.rodege.e.ativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico Departamento de Investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico Unidad de Investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico Unidad Periférica de ne.rociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakene. but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of N-methyl-D-aspartate glutamate *** has se.e.al advantages over developing a ne. drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in ne.roprotection and ne.roplasticity of memantine.in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine ne.roplasticity ne.roprotection stroke therapy

efficacy of medium-chain fatty acid salts distilled from coconut oil against two enteric pathogen challenges in weanling piglets

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Journal of Animal Science and Biotechnology 2020年第1期11卷 251-267页

作者： Paola López-Colom Lorena Castillejos Agustina Rodríguez-Sorrento Mónica Puyalto Juan JoséMallo Susana maría martín-Orúe Animal Nutrition and Welfare Service Animal and Food Science DepartmentFacultat de VeterinàriaUniversitat Autònoma de BarcelonaBellaterraSpain Norel S.A MadridSpain.

Background:The search for alternatives to antibiotics in pig production has increased the interest in natural resources with antimicrobial properties,such as medium-chain fatty acids(MCFA)as in-feed *** study evaluated the potential of a novel blend of MCFA salts(DIC)from distilled coconut oil with a lauric acid content to reduce enteropathogens and control intestinal diseases around *** experimental disease models were implemented in early-weane. piglets,consisting of two oral challenges:Salmone.la Typhimurium(1.2×10~8 CFU)or enterotoxigenic escherichia coli(eTeC)F4(1.5×10~9 CFU).The parameters assessed we.e.animal performance,clinical signs,pathogen excretion,intestinal fermentation,immune.inflammatory response,and intestinal ***:The Salmone.la challenge promoted an acute course of diarrhea,with most of the parameters responding to the challenge,whereas the eTeC F4 challenge promoted a mild clinical course.A consistent antipathogenic effect of DIC was observed in both trials in the hindgut,with reductions in Salmone.la *** counts in the cecum(P=0.03)on d 8 post-inoculation(PI)(Salmone.la trial),and of enterobacteria and total coliform counts in the ileum and colon(PeTeC F4 trial).When analyzing the entire colonic microbiota(16 S rRNA gene.sequencing),this additive tended(P=0.13)to reduce the Firmicutes/Bacteroidetes ratio and enriched Fibrobacteres after the Salmone.la *** the eTeC F4 challenge,DIC prompted structural changes in the ecosystem with increases in Dialister,and a trend(P=0.14)to increase the Veillone.laceae *** parameters such as the intestinal fermentation products or serum pro-inflammatory mediators were not modified by DIC supplementation,nor were the histological *** the intraepithelial lymphocyte(IeL)counts were lowered by DIC in animals challenged with Salmone.la(P=0.07).With eTeC F4,the IeL counts were higher with DIC on d 8 PI(P=0.08).Conclusions:This study c

关键词： enteric pathogen Gut microbiota Intestinal immunity Medium-chain fatty acids Weaning pig

Common interacting gene.ic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared gene.ic markers

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Gene. & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De egea Alex Dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng elkin Navarro-Quiroz Zilac espitaleta Kenny Del Toro-Camargo Leticia martine.-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos eduardo egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune.diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Parametrization of the Teichmüller Space of Bordered Surface ne. Groups

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Acta Mathematica Sinica,english Series 2008年第6期24卷 1039-1056页

作者： B.eSTRADA e.martíne. Departamento de Matemdticas Fundamentales UNEDPaseo Senda del Rey 928040 MadridSpain

A non-euclidean crystallographic group F （ne. group, for short） is a discrete subgroup of isometries of the hyperbolic plane.H, with compact quotient space H/Г. These groups uniformize Klein surfaces, surfaces endowed with dianalytic structure. These surfaces can be seen as a ge.e.alization of Riemann surfaces. Fundamental polygons play an important role in the study of parametrizations of the Teichmuller space of ne. groups. In this work we construct a class of right-angled polygons which are fundamental regions of bordered surface ne. groups. The free parameters used in the construction of the polygons give a parametrization of the Teichmuller space. From the parameters we obtain explicit matrices of the ge.e.ators of the groups. Finally, we give.e.amples to exhibit how different relations between the parameters reflect the existence of automorphisms on the quotient surfaces.

