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Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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Journal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-martinez Pedro JoseFlores-Blanco Juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro Francisco Arregui-Montoya Francisca maria Munoz-Franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo Domingo Andres Pascual-Figal Sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of *** aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December *** was defined as moderate or severe according to European echocardiography guidelines ***,ATRIA and ORBIT scores were used to evaluate the bleeding *** was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of *** 168(5.8%)patients had *** with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest *** and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of *** In this population,AS was associated with an increased risk for MB at midterm *** three scoring systems showed a moderate discriminatory ability for ***,the addition of AS was associated with a significant improvement in their predictive *** suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Major bleeding Valvular disease

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Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units

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Journal of Geriatric Cardiology 2020年第1期17卷 35-42页

作者： Victoria Lorente Jaime Aboal Cosme Garcia Jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra margarida Pujol Isabel Hernandez maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Hospital Unversitari Josep Trueta GironaSpain Hospital Universitari Germans Trias i Pujol Badalona BarcelonaSpain Hospital de la Santa Creu i Sant Pau Instituto de Investigación Biomedica IIB Sant PauUniversitat Autonoma de Barcelona(UAB)BarcelonaSpain Hospital Universitari de la Vall d’Hebron BarcelonaSpain Hospital Clinic i Provicial BarcelonaSpain Hospital Arnau de Vilanova LleidaSpain Hospital Joan XXIII TarragonaSpain the Grup de Treball de Cures Agudes Cardiologiques de la Societat Catalana de Cardiologia

Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical *** All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively *** was defined as hemoglobin<130 g/L in men and<120 g/L in *** association between anemia and mortality or readmission at six months was assessed by the Cox regression *** A total of 629 patients were *** age was 66.6 years.A total of 197 patients(31.3%)had *** angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score *** with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement *** ICCU and hospital stay were significantly longer in patients with *** the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had *** patients underwent coronary *** was independently associated to poorer outcomes at 6 months.

关键词： Acute coronary syndromes Anemia Intensive cardiac care units Prognosis

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Comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional Chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton Ricardo Alonso Fabrício Campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe Cabanillas Fernanda Aparecida Sampaio Mendonça Gláucia maria Tech dos Santos Andrea Aparecida de Aro Edson Rosa Pimentel maria Esméria Corezola do Amaral marcelo Augusto marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJECTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:C-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the C on the14 th and 21 st *** number of granulocytes was lower than C on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than C in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than C on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than C on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings

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Long COVID: A Molecular, Cellular and Histopathology Overview

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Journal of Biosciences and Medicines 2023年第9期11卷 90-113页

作者： Bárbara Rafaela da Silva Barros Leonardo Carvalho de Oliveira Cruz Georon Ferreira de Sousa Guilherme Antonio Souza-Silva marília R. C. F. de Lima Elifrances G. Oliveira Anna Jéssica Duarte Silva Larissa S. Macêdo Lígia R. S. Leal Bianca F. São marcos Carolina Elsztein maria da Conceição V. Invenção Antonio Carlos de Freitas Cristiane Moutinho-Melo Immunological and Antitumor Analysis Laboratory (LAIA) and Keizo Asami Immunopathology Laboratory Institute (iLIKA) Federal University of Pernambuco Recife Brazil Laboratory of Neuroendocrinology and Metabolism Federal University of Pernambuco Recife Brazil Laboratory of Molecular Studies and Experimental Therapy Federal University of Pernambuco Recife Brazil

Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of the disease. Persistent symptoms such as dry cough, fatigue, and dyspnea can remain after six months of COVID-19 cure. Others such as lung fibrosis, kidney injury, and thrombotic risk also are observed. Here, a deep review of each human organ and system infected by the virus was performed aiming to show how molecules expression and cell signaling can induce the organism cure or injuries and, subsequently sequelae. The review also suggests the importance of public health surveillance for these cases including a more comprehensive analysis of molecular biology tools that can clarify and assist in the prognosis, treatment, and preventive methods for potentially more serious disorders in post-COVID-19 patients.

