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CD300a inhibits CD16-mediated NK cell effector functions in HIv-1-infected patients

Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc vidal JoséA.Iribarren carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIv)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIv-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIv-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIv-1 infected individuals.

关键词： CD16 CD30 ADCC

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Strength Developing in Clay-Andesite Brick

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Materials Sciences and Applications 2016年第8期7卷 403-420页

作者： víctor Julio García Alonso R. Zúñiga-Suárez carmen Omaira Márquez Juan G. Pérez Francisco Fernández-martínez Francisco Hernández-Olivares Universidad Nacional de Chimborazo Riobamba Ecuador Universidad Técnica Particular de Loja Loja Ecuador Universidad de Los Andes Mérida Venezuela Universidad Politécnica de Madrid Madrid Espana

The objective of this work was to develop a more and better understanding of the strength developing in clay-andesite fired brick. The purpose was to improve the quality of the clay bricks that are handmade in the southern region of Ecuador to make them suitable for more widespread use in the local construction industry. To achieve our goal, we first physically, chemically, and mechanically characterized the “clayey” and “sandy” materials used in the fabrication of handmade bricks in the region. Second, the optimal mixture (OM): the optimal proportion between the amounts of “clayey” and “sandy” material was sought. Third, clay bricks were prepared using the OM, baked at 950°C, and characterized. In addition, bricks produced by regional artisans were characterized, and the results were compared with the results obtained for the bricks prepared using the OM. Our data reveal that the optimal mixture is 50% “clayey” material and 50% “sandy” material and that with this mixture, an average improvement in brick quality of 300% can be achieved;thus, the use of the OM makes it possible to expand the use of these bricks in the local construction industry and enables an environmentally friendly production process by reducing the intensive exploitation of regional clay deposits. This improvement is achieved by virtue of the anorthite enrichment that occurs in the solid solution, which results from the evolution of andesine. The anorthite contributes to the formation of a stronger matrix among the different grains of the material. Conditions are favorable for this enrichment process to occur when “sandy” materials with high contents of andesite, which is common in Ecuadorian soils, are used.

关键词： Anorthite Andesine Andesite Component Fired Bricks Brazilian Test

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Chlorophyll Concentration and Morphological Diversity in Corn Lines at Different vegetative Stages

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American Journal of Plant Sciences 2016年第7期7卷 1067-1076页

作者： mariano Mendoza Elos Gilberto Rodríguez Pérez Francisco Cervantes Ortíz Luis Patricio Guevara Acevedo Enrique Andrio Enríquez Ma. del carmen Ojeda Zacarías Isabel Presa Figuereo Sergio Alfredo Rodríguez Herrera José Antonio Rangel Lucio José Guadalupe Rivera Reyes Division of Graduate Studies and Research Institute Technologic of Roque Guanajuato Mexico University Autonomous Agrarian of Nuevo León Monterrey México University Autonomous Agrarian Antonio Narro Saltillo México

The objective of this study was to assess the chlorophyll content of corn lines at different vegetative stages and the diversity between them. The study was conducted in the experimental field of the Roque Institute of Technology (ITR) located in Roque, Celaya, Guanajuato, Mexico. We used 32 corn lines from CIMMYT and four lines from the breeding program of the ITR. The evaluation was conducted in the spring-summer cycle of 2014 at two planting dates. We used a completely randomized block design with three replications. The experimental unit consisted of two rows of five linear meters with a distance of 0.75 meters between rows. Chlorophyll was measured at six different stages: v6, vT, R3, R4, R5 and MF. The agronomic variables recorded were: PH, CH, LAC, LBC, FF, MF, PM, CC, CL, DC, RC, KR and GY. The results of the analysis of variance showed significant differences between lines, dates and their interaction. On average, 18 lines were found with chlorophyll concentrations above 51 SPAD units in the two environments. This indicated that these materials had a high potential for field performance. Using cluster analysis UPGMA method, we identified seven groups for chlorophyll and eight groups for agronomic characteristics for a breeding program. The groups were associated to the homogeneous characteristics of each variable.

