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Mexican Guidelines for the Diagnosis and Treatment of Chronic Myeloid Leukaemia

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Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ramón Rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas Myrna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ramírez Jorge Aquino Guillermo Díaz mariela Cardiel margarita Rodríguez Patricia Montoya Juan Contreras maría Chávez Sandra Chávez David Gómez Olga Cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias Clinic at ISSEMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid Leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic Myeloid Leukaemia Management Guidelines Diagnosis Treatment.

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欧洲文化统计

中国文化产业评论 2019年第1期27卷 127-152页

作者：文森特·科利-塞拉诺克里斯蒂娜·帕尔多-加西亚玛利亚·卡瓦列尔-塔拉索纳王莹(译) 西班牙瓦伦西亚大学云南大学

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得... 详细信息

文化作为价值和认同的源泉,是欧洲独特性的重要特征和主要优势之一。随着文化在欧洲国内生产总值(GDP)中的比重日益增长,以证据为基础的文化测量活动具有重要意义。因此,文化数据库的可靠性和可获得性对政策制定者和社会科学研究者显得尤其重要。在此背景下,本文汇编了国际机构在文化统计和测量方面的最新努力,为文化经理人的工作提供便利。具体而言,本文总结了欧洲国家和欧盟层面现有的文化统计资源,其中包括一组欧洲文化观测台的汇总表。

关键词：文化文化统计欧洲统计局国家统计局

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

CT为基础的肺叶通气与3He-MR成像通气测量的比较

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国际医学放射学杂志 2016年第2期 197-197页

作者： B.A.Tahir C.V.Holsbeke R.H.Ireland A.J.Swift F.C.Horn H.mar-shall 韩宁 Academic Units of Academic Radiology University of SheffieldC FloorRoyal Hallamshire Hospital INSIGNEO Institute of In-silico Medicine

摘要目的比较吸气相及呼气相肺叶通气CT数据与超极化3He-MR成像上直接测量的肺通气数据,利用与3HeMR成像相同屏气时段所获得的1H-MR成像来配准多模态影像。材料与方法本研究经国家研究伦理委员会批准,并获得病人书面同意。30例哮喘病人... 详细信息

摘要目的比较吸气相及呼气相肺叶通气CT数据与超极化3He-MR成像上直接测量的肺通气数据,利用与3HeMR成像相同屏气时段所获得的1H-MR成像来配准多模态影像。材料与方法本研究经国家研究伦理委员会批准,并获得病人书面同意。30例哮喘病人在总肺容量及功能余气量的状态下屏气行CT检查。在功能余气量加上1 L的肺容量状态下相同屏气时段获得3He-MR和1H-MR影像。通过主

关键词：肺叶 MR 通气量 CT 左肺上叶

间接竞争酶联免疫吸附法应用于采后水果组织中葡萄孢菌的定量分析

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保鲜与加工 2012年第2期 56-56页

作者： martín A Fernndez-Baldo Jorge G Fernández Sirley V Pereira Germn A Messina Eloy Salinas Julio Raba maría I Sanz Ferramola INQUISAL Departamento de Química.Universidad Nacional de San Luis

灰霉病是导致水果采后巨大经济损失的主要病害,其致病菌为葡萄孢菌。葡萄孢菌通常以潜伏侵染的形式存在,一旦病原菌发展蔓延则引起健康果实的迅速腐烂变质。因此,开发快速、灵敏的葡萄孢菌检测和定量分析方法势在必行。本文介绍了一种... 详细信息

灰霉病是导致水果采后巨大经济损失的主要病害,其致病菌为葡萄孢菌。葡萄孢菌通常以潜伏侵染的形式存在,一旦病原菌发展蔓延则引起健康果实的迅速腐烂变质。因此,开发快速、灵敏的葡萄孢菌检测和定量分析方法势在必行。本文介绍了一种用于测定苹果(Red Delicious)、鲜食葡萄(Pink Moscatel)和梨(William’s)组织中葡萄孢菌的间接竞争酶联免疫吸附法(ELISA)。该方法的原理是基于水果组织中葡萄孢菌抗原与交联固定在微量滴定板表面的葡萄孢菌纯化抗原对于单克隆抗体结合位点的竞争作用。为了验证该方法的有效性,进行了如选择性、线性分析、精密度、准确性、灵敏性等大量的参数测定。该方法对于葡萄孢菌抗原的检测限为0.97μ***-1,为了保证测定的稳定性,事先将纯化抗原固定长达4个月。应用该方法可以对尚未表现症状的任何水果中的葡萄孢菌进行检测定量分析。通过与一项DNA定量测试结果进行对比,表明ELISA法的测定结果与DNA分析结果具有很好的相关性。本研究结果表明,新开发的测试方法实现了对无发病症状的果实中葡萄孢菌的检测分析,具有成本低廉、操作简便、快捷等优点,可将其应用于世界各国对水果等植物的病害检疫领域。

关键词：采后间接竞争酶联免疫吸附法葡萄水果定量分析

Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil

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Infectious Diseases of Poverty 2017年第1期6卷 1043-1053页

