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Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

Journal of geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel anguita-Sánchez Juan Luis Bonilla-Palomas maría anguita-gámez maría garcía JoséLuis Bernal Náyade Del Prado Cristina Fernández-Pérez Julián Pérez-Villacastin Juan Joségómez-Doblas Francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKgROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older patients.However,there are little data on in-hospital mortality in patients with HF≥75 years in Spain.METHODS A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and 2019.Coding was performed using the International Classification of Diseases,10th Revision.Patients≥75 years with HF as the principal diagnosis were selected.We calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the hospital.RESULTS We included 354,792 HF episodes of patients over 75 years.The mean age was 85.2±5.5 years,and 59.2%of patients were women.The most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,Pgenic shock(OR=19.5,95%CI:16.8–22.7,Pgher in males and elderly patients.The main predictors of mortality were cardiogenic shock,stroke,and advanced cancer.There was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

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The ILux^(®) compared to the mechanical meibomian gland expression for the treatment of moderate and severe meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1042-1048页

作者： maría Ximena Núñez Andrea Acosta-Ortega guillermo Raul Vera-Duarte Catalina gómez-Duarte Unit of Cornea Cataract and Refractive SurgeryVision Sana Research GroupClínica de Oftalmología de CaliFaculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Department of Ophthalmology Faculty of Medicine Pontificia Universidad Javeriana CaliCali 760031Colombia Department of Ophthalmology Hospital de ClínicasNational University of AsunciónAsunción 111421Paraguay

AIM:To compare the safety and effectiveness of eyelid treatment with the ILux®-MgD Treatment System in one session versus five sessions of mechanical meibomian gland expression(MMgE)in patients with moderate to severe meibomian gland dysfunction(MgD).METHODS:A prospective,randomized,open-label,and controlled clinical trial that compared one session of the ILux®MgD Treatment System versus five sessions of MMgE in both eyes of 130 patients aged≥18y with Ocular Surface Disease Index(OSDI)scores≥13,total meibomian gland scores(MgS)ofgE.RESULTS:The mean age was 58±17.49y.Baseline total MgS scores in both treatment groups were comparable.During follow-up,there were significant differences in total MgS and per sector with Pg generalized estimating equations corresponding to the generalized linear model for repeated means to determine the treatment relationship with total MgS,NIBUT,and OSDI.There was a significant difference between ILux®and MMgE(PgS,NI-BUT,and OSDI scores.No adverse events were reported.CONCLUSION:ILux®treatment compared to MMgE significantly improves symptoms and signs in patients with moderate to severe MgD for one year without adverse events.

关键词： meibomian gland dysfunction ILux® ocular surface dry eye

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Stress tensors and quantification of fracture patterns to analyze connectivity and potential fluid flow in a mesa landform of the Northern Andes

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Journal of Mountain Science 2024年第1期21卷 271-291页

作者： gARCÍA-ARIAS Sergio VELANDIA Francisco ALVAREZ Angélica SANABRIA-gÓmez JoséD TARAZONA Yessenia VARgAS maría Camila Escuela de geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern Cordillera of Colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and a conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and a random distribution in the southwestern block. WinTensor treatment of slickensides yielded a maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used Frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos Colombia Win-Tensor FracPaQ Strike-slip faults Fractured aquifers

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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： maría Rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-garcía Cristina Molina-Hidalgo Manuel gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels modulation.We aimed to explore the relationship between physical activity and Aβin middle-aged and older adults.Methods:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,2022.Studies were eligible if they included physical activity and Aβdata in adults aged 45 years or older.Multi-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβlevels.Results:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and blood.Higher physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older adults.However,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included studies.In observational studies,higher levels of physical activity were positively associated with Aβonly in CSF.Therefore,further research is needed to understand the modulating role of physical act

关键词： Aging Cognitive impairment Dementia Exercise PET

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Research foresight in bridging open science and open innovation:Overview based on the complex thinking paradigm

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International Journal of Innovation Studies 2024年第1期8卷 59-75页

作者： Jorge Sanabria-Z marco Cruz-Sandoval Athziri Moreno-Romo Sofía Bosch-gómez maría Soledad Ramírez-Montoya Institute for the Future of Education Tecnologico de MonterreyZapopan45201Mexico Central Bohemian Innovation Center(SIC) PragueCzech Republic The Burnes Center for Social Change Northeastern UniversityBostonMA02115USA Institute for the Future of Education Tecnologico de MonterreyMonterrey64700Mexico

Open innovation benefits from access to cutting-edge discoveries to increase their transformation into tangible applications for the benefit of society.Improving research quality has been proposed as a primary objective of open science by the United Nations,to increase science reproducibility,impact,and trust,leading to robust decision-making and policies.However,opening access to data and processes is insufficient for researchers to achieve open innovation in the context of globalization,for example,by gathering insights from external and internal sources.Developing the appropriate mindset to manage complexity and generate synergy among researchers in academia,industry,and the government is essential to catalyze knowledge and transform it into relevant innovations for society.To gain insights into the roles and challenges of researchers aiming to bridge the gap between open science and open innovation,a decade-plus Mapping Literature Review was conducted based on the complex thinking paradigm.Complex thinking allows for novel connections of the information collected through open science and open innovation,considering different forms of engaging with alternative means of knowledge creation that may promote innovative and critical thinking.The findings revealed:a)broad positioning of the terms in the European Union;b)open access and open data as current driving themes;c)a constant trade-off between the terms“open data”and“information protection”;d)lack of studies on researchers’complex thinking to help them manage openness;e)absence of the environmental helix in the initiatives;and(f)challenges in innovative communication and collaborative practices among public and private entities.Overall,we identified an opportunity to develop researchers’complex thinking such that the openness of information becomes a shared responsibility among partners across multiple helices.This shared responsibility can have methodological implications that permeate how open science and open innovation are theorized and,in practice,facil

