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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNs)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNs injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNs disorders.

关键词： viable injury instru

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures

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Journal of Computer science & Technology 2013年第3期28卷 508-524页

作者： Andrés Ortiz Julio Ortega Antonio F.díaz Alberto Prieto department of Communications Engineering University of Málaga department of Computer Architecture and Technology/CITIC University of Granada

Improving the network interface performance is needed by the demand of applications with high communication requirements （for example, some multimedia, real-time, and high-performance computing applications）, and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present Os network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location （proximity to the memories where the different data structures are stored） and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections.

关键词： interrupt affinity processor affinity network interface offioading, sIMICs

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(Ad)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,Ad is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic Ad accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain Ad pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of Ad.

关键词： Alzheimer Aβ cerebral

Glutathione depleting drugs, antioxidants and intestinal calcium absorption

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World Journal of Gastroenterology 2018年第44期24卷 4979-4988页

作者： Luciana Moine maría Rivoira Gabriela díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni Laboratorio "dr. Fernando Canas" Cátedra de Bioquímica y Biología Molecular Facultad de Ciencias Médicas INICSA (CONICET-Universidad Nacional de Córdoba) Córdoba 5000 Argentina

Glutathione （GsH） is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GsH in the intestine is essential to optimize the intestinal Ca2＋ absorption. The use of GsH depleting drugs such as dL-buthionine-s,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2＋ ab-sorption. The GsH depleting drugs switch the redox state towards an oxidant condition provoking oxida-tive/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca transport or the paracellular Ca route are altered by GsH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2＋ pathway are decreased. The favonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2＋ absorption, not only by restoration of the GsH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2＋ transport caused by GsH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2＋ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety,pharmacokinetics and pharmacodynamics of them.

关键词： Glutathione Transcellular and paracellular Ca^2+pathways dL-buthionine-s,R-sulfoximine Fructose rich diet Menadione sodium deoxycholate Glutamine Ursodeoxycholic acid Melatonin Quercetin Naringin

single photo and electroproduction of pions at EBAC@JLAB

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Chinese Physics C 2009年第12期33卷 1296-1301页

作者： B. Juli-díaz department d'Estructura i Constituents de la Matèria and Institut de Ciències del Cosmos Universitat de Barcelona E-08028 Barcelona Spain Excited Baryon Analysis Center (EBAC) Thomas Jefferson National Accelerator Facility Newport News VA 23606 USA

Within the Excited Baryon Analysis Center we have performed a dynamical coupled-channels analysis of the available p（e,e＇π）N data in the region of W ≤ 1.6 GeV and Q2 ≤1.45 （GeV/c）2. The channels included are γ＊N, π＊N, ηN, and ηN which has π△, pN, and σN components. With the hadronic parameters of the model determined in our previous investigations of πN→ πN reaction, we have found that the available data in the considered W ≤ 1.6 GeV region can be fitted well by only adjusting the bare γ＊N → N＊ helicity amplitudes for the lowest N＊ states in P33, P11, s11 and d13 partial waves. The meson cloud effect, as required by the unitarity conditions, on the γ＊N → N＊ form factors are examined.

关键词： meson electroproduction helicity amplitudes

Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

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World Journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： maría Belén Novoa díaz Pedro Carriere Graciela Gigola Ariel Osvaldo Zwenger Natalia Calvo Claudia Gentili departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro de Estudios Clínicos sAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUNd Parathyroid hormone-related peptide(PTHrP)plays a key role in the development and progression of many *** found that in colorectal cancer(CRC)HCT116 cells,the binding of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated with an aggressive *** HCT116 cell xenografts,PTHrP modulates the expression of molecular markers linked to tumor *** evidence suggests that the Met receptor is involved in the development and evolution of *** on these data,we hypothesized that the signaling pathway trigged by PTHrP could be involved in the transactivation of Met and consequently in the aggressive behavior of CRC *** To elucidate the relationship among PTHR1,PTHrP,and Met in CRC *** For in vitro assays,HCT116 and Caco-2 cells derived from human CRC were incubated in the absence or presence of PTHrP(1-34)(10-8 M).Where indicated,cells were pre-incubated with specific kinase inhibitors or dimethylsulfoxide,the vehicle of the *** protein levels were evaluated by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried out to determine the changes in gene *** healing assay and morpho logical monitoring were performed to evaluate cell migration and changes related to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted by trypan blue dye exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or doxorubicin(dOXO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old male N:NIH(s)_nu mice received daily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered saline(PBs)or the vehicle(PBs)as a control during 20 *** slaughter was carried out and the tumors were removed,weighed,and fixed in a 4%formaldehyde solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we studied 23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid hormone receptor type 1 Colorectal cancer drug resistance

