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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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ne.ral Rege.e.ation Research 2024年第8期19卷 1835-1841页

作者： Irene.Navarro-Lobato mariam Masmudi-martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero marta Carretero-Rey Sinforiano Posadas maría e.Quiros-Ortega Zafar U.Khan Laboratory of ne.robiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de enfermedades ne.rodege.e.ativas(CIBeRne.) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of ne.robiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,ne.rological,and ne.rodege.e.ative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene.corresponding to the RGS14414protein in visual area V2,a brain area conne.ted with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in ne.rodege.e.ative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of ne.ronal arbo rization and spine.density,as well as an increase in brain-derived ne.rotrophic factor(BDNF).A knockdown of BDNF gene.in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of ne.ronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated ne.ronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene.mediated activation of ne.ronal circuits in visual area V2 have therapeutic re.e.ance in the treatment of memory deficits.

关键词： behavioral performance brain-derived ne.rotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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5-Bromo-2'-deoxyuridine.labeling:historical perspectives,factors infiuencing the detection,toxicity,and its implications in the ne.rogene.is

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ne.ral Rege.e.ation Research 2024年第2期19卷 302-308页

作者： Joaquín martí-Clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine.5-bromo-2′-deoxyuridine.BrdU)is an exogenous marker of DNA *** the introduction of monoclonal antibodies against BrdU,an increasing number of methodologies have been used for the immunodetection of this synthesized bromine.tagged base analogue into replicating *** labeling is widely used for identifying ne.ron precursors and following their fate during the embryonic,perinatal,and adult ne.rogene.is in a variety of vertebrate species including birds,reptiles,and *** to BrdU toxicity,its incorporation into replicating DNA presents adverse consequences on the ge.e.ation,survival,and settled patterns of *** may lead to false results and misinterpretation in the identification of proliferative *** this review,I will indicate the detrimental effects of this nucleoside during the development of the central ne.vous system,as well as the reliability of BrdU labeling to detect proliferating ***,it will show factors influencing BrdU immunodetection and the contribution of this nucleoside to the study of prenatal,perinatal,and adult *** adult ne.rogene.is will also be *** is my hope that this review serves as a reference for those researchers who focused on detecting cells that are in the synthetic phase of the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult ne.rogene.is human adult ne.rogene.is labeling pitfalls prenatal ne.rogene.is proliferation S-phase suturing S-phase toxicity

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Soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo marcelo Nosetto Pablo e.Villagra ezequiel Balducci martín Pinazo Roxana P.eclesia Alejandra Von Wallis Sebastián Villarino Francisco Alaggia marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla martín Mónaco Jimena e.Chaves Ariel Medina Ignacio Gasparri eugenio Alvarez Arne.i maría Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe echevarria Pedro Fernández marina Morsucci Dardo López Juan Manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La Manna Sebastián Barbaro Cecilia Blundo Ximena Sirimarco Laura Cavallero Gualberto Zalazar Guillermo martíne. Pastur Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de estudio de Agroecosistemas y Paisajes Rurales (GeAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigacione. en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigacione. en ene.gía No Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección Nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de estudio de Agroecosistemas y Paisajes Rurales (GeAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigacione. en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administración de Parques Nacionales (APN) Parque Nacional Los Alerces Centro de estudios Ambientales Integrados (CeAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determine. contribution（NDC） presented by Argentina within the framework of the Paris Agreement is aligne. with the decisions made in the context of the United Nations Framework Conven-tion on Climate Change（UNFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（ReDD+）. In addition, climate change constitutes one.of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（SOC） stocks of native forests have not been incorporated into the Forest Reference emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model SOC stocks to 30 cm of native forests at a national scale using climatic, topographic and ve.e.ation as predictor variables, and（ii） to relate SOC stocks with spatial–temporal remotely sensed indices to determine.biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to ge.e.ate spatially explicit estimates of SOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of SOC. All covariate maps were uploaded to the Google earth engine.cloud-based computing platform for subsequent modelling. To determine.the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on enhanced Ve.e.ation Index（eVI） and land surface temperature（LST） images from Landsat *** SOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean SOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic carbon Biodiversity Native forest Climate change mitigation Modelling Resilience

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez mariana e.Carro Paulo e.Llambías Grupo de Investigacion en ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population *** numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the ***,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We.e.aluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival *** found that the probability of adult survival decreased as the abundance of breeding adults *** density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine.an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

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Supplementation of vitamin e or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermone.tral or heat-stressed conditions

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1101-1118页

作者： Ysenia V.Silva‑Guillen Consuelo Arellano Jeffrey Wiegert R.Dean Boyd Gabriela e.martine. eric van Heugten Department of Animal Science North Carolina State UniversityRaleighNC 27695USA Department of Statistics North Carolina State UniversityRaleighNC 27695USA Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA Animal Nutrition Research LLCAlvatonKY 42122USA.