关键词： Long COVID COVID-19 Sequelae Public Health Surveillance

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陶瓷和金属的钎焊

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沈阳建筑工程学院学报 1997年第4期13卷 410-414页

作者：常松郝兆星孙红沈阳建筑工程学院沈阳110015

综述陶瓷与金属钎焊时界面的形成、界面反应和界面残余应力等界面理论，介绍陶瓷钎焊所用钎料及典型工艺方法．

关键词：陶瓷金属钎焊残余应力

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自然康复中室外环境、设施和项目标准的质量保证框架

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风景园林 2024年第5期31卷 91-102页

作者：萨拉·凯罗·维斯勒安娜·玛丽亚·帕尔斯多蒂尔李同予(译) 周硕(译) 娜何雅(译) 瑞典农业科学大学阿尔纳普校区风景园林、园艺和作物生产科学学院瑞典农业科学大学阿尔纳普校区风景园林、园艺和作物生产科学学院人与社会系哈尔滨工业大学建筑与设计学院哈尔滨工业大学寒地城乡人居环境科学与技术工业和信息化部重点实验室

【目的】在瑞典斯科讷省,自然康复(nature-based rehabilitation, NBR)项目的创新性体现在医疗保健方面,该项目倡导自然环境的疗愈潜力。作为基础医疗保健服务的组成部分,NBR项目旨在满足人们面对与压力相关的复杂心理健康挑战时的个人... 详细信息

【目的】在瑞典斯科讷省,自然康复(nature-based rehabilitation, NBR)项目的创新性体现在医疗保健方面,该项目倡导自然环境的疗愈潜力。作为基础医疗保健服务的组成部分,NBR项目旨在满足人们面对与压力相关的复杂心理健康挑战时的个人需求。【方法/过程】在将NBR概念应用于医疗保健之前,基于在阿尔纳普康复花园(Alnarp Rehabilitation Garden)生活实验室进行的全面的实证和描述性研究以及一项为期2年的试点研究,对NBR项目进行了测试,并根据在NBR项目中获取到的个人从与压力相关的精神疾病中恢复的最新证据对其定期更新。该项目由斯科讷省区域办事处(Region Sk?ne)促成,旨在促进与10家精选的NBR服务供应商的合作,战略性地提供全面和整体的恢复方法。【结果/结论】与传统医疗不同,NBR项目侧重于康复,希望通过自然(即支持性户外环境)支持的活动,增益身体、心理和社会福祉。NBR体系强调参与者的休息、有意义的参与和支持性户外环境。与自然相结合的日常活动为个人喜好提供了灵活的选择。NBR体系化的恢复方法包括晨会、参与者自己的时间、基于自然的活动、闭幕集会。维持NBR的质量需要详细的记录,定期现场访问以鼓励公开对话,并确保NBR项目的合规性。这一质量要求可以确保参与者在他们的自然疗愈(nature-based intervention, NBI)之旅中获得高质量的服务。

关键词：循证健康设计医疗保健自然与动物辅助干预自然关联性

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HIV screening and retention in care in people who use drugs in Madrid, Spain: a prospective study

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Infectious Diseases of Poverty 2021年第4期10卷 77-85页

作者： Pablo Ryan Jorge Valencia Guillermo Cuevas Jesus Troya Juan Torres-Macho maria Jose Munoz-Gomez Nuria Munoz-Rivas Isabel Canorea Sonia Vazquez-Moron Salvador Resino Hospital Universitario Infanta Leonor MadridSpain Universidad Complute nse de Madrid(UCM) MadridSpain Instituto de Investigacion Sanitaria Gregorio maranon(liSGM) MadridSpain Unidad de Reduccion de Darios"SMASD"Madrid Spain Unidad de Infeccion Viral e Inmunidad Centro Nacional de MicrobiologiaInstituto de Salud Carlos IIICarretera Majada-honda-PozueloKm 2.228220 MajadahondaMadridSpain