关键词： non-euclidean crystallographic groups hyperbolic polygons Klein surfaces automorphisms of surfaces Teichmfiller space

Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance

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World Journal of Gastroenterology 2022年第26期28卷 3027-3046页

作者： maría Belén Novoa Díaz maría Julia martín Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Argentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Argentina

Colorectal cancer(CRC)continues to be one.of the main causes of death from cancer because patients progress unfavorably due to resistance to current *** of the Wnt/β-catenin pathway plays a fundamental role in the gene.is and progression of se.e.al types of cancer,including *** many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli ***,it can also be associated with other *** recent years,studies of the tumor microenvironment(TMe)have demonstrated its importance in the development and progression of *** this tumor ne.t,se.e.al cell types,structures,and biomolecules interact with ne.plastic cells to pave the way for the spread of the ***-communications between tumor cells and the TMe are then established primarily through paracrine.factors,which trigger the activation of numerous signaling *** advances in the field of oncology have been made in the last *** Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressivene.s,focusing on crosscommunication between CRC cells and the *** this analysis,our main objective was to increase the understanding of this complex disease considering a more global *** many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies.

关键词： Colorectal cancer β-catenin pathway Tumor stroma Tumor microenvironment factors Cancer progression Drug resistance

In-port-plug transmission line.design of the ITeR plasma position reflectometer

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Plasma Science and Technology 2020年第6期22卷 15-20页

作者： J martÍne.-FeRNÁNDeZ ÁCAPPA A SIMOne.TO T eSTRADA e De LA LUNA e J BLANCO Laboratorio Nacional de Fusión.CIeMAT Avda Complutense 40.Madrid 28040Spain CNR-ISTP via Cozzi 5320125 MilanoItaly

This work describes the microwave design of the transmission line.housed in the in-port-plug region of the ITeR plasma position reflectometer(PPR).The design of the compone.ts of the inport-plug reflectometers(located in equatorial port-plug 10(ePP10) and in upper-port-plug 01(UPP01)) is *** a 3 D ray tracing code, the spatial position and optimum orientation angles of each set of emission and detection antennas were determine..A feasible path was then created from the obtaine. antenna positions and orientations to the primary vacuum *** tall waveguides were chosen to reduce ohmic *** to space constraints in the ITeR crowded environment, bends in oversized waveguides were unavoidable, and thus mode conversion was *** keep mode conversion losses at bay, hyperbolic secant curvature bends had to be used whene.er ***, e-plane.bends in tall waveguides proved to be especially critical, making it ne.essary to employ other approaches when higher bending angles were *** conversion results were obtaine. by evaluating the mode coupling *** losses have also been computed and their results compared with commercial simulators, obtaining a perfect agreement.

关键词： reflectometry microwave technology ITeR diagnostic

The largest dengue outbreak in Argentina and spatial analyses of dengue cases in relation to a control program in a district with sylvan and urban environments

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 227-234页

作者： Aníbal e Carbajo Alejandra Rubio maría J Viani maría R Colombo Laboratorio de eoclogía de enfermedades Transmitidas por Vectores Instituto de Investigación e Ingeniería AmbientalUniversidad Nacional de General San Martín Consejo Nacional de Investigacione. Científicas y Técnicas Secretaria de Política Sanitaria y Desarrollo Humano Municipio de Tigre

Objective: To analyze the largest outbreak of dengue in Argentina in the municipality of Tigre during 2016, through detailed spatial analyses of the occurrence of cases in relation to demographic factors and vector control actions. Methods: Detailed and georreferenced data on dengue cases with laboratory results(NS1 or IgM) we.e.analyzed. The occurrences of imported and autochthonous cases by census tract were modeled using demographic variables(population by age class, proportion of foreigne.s, proportion with university grade, proportion of males), dwelling variables(number of homes, proportion of dwellings with latrine. number of dwellings, proportion of houses, proportion of flats, proportion of slums) and census tract area as explanatory variables. The probability of occurrence of autochthonous and imported cases was modeled separately. The spatio-temporal occurrence of cases was studied in relation to focal and perifocal control actions(involving education campaigns, removal of Aedes aegypti breeding sites and exhaustive insecticide spraying) to assess the efficiency in stopping autochthonous cases spreading. Results: All autochthonous cases occurred in the urban environment with no sylvan cases. The majority of the imported cases registered came from Paraguay and Northeastern Argentina. The age structure of imported and autochthonous cases did not differ from the age structure of the municipality, while that of the ne.ative cases *** studied spatially, the occurrence of imported cases by census tract was mildly associated with a higher proportion of foreign population and more people at active age, while occurrence of autochthonous cases was not significantly associated with any of the studied *** census tracts with laboratory confirmed results, the models showed higher probability of autochthonous cases related to higher population density and population age structure. The clustering of autochthonous cases was ge.e.ally mild, with prevailing i