关键词： Open innovation Open science Complex thinking Ecosystems Research enhancement Educational innovation Higher education

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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： Ricardo gómez-Oliva Pedro Nunez-Abades Carmen Castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic mechanisms.This is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)neurons.These neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the SVZ.First,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate neuroblasts.The latter are cells that maintain a proliferative phenotype while in an immature phase.However,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

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High CO_(2)permeation using a new Ce_(0.85)gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： Daniela gonzález-Varela JFrancisco gómez-garcía gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)gd_(0.15)O_(2-δ)-LaNiO_(3)(Cg-LN)composites,where the fluorite-perovskite ratio(Cg:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity properties.Later,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were conducted.Here,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane side.Specifically,the gC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

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Predicting intensive care unit-acquired weakness:A multilayer perceptron neural network approach

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World Journal of Clinical Cases 2024年第12期12卷 2023-2030页

作者： Carlos martin Ardila Daniel gonzález-Arroyave Mateo Zuluaga-gómez Department of Basic Sciences University of AntioquiaMedellín 52-59Colombia Department of Surgery Pontificia Universidad BolivarianaMedellín 0057Colombia Department of Emergency Universidad Pontificia BolivarianaMedellín 0057Colombia

In this editorial,we comment on the article by Wang and Long,published in a recent issue of the World Journal of Clinical Cases.The article addresses the challenge of predicting intensive care unit-acquired weakness(ICUAW),a neuromuscular disorder affecting critically ill patients,by employing a novel processing strategy based on repeated machine learning.The editorial presents a dataset comprising clinical,demographic,and laboratory variables from intensive care unit(ICU)patients and employs a multilayer perceptron neural network model to predict ICUAW.The authors also performed a feature importance analysis to identify the most relevant risk factors for ICUAW.This editorial contributes to the growing body of literature on predictive modeling in critical care,offering insights into the potential of machine learning approaches to improve patient outcomes and guide clinical decision-making in the ICU setting.

关键词： Intensive care units Intensive care unit-acquired weakness Risk factors Machine learning Computer neural network

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Spark Plasma Sintering of Boron Carbide Using Ti_(3)SiC_(2) as a Sintering Additive

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 645-650页

作者： Hülya Biçer Mustafa Tuncer Hasan göçmez Iurii Bogomol Valerii Kolesnichenko Andrey Ragulya Kutahya Dumlupinar University School of EngineeringDepartment of Metallurgical and Materials EngineeringKütahya 43100Tur-key Boron Based Advanced Ceramics Application and Research Center Kütahya Dumlupınar UniversityKütahya 43100Turkey Advanced Technologies Center(İLTEM) Kütahya Dumlupınar UniversityKütahya 43000Turkey Department of High-Temperature Ma-terials and Powder Metallurgy National Technical University of Ukraine“Igor Sikorsky Kyiv Polytechnic Institute”Kyiv 03056Ukraine Frantsevich Institute for Problems of Materials Science National Academy of Sciences of UkraineKyiv 03056Ukraine

Boron carbide has unique properties for wide application possibilities;however,poor sinterability limits its applications.One approach to overcome this limitation is the addition of secondary phases into boron carbide.Boron carbide based composite ceramics are produced by the direct addition of secondary phases into the structure or via reactive sintering using a sintering additive.The present study investigated the effect of Ti_(3)SiC_(2) addition to boron carbide by reactive spark plasma sintering in the range of 1700-1900℃.Ti_(3)SiC_(2) phase decomposed at high temperatures and reacted with B4C to form secondary phases of TiB2 and SiC.The results demonstrated that the increase of Ti_(3)SiC_(2) addition(up to 15 vol%)effectively promoted the densification of B4C and yielded higher hardness.However,as the amount of Ti_(3)SiC_(2) increased further,the formation of microstructural inhomogeneity and agglomeration of secondary phases caused a decrease in hardness.

关键词： reactive sintering SPS boron carbide MAX phase

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Estimation of Equivalent Model of Photovoltaic Array Using Unscented Kalman Filters

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 819-827页

作者： M.A.gonzález-Cagigal José A.Rosendo-Macías A.gómez-Expósito the Department of Electrical Engineering University of Seville IEEE ENgREEN Laboratory of Engineering for Energy and Environmental Sustainability

This paper proposes the use of the unscented Kalman filter to estimate the equivalent model of a photovoltaic(PV) array, using external measurements of current and voltage at the inverter level. The estimated model is of interest to predict the power output of PV plants, in both planning and operation scenarios, and thus improves the efficient operation of power systems with high penetration of renewable energy. The proposed technique has been assessed in several simulated scenarios under different operating conditions. The results show that accurate estimates are provided for the model parameters, even in the presence of measurement noise and abrupt variations under the external conditions.

关键词： Mathematical models Estimation Power systems Power system dynamics Kalman filters Parameter estimation Voltage measurement

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