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5-Bromo-2'-deoxyuridine labeling:historical perspectives,factors infiuencing the detection,toxicity,and its implications in the neurogenesis

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neural Regeneration Research 2024年第2期19卷 302-308页

作者： Joaquín martí-Clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine 5-bromo-2′-deoxyuridine(BrdU)is an exogenous marker of DnA *** the introduction of monoclonal antibodies against BrdU,an increasing number of methodologies have been used for the immunodetection of this synthesized bromine-tagged base analogue into replicating *** labeling is widely used for identifying neuron precursors and following their fate during the embryonic,perinatal,and adult neurogenesis in a variety of vertebrate species including birds,reptiles,and *** to BrdU toxicity,its incorporation into replicating DnA presents adverse consequences on the generation,survival,and settled patterns of *** may lead to false results and misinterpretation in the identification of proliferative *** this review,I will indicate the detrimental effects of this nucleoside during the development of the central nervous system,as well as the reliability of BrdU labeling to detect proliferating ***,it will show factors influencing BrdU immunodetection and the contribution of this nucleoside to the study of prenatal,perinatal,and adult *** adult neurogenesis will also be *** is my hope that this review serves as a reference for those researchers who focused on detecting cells that are in the synthetic phase of the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult neurogenesis human adult neurogenesis labeling pitfalls prenatal neurogenesis proliferation S-phase suturing S-phase toxicity

A note on Transition Kernels for the Most UnfavourableMixed Strategies of the market

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Journal of the Operations Research Society of China 2024年第1期12卷 35-50页

作者： Sergey n.Smirnov Faculty of Computational Mathematics and Cybernetics Lomonosov Moscow State UniversityMoscowRussian Federation 119991

We consider a deterministic model of market evolution with trading constraints andapply a game-theoretic approach to the superhedging *** obtain sufﬁcientconditions for the game equilibrium and prove under these conditions the existenceof a Borel-measurable transition kernel describing dependence on price prehistory ofthe most unfavourable mixed strategy of the market.

关键词： Superhedging Guaranteed deterministic approach Optimal mixedstrategies of the market Borel-measurable transition kernel Game equilibrium

Role of lipids in the control of autophagy and primary cilium signaling in neurons

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neural Regeneration Research 2024年第2期19卷 264-271页

作者： maría Paz Hernández-Cáceres Daniela Pinto-nuñez Patricia Rivera Paulina Burgos Francisco Díaz-Castro Alfredo Criollo maria Jose Yañez Eugenia Morselli Instituto de Investigación en Ciencias Odontológicas(ICOD) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPCR lysosomal storage diseases neurons nPC1 phosphoinositides primary cilium

Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： n.HUMnEKAR D.SRInIVASACHARYA Department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** DarcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional and completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the Darcy number,the Lewis number,the Dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

Dynamic and electrical responses of a curved sandwich beam with glass reinforced laminate layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 155-178页

作者： n.SHAHVEISI S.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic responses and generated voltage in a curved sandwich beam with glass reinforced laminate(GRL)layers and a pliable core in the presence of a piezoelectric layer under low-velocity impact(LVI)are *** current study aims to carry out a dynamic analysis on the sandwich beam when the impactor hits the top face sheet with an initial *** the layer analysis,the high-order shear deformation theory(HSDT)and Frostig's second model for the displacement fields of the core layer are *** classical non-adhesive elastic contact theory and Hunter's principle are used to calculate the dynamic responses in terms of *** order to validate the analytical method,the outcomes of the current investigation are compared with those gained by the experimental tests carried out by other researchers for a rectangular composite plate subject to the *** element(FE)simulations are conducted by means of the ABAQUS *** effects of the parameters such as foam modulus,layer material,fiber angle,impactor mass,and its velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved sandwich beam glass reinforced laminate(GRL) pliable core low-velocity impact(LVI) classical non-adhesive elastic contact theory

Magnetic,dielectric and electrical modulus of Ce^(3+) doped cobalt-magnesium ferrite nanoparticles

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Journal of Rare Earths 2024年第2期42卷 373-382,I0005页

作者： n.M.Basfer Hanaa Almaghamsi Department of Physics Umm AL-Qura UniversityMakkahSaudi Arabia Physics Department College of Science and ArtKing Abdulaziz UniversityPOB344Rabigh291Saudi Arabi

In this work,the magnetic,dielectric properties and electric modulus of Ce^(3+) substituted cobaltmagnesium(Co_(0.7)Mg_(0.3)Ce_(x)Fe_(2-x)O_4)(labeled as CMCF) ferrite nanoparticles were investigated in *** magnetization decreases from 50.05 to 34.87 emu/g for further substituting Ce^(3+) ***,coercivity increases from 738.22 Gs for the CMCFO sample to 912.10 Gs for the CMCF2 sample,then decreases monotonically to 762.1 Gs for the CMCF5 *** cerium content and particle size play important roles in controlling the magnetization and coercivity of the CMCF *** CMCF nanoferrites are suitable for microwave applications since their high-frequency response ranges from 7.72 to 11.07 *** CMCF nanoferrites' dielectric parameter dispersion exhibits normal *** pristine Co-Mg nanoferrite only has ε' value of 28.25,but the nanoferrite MCMF2 has ε' value of365.03,with an enhancing ratio of 1192%.The conduction mechanism of the MCMF nanoferrites was determined by fitting the σ_(ac) results via the Jonscher power *** 653 K,large polaron tunnelling is thought to be responsible for this conduction process,which is followed by electron barrier hopping at higher ***-Cole diagrams at different temperatures,assuring the contributions of the grains and their boundaries at lower temperatures(653 K) and only the grains at higher *** on our results,the CMCF nanoferrites hold magnetic and semiconducting nature,which can be used in magnetic devices and dielectrics in lower-frequencies or conductors in higher-frequencies.