Background::The burden of human immunodeficiency virus(HIV)infection in people who use drugs(PWUD)is *** aimed to screen HIV infection among PWUD and describe their retention in HIV ***,we also screen for hepatitis C virus(HCV)infection among HIV-seropositive PWUD and describe their linkage to ***::We conducted a prospective study in 529 PWUD who visited the"Ca?ada Real Galiana"(Madrid,Spain).The study period was from June 1,2017,to May 31,*** diagnosis was performed with a rapid antibody screening test at the point-of-care(POC)and HCV diagnosis with immunoassay and PCR tests on dried blood spot(DBS)in a central *** PWUD were referred to the *** used the Chi-square or Fisher’s exact tests,as appropriate,to compare rates between ***::Thirty-five(6.6%)participants were positive HIV antibodies,but 34 reported previous HIV diagnoses,and 27(76%)had prior antiretroviral *** patients with a positive HIV antibody test,we also found a higher prevalence of homeless(P<0.001)and injection drug use(PWID)(P<0.001),and more decades of drug use(P=0.002).All participants received HIV test results at the *** the 35 HIV positives,28(80%)were retained in HIV medical care at the end of the HIV screening study(2018),and only 22(62.9%)at the end of ***,12/35(34.3%)were positive for the HCV RNA *** the latter,10/12(83.3%)were contacted to deliver the HCV results test(delivery time of 19 days),5/12(41.7%)had an appointment and were attended at the hospital and started HCV therapy,and only 4/12(33.3%)cleared ***::We found almost no new HIV-infected PWUD,but their cascade of HIV care was low and remains a challenge in this population at *** high frequency of active hepatitis C in HIV-infected PWUD reflects the need for HCV screening and reinforcing the link to care.

关键词： HIV Point-of-care Screening People who use drugs Retention in care Hepatitis C Dried blood spot Antiviral treatment

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时间趋势、环境因素和遗传基础特性对商业条件下荷斯坦公牛精液性状的影响

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饲料博览 2011年第9期21卷 9-9页

作者： Sofiene K Clara D Magdalena S Roger C Idoia C maría J C

人工受精(AI)的结果是降低已经进行过高度选择雄性繁殖力评价的奶牛种群数量。1990-2007年采集502头荷斯坦公牛的42348个精液数据进行贝叶斯框架分析,对过去十几年在人工受精中心常规收集的精液进行精液特征进化和遗传参数的评估。主要... 详细信息

人工受精(AI)的结果是降低已经进行过高度选择雄性繁殖力评价的奶牛种群数量。1990-2007年采集502头荷斯坦公牛的42348个精液数据进行贝叶斯框架分析,对过去十几年在人工受精中心常规收集的精液进行精液特征进化和遗传参数的评估。主要考虑的特性是精子数量(VOL)、浓度(CONC)、每次射精的精子数量(NESPZ)、总体精子活力(MM)、个体精子活力(IM)以及解冻后活力(PTM)。研究环境因素随时间的变化时,根据环境和技术条件的改变,年龄的变化、射精顺序、提前收集的时间点(TPC)以及收集和冻结期间的时间点(TCF)对其进行每季度和每周的收集,公牛近交系数(Fi)、永久环境和添加剂遗传因素也被考虑在内,运用贝叶斯因子对此降低模型的使用进行评价。在该模型中对所有的系统效应进行测试并除了Fi影响精子活性和TCF影响PTM之外,得出有力的数据证明模型的正确性。观察中发现除PTM外,环境影响没有系统时间的趋势,这表明环境改变的趋势参与精子冻融的改善。遗传力评价除IM外均处于中度(0.16-0.22),其中存在一个低值(0.07)。精子之间活力的相互作用以及精子活力与CONC之间的相互作用存在较大的遗传相关性(0.38-0.87),VOL与CONC显示出负相关性(-0.13)。如果要求使用这些特征作为判断公牛育种精子活力的指标,需要增大遗传性能有效的选择。

关键词：精液质量育种健全评价贝叶斯分析

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