关键词： Chlorophyll Content Phenological Stages Clusters and Corn Lines

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短脉冲Nd∶YAG激光对眼睛微外科手术的生理效应

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激光与红外 1986年第7期 4-5页

作者： carmen A.Puliafito

能用高峰值功率短脉冲Nd:YAG激光进行无痛的眼科外科手术。这种短脉冲技术是利用电离和等离子体形成所产生的声和冲击波切割眼内的膜和其他结构。Q开关和锁模Nd:YAG激光系统对于切割不透明膜最有效,例如进行白内障外科手术。本文评述短... 详细信息

能用高峰值功率短脉冲Nd:YAG激光进行无痛的眼科外科手术。这种短脉冲技术是利用电离和等离子体形成所产生的声和冲击波切割眼内的膜和其他结构。Q开关和锁模Nd:YAG激光系统对于切割不透明膜最有效,例如进行白内障外科手术。本文评述短脉冲激光与组织互作用过程的物理机理。一、光学击穿和等离子体形成当辐照的光功率密度在1010至1012W/cm2时,就能产生等离子体。诱发光击穿所必需的Q开关激光的电场强度应超过107v/cm。图1示出了Q开关和锁模激光击穿的过程。Q开关

关键词：激光电场电磁场光击穿 YAG 激光脉冲等离子体冲击波脉冲(力学) 锁模脉冲 Nd 外科手术

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Unprotected left main coronary artery stenting with everolimus (Xience v) drug-eluting stents: A single center retrospective experience

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World Journal of Cardiovascular Diseases 2013年第2期3卷 183-190页

作者： Juan C. Fernandez-Guerrero Juan A. Herrador Manuel Guzman victor Aragon carmen Adamuz Unidad de Hemodinámica Servicio de Cardiología Complejo Hospitalario de Jaén Jaén Spain

Objectives: We sought to evaluate the efficacy and safety of unrestricted implantation of everolimus eluting stent Xience v (EES-Xv) in a cohort of real- world patients with unprotected left main coronary disease (ULMCD). Background: The second-generation EES-Xv stent is currently one of the most commonly used drug-eluting stents in clinical practice. It has been shown to be superior to paclitaxel-eluting stents, but its relative merits on unprotected left main coronary disease have been less extensively assessed. Methods: Between 2007 and 2010, in this single-center registry, we evaluated the clinical outcomes of 98 patients with ULMCD who underwent percutaneous coronary intervention (PCI) with EES-Xv. Results: There were no in-hospital deaths. At 25.63 ± 14.41 months of follow-up, 17 patients (17.3%) experienced major adverse coronary event (MACE), death from cardiovascular disease (n = 6;6.1%) and target lesion revascularization (TLR;n = 7;7.1%). The predictors of death from cardiovascular disease were: previous PCI and left ventricular dysfunction. The only predictor of TLR was the placement of 2 stents in the left main coronary artery. Conclusions: In this single- center real-world registry, we found that elective ULMCD stenting with EES-Xv provided good short-, medium- and long-term outcomes, with an estimated cumulative need for TLR of 7.1%, a cardiac mortality rate of 6.1%, and a MACE rate of 17.3% at 2 years.

关键词： Percutaneous Coronary Interventions “Off Label” Lesions Prognosis

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Perinatally Imposed Essential Fatty Acid Deficiency Changes Renal Function of the Adult Rat

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Food and Nutrition Sciences 2014年第20期5卷 1991-1999页

作者： valdilene S.Ribeiro Edjair v.Cabral Alexsandra R.Silva Silvio F.Pereira-Junior vera L.M.Lima vera C.O.Carvalho Leucio D.v.Filho Ana D.O.Paixao carmen Castro-Chaves Department of Physiology and Pharmacology Federal University of PernambucoRecifeBrazil Department of Biochemistry Federal University of PernambucoRecifeBrazil

