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Petroleum Science 2021年第5期18卷 1409-1426页

作者： Miguel Angel Roncoroni Pedro Romero Jesús Montes Guido Bascialla Rosario Rodríguez Ramón Rodríguez Pons-Esparver Luis Felipe Mazadiego maría flor garcía-mayoral Universidad Politécnica de Madrid MadridSpain CEPSA Research Center MadridSpain CEPSA E&P MadridSpain

This work presents the design of a robust foam formulation that tolerates harsh reservoir conditions(high salinity,high divalent ion concentration,high temperature,light oil,and hydrocarbon injection gas)in a sandstone reservoir.For this,we selected anionic Alpha Olefin Sulfonate(AOS)surfactants and studied their synergistic effects in mixtures with zwitterionic betaines to enhance foam performance.The laboratory workflow used to define the best formulation followed a de-risking approach in three consecutive phases.First,(phase 1)the main surfactant(AOS)was selected among a series of commercial candidates in static conditions.Then,(phase 2)the betaine booster to be combined with the previously selected AOS was chosen and their ratio optimized in static conditions.Subsequently,(phase 3)the surfactant/booster ratio was optimized under dynamic conditions in a porous medium in the absence and the presence of oil.As a result of this study,a mixture of an AOS C14-C16 and cocamidopropyl hydroxysultaine(CAPHS)was selected as the one having the best performance.The designed formulation was proven to be robust in a wide range of conditions.It generated a strong and stable foam at reservoir conditions,overcoming variations in salinity and foam quality,and tolerated the presence of oil.

关键词： Gas mobility control Foam enhanced oil recovery(EOR) Foam stability High temperature high salinity reservoir Surfactant formulation

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells:Impact on disease progression

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World Journal of Stem Cells 2023年第5期15卷 421-437页

作者： Daniel garcía-Sánchez Alberto González-González Ana Alfonso-Fernández Mónica Del Dujo-Gutiérrez flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y Cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

Multiple myeloma(MM)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(BM).The interaction between MM cells and the BM microenvironment,and specifically BM mesenchymal stem cells(BM-MSCs),has a key role in the pathophysiology of this disease.Multiple data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs,aiding the progression of this hematological tumor.The relation of MM cells with the resident BM-MSCs is a two-way interaction.MM modulate the behavior of BM-MSCs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence markers.In turn,modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease progression.The interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs,long non-coding RNAs or other molecules.However,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling nanotubes.Thus,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

关键词： Multiple myeloma Mesenchymal stem cells Bone marrow microenvironment Soluble factors Extra-cellular vesicles Cells adhesion molecules Tunnellingnanotubes

Impact of artificial intelligence in the management of esophageal,gastric and colorectal malignancies

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Artificial Intelligence in Gastrointestinal Endoscopy 2024年第2期5卷 1-14页

作者： Ayrton Bangolo Nikita Wadhwani Vignesh K Nagesh Shraboni Dey Hadrian Hoang-Vu Tran Izage Kianifar Aguilar Auda Auda Aman Sidiqui Aiswarya Menon Deborah Daoud James Liu Sai Priyanka Pulipaka Blessy George flor Furman Nareeman Khan Adewale Plumptre Imranjot Sekhon Abraham Lo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States

The incidence of gastrointestinal malignancies has increased over the past decade at an alarming rate.Colorectal and gastric cancers are the third and fifth most commonly diagnosed cancers worldwide but are cited as the second and third leading causes of mortality.Early institution of appropriate therapy from timely diagnosis can optimize patient outcomes.Artificial intelligence(AI)-assisted diagnostic,prognostic,and therapeutic tools can assist in expeditious diagnosis,treatment planning/response prediction,and post-surgical prognostication.AI can intercept neoplastic lesions in their primordial stages,accurately flag suspicious and/or inconspicuous lesions with greater accuracy on radiologic,histopathological,and/or endoscopic analyses,and eliminate over-dependence on clinicians.AI-based models have shown to be on par,and sometimes even outperformed experienced gastroenterologists and radiologists.Convolutional neural networks(state-of-the-art deep learning models)are powerful computational models,invaluable to the field of precision oncology.These models not only reliably classify images,but also accurately predict response to chemotherapy,tumor recurrence,metastasis,and survival rates post-treatment.In this systematic review,we analyze the available evidence about the diagnostic,prognostic,and therapeutic utility of artificial intelligence in gastrointestinal oncology.

