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Morphological and biochemical effects of weekend alcohol consumption in rats: Role of concentration and gender

World Journal of Hepatology 2018年第2期10卷 297-307页

作者： José A morales-González maría de lourdes sernas-morales ángel morales-González Laura Ligía González-López Eduardo Osiris Madrigal-Santillán Nancy Vargas-Mendoza Tomás Alejandro Fregoso-Aguilar Liliana Anguiano-Robledo Eduardo Madrigal-Bujaidar Isela álvarez-González Germán Chamorro-Cevallos Laboratorio de Medicina de Conservación Escuela Superior de Medicina Instituto Politécnico Nacional Escuela Superior de Cómputo Instituto Politécnico Nacional área Académica de Nutrición ICSa Universidad Autónoma del Estado de Hidalgo depto. de Fisiología Laboratorio de Hormonas y Conducta ENCB campus Zacatenco Instituto Politécnico Nacional Laboratorio de Farmacología Molecular Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina-Instituto Politécnico Nacional Laboratorio de Genética Escuela Nacional de Ciencias Biológicas IPN departamento de Farmacia Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional

AIM To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in *** Wistar rats weighing 170-200 g were divided into groups as follows:(1) Control groups; and(2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations:(1) Group of males or females with a consumption of a solution of alcohol at 40%; and(2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase(ALT), Aspartate Aminotransferase(AST), Lactate dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light *** In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocel ular disorganization CONCLUSION The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.

关键词： Weekend alcohol consumption Liver morphology Transaminases Damage

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Adsorption of Mn^(2+) from aqueous solution using Fe and Mn oxide-coated sand

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Journal of Environmental Sciences 2013年第7期25卷 1483-1491页

作者： Chi-Chuan Kan Mannie C Aganon Cybelle morales Futalan maria lourdes P Dalida Institute of Hot Spring Industry Chia Nan University of Pharmacy and Science Environmental Engineering Unit University of Philippines Diliman department of Chemical Engineering University of Philippines Diliman

The adsorption of Mn2＋ onto immobilized Mn-oxide and Fe-oxide adsorbent such as manganese oxide-coated sand 1 （MOCS1）, manganese oxide-coated sand2 （MOCS2）, iron oxide-coated sand2 （IOCS2）, and manganese and iron oxide-coated sand （MIOCS）was investigated. The effects of pH （5.5 to 8.0） and temperature （25 to45°C） on the equilibrium capacitywere examined. Equilibrium studies showed that there is a good fitwith both Freundlich and Langmuir isotherm,which indicates surface heterogeneity and monolayer adsorption of the adsorbents. Kineticdata showed high correlationwith the pseudo second-order model,which signifies a chemisorption-controlled mechanism. The activation energies, activation parameters （ΔG＊,ΔH＊,ΔS＊）, and thermodynamic parameters （ΔG0 , ΔH0 , ΔS0 ） confirmed that adsorptionwith MIOCSwas endothermic and more spontaneous at higher temperaturewhile an opposite trendwas observed for the other adsorbents. Thermodynamic studies showed that adsorption involved formation of activated complex,where MOCS1 and MIOCS follow a physical-chemical mechanism,while MOCS2 and IOCS2 follows purely chemical mechanism.

关键词： activation energy iron oxide kinetics manganese oxide thermodynamics

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Thematic Trends in Complementary and Alternative Medicine Applied in Cancer-Related Symptoms

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Journal of Data and Information Science 2018年第2期3卷 1-19页

作者： Jose A.Moral-Munoz Manuel Arroyo-morales Barbara F.Piper Antonio I.Cuesta-Vargas lourdes Díaz-Rodríguez William C.S.Cho Enrique Herrera-Viedma Manuel J.Cobo dept. Nursing and Physiotherapy University of Cádiz Cádiz Spai Institute of Research and Innovation in Biomedical Sciences of the Province of Cádiz （INiBICA） University of Cádiz Cádiz Spain 3Dept. Physical Therapy University of Granada Granada Spain 4dept. Nursing School of Health and Human Services National University San Diego CA US 5School Clinical Science Queensland University of Technology Brisbane QLD Australi 6Instituto Biosanitario （IBS） University of Granada Granada Spai 7Hospital Authority Hong Kong Chin 8dept. Computer Science and Artificial Intelligence University of Granada Granada Spai 9dept. of Computer Science and Engineering University of Cádiz Cádiz Spai

