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Extreme Rainfall Indices in the Hydrographic Basins of Brazil

Open Journal of Modern Hydrology 2014年第1期4卷 10-26页

作者： maría c.valverde Jose A.marengo Urban and Environmental Engineering Federal University of ABC(UFABC)Santo AndréBrazil center for Earth System Science National Institute for Space Research(INPE)Sao Josédos CamposBrazil

The authors analyze climate extremes indices (cEI) of rainfall over the largest basins of the Brazilian territory: Amazon (AMA), S?o Francisco (SF), Tocantins (TO) and Paraná (PAR) rivers. The cEI represent the frequency of heavy precipitation events (R30mm and R95p) and short duration extreme rainfall (RX5day and RX1day). Droughts (cDDd) are identified based on two indicators: The longest dry period (cDD) and the annual cycle. The results demonstrate that cDDd, RX1day and RX5day occurred with more frequency and intensity in SF basin during El Ni?o events. cDDd was of greater magnitude in the TO basin during La Ni?a events, while an increase of RX1day occurred in El Ni?o. The strong El Ni?o events (1983 and 1997) caused more intense and frequent RX1day and R30mm over the PAR basin. Amazon droughts occurred in two out of the six El Ni?o events. Moreover, the relationship between the positive (negative) sea superficial temperatures anomalies in North (South) Tropical Atlantic and drought in AMA basin was corroborated. A gradual warming of SST was observed at the start of 2003 until it achieved a maximum in 2005 associated with the southwestern Amazon drought. The second highest anomaly of SST was in 2010 linked with drought that was more spatially extensive than the 2005 drought. The spatial distribution of annual trends showed a significant increase of cDD in south-eastern AMA, Upper SF, northern PAR and throughout the TO basins. R20mm, RX1day and RX5day tend to increase significantly in southwestern (northeast) PAR (AMA) and northwestern TO basins. comparisons between cEI derived from daily precipitation data from climate Prediction center (cPcp) and of the ETA_HadcM3 model showed that the model overestimated RX1day, RX5day and cDD, in the four basins. Future scenarios show that dry periods will occur with greatest magnitude in all the basins until 2071-2099 time slice, while RX1day will be more intense in the TO and SF basins.

关键词： climate Extreme Indices Future Scenarios of climate Hydrological Basins of Brazil ETA_HadcM3 Model

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-Muñoz maría Portela-Lomba Paloma Sobrado-calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez JoséMcabrera-Maqueda Javier Sierra Manuel Vidal-Sanz maría Teresa Moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHcII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Quantum communication via controlled holes in the statistical distribution of excitations in a nanoresonator coupled to a cooper pair box

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chinese Physics B 2012年第3期21卷 74-79页

作者： c.valverde A.T.Avelar B.Baseia Universidade Paulista Rod.BR 153km 774845-090 Goia niaGOBrazil Universidade Estadual de Goiás Rod.BR 153310575132-903 AnápolisGOBrazil Instituto de Física Universidade Federal de Goiás74001-970 Goia niaGOBrazil

We propose a scheme to transmit information via the statistical distribution of excitations of a nanomechanical resonator. It employs a controllable coupling between this system and a cooper pair box. The success probability and the fidelity are calculated and compared with those obtained in an atom-field system in different regimes. Addtionaly, the scheme can also be applied to prepare low excited Fock states.

关键词： quantum communication quantum state engineering superconducting circuits nanome- chanical resonator

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado maría JoséMorillo-Bargues carla Perpiñá-clérigues Francisco García-García Victoria Moreno-Manzano consuelo Guerri maría Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSc-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and c–X3–c motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSc-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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controlling Excitation Inversion of a cooper Pair Box Interacting with a Nanomechanical Resonator

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chinese Physics Letters 2012年第8期29卷 20-24页

作者： c.valverde H.c.B.de Oliveira A.T.Avelar B.Baseia Instituto de Química Universidade de Brasília70919-970BrasíliaDFBrazil Universidade Estadual de Goiás Rod.BR 15375132-903 AnápolisGOBrazil Universidade Paulista Rod.BR 153km 774845-090 GoianiaGOBrazil Instituto de Física Universidade Federal de Goiás74001-970 GoianiaGOBrazil

We investigate the action of time-dependent detunings upon the excitation inversion of a cooper pair box interacting with a nanomechanical *** method employs the Jaynes–cummings model with damping,assuming different decay rates of the cooper pair box and various fixed and time-dependent *** is shown that,when the presence of damping plus constant detunings destroys the collapse/revival effects,convenient choices of time-dependent detunings allow one to reconstruct such events in a perfect *** is also shown that the mean excitation of the nanomechanical resonator is more robust against damping of the cooper pair box for convenient values of time-dependent detunings.

关键词： cooper tuning excitation

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Potential of RP-UHPLc-DAD-MS for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： maría del mar contreras Aránzazu Morales-Soto Antonio Segura-carretero Javier valverde Department of Analytical chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food centre (cIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis c virus(HcV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLc) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation ction and quantification limits were 0.07 μg/mL and 0.36 μg/mL, ***, the use of high-resolution MS enabled us to ensure the specificity, check impurities and better sensitivity. Therefore, this methodology promises to be suitable not only for the routine analysis of sofosbuvir in pharmaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLc Sofosbuvir

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Acoustic streaming and Sun's meridional circulation

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Research in Astronomy and Astrophysics 2016年第9期16卷 101-106页

作者： Jose Manuel valverde Faculty of Physics University of Seville

A vast number of physical processes involving oscillations of a bounded viscous fluid are relevantly influenced by acoustic streaming. When this happens a steady circulation of fluid develops in a thin boundary adjacent to the interface. Some examples are refracted sound waves, a fluid inside a spherical cavity undergoing torsional oscillations or a pulsating liquid droplet. Steady streaming around circular interfaces consists of a hemispherically symmetric recirculation of fluid from the equatorial plane to the polar axes closely resembling the meridional circulation pattern observed in the Sun＇s convection zone that determines the solar cycle. In this paper, it is argued that the acoustic pulsations exhibited by the Sun would lead to acoustic streaming in the boundary of the convection zone. A simple estimation using a typical dominant frequency of 3 mHz and the observed surface oscillation amplitude yields a steady streaming velocity Us - 10 m s^-1, which is on the order of the meridional circulation velocity observed in the Sun＇s convection zone.

关键词： Sun general -- Sun helioseismology -- Sun granulation -- Sun oscillations -- Sun fun-damental parameters -- Sun activity

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