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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo martínez Ávila Lliset Álvarez Pérez Gisselle martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano margarita De Quesada Amigó Rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa maría Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

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橄榄林中的乡村酒店

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现代装饰 2021年第4期 138-145页

作者： Antonio josé Galisteo Espartero álvaro Fernández Navarro Francisco Jesús Camacho Gómez David Melero Herrera.Arquitecto Fausto Santarosa.Arquitecto Juan Francisco Mata Díaz.Ingeniero ángel Gabriel Pacheco Rodado.Ingeniero Daniel Montoya López.Aparejador Francisco Torreblanca Herrero 郭映琴

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特...

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特的自然环境致以最真诚的敬意,四周的美景令人印象深刻。设计的关键在于使室内外空间相互渗透,不破坏原有建筑的特质。城市规划发展组织将与酒店相连的另一栋用于农业开发的仓库一并纳入了该项目,复杂的行政程序使得这两栋建筑只能进行简单的改造,而该项目的翻新和扩建的设计方案有效地满足了此需求。

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中国军人是值得信赖的朋友

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中国军队（中英文版） 2022年第5期 44-45页

作者：何赛·里维罗·莫里约(口述) 钱晓虎(整理) 程安琪(整理) 李浩然(整理) 不详

来中国库尔勒参加“苏沃洛夫突击”比赛前,我对中国军队的印象停留在阅兵式上铿锵有力的步伐和先进的武器装备。通过近一个月的备赛和比赛,我充分感受到中国军人的热情友善和过硬素质,他们是值得信赖的朋友。此次参赛,我们使用中方提供... 详细信息

来中国库尔勒参加“苏沃洛夫突击”比赛前,我对中国军队的印象停留在阅兵式上铿锵有力的步伐和先进的武器装备。通过近一个月的备赛和比赛,我充分感受到中国军人的热情友善和过硬素质,他们是值得信赖的朋友。此次参赛,我们使用中方提供的装备。为了让我们更快熟悉装备和比赛规则,中方给我们配备了教练员和保障人员,负责装备操作教学和维修保养。

关键词：操作教学比赛规则维修保养库尔勒武器装备阅兵式信赖军人

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考古植物遗存中的碳稳定同位素

东方考古

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东方考古 2024年第1期 146-179页

作者： Juan Pedro Ferrio Mònica Aguilera Jordi Voltas josé Luis Araus 褚黎明阿拉贡研究与发展机构(ARAID) 阿拉贡农业研究与技术中心(CITA)森林资源部 CTFC-AGROTECNIO联合研究单位莱里达大学农作物与森林科学系巴塞罗那大学生物学院植物生理学部综合作物生理生态学组农业技术研究中心(AGROTECNIO) 山东大学文化遗产研究院

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面... 详细信息

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面的线索。本文全面介绍了分析植物遗存的碳稳定同位素在考古学中的潜在应用。在对决定植物碳稳定同位素特性的广泛生理和环境因素进行解释之后,对最相关的方法问题进行了讨论。其中,本文对样品的前处理方式、与大气变化有关的不确定性以及植物遗存在土壤中沉积前后经历的潜在变化进行了评述。以选定的案例研究为例,为碳稳定同位素在考古学中的应用提供了方法和概念上的线索。同时,也强调了依旧存在的挑战。

关键词：碳稳定同位素植物考古环境农业

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Prognostic factors and predictive model for in-hospital mortality following hip fractures in the elderly

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Chinese Journal of Traumatology 2018年第3期21卷 163-169页

作者： J. Sanz-Reig J. Salvador marin J. Ferrandez martinez D. Orozco Beltran J.F. martinez Lopez J.A. Quesada Rico Department of Orthopedic Surgery Sant Joan d' Alacant University Hospital Alicante Spain Department of Medicine Miguel Hernandez University Elche Spain

