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Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael franco Claudia Garrigós Toni Capó Joan Serrano-marín Rafael Rivas-Santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

The short form of the SUR1 and its functional implications in the damaged brain

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neural Regeneration Research 2022年第3期17卷 488-496页

作者： Iván Alquisiras-Burgos Javier franco-pérez Moisés Rubio-Osornio penélope Aguilera Laboratorio de patología Vascular Cerebral Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio de Formación Reticular Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico Laboratorio Experimental de Enfermedades neurodegenerativas Instituto Nacional de Neurología y Neurocirugía“Manuel Velasco Suárez”CDMXMexico.

Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATp)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the ***8 and Abcc9 genes code for the proteins SUR1 and SUR2,*** SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other *** is well known that SUR1 assembles with Kir6.2 and TRpM4 to establish K_(ATp) channels and non-selective cation channels,***8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental ***,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are ***,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the *** evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the *** structural changes in short forms of SUR modify its affinity to ATp,regulation of its expression might represent an advantage in pathologies where ATp concentrations decrease and a therapeutic target to induce ***,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(*** stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function.

关键词： brain edema epilepsy parkinson's disease stroke sulfonylurea receptor 1 SUR1 traumatic brain injury TRpM4

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri franco Valzania Department of neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine ph.D.program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Conductometric Titration for the prediction of Conductivity in Solutions with polymeric Membranes

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Journal of Electronic Science and Technology 2017年第4期15卷 342-350页

作者： maría José Lavorante Juan Isidro franco Research and Development of Renewable Energy Department at CITEDEF Institute of Scientific and Technical Research for the Defense Villa Martelli B1603ALO Argentina

The analytical technique of conductometric titration is used to characterize polymeric *** technique allows obtaining the polymer dry weight capacity(DWC) and the extent of reaction and establishing the optimal number of water molecules per sulfonic *** this particular case the polymer material under study was nafion?*** different reactions were made: neutralization and *** of them allow obtaining the same *** titrations could be considered as a good method to study the neutralization and exchange reactions for polymeric materials used in fuel cells or *** implementation of this analytical technique allows reducing operation time of those types of *** waiting time between determinations permits to say that the amount of reactant consumed and products obtained were the same after each addition of titrant.

关键词： Conductivity conductometric titration polymeric membranes

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel Manuel Méndez-Bailón Josépérez-Silvestre Josémaría Fernández-Rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro González-franco Alicia Conde-martel Sara Carrascosa-García marta Sánchez-marteles JoséManuel Cerqueiro-González noel Lorenzo-Villalba Manuel Montero-pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUnD Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** pIOnEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced nT-proBnp levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and november 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).COnCLUSIOn Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

Importance of Quercus *** diversity and biomass of vascular epiphytes in a managed pine-oak forest in Southern Mexico

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Forest Ecosystems 2022年第3期9卷 366-377页

作者： nayely martínez-Meléndez neptalí Ramírez-marcial José G. García-franco Manuel Jesús Cach-pérez pablo martínez-Zurimendi Departamento de Conservacion de la Biodiversidad El Colegio de la Frontera Sur(ECOSUR)San Cristobal de Las Casas29290ChiapasMexico Red de Ecología Functional Instituto de EcologíaA.C.Xalapa91073VeracruzMexico Departamento de Agricultura Sociedad y AmbienteEl Colegio de la Frontera Sur(ECOSUR)Villahermosa86280TabascoMexico