关键词： nanoferrites Rare earth ions Magnetic properties Dielectric parameters Impedance spectroscopy

Influence of biomass burning on ozone levels in the Megalopolis of Central Mexico during the COVID-19 lockdown

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Journal of Environmental Sciences 2024年第9期143卷 99-115页

作者： Victor Almanza Luis Gerardo Ruiz-Suárez Ricardo Torres-Jardón Agustín García-Reynoso Iván Y.Hernández-Paniagua Institute for Atmospheric Sciences and Climate Change National Autonomous University of MexicoCoyoacan 04510Mexico CityMexico

The massive reductions in anthropogenic emissions resulting from the COVID-19 lockdown provided a unique opportunity to evaluate the effect of mitigation measures aiming to abate air *** Mexico,the total lockdown period took place during the dry-hot season when biomass burning activity is ***,we investigate the role of biomass burning emissions on regional ozone levels in the Megalopolis of Central *** studied period covers the lockdown phases 2 and 3,and the first month of the new *** applied a factor separation technique and process analysis to estimate the pure and synergistic contributions of emission reductions under lockdown and that from biomass burning to daily ozone maximum concentrations in 7 metropolitan areas of different states in the *** results revealed that biomass burning plumes likely masked the effect of massive reductions from mobile emissions,impacted the PBL development during phase 3 and favored transition and mixed nO_(x)-limited and VOC-limited regional *** contributed to increased ozone production in the middle to lower PBL by changing the regional background levels which potentially could bias high ozone production efficiency *** the Megalopolis contribution to economic and societal development at national scale,our study suggests that ozone mitigation measures during the dry-hot season targeting mainly mobile emissions will likely be offset by biomass burning plumes.A regional and synergic policy aiming to control biomass burning would help to reduce the occurrence of high ozone levels in Central Mexico with the co-benefit of tackling short-lived climate pollutants.

关键词： COVID-19 Mexico Megalopolis Ozone Factor Separation Process Analysis

Structural Stability of the Financial market Model: Continuity of Superhedging Price and Model Approximation

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Journal of the Operations Research Society of China 2024年第1期12卷 215-241页

作者： Sergey n.Smirnov Faculty of Computational Mathematics and Cybernetics Lomonosov Moscow State UniversityMoscow119991Russian Federation

The present paper continues the topic of our recent paper in the same journal,aiming to show the role of structural stability in financial *** the context of financial market modeling,structural stability means that a specific“no-arbitrage”property is unaffected by small(with respect to the Pompeiu–Hausdorff metric)perturbations of the model’s *** formulate,based on our economic interpretation,a new requirement concerning“no arbitrage”properties,which we call the“uncertainty principle”.This principle in the case of no-trading constraints is equivalent to structural *** demonstrate that structural stability is essential for a correct model approximation(which is used in our numerical method for superhedging price computation).We also show that structural stability is important for the continuity of superhedging prices and discuss the sufficient conditions for this continuity.

关键词： Uncertainty Structural stability no arbitrage Continuity of superhedging price Compact-valued multifunction Financial market model approximation Trading constraints

Maximizing aged photovoltaic array power: a computer modelling study

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CLEAn EnERGY 2024年第1期8卷 171-187页

作者： Sibai, Fadi n. Gulf Univ Sci & Technol Elect & Comp Engn Dept Mishref Kuwait

Photovoltaic (PV) modules age with time for various reasons such as corroded joints and terminals and glass coating defects, and their ageing degrades the PV array power. With the help of the PV array numerical model, this paper explores the effects of PV module ageing on the PV array power, and the power gains and costs of rearranging and recabling aged PV modules in a PV array. The numerical PV array model is first revised to account for module ageing, rearrangement and recabling, with the relevant equations presented herein. The updated numerical model is then used to obtain the array powers for seven different PV arrays. The power results are then analysed in view of the attributes of the seven PV array examples. A guiding method to recommend recabling after rearranging aged modules is then proposed, leading to further significant power gains, while eliminating intra-row mismatches. When certain conditions are met, it was shown that recabling PV modules after rearranging them may lead to further significant power gains, reaching 57% and 98% in two considered PV array examples. Higher gains are possible in other arrays. A cost-benefit analysis weighing annual power gains versus estimated recabling costs is also given for the seven considered PV array examples to guide recabling decisions based on technical and economic merits. In the considered examples, recabling costs can be recovered in ns due to our proposed rearranging and recabling the PV arrays ranged between 73% and 131% in the considered examples-well over the gains reported in the literature. Moreover, the cost of our static module rearrangement and recabling method outshines the costs of dynamic reconfiguration methods recently published in the literature.

关键词： solar energy optimizing array power photovoltaic array modelling photovoltaic modules ageing photovoltaic module rearrangement module recabling and reconfiguration PV array mismatch POInT TRACKInG MODULE RECOnFIGURATIOn PERFORMAnCE SIMULATIOn IMPACT CELL