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Volatile Components in the Flower, Pedicellate Ovary and Aqueous Residue of <i>Cymbidium</i>sp. (ORCHIDACEAE)

Journal of Analytical Sciences, Methods and Instrumentation 2013年第4期3卷 212-218页

作者： Víctor García Gaytán maría de las nieves rodríguez mendoza marcos Soto Hernández Libia I. Trejo-Téllez martha E. Pedraza Santos Guadalupe Valdovinos Ponce Facultad de Agrobiología “Presidente Juárez” Uruapan México 4Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Postgrado en Botánica Colegio de Postgraduados Texcoco México Postgrado en Edafología Colegio de Postgraduados Texcoco México Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Víctor García Gaytán

Cymbidium sp. has several ornamental, medicinal and cosmetic uses. Essential oils were obtained through extraction by hydrodistillation of flower and pedicellate ovary. The chromatographic profile was obtained by thin layer chromatography (TLC), combined with gas chromatography-mass spectrometry (GC/MS), for the identification and relative quantification of various substances in three samples from the orchid (flower, pedicellate ovary and aqueous residue). With TLC, five compounds were identified in the flower, with the most abundant being terpineol, linalool and zingiberene, and five in the pedicellate ovary, with borneol, cineole, and β-bisabolene being in the greatest concentration, while for the aqueous residue, the most abundant was geraniol. Using GC/MS, 25 volatile components associated with the flower were identified, of which the most abundant were linalool (22.92%), 4-methyl-phenol (15.07%) and p-Menth-1-en-8-ol (12.32%). In pedicellate ovaries, 13 components were identified, with the most abundant being 4-methyl-phenol (31.24%), bicycle [4.4.0] dec-1-ene, 2-isopropyl-5-methyl-9-methylene-(17.74%) and 2-hexanone (10.24%), while in the aqueous residue 18 components were found, with the most abundant being 4-methyl-phenol (18.71%) and 2- cyclohexen-1-ol (14.60%).

关键词： Thin Layer Chromatography Gas Chromatography Orchidaceae Hydrodistillation

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Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina martínez-Galán Cristina Jiménez-Luna Isabel rodriguez Elisabeth Maza Carlos García-Collado Antonio rodríguez-Fernández Javier Luis López-Hidalgo Octavio Caba department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMmarY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma Lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： maría rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment dementia Exercise PET

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demographic and behavioral responses of the White-winged Dove to human disturbances during winter in northwestern Mexico

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Avian Research 2022年第4期13卷 437-444页

作者： Ruben Ortega-Alvarez Jovani Le on-Aguilar Antonio Isain Contreras-rodríguez Gustavo Casta neda de los Santos Instituto de Investigaciones en Ecosistemas y Sustentabilidad(IIES)-Universidad Nacional Autonoma de Mexico Campus MoreliaAntigua Carretera a Patzcuaro 8711Col.San Jose de la HuertaMoreliaMichoacan58190Mexico Programa de Aves Urbanas(PAU) Los MochisSinaloaMexico Quirino mendoza#320 Colonia del CarmenXochimilcoCiudad de Mexico16720Mexico departamento de Educacion Ambiental Jardín Bot anico Benjamin Francis JohnstonSinaloaMexico

The simultaneous study of demography and behavior might provide a more comprehensive understanding about animal responses to anthropogenic *** White-winged Dove(Zenaida asiatica)is a frequent dweller of urban and agricultural habitats in North America,Central America,and the ***,research on the species is heavily biased to the *** analyzed the response of the species to human disturbances during winter across an urban-agricultural landscape in northwestern Mexico through a demographic and behavioral *** modeled the effect of disturbance types(pedestrians,cars,pavement and building cover)on the density of the ***,we investigated if surveillance behavior varied across the landscape by estimating and comparing perching proportion among land uses(urban grey areas,urban green areas,cropfields,shrublands).We did not detect the species within cropfields,possibly because food resources were not available for the dove during winter in this land *** cover limited species’density,as it might reduce the surface of the preferred feeding substrates of the *** and building cover increased the density of the species,as they might provide food and shelter for the dove,*** behavior peaked in urban grey areas,whereas it dropped in urban green *** on threat levels,threat type,and protective cover among land uses might in-fluence such behavioral *** approach contributes to the knowledge of the species and demonstrates that both demographic and behavioral cues provide complementary evidence for analyzing the impact of human disturbances on animals.