Background:Forestry management modifies the diversity,structure,and functioning of intervened *** extraction reduces tree density and basal area,leading to changes in the communities of vascular *** objective of this study was to evaluate the diversity and biomass of vascular epiphytes in Quercus trees remaining in two pine-oak forest stands that have been subjected to two stages of the Silvicultural Development Method(release cutting,and thinning)in comparison with an unharvested old-secondary forest in southern *** each treatment,richness of epiphytes present on 60 oak trees was recorded and their dry biomass *** calculated the true diversity(Hill numbers)and beta diversity using the Jaccard coefficient of similarity,and generated rank abundance curves per taxonomic epiphyte group(bromeliads,orchids,ferns and others).For each treatment,the relationships between overall diversity and epiphyte biomass to the host trees basal area were analyzed using log linear ***:We recorded a total of 67 species of epiphytes species belonging to 10 families hosted by five species of *** greatest species richness(^(0)D)was recorded in the old-secondary *** common(^(1)D)and dominant(^(2)D)species were recorded in the release cutting than in the other *** diversity and biomass were both slightly related to host tree basal *** of epiphytes was similar(60%)among treatments,although orchids,bromeliads,and other families were more diverse in the old-secondary *** bromeliad species were shared across all treatments,although orchids presented the most exclusive species in the unharvested *** bromeliad Tillandsia seleriana provided the greatest contribution to biomass in all treatments,followed by the orchid Camaridium *** linear models indicated that epiphyte diversity was significantly related to treatment,and epiphyte biomass to basal area of host ***:Alt

关键词： Bromeliads Chiapas Ferns Orchids Richness Sierra Madre Silvicultural development method(SDM)

Local renin angiotensin system and sperm DnA fragmentation

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Asian Journal of Andrology 2022年第2期24卷 139-146页

作者： maría Victoria Aparicio prieto maría Victoria Rodríguez Gallego Asier Valdivia palacín Yosu franco Iriarte Gotzone Hervás Barbara Enrique Echevarría Orella Luis Casis Saenz Human Reproduction Unit Cruces University HospitalBarakaldo 48903Spain Human Reproduction Unit San Pedro HospitalLogroño 26006Spain Department of physiology Faculty of Medicine and NursingUniversity of the Basque Country(UPV/EHU)Leioa 48940Spain Human Reproduction Unit Ruber International HospitalMadrid 28034Spain

The renin angiotensin system(RAS)appears to influence male fertility at multiple *** this work,we analyzed the relationship between the RAS and DnA *** male volunteers were divided into two groups(25 each):control(DnA fragmentation≤20%)and pathological(DnA fragmentation>20%)*** of five peptidases controlling RAS were measured fluorometrically:prolyl endopeptidase(which converts angiotensin[A]I and A II to A 1–7),neutral endopeptidase(nEp/CD10:A I to A 1–7),aminopeptidase n(Apn/CD13:A III to A IV),aminopeptidase A(A II to A III)and aminopeptidase B(A III to A IV).Angiotensin-converting enzyme(A I to A II),Apn/CD13 and nEp/CD10 were also assessed by semiquantitative cytometry and quantitative flow cytometry assays,as were the receptors of all RAS components:A II receptor type 1(AT1R),A II receptor type 2(AT2R),A IV receptor(AT4R or insulin-regulated aminopeptidase[IRAp]),(pro)renin receptor(pRR)and A 1–7 receptor or Mas receptor(MasR)none of the enzymes that regulate levels of RAS components,except for Apn/CD13(decrease in fragmented cells),showed significant differences between both *** of RAS receptors revealed no significant differences in immunolabeling patterns between normozoospermic and fragmented *** of AT1R(94.3%normozoospermic vs 84.1%fragmented),AT4R(96.2%vs 95.3%)and MasR(97.4%vs 87.2%)was similar between the ***2R(87.4%normozoospermic vs 63.1%fragmented)and pRR(96.4%vs 48.2%)were higher in non-fragmented *** findings suggest that fragmented DnA spermatozoa have a lower capacity to respond to bioactive RAS peptides.

