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Sulodexide and Alzheimer’s Disease: A Preliminary Prospective Study

World Journal of Cardiovascular Diseases 2016年第2期6卷 54-71页

作者： Joaquín Lasierra-Cirujeda maría josé aza pascual-salcedo maría Mercedes aza pascual-salcedo C. Medicine Hematology Logrono Spain The Rioja and Pharmaceutical Act Ministry of Health The Rioja Regional Government Logrono Spain Aragon Health Service Zaragoza Spain

The purpose of this prospective study is to determine the relative incidence of Alzheimer’s disease in patients treated for at least three years, with sulodexide (n = 46, 76.48 ± 7.02 years old) or acenocoumarol (n = 47, 78.21 ± 6.66 years old) in order to prevent primary and secondary venous thromboembolism and atherothrombotic disease. In the sulodexide group, there was an apparent prevention of cognitive and behavioural impairment (relative incidence: 2.02) compared with acenocoumarol group (relative incidence: 4.86). The favourable results in sulodexide group may be related to their pharmacodynamic actions of inhibition of PAI-1, which may interfere with the pathogenesis of Alzheimer’s disease, and to the role of glutathione and PAI-1 in the β-amyloid system in the brain.

关键词： Sulodexide Alzheimer’s Disease Glutathione t-PA PAI-1 Plasminogen Plasmin

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Aging: Thromboembolic Disease, Metabolic Syndrome, Type 2 Diabetes Mellitus, and Alzheimer’s Disease

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Journal of Biosciences and Medicines 2016年第5期4卷 1-20页

作者： Joaquín Lasierra-Cirujeda maría josé aza pascual-salcedo Alicia Lasierra-Ibañez Carmen Lasala aza maría Mercedes aza pascual-salcedo Centro Médico Hematológico Logrono Spain Pharmaceutical Act Ministry of Health La Rioja Regional Government Logrono Spain Aragon Health Service Zaragoza Spain

Aging can be interpreted as an unavoidable process whose end point is the death. Aging entails, in the hemostasis field, some changes that favour blood hypercoagulability. Both the plasminogen activator inhibitor (PAI-1), specific inhibitor of the tissue plasminogen activator (t-PA), accompanied by the oxidative stress and the marked decrease of the main antioxidant—glutathione are fundamental in the bases of elderly pathologies which can cause death. There is some scientific evidence of the relationship between aging, neuro-degenerative diseases, an excessive production of reactive oxygen species and the decrease of proteolysis in brain. The cerebral plasminogen/plasmin system represents the essential proteolytic mechanism that degrades amyloid peptides (β-amyloidosis) for action of plasmin with effectiveness. This physiologic process is being considered as a preventive neurodegenerative mechanism. At the same time, the decrease of glutathione levels in aging entails a decrease of cerebral plasmin activity and a progressive descent of t-PA activity due to a descent in t-PA expression and an increase in PAI production. All of them entail an increment of amyloid beta peptides (Aβ) production and a lower level of their clearance. Both mechanisms, oxidative stress, direct consequence of the oxygenate metabolism of aerobics cells, and changes in the systemic fibrinolysis and cerebral b-amyloidolytic activity, play a very important role in thromboembolic disease, metabolic syndrome—obesity, insulin resistance, hyperglycemia—, type 2 Diabetes Mellitus and Alzheimer’s disease, clinical processes that accompany the aging. In this revision we show the importance of the interaction between glutathione, proteolytic t-PA/plasminogen/plasmin system, and the inhibitor PAI-1 in aging physiopathology, whose results suggest the hypothesis of the importance of a therapeutic strategy using the inhibition of PAI-1 as a goal, because it is increased in the different aging pathologic pro

关键词： Aging Alzheimer’s Disease T2DM PAI-1 Glutathione

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Exposure Time Between Lifts at RCC Dams.A New Method Used at“EL Esparragal”Spanish Dam

Exposure Time Between Lifts at RCC Dams.A New Method Used at...

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The Fifth International Symposium on Roller Compacted Concrete(RCC) Dams

作者： Emilio Benítez pascual Manuel Enrique Grosso Casalini Juan Carlos de Cea aza edo joséCamero Flores RCC Private Consultant.C/Miguel Cid 60.SevillaSpain Ministerio de Medio Ambiente C.H. del Guadalquivir.C/República Argentina 43.Sevilla.Spain Ministerio de Medio Ambiente.Plz.San Juan de la Cruz s/n°.Madrid.Spain Geocisa Carretera del Copero s/n.Sevilla.Spain

＜正＞At the EL Esparragal Spanish RCC clam the exposure times（ET in the future of this paper）have been estimated using the results of compressive strengths tests of concrete cylinder at short-term,during the laboratory tests phase,that would do unnecessary to these effects the full-scale trial construction,although in this case also has been *** is informed,also,about the good performance of the ***,they are listed the other actual methods to evaluate these ET.

关键词： exposure time Esparragal bond between lifts maturity early compressive test

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