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Immunogenicity and mechanisms impairing the response to vaccines in inflammatory bowel disease

World Journal of Gastroenterology 2015年第40期21卷 11273-11281页

作者： Alicia C marín Javier P Gisbert maría Chaparro Gastro- enterology Unit Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas28021 MadridSpain

Inflammatory bowel disease(IBD) is an immunological disorder that is usually treated with immunosuppressive therapy,potentially leading to increases in vulnerability to infections. Although many infections can be pre-vented by vaccination,vaccination coverage in these patients in clinical practice is insufficient. Therefore,the seroprotection condition should be verified,even for routine vaccines,such as hepatitis B or pneu-mococcus. Response to vaccines in IBD patients is thought to be impaired due to the immunological alterations generated by the disease and to the immunomodulatory treatments. The immunogenicity of hepatitis B,influenza,and pneumococcal vaccines is impaired in IBD patients,whereas the response to papillomavirus vaccine seems similar to that observed in the healthy population. On the other hand,data on the immunogenicity of tetanus vaccine in IBD patients are conflicting. Studies assessing the response to measles-mumps-rubella,varicella,and herpes zoster vaccines in IBD patients are scarce. The cellular and molecular mechanisms responsible for the impairment of the response to vaccination in IBD patients are poorly understood. Studies aiming to assess the response to vaccines in IBD patients and to identify the mechanisms involved in their immunogenicity are warranted. A better understanding of the immune response,specifically to vaccines,in patients with immune-mediated diseases(such as IBD),is crucial when developing vaccines that trigger more potent immunologic responses.

关键词： Crohn’s disease Inflammatory bowel disease Tumor n

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Weighted Inequalities for Fractional Type Operators with Some Homogeneous Kernels

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Acta Mathematica Sinica,English Series 2013年第3期29卷 449-460页

作者： maría Silvina RIVEROS marta URCIUOLO FaMAF-UNC CIEM-CONICET Ciudad Universitaria

In this paper, we study integral operators of the formappropriate weighted BMO and weak type estimates for certain weights satisfying the above inequality. We also give a Coifman type estimate for these operators.

关键词： Fractional operators Calderon-Zygmund operators BMO Muckenhoupt weights

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Brain and spinal cord trauma:what we know about the therapeutic potential of insulin growth factor 1 gene therapy

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Neural Regeneration Research 2023年第2期18卷 253-257页

作者： maría Jose Bellini Florencia Labombarda Lab de Bioquímica del Envejecimiento INIBIOLP-CONICETFacultad de Ciencias MedicinaUniversidad Nacional de La PlataLa PlataArgentina Laboratory of Neuroendocrine Biochemistry IBYME-CONICETBuenos AiresArgentina Department of Human Biochemistry Faculty of MedicineUniversidad de Buenos AiresBuenos AiresArgentina

Although little attention has been paid to cognitive and emotional dysfunctions observed in patients after spinal co rd injury,several reports have described impairments in cognitive *** group also has contributed significantly to the study of cognitive impairments in a rat model of spinal co rd *** findings are very significant because they demonstrate that cognitive and mood deficits are not induced by lifestyle changes,drugs of abuse,and combined *** are related to changes in brain structures involved in cognition and emotion,such as the *** spinal cord injury decreases neurogenesis,enhances glial reactivity leading to hippocampal neuroinflammation,and trigge rs cognitive *** brain distal abnormalities are recently called te rtiary *** that there is no treatment for Tertiary Damage,insulin growth factor 1 gene therapy emerges as a good *** growth factor 1 gene thera py recove rs neurogenesis and induces the polarization from pro-inflammato ry towards anti-inflammatory microglial phenotypes,which represents a potential strategy to treat the neuroinflammation that supports te rtiary *** growth factor 1 gene therapy can be extended to other central nervous system pathologies such as traumatic brain injury where the neuroinflammatory component is *** growth factor 1 gene therapy could emerge as a new therapeutic strategy for treating traumatic brain injury and spinal cord injury.

关键词： cognitive impairments gene therapy hippocampus insulin growth factor 1 microglial cells neurodegeneration neurogenesis neuroinflammation spinal cord injury traumatic brain injury

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Cellular automata model for traffic flow with safe driving conditions

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Chinese Physics B 2014年第5期23卷 216-226页

作者： maría Elena Lárraga Luis Alvarez-Icaza Instituto de Ingeniería Universidad Nacional Autónoma de México04510Coyoacán D.F.México

In this paper, a recently introduced cellular automata （CA） model is used for a statistical analysis of the inner micro-scopic structure of synchronized traffic flow. The analysis focuses on the formation and dissolution of clusters or platoons of vehicles, as the mechanism that causes the presence of this synchronized traffic state with a high flow. This platoon formation is one of the most interesting phenomena observed in traffic flows and plays an important role both in manual and automated highway systems （AHS）. Simulation results, obtained from a single-lane system under periodic boundary conditions indicate that in the density region where the synchronized state is observed, most vehicles travel together in pla- toons with approximately the same speed and small spatial distances. The examination of velocity variations and individual vehicle gaps shows that the flow corresponding to the synchronized state is stable, safe and highly correlated. Moreover, results indicate that the observed platoon formation in real traffic is reproduced in simulations by the relation between vehicle headway and velocity that is embedded in the dynamics definition of the CA model.