This study was designed to investigate whether essential fatty acid deficiency early during development could change the content of phospholipids and cholesterol in whole membranes of the kidney and renal function at adult life. For this, female Wistar rats were maintained on a standard diet or on an essential fatty acid deficient diet (EFAD) from the age of 30 days, throughout the pregnancy, at age of 90 days and until the weaning, for evaluation of their offspring. Weanling rats were maintained on a standard diet until the age of 13 weeks. Systolic blood pressure (SBP), glomerular filtration rate (GFR), urinary sodium excretion (UNa+v), positive cells for angiotensin II (Ang II) and cholesterol and phospholipids in whole membranes of the kidney were evaluated. Cholesterol, total phospholipids and the relative content of classes of phospholipids were unaltered in the cortex and medullary kidney. SBP, GFR and UNa+v were also unaltered in the EFAD group. However, the number of positive cells for Ang II in the tubulointerstitial area of the renal cortex was higher in the EFAD group. Therefore, these findings indicated that although cholesterol and phospholipids were unaltered and urinary sodium excretion was unchanged, Ang II expression in the kidney was erroneously programmed and later hindering of renal function was not ruled out.

关键词： Angiotensin II Phospholipids Glomerular Filtration Rate

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Corrosion Behavior of API 5L X52 Steel under High Concentrations of H₂S/CO₂ Gases

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Materials Sciences and Applications 2016年第10期7卷 623-643页

作者： Mónica Jazmín Hernández Gayosso Gerardo Zavala Olivares Saúl Bautista Fragoso Gabriel Ernesto Blanco del valle Daniel Mauricio Godínez Oidor víctor Ángel Rodríguez Gómez Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152 San Bartolo Atepehuacan Gustavo A. Madero Ciudad de México México Pemex Exploración Producción Carretera Carmen-Puerto Real Km 4.5 Colonia Renovación Edificio Kaxan Campeche México

In the present work, the susceptibility of API 5L X52 steel to corrosion processes was evaluated in the presence of high contents of hydrogen sulfide and carbon dioxide. Gravimetric tests and surface analyses were carried out to establish both the corrosion rate and damage type exhibited by the metal. The obtained results indicate that the hydrogen sulfide is the most active gas in the corrosion processes that took place, quite above carbon dioxide. The main observed corrosion products were iron sulfides and the typical damage associated with hydrogen sulfide presence was Sulfide Stress Cracking (SSC). The surface damage evidences the presence of cracks with considerable magnitude and metal loss as consequences of the corrosion processes. Likewise, the presence of oxygen in the system modifies the displayed corrosion type, where corrosion products such as iron oxides and reduction in the number and extent of cracks are observed. On the other hand, the addition of a film-forming corrosion inhibitor based on modified imidazolines eliminates completely the development of cracks, although under certain test conditions, it can favor localized pitting corrosion.

关键词： H2S Corrosion Cracking Corrosion Inhibition

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最大板间地震的长期前兆变化

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世界地震译丛 2013年第2期44卷 18-23页

作者： M.Bouchon v.durand D.marsan H.Karabulut J.Schmittbuhl 冯万鹏中国地震局地球物理研究所

很多地震会伴有前震(Jones and Molnar,1976,1979)。但是,对产生前震的机制和为什么有些地震有前震而其他却没有的原因,目前尚不清楚(Abercrombie and Mori,1996;Reasenberg,1999;Jones,1984;Doser,1990;Maeda,1999;McGuireetal,2005)。这里我们利用在北太平洋区域有最佳仪器记录地区的地震目录,来分析1999年到2011年间所有震级大于6.5、震源深度小于50km的地震的前震序列。所用数据包括了31例发生在板块边界的地震和31例板内地震。我们发现,与板内地震相比,板间地震的前震序列有显著不同的特点。北太平洋地区,发生在板块边界的最大地震在之前数月到数天时间内,会出现地震活动加速现象,并最终导致主震发生。相反,板内环境下前震出现的机会就非常少。我们认为,在板块边界地区大地震的破裂前,两个板块的分界面便开始了缓慢的滑动。这种相对长期的前兆性变化可能有助于减缓板块边界的地震灾害。