Background Heat stress has severe ne.ative consequences on performance and health of pigs,leading to significant economic *** objective of this study was to investigate the effects of supplemental vitamin e and a botanical extract in feed or drinking water on growth performance,intestinal health,and oxidative and immune.status in grow-ing pigs housed under heat stress *** Duplicate experiments were conducted,each using 64 crossbred pigs with an initial body weight of 50.7±3.8 and 43.9±3.6 kg and age of 13-week and 12-week,***(n=128)were housed individually and assigne. within weight blocks and sex to a 2×4 factorial arrangement consisting of 2 environments(thermo-ne.tral(21.2℃)or heat-stressed(30.9℃))and 4 supplementation treatments(control diet;control+100 IU/L of D-α-tocopherol in water;control+200 IU/kg of DL-α-tocopheryl-acetate in feed;or control+400 mg/kg of a botanical extract in feed).Results Heat stress for 28 d reduced(P≤0.001)final body weight,average daily gain,and average daily feed intake(-7.4 kg,-26.7%,and-25.4%,respectively)but no effects of supplementation were detected(P>0.05).Serum vitamin e increased(Pe supplementation in water and in feed(1.64 vs.3.59 and 1.64 vs.3.24),but not for the botanical extract(1.64 vs.1.67 mg/kg)and was greater when supplemented in water ***(P=0.002).Liver vitamin e increased(Pe supplementations in water(3.9 vs.31.8)and feed(3.9 vs.18.0),but not with the botanical extract(3.9 vs.4.9 mg/kg).Serum malondialdehyde was reduced with heat stress on d 2,but increased on d 28(interaction,Peater(Pementation compared to *** proliferation was reduced(P=0.037)in the jejunum under heat stress,but increased in the ileum when vitamin e was supplemented in feed and water under heat stress(interaction,P=0.04).Tumor ne.rosis factor-αin jejunum and ileum mucosa decreased by heat stress(Pe

关键词： Botanical extract Growing pigs Heat stress Immune.status Oxidative status Tocopherol Water

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CO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(Cu,Co,Ag and Pt)

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Journal of Rare earths 2024年第9期42卷 1669-1681,I0002页

作者： J.C.martíne.-Munuera M.P.Yeste A.García-García MCMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Chemistry and Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,se.e.al ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were prepared,characterised and tested for the CO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(DOC) system from a diesel engine.and those encountered under gasoline.exhaust(λ=1).The metals chosen are Cu,Co,Ag and Pt(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity despite quite similar structural and textural properties of the catalysts,showing differences among dispersion(Ag-catalyst seems to present a low level of dispersion).This catalyst seems to be characterised,as well,by a strong electronic interaction between Ce and Ag centres which is suggested to yield an improved reducibility under H_(2)-TPR ***,the order in catalytic activity(Cu>Ag>Co≈Pt>>support) seems not to follow the order found in reducibility and the Cu-catalyst seems to be the most active independently on the reaction conditions,yielding ne.rly overlapped CO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSC values of the Ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSC parameter measured at 150℃ can be used as a re.e.ant descriptor to evaluate the CO oxidation activity at low and medium conversions for the investigated catalysts,much better than the H_(2)-TPR measurements.

关键词： CO oxidation Low metal content Ceria-zirconia Copper species OSC parameter Rare earths

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Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres marina martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo e.e.a Gomez-Rubio Sonsoles martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Ve.e.al Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigacione. Biologicas margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(eCDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific eCD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,Nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine.rich repeat and Malectin domains in their eCDs(LRR-MAL RKs),Catharanthus roseus ReCePTOR-LIKe KINASe 1-LIKe group(CrRLK1L)with Malectin-like domains in their eCDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

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Sex-dependent resilience to extreme drought events: implications for climate change adaptation of a South American endangered tree species

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ecological Processes 2024年第02期13卷 48-60页

作者： Sergio Piraino martín Ariel Hadad Yanina Antonia Ribas-Fernández Fidel Alejandro Roig Laboratorio de Dendrocronología e Historia Ambiental (IANIGLA CONICeT ) Facultad de Ciencias Agrarias Universidad Nacional de Cuyo Laboratorio de Dendrocronología de Zonas áridas (CIGeOBIO CONICeT ) Gabinete de Geología Ambiental (INGEO UNSJ) Hémera Centro de Observación de la Tierra Facultad de Ciencias Universidad Mayor