关键词： Aedes aegypti Vector-borne.diseases Vector control Dengue epidemic

Oxidative stress,the blood-brain barrier and ne.rodege.e.ative diseases:The critical bene.icial role of dietary antioxidants

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Acta Pharmaceutica Sinica B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma Ares marta martíne. Bernardo Lopez-Torres maría-Rosa martíne.-Larran aga Xu Wang Arturo Anadon maría-Aranzazu martíne. National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural UniversityWuhan 430070China MAO Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products Huazhong Agricultural UniversityWuhan 430070China Department of Pharmacology and Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent years,growing awarene.s of the role of oxidative stress in brain health has prompted antioxidants,especially dietary antioxidants,to receive growing attention as possible treatments strategies for patients with ne.rodege.e.ative diseases(NDs).The most widely studied dietary antioxidants include active substances such as vitamins,carotenoids,flavonoids and *** antioxidants are found in usually consumed foods such as fresh fruits,ve.e.ables,nuts and oils and are gaining popularity due to recently growing awarene.s of their potential for preventive and protective agents against NDs,as well as their abundant natural sources,ge.e.ally non-toxic nature,and ease of long-term *** review article.e.amine. the role of oxidative stress in the development of NDs,explores the‘two-sidedne.s’of the blood-brain barrier(BBB)as a protective barrier to the ne.vous system and an impeding barrier to the use of antioxidants as drug medicinal products and/or dietary antioxidants supplements for prevention and therapy and reviews the BBB permeability of common dietary antioxidant suplements and their potential efficacy in the prevention and treatment of ***,current challenges and future directions for the prevention and treatment of NDs using dietary antioxidants are discussed,and useful information on the prevention and treatment of NDs is provided.

关键词： Dietary antioxidant supplements Oxidative stress Blood-brain barrier ne.rodege.e.ative diseases Vitamins Carotenoids Flavonoids Polyphenols

Residual activity of cetrimide and chlorhexidine.on enterococcus faecalis-infected root canals

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International Journal of Oral Science 2014年第1期6卷 46-49页

作者： Carmen maría Ferrer-Luque maría Te.e.a Arias-Moliz Matilde Ruíz-Linares maría e.e.a martíne. García Pilar Baca Department of Stomatology School of Dentistry University of Granada Department of Microbiology School of Dentistry University of Granada

effective final irrigation regimen is an important step in order to achieve better disinfection and ensure residual antimicrobial effects after root canal preparation. The aim of this study was to compare the residual antimicrobial activity of 0.2% cetrimide, and 0.2% and 2% chlorhexidine.in root canals infected with enterococcus faecalis. Biofilms of e. faecalis were grown on uniradicular roots for 4 weeks. After root canal preparation, root canals were irrigated with 17% ethylene.iamine.etraacetic acid （eDTA） to remove the smear layer. The roots were randomly divided into three experimental groups （n=26） according to the final irrigating solution： Group I, 5 mL 0.2% cetrimide; Group II, 5 mL 0.2% chlorhexidine. and Group III, 5 mL 2% chlorhexidine. Samples were collected for 50 days to denote the presence of bacterial growth. The proportion of ungrown specimens over 50 days was evaluated using the nonparametric Kaplan-Meier survival analysis. Differences among groups were tested using the log-rank test and the level of statistical significance was set at P〈0.05. The highest survival value was found with 2% chlorhexidine. showing statistically significant differences from the other two groups. At 50 days, e. faecalisgrowth was detected in 69.23% specimens in Groups I and II, and in 34.61% specimens of Group III. There were no significant differences between 0.2% cetrimide and 0.2% chlorhexidine. Final irrigation with 2% chlorhexidine.showed greater residual activity than 0.2% chlorhexidine.and 0.2% cetrimide in root canals infected with e. faecalis.

关键词： antimicrobial effects biofilms cetrimide chlorhexidine enterococcus faecalis final irrigation residual activity