关键词：板间地震前兆前震序列板块边界板内地震太平洋区域太平洋地区 Mori

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70kv和80kv影像质量比较:应用于儿科心脏CT

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国际医学放射学杂志 2015年第1期 92-93页

作者： S.durand J.F.Paul Radiology Department Institut Mutualiste Montsouris

目的评估产生相同CT剂量指数的不同k v-m As组合的噪声水平和对比噪声比（CNR）。比较80 k v与70 k v。方法用10个10;8 cm不同直径的卵圆形水模型测量噪

关键词：剂量指数对比噪声比 As CNR 噪声水平 CT 对比增强 kv

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Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence

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材料科学与工程（中英文B版） 2011年第1期1卷 48-81页

作者： Roberto Cesareo Angel Bustamante D Julio Fabian S Sandra Zambrano A Walter Alva Luis Chero del carmen Espinoza C Rosendo Rodriguez R marco Seclen F Fidel Gutierrez v E.B. Ldvano Gonzales A. marcia A. Rizzutto Enrico Poli Cristiane Calza marcelino dos Anjos Ricardo T. Lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada victor Curay Castillo G and Fabio Lopes Dipartimento di Matematica e Fisica Universith di Sassari Sassari Italy Universidad Nacional Mayor de San marcos Lima Peri4 Museo ＂Tumbas Reales de Sip6n ＂ Lambayeque Perlt Instituto de Fisica Universidade de S6o Paulo SP Brasil Asociaci6n cultural e Museo Enrico Poli Lima Peru COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Dipartimento di Energetica Universith di Roma ＂La Sapienza ＂ Rome Italy lstituto Studio dei Materiali Nanostrutturati-CNR Area Ricerca RM1-Montelibretti Rome Italy Museo de Sic6n Ferrahqfe Perit Istituto Nacional de Cultura Piura Peru Universidade Estadual de Londrina Londrina PR Brasil

On the north coast of present-day Peru, between the Andes and the Pacific Ocean, prospered approximately between 1000 BC and 1375 AD, several relevant cultures: Chavín (1000-200 BC), vicús and Frías (200 BC - 300 AD), Moche (400 BC-700 AD), Sicán (700-1375 AD). These cultures are interconnected and characterized by a high metallurgical ability, demonstrated by the presence of beautiful artifacts on gold, silver and copper alloys. More than hundred metal artefacts from these cultures were analyzed with a portable equipment which uses the non-destructive and non-invasive technique of energy-dispersive X-ray fluorescence (EDXRF). Following objects were analyzed: (1) gold, silver and copper objects from the Chavín culture (Museo Municipal of Piura and and Museo Enrico Poli in Lima); (2) gold and silver objects from the vicús and Frías cultures (Museo Municipal of Piura); (3) gold, silver and copper objects from the Moche culture ("Museo Tumbas Reales de Sipán", "Museo de Sitio de Huaca Rajada" in Lambayeque and Museo Enrico Poli in Lima); (4) gold, silver and copper objects from the Sicán culture (Museum of Sicán, Ferra?afe). Portable equipments were employed, mainly composed of a small size X-ray tube and a thermoelectrically cooled, small size, Si-PIN or Si-drift X-ray detectors. The main characteristics of the EDXRF-technique is of being non destructive and multi-elemental. Standard samples of gold and silver alloys were employed for calibration and quantitative analysis. The aims of this campaign of analysis were: (1) to analyze a large number of objects; (2) to differentiate gold, gilded copper and tumbaga (this last being a poor gold alloy enriched at the surface by depletion gilding); (3) to correlate, when possible, composition of analyzed alloys to the specific culture; (4) to determine a possible evolution of metallurgy; (5) to better determine characteristics and beginning time of tumbaga production. It was determined that the analyzed artefacts are composed

关键词： X射线荧光技术能量色散侵入性冶金鲁北设备使用便携式哥伦布

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