determination and(Re)Parametrization of Rational developable surfaces

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Journal of systems science & Complexity 2015年第6期28卷 1426-1439页

作者： sHEN Liyong PREZ-díaz sonia school of Mathematical sciences University of Chinese Academy of Sciences Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science Chinese Academy of Sciences Key Laboratory of Big data Mining and Knowledge management Chinese Academy of Sciences dpto de Física y Matemáticas Universidad de Alcalá

The developable surface is an important surface in computer aided design, geometric modeling and industrial manufactory. It is often given in the standard parametric form, but it can also be in the implicit form which is commonly used in algebraic geometry. Not all algebraic developable surfaces have rational parametrizations. In this paper, the authors focus on the rational developable surfaces. For a given algebraic surface, the authors first determine whether it is developable by geometric inspection, and then give a rational proper parametrization in the affrmative case. For a rational parametric surface, the authors also determine the developability and give a proper reparametrization for the developable surface.

关键词： Parametrization proper rational developable surface reparametrization

survival effect of probiotics in a rat model of colorectal cancer treated with capecitabine

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1518-1531页

作者： Graciela Gigola Pedro Carriere maría Belén Novoa díaz Gabriela Perdigon Ariel Osvaldo Zwenger Claudia Gentili Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos Aires ProvinciaArgentina San Miguel de Tucumán 4000Argentina Centro de Estudios Clínicos sAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUNd Probiotics are used to manage a number of gastrointestinal disorders due to their beneficial *** reports showed that probiotics also improve the life quality of patients with colorectal cancer(CRC)subjected to oncologic *** a CRC animal model,probiotics supplementation has the potential to decrease the formation of aberrant crypts and ameliorate tumor malignancy,enhancing the antitumor effect of 5-fluorouracil(5-FU)*** on these data,we hypothesize that the administration of probiotics impact positively in the overall survival and life quality of rats with CRC under the treatment of capecitabine,which is the pro drug of *** To evaluate the probiotics effects in a rat CRC model treated with capecitabine and followed until the end of *** 1,2-dimethylhidrazine dihydrochloride(1,2-dMH)was employed as carcinogen inductor of *** male Wistar-Lewis rats were randomly assigned to one of five following groups:Control(n=5),Control+probiotics(Control-P group,n=5),1,2-dMH alone(dMH group,n=10),1,2-dMH+capecitabine(dMH-C group,n=10),1,2-dMH+probiotics(dMH-P group,n=10)and 1,2-dMH+capecitabine+probiotics(dMH-C-P group,n=10).All parametric data were expressed as the mean±*** statistical significance of differences was analyzed using one-way *** were analyzed with Infostat *** results were considered statistically significant at Psurvival was evaluated with the Kaplan-Meier estimator with the log-rank *** The data of mean overall survival for dMH,dMH-P,dMH-C,dMH-C-P,Control and Control-P groups were 250 d[95%confidence interval(CI):242.5-253.1],268 d(95%CI:246.3-271.4),380 d(95%CI:337.8-421.9),480 d(95%CI:436.9-530.7),588 d(95%CI:565.8-609.3)and 590 d(95%CI:564.3-612.9),respectively,with a significant difference between dMH-C and dMH-C-P groups(P=0.001).Comparing all groups by Kaplan-Meier estimator,we found a significantly different in the overall survival of dMH and dMH-

关键词： Colorectal cancer Capecitabine Probiotics survival Life quality Animal experimentation