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Viral hepatitis update: Progress and perspectives

World Journal of Gastroenterology 2021年第26期27卷 4018-4044页

作者： maría b pisano Cecilia G Giadans Diego M Flichman Viviana E Ré maría V Preciado Pamela Valva Virology Institute CONICETSchool of Medical SciencesNational University of CórdobaCordoba X5016Argentina Multidisciplinary Institute for Investigation in Pediatric Pathologies(IMIPP)CONICET-GCbA Laboratory of Molecular BiologyPathology DivisionRicardo Gutiérrez Children’s HospitalCABA C1425Buenos AiresArgentina Institute of biomedical Investigations in Retrovirus and AIDS(INbIRS) School of MedicineUniversity of Buenos AiresCONICETCABA C1121ABGBuenos AiresArgentina

Viral hepatitis,secondary to infection with hepatitis A,b,C,D,and E viruses,are a major public health problem and an important cause of morbidity and *** the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and *** review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research *** hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food *** the case of hepatitis b virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine *** hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and *** hepatitis D virus,we describe diagnostic methodology,pathogenesis,and ***,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance.

关键词： Viral hepatitis Hepatitis A virus Hepatitis b virus Hepatitis C virus Hepatitis D virus Hepatitis E virus

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Galileo and Kepler： On Theoremata Circa Centrum Gravitatis Solidorum and Mysterium Cosmographicum

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History Research 2012年第2期2卷 110-145页

作者： Raffaele pisano Paolo bussotti Cirphles-Ecole Normale Superieure Paris Paris FranceRCTHS-University of West Bohemia Pilsen Czech Republic Edizione Nazionale Opere Enriques Livomo Italy

This paper deals with two case studies：（a） The role played by geometry and physical objects in Galileo＇s Theoremata Circa Centrum Gravitatis Solidorum comparing with Archimedean approach-mental experiments, and method of composition and de-composition, circumscribed and inscribed figures on centre of gravity studies; （b） The complex network of relations, which in Mysterium Cosmographicum, links the experimental part of astronomy to the theoretical aspect and, in the case of Kepler, the metaphysical aspect. The authors focus their efforts on understanding why Kepler reached such a strange, genial and original connection between practice and theory. The aim of this paper is to discuss the relationship between physics-mathematics （-metaphysics） and between experiments-observations-theory in the work of two scientists, Galileo and Kepler.

关键词： Galileo Kepler centre of gravity Theoremata Cosmographicum astronomy relationship experimentsand theory

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Silicon carbide resonant tuning fork for microsensing applications in high-temperature and high G-shock environments

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Engineering Sciences 2012年第5期10卷 36-41页

作者： David R Myers Kan bun Cheng babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu b J Wijesundara Albert P pisano Department of Mechanical Engineering Berkeley Sensor and Actuator Center University of CaliforniaBerkeley California 94720USA Department of Electrical Engineering and Computer Science Cleveland Case Western Reserve University Cleveland Ohio 44106 USA)

We present the fabrication and testing of a silicon carbide （SiC） balanced mass doublended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth. The device features a material stack that survives corrosive environments and enables high-temperature operation. To perform hightemperature testing, a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics. The tuning fork has been operated at 600°C in the presence of dry steam for short durations. This tuning fork has also been tested to 64 000 G using a hard-launch, soft-catch shock implemented with a light gas gun. However, the device still has a strain sensitivity of 66 Hz/μe and strain resolution of 0. 045 μe in a 10 kHz bandwidth. As such, this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges, accelerometers, gyroscopes, and pressure transducers. Given the adaptable fabrication process flow, this device could be useful to micro-electro-mechanical systems （MEMS） designers creating sensors for a variety of different applications.

关键词： MEMS SiC thermal effects double ended tuning fork (DETF) harsh environment high temperature high shock inertial strain sensors

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全景数字化乳腺X线摄影软拷贝与硬拷贝阅读对比

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国际医学放射学杂志 2009年第3期 285-286页

作者： R.M.Nishikawa S.Acharyya C.Gatsonis E.D.pisano E.b.Cole H.S.marques 翟宁 Vyborny Translation Laboratory for breas Imaging Research Department of Radiology and the Committee on Medical PhysicsUniversity of Chicago5841 S Maryland AveMC-2026ChicagoIL 60637USA

目的对比放射诊断人员通过监视器或胶片阅读全景数字化乳腺X线摄影(FFDM)图像发现乳腺癌能力。方法该研究获得审查委员会批准并符合HIPAA的相关规定,无需病人知情同意。该阅读研究由26名放射学专家通过高分辨率显示器(数字软拷贝)和打... 详细信息

目的对比放射诊断人员通过监视器或胶片阅读全景数字化乳腺X线摄影(FFDM)图像发现乳腺癌能力。方法该研究获得审查委员会批准并符合HIPAA的相关规定,无需病人知情同意。该阅读研究由26名放射学专家通过高分辨率显示器(数字软拷贝)和打印胶片(数字硬拷贝)阅读FFDM图像完成。由数字化乳腺摄影图像筛选试验筛选研究中挑选333例(n=49528)病例。其中,117例病人在接受乳腺X线检查后15个月内诊断为乳腺癌。

关键词：乳腺乳房软拷贝软复本硬拷贝硬副本摄影美术

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ACRIN数字化乳腺X线摄影筛查试验的放射医生Logistic回归模型分析

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国际医学放射学杂志 2009年第5期32卷 493-493页

作者： E.D.pisano S.Acharyya E.b.Cole H.S.marques M.J.Yaffe M.blevins 秦乃姗 Dept of Radiology Lineberger Comprehensive Cancer Centerand Biomedical Research Imaging CenterUniversity of North Carolina at Chapel Hill

目的确定影响数字化乳腺X线摄影筛查试验（DMIST）中癌肿检出结果的因素。材料与方法此研究经学术审核委员会通过，符合健康医疗保险要求。7位影像医师复习DMIST癌肿病例的胶片硬拷贝（屏-片）和数字乳腺X线影像，并评价影响两种影像中... 详细信息

目的确定影响数字化乳腺X线摄影筛查试验（DMIST）中癌肿检出结果的因素。材料与方法此研究经学术审核委员会通过，符合健康医疗保险要求。7位影像医师复习DMIST癌肿病例的胶片硬拷贝（屏-片）和数字乳腺X线影像，并评价影响两种影像中病灶显示的因素。阅片者对数字化和屏一片影像的配对资料进行分级，采用两种多项式Logistic回归模型分析联合与浓缩显示的分级。

关键词：数字化乳腺X线摄影 Logistic 回归模型分析筛查试验放射医生 X线影像检出结果医疗保险

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