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Does enhanced recovery after surgery programs improve clinical outcomes in liver cancer surgery?

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 255-258页

作者： Belinda sánchez-pérez JoséM Ramia Department of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of surgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after surgery(ERAs)programs have been widely applied in liver surgery since the publication of the first ERAs guidelines in 2016 and the new recommendations in *** surgery is usually performed in oncological patients(liver metastasis,hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver surgery ERAs programs in oncological outcomes is not clearly *** advantages of ERAs programs are:ERAs decreases postoperative complication rates and has been demonstrated a clear relationship between complications and oncological outcomes;a better and faster posto-perative recovery should let oncologic teams begin chemotherapeutic regimens on time;prehabilitation and nutrition actions before surgery should also improve the performance status of the patients receiving ***,ERAs could be another way to improve our oncological *** will discuss the literature about liver surgery ERAs focusing on its oncological implications and future investigations projects.

关键词： Enhanced recovery after surgery programs Liver surgery Key components Long-term oncological outcomes Enhanced recovery after surgery compliance

Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMiR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco marín Manuel Anguita sánchez iñaki Lekuona marcelo sanmartín Fernán-dez Vivencio Barrios Carlos perez Muñoz Juan Cosín-sales Alejandro ipérez Cabeza Vanesa Roldán schilling Carles Rafols priu Esteban Orenes-piñero maría Asunción Es-teve-pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.s) at *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2Ds2-VAsc(4.5 ± 1.3 vs.3.0 ± 1.4;p s-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;p se of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;p = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAs-BLED score with major *** in clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

Ca-based materials derived from calcined cigarette butts for CO_(2)capture and thermochemical energy storage

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Journal of Environmental sciences 2024年第6期140卷 230-241页

作者： Nabil Amghar Virginia Moreno pedro E.sánchez-Jiménez Antonio perejón Luis A.pérez-Maqueda instituto de Ciencia de Materiales de sevilla C.S.I.C.-Universidad de SevillaC.Américo Vespucio4941092 SevillaSpain instituto de Tecnología de Materiales(iTM) Universitat Politècnica de València(UPV)Plaza Ferrándiz y Carbonell 1AlcoyAlicante 03801Spain Departamento de Química inorgánica Facultad de QuímicaUniversidad de Sevilla41012 SevillaSpain

Cigarette butts(CBs)are one of the most common types of litter in the *** to the toxic substances they contain,the waste generated poses a harmful risk to the environment,and therefore there is an urgent need for alternative solutions to landfill ***,this work presents a possible revalorization of this waste material,which implies interesting environmental *** were used as sacrificial templates for the preparation of CaO-based materials by impregnation with calcium and magnesium nitrates followed by flaming *** materials presented enhanced porosity for their use in the Calcium Looping process applied either to thermochemical energy storage or CO_(2)capture *** influence of the concentration of Ca and Mg in the impregnating solutions on the multicycle reactivity of the samples was *** improved multicycle performance was obtained in terms of conversion for both applications.

关键词： Cigarette butts Calcium-Looping CO_(2)Capture Thermochemical energy storage

New therapeutic strategy with extracorporeal membrane oxygenation for refractory hepatopulmonary syndrome after liver transplant: A case report

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World Journal of Transplantation 2024年第1期14卷 210-214页

作者： Belinda sánchez pérez maría pérez Reyes Jose Aranda Narvaez Julio santoyo Villalba Jose Antonio perez Daga Claudia sanchez-Gonzalez Julio santoyo-santoyo Hepatobiliary and Trasplantation Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Department of General and Digestive surgery Regional University Hospital of MalagaMalaga 29010Spain