关键词： Agriculture density Perch Sinaloa Urbanization Zenaida asiatica

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Allicin neuroprotective effect during oxidative/inflammatory injury involves AT1-Hsp70-iNOS counterbalance axis

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BIOCELL 2020年第4期44卷 671-681页

作者： LUCIANA MAZZEI marÍA BELÉN RUIZ-ROSO NATALIA de las HERAS SANDRA BALLESTEROS CAROLINA TORRESPALAZZOLO LEÓN FERdeR ALEJANDRA BEATRIZ CAmarGO WALTER MANUCHA Instituto de Medicina y Biología Experimental de Cuyo(IMBECU) Consejo Nacional de Investigaciones Científicas y Tecnológicas(CONICET)Mendoza5500Argentina Área de Farmacología Departamento de PatologíaFacultad de Ciencias MédicasUniversidad Nacional de Cuyo Centro UniversitarioMendoza5500Argentina departamento de Fisiología Facultad de MedicinaUniversidad ComplutenseMadrid34523España IBAM Universidad Nacional de CuyoCONICETFacultad de Ciencias AgrariasMendozaM5528AHBArgentina department of Pediatrics Nephrology DivisionMiller School of MedicineUniversity of MiamiMiami33012USA

The ancestral cultures have described many therapeutic properties of garlic,therefore,it is of central interest to elucidate the molecular basis explaining this millenary empirical ***,it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic-linked to oxidative-inflammatory *** improved neuronal injury by heat shock protein 70(Hsp70)and inducible nitric oxide synthase(iNOS)***,allicin exerts renal protection involving a possible angiotensin type 1 receptor(AT1)*** connection,AT1 overexpression has been recognized as a central deleterious factor in many brain ***,there are no studies that evaluate AT1-Hsp70-iNOS interaction as a mechanism linked to ***,our central aim is to evaluate if the allicin protective effect is associated with an AT1-Hsp70-iNOS counterbalance *** this study,a murine microglial cell line(BV-2)was injured with lipopolysaccharides and treated or not with ***,it was evaluated cell viability,proinflammatory cytokine levels,cellular oxidative stress,iNOS,Hsp70,and AT1 protein expression(cellular and mitochondrial fractions),nitrite levels,and protein-protein *** results demonstrated that allicin could prevent neuronal injury due to a reduction in oxidative stress and inflammatory status mediated by an AT1-Hsp70-iNOS counterbalance axis linked to direct protein-protein interaction.

关键词： Allicin neuroinflammation BV-2 cells AT1 receptors iNOS Hsp70

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1990-2020年阿根廷门多萨流域冰川变化研究

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中国农村水利水电 2024年第5期 78-86页

作者：林媛媛王飞戈文艳韩剑桥 Fidel Alejandro Roig Elena maría Abraham 陈昊西北农林科技大学水土保持科学与工程学院陕西杨凌712100 中国科学院水利部水土保持研究所陕西杨凌712100 Instituto Argentino de Nivología Glaciología y Ciencias Ambientales(IANIGLA-CONICET)CCT MendozaArgentina5500 Instituto Argentino de Investigaciones de las Zonas Áridas(IADIZA-CONICET) CCT MendozaArgentina5500

冰川是南美洲阿根廷门多萨流域(33°S)重要的淡水资源,冰川作为气候变化的敏感指示器,对于理解和评估全球和区域气候变化具有重要意义。为了解门多萨流域冰川分布及变化趋势,探讨其对区域水资源和生态系统的影响,为应对气候变化提供科... 详细信息

冰川是南美洲阿根廷门多萨流域(33°S)重要的淡水资源,冰川作为气候变化的敏感指示器,对于理解和评估全球和区域气候变化具有重要意义。为了解门多萨流域冰川分布及变化趋势,探讨其对区域水资源和生态系统的影响,为应对气候变化提供科学依据,研究基于1990-2020年Landsat遥感影像,参考RGI冰川编目数据和阿根廷国家冰川清单,通过比值阈值法和人工解译法得到7期冰川边界,研究了门多萨流域冰川面积分布与变化特征。并结合TerraClimate气候数据,揭示了该区域在研究期间的气候变化趋势,探讨了区域气候变化对冰川变化的影响。结果表明:①2020年门多萨流域冰川面积为134.09±11.86 km^(2),1990-2020年冰川总体呈极显著波动下降趋势(p10 km^(2)占比最大,10 km^(2)规模冰川退缩速度最大;冰川主要分布在南坡,西北坡冰川最少,东南、东北坡冰川退缩速度最大;冰川主要分布在坡度5°~40°之间,50°~55°的冰川退缩速度最大;冰川主要分布在海拔4200~5400 m之间,<4000 m冰川退缩速率最大。③20世纪50年代末以来门多萨地区气温整体呈现极显著的上升趋势(p<0.001),研究区年均最高、最低气温每十年上升0.53、0.29℃。气温持续上升是门多萨流域冰川退缩的长期原因,降水变化是该区域冰川变化的短期原因。本研究为门多萨流域预防冰川变化导致的水资源可用性变化和地质灾害预防提供参考。