Purpose： The incidence of hip fractures is increasing within the aging population. Our objective was to identify and quantify the risk factors and develop a predictive model for the in-hospital mortality among hip fracture patients older than 65 years. Methods： This is a prospective study conducted on 331 hip fracture patients older than 65 years admitted to our hospital from 2011 to 2014. Patients＇ demographics, prehospitalization residential status, pre- fracture comorbidity data, anti-aggregant and anticoagulant medication, preoperative hemoglobin value, type of fractures, type of treatments, time to surgery, and complications were recorded. Results： The average age was 83 years, 73% female, and 57% of them sustained a femoral neck fracture. In 62.8% of patients, the number of pre-fracture baseline comorbidities was 〉2. The in-hospital mortality rate was 11.4%. In multivariate analysis, age over 90 years, congestive heart failure, asthma, rheumatologic disease, lung cancer, and not taking antiaggregant medication were independently associated with in-hospital mortality. A formula and risk stratification scoring for predicting the risk for in-hospital mortality was developed, Risk-adjustment model based on these variables had acceptable accuracy for predicting in-hospital mortality （c-statistic 0.77）. Conclusion： Advanced age, and five prefracture comorbidities have a strong association with in-hospital mortality in a hip fracture patient older than 65 years old. Our predictive model was specifically designed for the old hip fracture population. It has an accuracy similar to other risk models. The specificity, positive predictive value, and negative predictive value are high. In addition, it could discriminate a high risk patient from a low risk patient for in-hospital mortality.

关键词： Hip fractures In-hospital mortality Prognostic factors Elder population

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Managament Wound Healing: The Importance of a Wound Clinic in Hospital Centers

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Modern Plastic Surgery 2023年第4期13卷 118-125页

作者： Alfredo Chama Naranjo Cuahutémoc Márquez Espriella Alberto Ignacio Cahuana Quispe Barbosa Villarreal Fernando Ana Priscila Campollo López Mauricio Gutiérrez Álvarez Carlos Emiliano García Córdova Jesús Ricardo García Corral Cuervo Vergara marco Antonio Jorge Luis Rosales Becerra Dávila Díaz Rodrigo Edgar Alan Guillen martínez marín Canto Miguel Eduardo Luis Arturo Herrera Lozano Ochoa Contreras Erick Cesar martinez Villalobos Claudia Nallely Cruz Soto Randall Camacho Rodriguez Hayah Ricardo Alberto Pulido López Edwing Michel Jaimes Durán Department of Plastic and Restrictive Surgery Hospital Central Sur de Alta Especialidad Pemex Mexico City Mexico

Background: In clinical practice, acute and chronic wounds continue to be a challenge. Unfortunately, wound care is often inadequate or inappropriate. The implementation of wound clinics involving an interdisciplinary team for wound care and treatment yields favorable clinical outcomes as well as a reduction in economic expenses due to a higher rate of healing, a decrease in hospital stays, and a reduction in the number of readmissions. The establishment of wound clinics enhances the utilization of diagnostic, preventive, and therapeutic resources, improving the quality of life of patients and facilitating their reintegration into their normal lives. The objective is solely to describe the importance of wound clinics in the medical profession. Methods: A retrospective literature search was conducted to include articles no more than 10 years old that reported measures or results of the study in order to perform a literature review and describe the importance of wound clinics in medical practice. Results: A total of 7 articles were obtained with the inclusion criteria, the most recent being from the year 2023 and the oldest from 2013. Conclusion: An important area for improvement in the healthcare industry is the management and treatment of complex wounds. The establishment of wound clinics offers comprehensive and specialized care for both acute and chronic complex wounds with the goal of enhancing secondary illness patients’ prevention, treatment, and rehabilitation.

关键词： Wound Clinic Pressure Ulcer Chronic Wound Wound Healing Quality of Life

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Highlighting COVID-19:What the imaging exams show about the disease

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World Journal of Radiology 2021年第5期13卷 122-136页

作者： Lorena Sousa de Carvalho Ronaldo Teixeira da Silva Júnior Bruna Vieira Silva Oliveira Yasmin Silva de Miranda Nara Lúcia Fonseca Rebouças Matheus Sande Loureiro Samuel Luca Rocha Pinheiro Regiane Santos da Silva Paulo Victor Silva Lima Medrado Correia maria josé Souza Silva Sabrina Neves Ribeiro Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Rafael Augusto Oliveira Sodré Leal Márcio Vasconcelos Oliveira Fabrício Freire de Melo Department of Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease 2019(COVID-19),a global emergency,is caused by severe acute respiratory syndrome coronavirus *** gold standard for its diagnosis is the reverse transcription polymerase chain reaction,but considering the high number of infected people,the low availability of this diagnostic tool in some contexts,and the limitations of the test,other tools that aid in the identification of the disease are *** this scenario,imaging exams such as chest X-ray(CXR)and computed tomography(CT)have played important *** is useful for assessing disease progression because it allows the detection of extensive consolidations,besides being a fast and cheap *** the other hand,CT is more sensitive for detecting lung changes in the early stages of the disease and is also useful for assessing disease *** note,ground-glass opacities are the main COVID-19-related CT *** emission tomography combined with CT can be used to evaluate chronic and substantial damage to the lungs and other organs;however,it is an expensive *** ultrasound(LUS)has been shown to be a promising technique in that context as well,being useful in the screening and monitoring of patients,disease classification,and management related to mechanical ***,LUS is an inexpensive alternative available at the ***,magnetic resonance imaging,although not usually requested,allows the detection of pulmonary,cardiovascular,and neurological abnormalities associated with ***,it is important to consider the challenges faced in the radiology field in the adoption of control measures to prevent infection and in the follow-up of post-COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Pneumonia Pandemic Radiology Tomography