关键词： traffic flow models synchronized traffic cellular automata platoons formation

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Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 142-153页

作者： Omar ramos-Lopez Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

Globally,type 2 diabetes mellitus(T2DM)is one of the most common metabolic disorders.T2DM physiopathology is influenced by complex interrelationships between genetic,metabolic and lifestyle factors(including diet),which differ between populations and geographic *** fact,excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM,whereas habitual intakes of plant-based healthy diets usually exert a protective ***,genomic studies have allowed the characterization of sequence DNA variants across the human genome,some of which may affect gene expression and protein functions relevant for glucose *** comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease progression,some of which have demonstrated a value as biomarkers of personal responses to certain nutritional ***,novel genotype-based dietary strategies have been developed for improving T2DM control in comparison to general lifestyle ***,progresses in other omics areas(epigenomics,metagenomics,proteomics,and metabolomics)are improving current understanding of genetic insights in T2DM clinical *** more investigation is still needed,the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of T2DM as well as offer further opportunities to personalize the screening,prevention,diagnosis,management,and prognosis of T2DM through precision nutrition.

关键词： Type 2 diabetes mellitus Nutrigenetics Single nucleotide polymorphism Genotype Diet Precision nutrition

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Heuristics of node selection criteria to assess robustness of world airport network

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Chinese Journal of Aeronautics 2017年第4期30卷 1473-1480页

作者： Manel SORIA Oriol LORDAN Josmaría SALLAN Department of Physics Aeronautics Engineering Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain Department of Management Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain

The world airport network（WAN） is one of the networked infrastructures that shape today＇s economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the *** addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection.

关键词： Adaptive strategy Air route networks Complex networks Intentional attacks Network robustness

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Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero Josémarco-Contelles Eva ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling

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Potential of RP-UHPLC-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： maría del mar Contreras Aránzazu Morales-Soto Antonio Segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation < 5%). The detection and quantification limits were 0.07 μg/mL and 0.36 μg/mL, ***, the use of high-resolution MS enabled us to ensure the specificity, check impurities and better sensitivity. Therefore, this methodology promises to be suitable not only for the routine analysis of sofosbuvir in pharmaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir

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Modelling and simulation of flight control electromechanical actuators with special focus on model architecting, multidisciplinary effects and power flows

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Chinese Journal of Aeronautics 2017年第1期30卷 47-65页

作者： Fu Jian Jean-Charles maré Fu Yongling School of Mechanical Engineering and Automation Beihang University Beijing 100083 China Institut Clement Ader (CNRS UMR 5312) INSA-Toulouse Toulouse 31077 France

In the aerospace field, electromechanical actuators are increasingly being implemented in place of conventional hydraulic actuators. For safety-critical embedded actuation applications like flight controls, the use of electromechanical actuators introduces specific issues related to thermal balance, reflected inertia, parasitic motion due to compliance and response to failure. Unfortunately, the physical effects governing the actuator behaviour are multidisciplinary, coupled and nonlinear. Although numerous multi-domain and system-level simulation packages are now available on the market, these effects are rarely addressed as a whole because of a lack of scientific approaches for model architecting, multi-purpose incremental modelling and judicious model implementation. In this publication, virtual prototyping of electromechanical actuators is addressed using the Bond-Graph formalism. New approaches are proposed to enable incremental modelling,thermal balance analysis, response to free-run or jamming faults, impact of compliance on parasitic motion, and influence of temperature. A special focus is placed on friction and compliance of the mechanical transmission with fault injection and temperature dependence. Aileron actuation is used to highlight the proposals for control design, energy consumption and thermal analysis, power network pollution analysis and fault response.

关键词： Bond Graph Electro-hydrostatic actuator Electromechanical actuator More electric aircraft Modelling Power-by-wire Power loss Simulation

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A geomechanics classification for the rating of railroad subgrade performance

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Railway Engineering Science 2022年第3期30卷 323-359页

作者： Antonio Gomes Correia Ana ramos Department of Civil Engineering ISISEUniversity of MinhoGuimara˜esPortugal

The type of subgrade of a railroad foundation is vital to the overall performance of the track *** the train speed and tonnage increase,as well as environmental changes,the evaluation and influence of subgrade are even more paramount in the railroad track structure performance.A geomechanics classification for subgrade is proposed coupling the stiffness(resilient modulus)and permanent deformation behaviour evaluated by means of repeated triaxial loading *** classification covers from fine-to coarse-grained soils,grouped by UIC and *** this achievement,we first summarize the main models for estimating resilient modulus and permanent deformation,including the evaluation of their robustness and their sensitivity to mechanical and environmental *** is followed by the procedure required to arrive at the geomechanical classification and rating,as well as a discussion of the influence of environmental *** work is the first attempt to obtain a new geomechanical classification that can be a useful tool in the evaluation and modelling of the foundation of railway structures.

关键词： Subgrade Resilient modulus Permanent deformation Geomechanical classification

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