Background Recent changes in climatic trends are resulting in an increased frequency and intensity of extreme events, with unknown effect on ecosystem dynamics in the ne.r future. extreme drought episodes are recognized as disturbance factors capable of modifying forest dynamics and tree growth. Within this context, dioecious tree species may be impacted by climatic extremes, affecting male/female proportions and, consequently, reproductive processes and species persistence. Therefore, there is an urgent ne.d for species-specific assessments of growth tolerance to extreme dry spells in dioecious tree species, to establish effective conservation strategies for these particular natural resources. Araucaria araucana(araucaria), an endangered dioecious Patagonian tree species, has recently undergone.decay and mortality episodes in response to increasing dry climatic conditions. While sex-dependent tolerance to extreme drought episodes has been assessed in the species' humid distribution range, there is still a lack of information on the gender-based resilience of trees growing in the drier environments of the species' *** We reconstructed, through dendrochronological methods, the sex-dependent response of 105 araucaria individuals(55 female and 50 male trees) to five regional extreme dry spells employing a set of different indices. Resistance, recovery period, and average growth reduction of standardized tree-ring growth were.e.amine., analysing the effect of biotic(sex, pre-drought stem tree growth) and abiotic(local climatic conditions before, during, and after extreme climatic episodes) factors on tree *** Sex influences only the species resistance to climatic disturbance, with male individuals showing lower tolerance to extreme drought events. Pre-drought radial growth rates and local meteorological conditions preceding, during, and following extreme dry spells strongly modulated araucaria radial growth resilience regardless of tree s

关键词： Araucaria Climate change Dendrochronology extreme drought event Resilience

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Burden of gallstone.disease in the United States population:Prepandemic rates and trends

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1130-1148页

作者： Aynur Unalp-Arida Constance e Ruhl National Institute of Diabetes and Digestive and Kidne. Diseases National Institutes of HealthBethesdaMD 20892-5458United States Social&Scientific Systems Inc.DLH Holdings Corp CompanySilver SpringMD 20910United States

BACKGROUND Gallstone.disease is one.of the most common digestive disorders in the United States and leads to significant morbidity,mortality,and health care *** To expand on earlier findings and investigate prepandemic rates and trends in the gallstone.disease burden in the United States using national survey and claims *** The National Ambulatory Medical Care Survey,National Inpatient Sample,Nationwide emergency Department Sample,Nationwide Ambulatory Surgery Sample,Vital Statistics of the United States,Optum Clinformatics®Data mart,and Centers for Medicare and Medicaid Services Medicare 5%Sample and Medicaid files were used to estimate claims-based prevalence,medical care including cholecystectomy,and mortality with a primary or other gallstone.*** we.e.age-adjusted(for national databases)and shown per 100000 *** Gallstone.disease prevalence(claims-based,2019)was 0.70%among commercial insurance enrollees,1.03%among Medicaid bene.iciaries,and 2.09%among Medicare bene.iciaries and rose over the previous ***,in the United States population,gallstone.disease contributed to approximately 2.2 million ambulatory care visits,1.2 million emergency department visits,625000 hospital discharges,and 2000 deaths *** had higher medical care rates with a gallstone.disease diagnosis,but mortality rates were higher among *** had higher ambulatory care visit and hospital discharge rates compared with Whites,but not mortality *** had lower ambulatory care visit and mortality rates,but similar hospital discharge rates compared with *** the study period,ambulatory care and emergency department visit rates with a gallstone.disease diagnosis rose,while hospital discharge and mortality rates *** commercial insurance enrollees,rates were higher compared with national data for ambulatory care visits and hospitalizations,but lower for emergency department ***

关键词： Gallstone.disease Burden Cholecystectomy Mortality Health care use Cholelithiasis Gallstone. epidemiology

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Unilateral rNurr1-V5 transgene.expression in nigral dopamine.gic ne.rons mitigates bilateral ne.ropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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ne.ral Rege.e.ation Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia martíne.-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes escobedo Mine.va Maldonado-Berny Me Gutierrez-Castillo Armando J.espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais e.Valenzuela-Arzeta Claudia Luna-Herrera Francisco e.Lopez-Salas Jaime Santoyo-Salazar Daniel martine.-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogéne.is Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la educación y Desarrollo y la Investigación Científica de Iztacala(Red MeDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating se.e.al clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we.e.aluated whether unilateral transfected of rNurr1-V5 transgene.via ne.rotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral ne.ropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the ne.ative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine.hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine.hydroxylase-positive ramifications in the *** addition,tyrosine.hydroxylase-positive cells displayed less sene.cence markerβ-galactosidase and more ne.ron-cytoskeleton markerβIII-tubulin and brain-derived ne.rotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and ne.rotoxic astrocytes(positive to glial fibrillary acidic protein and complement compone.t 3)and increased ne.rotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene.expression in nigral dopamine.gic ne.rons mitigates bilateral ne.rodege.e.ation(sene.cence and loss of ne.ron-cytoskeleton and tyrosine.hydroxylase-positive cells),ne.roinflammation(activated microglia,ne.rotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** ne.rotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene.therapy microglia motor deficits nanoparticles ne.rodege.e.ation ne.roinflammation sene.cence α-synuclein aggregates

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