关键词：冰川变化门多萨(mendoza) 南美洲气候变化

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Street floods in Metro Manila and possible solutions

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Journal of Environmental Sciences 2017年第9期29卷 39-47页

作者： Alfredo Mahar Lagmay Jerico mendoza Fatima Cipriano Patricia Anne delmendo Micah nieves Lacsamana marc Anthony Moises Nicanor Pellejera III Kenneth Nino Punay Glenn Sabio Laurize Santos Jonathan Serrano Herbert James Taniza Neil Eneri Tingin National Institute of Geological Sciences University of the PhilippinesQuezon City 1101Philippines Nationwide Operational Assessment of Hazards PhiI-LiDAR 1Flood Modelling Component UP NIGSQuezon City 1101Philippines

Urban floods from thunderstorms cause severe problems in Metro Manila due to road traffic. Using Light detection and Ranging（Li DAR）-derived topography, flood simulations and anecdotal reports, the root of surface flood problems in Metro Manila is *** of flood-prone areas are along the intersection of creeks and streets located in topographic lows. When creeks overflow or when rapidly accumulated street flood does not drain fast enough to the nearest stream channel, the intersecting road also gets *** solutions include the elevation of roads or construction of well-designed drainage structures leading to the creeks. Proposed solutions to the flood problem of Metro Manila may avoid paralyzing traffic problems due to short-lived rain events, which according to Japan International Cooperation Agency（JICA） cost the Philippine economy 2.4 billion pesos/day.

关键词： Flood modeling LiDAR Urban flooding

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BASKETBALL SCORING IN NBA GAMES:AN EXAMPLE OF COMPLEXITY

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Journal of Systems Science & Complexity 2013年第1期26卷 94-103页

作者： de SA GUERRA Yves marTíN GONZALEZ Juan Manuel SARMIENTO MONTESdeOCA Samuel rodrIguez RUIZ David ARJONILLA LóPEZ nieves GARCíA-MANSO Juan Manuel departament of Phisical Education University of Las Palmas de Gran Canaria departament of Physics University of Las Palmas de Gran Canaria

Scoring in a basketball game is a highly dynamic, non-linear process. NBA teams try to be more and more competitive each season. For instance, they incorporate into their rosters the best players in the world. This and other mechanisms concur to make the scoring process in NBA games exciting and rarely predictable. This paper is to study the behavior of timing and scoring in basketball gaines. The authors analyze all the games in five NBA regular seasons （2005-06, 2006-07, 2007-08, 2008-09, 2009-10）, for a total of 6150 games. Scoring does not behave uniformly; therefore, the authors also analyze the distributions of the differences in points in the basketball games. To further analyze the behavior of the tail of the distribution, the authors also carry out a semilog-plot and a log-log plot to verify whether this trend approaches a Poisson distribution or a PL. This paper reveals different areas of behavior related to the score, with specific instances of time that could be considered tipping points of the game. The presence of these critical points suggests that there are phase transitions where the dynamic scoring of the games varies significantly.

关键词： Complexity NBA non-linear Poisson power law.

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana maría Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain departamento de Neurología Hospital Virgen de las NievesGranadaSpain departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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商务西班牙语教材的内容设计评析

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现代交际 2019年第21期 221-222页

作者：翟红 Manuelade las nieves álvarez álvarez 西班牙德乌斯托大学

商务西班牙语作为西班牙语职业教育(应用本科与高职院校)的主要课程,尚缺少经济社会发展、区域外贸政策、职业发展规划等教材内容,难以满足企业和学生的实际需求。目前国内高校的应用西班牙语专业逐年增设,却较少发掘适合商务西班牙语... 详细信息

商务西班牙语作为西班牙语职业教育(应用本科与高职院校)的主要课程,尚缺少经济社会发展、区域外贸政策、职业发展规划等教材内容,难以满足企业和学生的实际需求。目前国内高校的应用西班牙语专业逐年增设,却较少发掘适合商务西班牙语教学需要的教材建设研究。通过对浙江省开设商务西班牙语及其相关课程教师的访谈,并结合常用教材进行文本分析,分析其不足之处,以质性研究方法提出商务西班牙语教材建设的建议。

关键词：商务西班牙语专门用途外语教材职业教育

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