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粉煤灰处理废水研究与应用的现状及发展

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沈阳建筑工程学院学报 1999年第4期15卷 348-351页

作者：李亚峰赵玉华刘军张吉库沈阳建筑工程学院城建系

介绍粉煤灰处理废水的研究现状及应用情况，分析讨论粉煤灰处理废水的机理，指出应用当中存在的问题及今后的研究方向．

关键词：粉煤灰废物利用废水处理机理

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门诊成人社区获得性肺炎的危险因素:生活方式和共病条件(NEUMO-ES-RISK项目)

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英国医学杂志中文版 2019年第8期22卷 483-483页

作者： Irene Rivero-Calle Miriam Cebey-López Jacobo Pardo-Seco josé Yuste Esther Redondo Diego A Vargas Enrique Mascarós jose Luis Díaz-maroto Manuel Linares-Rufo Isabel Jimeno Angel Gil Jesus Molina Daniel Ocana Federico martinón-Torres 崔晓霞(译) 不详北京协和医院呼吸科

背景社区获得性肺炎(CAP)风险在初级保健中的信息是有限的。我们评估了不同生活方式和共病条件作为初级保健成人CAP的危险因素。方法一项回顾性观察对照研究。使用国家初级保健数据监测系统检索了2009至2013年在西班牙初级保健部门诊断... 详细信息

背景社区获得性肺炎(CAP)风险在初级保健中的信息是有限的。我们评估了不同生活方式和共病条件作为初级保健成人CAP的危险因素。方法一项回顾性观察对照研究。使用国家初级保健数据监测系统检索了2009至2013年在西班牙初级保健部门诊断的成人CAP病例。匹配年龄和匹配性别的对照组采用发病率密度抽样(比例2∶1)。以百分比和比值比来表示关联分析。为了避免偏倚效应,建立二项回归模型。结果51 139例患者和102 372例对照组做比较。平均年龄为61.4(19.9)岁。危险因素与CAP的显著相关性如下:艾滋病[比值比(95%可信区间)5.21(4.35~6.27)]、慢性阻塞性肺病(COPD)[2.97(2.84~3.12)]、哮喘[2.16(2.07~2.26)]、吸烟[1.96(1.91~2.02)]和口腔卫生问题[1.45(1.41~1.49)]。患者组中有危险因素存在的平均患病率为82.2%,对照组为69.2%。CAP患病率的增加与危险因素和年龄的累积有关:1个危险因素时,在18~60岁老人中的风险相关性是1.42,在>60岁人中是1.57;2个危险因素时,是1.88和2.35;≥3个危险因素时,是3.11和4.34。结论成人CAP初级保健中的危险因素普遍较高。主要与危险因素相关的是艾滋病、COPD、哮喘、吸烟、口腔卫生问题。我们的风险叠加结果可以帮助临床医生确定肺炎风险较高的患者。

关键词：社区获得性肺炎危险因素生活方式成人共病慢性阻塞性肺病初级保健门诊

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内蒙锡林郭勒盟黄羊种群观察

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野生动物 1998年第2期19卷 13-14页

作者：王小明李明盛和林毕俊怀华东师范大学生物系上海200062 内蒙古师范大学生物系

1994年11～12月和1995年3～4月我们在内蒙古锡林郭勒盟共发现8029头黄羊,两次观察的黄羊群平均大小分别为293．5头和44．6头,雌雄成年性比为4:1。

关键词：黄羊种群保护动物内蒙锡林郭勒盟

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