Purpose： The main goal of this study is to discover the scientific evolution of Cancer-Related Symptoms in Complementary and Alternative Medicine research area, analyzing the articles indexed in the Web of Science database from 1980 to ***/Methodology/Approach： A co-word science mapping analysis is performed under a longitudinal framework（1980 to 2013）. The documental corpus is divided into two subperiods,1980–2008 and 2009–2013. Thus, the performance and impact rates, and conceptual evolution of the research field are ***： According to the results, the co-word analysis allows us to identify 12 main thematic areas in this emerging research field： anxiety, survivors and palliative care,meditation, treatment, symptoms and cancer types, postmenopause, cancer pain, low back pain, herbal medicine, children, depression and insomnia, inflammation mediators, and lymphedema. The different research lines are identified according to the main thematic areas,centered fundamentally on anxiety and suffering prevention. The scientific community can use this information to identify where the interest is focused and make decisions in different *** limitation： Several limitations can be addressed： 1） some of the Complementary and Alternative Medicine therapies may not have been included; 2） only the documents indexed in Web of Science are analyzed; and 3） the thematic areas detected could change if another dataset was *** implications： The results obtained in the present study could be considered as an evidence-based framework in which future studies could be ***/value： Currently, there are no studies that show the thematic evolution of this research area.

关键词： Cancer-related symptoms Complementary and Alternative Medicine Bibliometrics Science mapping analysis Thematic evolution H-index

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Ca^(2+)-亚氨二醋酸金属离子亲和色谱法吸附内毒素(英文)

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色谱 2012年第11期30卷 1194-1202页

作者： André Moreni LOPES Jorge Sánchez ROMEU Rolando Páez MEIRELES Gabriel marquez PERERA Rolando Perdomo morales Adalberto PESSOA lourdes Zumalacárregui CáRdeNAS department of Biochemical and Pharmaceutical Technology School of Pharmaceutical SciencesUniversity of So Paulo(FCF/USP) Purification development department Center for Genetic Engineering and Biotechnology(CIGB) Center for Pharmaceuticals Research and development(CIdeM) Higher Polytechnic Institute José Antonio Echeverría(CUJAE)

Endotoxins(also known as lipopolysaccharides(LPS)) are undesirable by-products of recombinant proteins,purified from Escherichia *** can be considered stable under a wide range of temperature and pH,making their removal one of the most difficult tasks in downstream processes during protein *** inherent toxicity of LPS makes their removal an important step for the application of these proteins in several biological assays and for a safe parenteral *** metal affinity chromatography(IMAC) enables the affinity interactions between the metal ions(immobilized on the support through the chelating compound) and the target molecules,thus enabling high-efficiency separation of the target molecules from other components present in a *** chromatography is applied with Ca2+-iminodiacetic acid(IDA) to remove most of the LPS contaminants from the end product(more than90%).In this study,the adsorption of LPS on an IDA-Ca2+ was *** adsorption Freundlich isotherm of LPS-IDA-Ca2+ provides a theoretical basis for LPS *** was found that LPS is bound mainly by interactions between the phosphate group in LPS and Ca2+ ligands on the *** factors such as pH(4.0 or 5.5) and ionic strength(1.0 mol/L) are essential to obtain effective removal of LPS for contaminant levels between endotoxin' concentration values less than100 EU/mL and 100 000 EU/*** new protocol represents a substantial advantage in time,effort,and production costs.

关键词： immobilized metal affinity chromatography(IMAC) lipopolysaccharides(LPS) endotoxin removal recombinant proteins isotherms protein purification

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