BACKGROUND Due to the lack of published literature about treatment of refractory hepatopulmonary syndrome(Hps)after liver transplant(LT),this case adds information and experience on this issue along with a treatment with positive *** is a complication of end-stage liver disease,with a 10%-30%incidence in cirrhotic *** can reverse the physiopathology of this process and restore normal ***,in some cases,refractory hypoxemia persists,and extracorporeal membrane oxygenation(ECMO)can be used as a rescue therapy with good *** sUMmarY A 59-year-old patient with alcohol-related liver cirrhosis and portal hypertension was included in the LT waiting list for *** had good liver function(Model for End-stage Liver Disease score 12,Child-pugh class B7).He had pulmonary fibrosis and a mild restrictive respiratory pattern with a basal oxygen saturation of 82%.The macroaggregated albumin test result was>*** demonstrated a forced expiratory volume in one second(FEV1)of 78%,forced vital capacity(FVC)of 74%,FEV1/FVC ratio of 81%,diffusion capacity for carbon monoxide of 42%,and carbon monoxide transfer coefficient of 57%.He required domiciliary oxygen at 2 L/min(16 h/d).The patient was admitted to the intensive care unit(iCU)and extubated in the first 24 h,needing high-flow therapy and non-invasive ventilation and inhaled nitric oxide *** was needed after 72 *** to the non-response to supportive therapies,installation of ECMO was decided with progressive recovery after 9 *** was possible on the tenth day,maintaining a high-flow nasal cannula and de-escalating to conventional oxygen therapy after 48 *** was discharged from iCU on postoperative day(pOD)20 with a 90%-92%oxygen *** recycling was needed twice for acute *** patient was discharged from hospital on pOD 27 with no symptoms,with an 89%-90%oxygen *** Due to the favorable results observed,ECMO could bec

关键词： Liver transplantation Hepatopulmonary syndrome Refractory hypoxemia Treatment Extracorporeal membrane oxygenation Case report

Calibration of the DEM sliding friction and rolling friction parameters of a cohesionless bulk material

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particuology 2024年第9期92卷 126-139页

作者： Jonatan marín pérez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding friction and rolling friction ***,these parameters are estimated using bulk calibration approach(BCA)where the draw down test has been suggested as an effective way to approach these *** test provides up to four bulk criteria,the angle of repose,shear angle,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodology *** experimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding and rolling friction parameters of a cohesionless bulk material can converge to a small feasible region in which a single combination of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method Calibration Draw down sliding friction Rolling friction particle shape

Mechanical Behavior of panels Reinforced with Orthogonal plant Fabrics: Experimental and Numerical Assessment

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Journal of Renewable Materials 2024年第10期12卷 1791-1810页

作者： martha L.sánchez G.Capote Universidad Militar Nueva Granada Programa de Ingeniería CivilBogotá110111Colombia Facultad de Ciencias Departamento de FísicaUniversidad Nacional de ColombiaBogotá111321Colombia

The construction sector is one of the main sources of pollution,due to high energy consumption and the toxic substances generated during the processing and use of traditional *** production of cement,steel,and other conventional materials impacts both ecosystems and human health,increasing the demand for ecological and biodegradable *** this paper,we analyze the properties of panels made from a combination of plant fibers and castor oil resin,analyzing the viability of their use as construction *** the research,orthogonal fabrics made with waste plant fibers supplied by a company that deals with the manufacture of furniture and craft products were *** fabrics were made with strips of plant fibers of the Calamus rotang,Bambusa vulgaris,Heteropsis flexuosa,and salix viminalis *** improve their compatibility with the castor oil resin,a cold argon plasma treatment was *** effect of the treatment on the properties of the fibers and the panels was *** density,water absorption capacity,and swelling percentage were ***,compression,static bending,and linear buckling tests were carried *** study found that panels made with treated fiber fabrics exhibited a reduction of approximately 10%in absorption capacity and up to 35%in swelling percentage *** made with Bambusa vulgaris fabrics exhibited the highest strength and stiffness *** models were constructed using commercial finite element *** comparing the numerical results with the experimental ones,differences of less than 15%were seen,demonstrating that the models allow adequately predicting the analyzed *** comparing the values obtained with the characteristic values of oriented strand board,the results suggest that panels made with unconventional materials could replace commercial panels traditionally made with wood-based fibers and particles and other composite materials in several applications in th

关键词： Unconventional materials nonstructural panels plantﬁbers surface treatment physical properties mechanical properties

A probabilistic Trust Model and Control Algorithm to protect 6G Networks against Malicious Data injection Attacks in Edge Computing Environments

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Computer Modeling in Engineering & sciences 2024年第10期141卷 631-654页

作者： Borja Bordel sánchez Ramón Alcarria Tomás Robles Department of Computer systems Universidad Politécnica de MadridMadrid28031Spain Department of Geospatial Engineering Universidad Politécnica de MadridMadrid28031Spain

