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Efficacy and safety of oral solution dosed misoprostol versus misoprostol vaginally in labour induction

Open Journal of Obstetrics and Gynecology 2013年第9期3卷 673-679页

作者： Longinos Aceituno Velasco maría teresa sánchez barroso maría Huertas segura García Valois González Acosta Ramón de la Fuente Pedrosa Ana Barqueros Ramírez Luis Delgado martínez Encarna Ruiz martínez Gynaecologic Clinic Management Unit Hospital “La Inmaculada” (Huercal-Overa) Healthcare Management Area North of Almeria Andalusian Health Service Andalusian Spain

Background: Labour induction is one of the most common medical procedures in obstetrics. The aim is to end the pregnancy when continuity is a risk to mother or fetus. Its main side effect is the increase in the cesarean rate, compared to spontaneous onset deliveries. On the other hand, mortality and morbidity in cesareans are higher. The most common pharmacological drugs used for induction are prostaglandins: dinoprostone and misoprostol. The “gold standard” for labour induction is vaginal misoprostol. The oral route is also effective and also has several benefits like faster onset and easear administration. In recent years several publications state that the administration of misoprostol oral solution, given in doses gradually, is associated with a lower cesarean and hyperstimulation rate than the cases where vaginal misoprostol has been used in pregnant women with unripe cervix. Furthermore, being its half life shorter, it may be very useful in case of uterine hyperstimulation and, probably, a high percentage of women prefer this oral administration to the vaginal one. The objective of this study is to compare the efficacy, safety and side effects on mother and fetus on use of oral versus vaginal administration for induction of labour for prolonged gestation (41 weeks) and premature rupture of membranes, both with live fetus. Methods/Design: Design: double blind controlled trial. study population: Pregnant women whose labour will be induced due to premature rupture of membranes or prolonged gestation. Inclusion Criteria: 1) Bishop Test equal to or less than 7;2) single pregnancy;3) Pregnancy at term (37 - 42 weeks);4) No history of uterine surgery;5) Cephalic presentation;6) Live fetus;7) No prostaglandins contraindications. Discussion: Nowadays induction rates are very high, ranging from 25% to 30% approximately. In these cases caesarean rates are higher than when the delivery starts spontaneously. That is one of the main reasons why caesareans have increased, ma

关键词： Cervical Ripening Labour Induction Misoprostol Administration Oral Intravaginal Oxytocin Dinoprostone Pregnancy Prolonged Fetal Membranes Premature Rupture

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Quality of Drugs Based on Ferrous sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region

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Pharmacology & Pharmacy 2022年第9期13卷 331-339页

作者： Amanda Gabryelle Nunes Cardoso Mello marceonia Costa dos santos Ana Gabriela Lisboa santos Danila teresa Valeriano Alves Daniella Paternostro de Araújo Grisolia Alan barroso Araújo Grisólia mariceli Baia Leão Barros Fabrícia de Jesus Paiva da Fonseca Manoel samuel da Cruz Neto Faculty of Pharmacy FIBRA University Center Belém Brazil Faculty of Biotechnology Federal University of Pará Belém Brazil Biological sciences Center Federal University of Pará Belém Brazil FACI WYDEN Faculty Belém Brazil

Background: For the WHO, anemia is a serious public health problem, with an emphasis on deprivation anemia, which has socioeconomic conditions as determining factors for its development. Among nutritional anemias, the most relevant is iron deficiency, whose main form of prevention and treatment is supplementation with ferrous sulfate dispensed in the public health system, with the need to periodically check whether the drug has the quality required by regulatory health agencies. Thus, the objective of this study was to analyze the quality of the ferrous sulfate medication, from the same laboratory, and dispensed in a basic health unit (BHU) and a commercial pharmacy (CF). Materials and Methods: An analytical, qualitative and quantitative study of ferrous sulfate heptahydrate (25 mg/mL in 100 mL syrup), carried out on 20 BHU and 10 from CF, both from the same laboratory, but in different batches. samples were subjected to organoleptic analysis and verification of iron content, pH, volume and density. Data were compared with values recommended by the Brazilian pharmacopoeia 5th edition. Results: Three batches were evaluated: 4659 of from the CF;4574 from the BHU1, and 4576 from the BHU2, stored in accordance with RDC 304/19 of ANVIsA. All showed compliance with some organoleptic characteristics;and stable values in pH (3.61 - CF;3.67 - BHU1;3.65 - BHU2), density (1.079 - CF;1.088 - BHU1;1.086 - BHU2) and individual volume (not less than 95% of the declared value). However, it was not possible to detect the odor of herbs;the average volume of batch BHU1 was below the declared value, and the iron content of both BHUs was above the maximum value of pharmacopoeia standards. Conclusion: samples did not show full compliance with the physical and chemical parameters evaluated, suggesting deviation in the quality of the medication.

关键词： Physical and Chemical Quality Control Ferrous sulfate Heptahydrate syrup

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