关键词： DnA fragmentation local renin angiotensin system sperm fertility

Impact of a colorectal cancer screening program implantation on delays and prognosis of non-screening detected colorectal cancer

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World Journal of Gastroenterology 2021年第39期27卷 6689-6700页

作者： Joaquin Cubiella maría Lorenzo franco Baiocchi Coral Tejido Alejandro Conde maría Sande-Meijide margarita Castro Department of Gastroenterology Complexo Hospitalario Universitario de OurenseOurense 32005OrenseSpain Department of preventive Medicine Complexo Hospitalario Universitario de OurenseOurense 32003OrenseSpain Department of Gastroenterology Hospital del BierzoPonferrada 24404LeonSpain Dirección Xeral de Saúde pública Conselleria de SanidadeSantiago de Compostela 15703Spain

BACKGROUnD The implementation of a colorectal cancer(CRC)screening programme may increase the awareness of primary Care physicians,reduce the diagnostic delay in CRC detected outside the scope of the screening programme and thus improve *** To determine the effect of implementation of a CRC screening programme on diagnostic delays and prognosis of CRC detected outside the scope of a screening *** We performed a retrospective intervention study with a pre-post *** identified 322 patients with incident and confirmed CRC in the pre-implantation cohort(June 2014–May 2015)and 285 in the post-implantation cohort(June 2017-May 2018)in the Cancer Registry detected outside the scope of a CRC screening *** each patient we calculated the different healthcare diagnostics delays:global,primary and secondary healthcare,referral and colonoscopyrelated *** addition,we collected the initial healthcare that evaluated the patient,the home location(urban/rural),and the CRC stage at *** determined the two-year survival and we performed a multivariate proportional hazard regression analysis to determine the variables associated with *** We did not detect any differences in the patient or CRC baseline-related variables.A total of 20.1%of patients was detected with metastatic *** was a significant increase in direct referral to colonoscopy from primary healthcare(25.5%,35.8%;p=0.04)in the post-implantation *** delay was reduced by 24 d(106.64±148.84 days,82.84±109.31 d;p=0.02)due to the reduction in secondary healthcare delay(46.01±111.65 d;29.20±60.83 d;p=0.02).However,we did not find any differences in CRC stage at diagnosis or in two-year survival(70.3%;p=0.9).Variables independently associated with twoyear risk of death were age(Hazard Ratio-HR:1.06,95%CI:1.04-1.07),CRC stage(II HR:2.17,95%CI:1.07-4.40;III HR:3.07,95%CI:1.56-6.08;IV HR:19.22,95%CI:9.86-37.44;unknown HR:9.24,95%CI:4.27-19.99),init

关键词： Colorectal cancer population based screening primary healthcare Diagnostic delay prognosis

Magnetic mitohormesis:A non-invasive therapy for inflammatory disorders?

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BIOCELL 2023年第2期47卷 239-244页

作者： ALFREDO franco-OBREGÓn Department of Surgery Yong Loo Lin School of MedicineInstitute of Health Technology and InnovationiHealthtechBiolonic Currents Electromagnetic Pulsing Systems LaboratoryBICEPSHealthy Longevity Translational Research ProgrammeNUS Centre for Cancer ResearchNational University of SingaporeSingapore

An organism’s survival depends on its ability to adapt to *** are the cellular integrators of environmental stressors that ultimately translate their responses at the organismal level,and are thus central to the process whereby organisms adapt to their respective *** produce molecular energy via oxidative phosphorylation that then allows cells to biosynthetically respond and adapt to changes in their *** oxygen species(ROS)are by-products of oxidative phosphorylation that can be either beneficial or damaging,depending on the context;ROS are hence both the conveyors of environmental stress as well as cellular“adaptogens”.Mitohormesis refers to the process whereby low levels of oxidative stress spur survival adaptations,whereas excessive levels stymie *** energy and frequency pulsing electromagnetic fields have been recently shown capable of stimulating mitochondrial respiration and ROS production and instilling mitohormetic survival adaptations,similarly to,yet independently of,exercise,opening avenues for the future development of Magnetic Mitohormetic interventions for the improvement of human *** viewpoint explores the possibilities and nuances of magnetic-based therapies as a form of clinical intervention to non-invasively activate magnetic mitohormesis for the management of chronic diseases.

关键词： ROS pulsed electromagnetic fields Mitochondria Myokines Inflammation