关键词： Artificial intelligence Gastrointestinal malignancies Machine learning Helicobacter pylori State-of-the-art deep learning models

Super gas wet and gas wet rock surface: State of the art evaluation through contact angle analysis

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Petroleum 2023年第1期9卷 1-7页

作者： Mohammad Azadi Tabar Abolfazl Dehghan Monfared flor Shayegh Farzad Barzegar Mohammad Hossein Ghazanfari Department of Chemical and Petroleum Engineering Sharif University of TechnologyTehran11155-9564Iran Department of Petroleum Engineering Faculty of PetroleumGas and Petrochemical EngineeringPersian Gulf UniversityBushehr75169-13817Iran Research Institute of Petroleum Industry Tehran14665-137Iran

Recently,super gas wet and gas wet surfaces have been extensively attended in petroleum industry,as supported by the increasing number of publications in the last decade related to wettability alteration in gas condensate reservoirs.In many cases,contact angle measurement has been employed to assess the wettability alteration.Even though contact angle measurement seems to be a straightforward approach,there exist many misuses of this technique and consequently misinterpretation of the corresponding results.In this regard,a critical inspection of the most recent updated concepts and the intervening parameters in the contact angle based wettability evaluation of liquid-solid-gas systems could aid to provide some remediation to alleviate this problem.To this end,this work presents a survey on the accurate terms and rigorous protocols based on the community of surface science and chemistry.As a preliminary step,advancing,receding,static,and the most stable contact angle terminology are defined.The study is followed by the definition of the contact angle hysteresis effect.The application of surface free energy in the selection of the best gas wet agent is then analyzed.Afterward,the impact of the size-dependent behavior of drop on contact angle is discussed.Finally,a sessile drop experiment is explained to achieve the defined parameters.For future contributions to petroleum industry journals,like this journal,this work could offer an easy use of the conceptual framework for analyzing the results and comparative evaluations in chemical wettability modifier agents.

关键词： Contact angle hysteresis Size-dependent behavior Surface free energy Stick-slip Wettability alteration Condensate reservoirs

Thermal and photoperiodic requirements of the seedling stage of three tropical forest species

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Journal of Forestry Research 2023年第1期34卷 209-220页

作者： Fabrina Bolzan martins Mábele de Cássia Ferreira Flávia Fernanda Azevedo Fagundes Gabriel Wilson Lorena florêncio Natural Resource Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

Air temperature and photoperiod play an important role in the seedling development for tropical forest species.Both variables are sensitive to climate,and so evaluating thermal and photoperiodic effects on seedling development is fundamental,especially for climate change studies.Methods to quantify thermal time and the energy required for plants to reach a development stage include air temperature and cardinal temperatures.The photoperiod will also affect physiological reactions of a plant and thus its development.Here we evaluated the six thermal time methods widely used to compute thermal requirement,and identified the influence of the photoperiod from the 2015 and2016 growing seasons and 12 sowing dates in Itajubá,Minas Gerais state,Brazil,on seedling development of three native tropical forest species Psidium guajava L.(Myrtaceae),Citharexylum myrianthum Cham.(Verbenaceae),and Bixa orellana L.(Bixaceae).The method used to quantify thermal time influenced the analytical results of seedling development;the one that considered three cardinal temperatures and compared them with the mean air temperature(Method5)performed better in computing thermal requirements.The influence of photoperiod on seedling development was inconclusive for the three species,but all three developed better in mild temperatures(between 13.3℃and 26.9℃)with a photoperiod shorter than 13 h.

关键词： Phyllochron Thermal time Day length Seedling stage Phenology

Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells

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World Journal of Stem Cells 2019年第10期11卷 748-763页

作者： Daniel garcía-Sánchez Darío Fernández JoséC Rodríguez-Rey flor M Pérez-Campo Department of Molecular Biology Faculty of MedicineUniversity of CantabriaCantabria 39011Spain Laboratorio de Biología Celular y Molecular Facultad de OdontologíaUniversidad Nacional del NordesteCorrientes W3400Argentina Consejo Nacional de Investigaciones científicas y Técnicas Ciudad de CorrientesCorrientes W3400Argentina

Mesenchymal stem cells(MSCs)are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing.MSC-based treatments are generally considered a safe procedure,however,the long-term results obtained up to now are far from satisfactory.The main causes of these therapeutic limitations are inefficient homing,engraftment,and osteogenic differentiation.Many studies have proposed modifications to improve MSC engraftment and osteogenic differentiation of the transplanted cells.Several strategies are aimed to improve cell resistance to the hostile microenvironment found in the recipient tissue and increase cell survival after transplantation.These strategies could range from a simple modification of the culture conditions,known as cell-preconditioning,to the genetic modification of the cells to avoid cellular senescence.Many efforts have also been done in order to enhance the osteogenic potential of the transplanted cells and induce bone formation,mainly by the use of bioactive or biomimetic scaffolds,although alternative approaches will also be discussed.This review aims to summarize several of the most recent approaches,providing an up-to-date view of the main developments in MSCbased regenerative techniques.