Future 6G communications are envisioned to enable a large catalogue of pioneering *** will range from networked Cyber-physical systems to edge computing devices,establishing real-time feedback control loops critical for managing industry 5.0 deployments,digital agriculture systems,and essential *** provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and *** full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and *** particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control ***,Denialof-service attacks can be executed by inundating the network with valueless *** anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical *** based on an exhaustive data collection to detect anomalies are precise but extremely *** models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors *** paper introduces a probabilistic trust model and control algorithm designed to address this *** model determines the probability of any node to be *** channels are pruned for those nodes whose probability is below a given *** trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and ***,anomalous nodes are identified using Gaussian mixture models and clustering ***,traffic patterns are studied using digital Bessel functions and the functional scalar ***,the in

关键词： 6G networks noise injection attacks Gaussian mixture model Bessel function traffic filter Volterra filter

Assessing the energy saving potential of using adaptive setpoint temperatures:The case study of a regional adaptive comfort model for Brazil in both the present and the future

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Building simulation 2024年第3期17卷 459-482页

作者： Daniel sánchez-García David Bienvenido-Huertas Carlos Rubio-Bellido Ricardo Forgiarini Rupp Department of Electrical Engineering University Carlos III of MadridMadridSpain Department of Building simulation ZEROCEM SLSevilleSpain Department of Building Constructions University of GranadaGranadaSpain Department of Building Constructions ii University of SevilleSevilleSpain section of Design for sustainability Department of Civil and Mechanical EngineeringTechnical University of DenmarkKgs.LyngbyDenmark

it has been found in recent years that using setpoint temperatures based on adaptive thermal comfort models is a successful method of energy *** studies using adaptive setpoint temperatures incorporate international models from AsHRAE standard 55 and *** study,however,has instead considered a regional Brazilian adaptive comfort *** study investigates the energy demand arising from the use of a local Brazilian comfort model in order to assess the energy implications from the use of the worldwide AsHRAE standard 55 adaptive model and various fixed setpoint *** of Brazil’s climate zones,full air-conditioning,mixed-mode building operating modes,present-day climate change scenarios,and future scenarios—specifically Representative Concentration pathways(RCp)2.6,4.5,and 8.5 for the years 2050 and 2100—have all been taken into account in building energy *** use of adaptive setpoint temperatures based on the Brazilian local model considering mixed-mode has been found to significantly reduce energy consumption when compared to static setpoint temperatures(average energy-saving values ranging from 52%to 58%)and the AsHRAE 55 adaptive model(average values ranging from 15%to 21%).Considering climate change and the mixed-mode Brazilian model,the overall energy demand for the three groups of climatic zones(annual average outdoor temperatures≤21℃,>21 and≤25℃and>25℃)ranged between 2%decrease and 5%increase,4%and 27%increase,and 13%and 45%increase,*** is concluded as a consequence that setting setpoint temperatures based on the Brazilian local adaptive comfort model is a very efficient energy-saving method.

关键词： adaptive thermal comfort building energy simulation energy efficiency climate change adaptive setpoint temperatures local comfort mode

Acoustic micro‐beam vortex generator for flow actuation inside droplets

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Droplet 2024年第1期3卷 125-135页

作者： Diego sánchez‐saldaña maria Fernandino Carlos A.Dorao Department of Energy and process Engineering Norwegian University of Science and TechnologyTrondheimNorway

Controlling acoustic streaming inside a droplet has excellent potential for enabling fluid and particle operations such as mixing,separation,and aggregation in various *** concepts for generating surface acoustic waves are based on the placement of an interdigitated transducer at the side of a droplet,thus externally acting on the *** this case,the flow structure inside the droplet is controlled by the relatively large scale of the interdigitated transducer compared to the droplet,thus limiting the local control of the *** possibility to overcome this drawback is to reduce the size of the actuator such that a highly focused ultrasound transducer can induce localized acoustic streaming in ***,we introduce a micro‐spiral interdigitated transducer smaller than a droplet size that can generate micro‐size vortices inside the *** step enables a new way of controlling the flow inside the droplet,facilitating mixing,separation,aggregation,and patterning of *** study the characteristics of the acoustic streaming and the potential application of the flow for the separation and patterning of *** simplicity of the concept provides in‐droplet particle manipulation toolsets for many applications such as biosensing,microbiology,and point‐of‐care devices.

关键词： flow separation aggregation