作者： Benigno A.M.Rocha Adriana O.Guilarde Angela F.L.T.Argolo marianna Peres Tassara Lucimeire Ada Silveira Isabela C.Junqueira marilia D.Turchi Valeria C.R.Feres Celina M.T.martelli Institute of Tropical Pathology and Public Health Federal University of GoiasGoianiaBrazil Faculty of Pharmacy Federal University of GoiasGoianiaBrazil School of Nursing State University of GoiasCeresBrazil

Multilingual abstracts:Please see Additional file 1 for translations of the abstract into the five official working languages of the United ***:Currently,in Brazil,there is a co-circulation of the four dengue(DENV-1 to DENV-4)*** study aimed to assess whether different serotypes and antibody response patterns were associated with the severity of the disease during a dengue outbreak,which occurred in 2012/2013 in centre of ***:We conducted a prospective study with 452 patients with laboratory confirmed dengue in central Brazil,from January 2012 to July *** clinical outcome was the severity of cases:dengue,dengue with warning signs,and severe *** patients were evaluated at three different *** sampling for laboratory testing and confirmatory tests for dengue infection were *** performed a multinomial analysis considering the three categories of the dependent variable,as outlined *** odds ratios(ORs)were calculated.A multinomial logistic regression model was applied for variables with a P-value<*** analysis was performed with STATA 12.0 ***:Four hundred fifty-two patients(452/632,71.5%)were diagnosed with *** dengue virus(DENV)serotypes were identified in 243 ***-4 was detected in 135 patients(55.6%),DENV-1 in 91(37.4%),DENV-3 in 13(5.3%),and DENV-2 in 4(1.6%).Patients with the DENV-1 serotype were more prone to present with several clinical and laboratory features as compared with DENV-4 patients,including spontaneous bleeding(P=0.03),intense abdominal pain(P=0.004),neurological symptoms(P=0.09),and thrombocytopenia(P=0.01).Secondary infection was more predominant among DENV-4 cases(80.0%)compared with DENV-1 cases(62.3%)(P=0.03).The univariate analysis showed that females(OR=2.12;95%CI:1.44-3.13;P<0.01)had a higher risk of having dengue with warning *** multinomial analysis showed that severe dengue cases with secondary infection had an adjusted OR o

关键词： Dengue Secondary infection Severe dengue Dengue type 4 Brazil

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Letter Concerning：＂Genotyping for Kidd, Kell, Duffy, Scianna, and RHCE Blood Group Antigens Polymorphisms in Jiangsu Chinese Han＂

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Chinese Medical Journal 2015年第12期128卷 1704-1704页

作者： CrisUane maria Colli marilia Goncalves Quirino Ana maria Sell Jeane Eliete Laguila Visentainer Department of Basic Health Science Maringa State University Maringa Parana Brazil

To the Editor： We have been genotyping blood group systems in Brazilian population and most of the techniques used by us have been the restriction fragment length polymorphism-polymerase chain reaction （PCR）, which...

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1-甲基环丙烯延长菠菜采后保鲜期的研究

保鲜与加工 2011年第4期 54-54页

作者： Gustavo Gergoff Grozeff maría E.Micieli Facundo Gómez Laura Fernández Juan J.Guiamet Alicia R.Chavesb Carlos G.Bartoli Instituto de Fisiología Vegetal Universidad Nacional de La Plata-CCT CONICET La Platacc327(1900)La PlataArgentina Centro de Investigacióny Desarrollo en Criotecnología de Alimentos Facultad de Ciencias ExactasUniversidad Nacional de La Plata-CCT CONICET La Plata47y116(1900)La PlataArgentina

分别对经0.1、1.0μL.L-1浓度的1-甲基环丙烯(1-MCP)处理和未经1-MCP处理的离体菠菜叶片的衰老特性进行研究。结果表明,与对照相比,经1-MCP处理的菠菜叶片在避光、23℃条件下贮藏6 d后,叶绿素含量和光系统Ⅱ最高光量子产量较高,溶质渗... 详细信息

分别对经0.1、1.0μL.L-1浓度的1-甲基环丙烯(1-MCP)处理和未经1-MCP处理的离体菠菜叶片的衰老特性进行研究。结果表明,与对照相比,经1-MCP处理的菠菜叶片在避光、23℃条件下贮藏6 d后,叶绿素含量和光系统Ⅱ最高光量子产量较高,溶质渗漏量较低,说明1-MCP处理可延缓菠菜叶片的衰老。贮藏3 d后,经1-MCP处理的菠菜叶片乙烯生成量增加,随后又下降至对照水平。经1-MCP处理的菠菜叶片中具有较高的抗坏血酸和谷胱甘肽含量及对于这两种物质较低的氧化还原比率。1-MCP处理还可以减少菠菜叶片中的铵盐积累及蛋白质的降解。综合上述结果可以得出,通过1-MCP抑制菠菜叶片对乙烯作用的敏感性可有效延长菠菜的采后保鲜期。

关键词： 1-甲基环丙烯铵盐抗坏血酸乙烯谷胱甘肽溶质渗漏衰老菠菜

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β阻滞剂在心衰病人中的不同作用(摘要)

岭南心血管病杂志 2001年第2期 150-150页

作者： mar cometra,MD,Raffaele Giubbini,MD,Savina nodari,MD,Emiliano Boldi,MD,maria Grazia Modena,MD,Livio Dei Cas,MD,易家骥广州医学院第一附属医院心内科