关键词： Mesenchymal stem cells Bone regeneration Hypoxia Anoikis Preconditioning Bioactive scaffolds Senescence Engraftment Homing Osteogenesis

Simulation Tools for a Fiber-Optic Based Structural Health Monitoring System

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第2期35卷 219-225页

作者： Alfredo Güemes Antonio Fernandez-Lopez Jaime garcía-Ramírez maria Eugenia Reyes-Perez flor Criado Zurita Laboratory for Composites & Smart Structures Department of AeronauticsPolytechnic University of Madrid

Probability of detection(POD)graphics allow for a change from qualitative to quantitative assessment for every damage detection system,and as such it is a main request for conventional non-destructive testing(NDT)techniques.Its availability can greatly help towards the industrialization of the corresponding Structural health monitoring(SHM)system.But having in mind that for SHM systems the sensors are at fixed positions,and the location of a potential damage would change its detectability.Consequently robust simulation tools are required to obtain the model assisted probability of detection(MAPOD)which is needed to validate the SHM system.This tool may also help for the optimization of the sensor distribution,and finally will allow a probabilistic risk management.INDEUS,simulation of ultrasonic waves SHM system,was a main milestone in this direction.This article deals with the simulation tools for a strain based SHM system,using fiber optic sensors(FOS).FOS are essentially strain/temperature sensors,either with multi-point or with distributed sensing.The simulation tool includes the finite element model(FEM)for the original and damaged structure,and algorithms to compare the strain data at the pre-established sensors locations,and from this comparison to extract information about damage occurrence and location.The study has been applied to the structure of an all-composite unmanned aircraft vehicle(UAV)now under construction,designed at Universidad Politecnica de Madrid for the inspection of electrical utilities networks.Distributed sensing optical fibers were internally bonded at the fuselage and wing.Routine inspection is planned to be done with the aircraft at the test bench by imposing known loads.From the acquired strain data,damage occurrence may be calculated as slight deviations from the baselines.This is a fast inspection procedure without requiring trained specialists,and it would allow for detection of hidden damages.Simulation indicates that stringer partial debondings are detected before they become

关键词： damage detection fiber optics distributed sensing finite element models probability of detection(POD) principal component analysis (PCA) fibre bragg gratings (FBG)

Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine

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World Journal of Stem Cells 2020年第12期12卷 1529-1552页

作者： Alberto González-González Daniel garcía-Sánchez Monica Dotta JoséC Rodríguez-Rey flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain

Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field.

关键词： Mesenchymal stem cells Secretome Soluble factors Extra-cellular vesicles Exosomes Bone regeneration

Smart bioadhesives for wound healing and closure

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Bioactive Materials 2023年第1期19卷 360-375页

作者： Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA16802USA AML Department of Engineering MechanicsTsinghua UniversityBeijing100084China Institute of Flexible Electronics Technology of THU ZhejiangJiaxing314000China Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802USA Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of ScienceSuzhou215011PR China School of Materials and Energy State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and Technology of ChinaChengdu610054PR China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA16802USA

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion,antibacterial effect,real-time sensing,wireless communication,and on-demand treatment capabilities.Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths,as well as tunable optical,electrical,and bio-dissolvable properties.Accelerated wound healing has been achieved via directly released antibacterial and growth factors,material or drug-induced host immune responses,and delivery of curative cells.Most recently,the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives,allowing real-time sensing of the physiological conditions(e.g.,pH,temperature,uric acid,glucose,and cytokine)with iterative feedback for drastically enhanced,stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation.Despite rapid advances in the burgeoning field,challenges still exist in the design and fabrication of integrated systems,particularly for chronic wounds,presenting significant opportunities for the future development of next-generation smart materials and systems.

关键词： Smart bioadhesives Immunomodulatory bioadhesives Mechanically/electrically active bioadhesives Closed-loop system On-demand treatments Wound healing and closure

p-Cresol mineralization and bacterial population dynamics in a nitrifying sequential batch reactor

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Journal of Environmental Sciences 2014年第9期26卷 1885-1893页

作者： Carlos David Silva Lizeth Beristain-Montiel flor de maria Cuervo-López Anne-Claire Texier Department of Biotechnology-CBS Universidad Autónoma Metropolitana-IztapalapaMexico City 09340Mexico Department of Process and Technology-CNI Universidad Autónoma Metropolitana-CuajimalpaMexico City 05300Mexico

The ability of a nitrifying sludge to oxidize p-cresol was evaluated in a sequential batch reactor （SBR）. p-Cresol was first transformed to p-hydroxybenzaldehyde and p-hydroxybenzoate, which were later mineralized. The specific rates of p-cresol consumption increased throughout the cycles. The bacterial population dynamics were monitored by using denaturing gradient gel electrophoresis 0DGGE） and sequencing of DGGE fragments. The ability of the sludge to consume p-cresol and intermediates might be related to the presence of species such as Variouorax paradoxus and Thauera mechernichensis, p-Cresol （25 to 200 mg C/L） did not affect the nitrifying SBR performance （ammonium consumption efficiency and nitrate production yield were close to 100% and 1, respectively）. This may be related to the high stability observed in the nitrifying communities. It was shown that a nitrifying SBR may be a good alternative to eliminate simultaneously ammonium and p-cresol, maintaining stable the respiratory process as the bacterial community.

关键词： Nitrificationp-Cresol oxidationSequential batch reactorPopulation dynamicsEcological indices