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TNF system in eutopic endometrium from women with endometriosis

Open Journal of Obstetrics and Gynecology 2013年第2期3卷 271-278页

作者： maría angélica boric marisa Torres Claudio Pinto maricela Pino Paulina Hidalgo Fernando Gabler Ariel Fuentes maría Cecilia Johnson Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile

The role of the tumor necrosis factor (TNF) system in endometriosis is not completely clear and therefore was the focus of this study. In eutopic endometria obtained from women with (n = 41) and without (controls;n = 34) endometriosis during laparoscopy, the subcellular location and the percentages for TNF, TNFR1, TNFR2 and CD45 positive-cells were determined (immunohistochemistry);the protein concentration (ELISA) of the soluble receptors (sTNFR1 and sTNFR2) were measured in 4h-explants culture media and the TNF concentration was performed in ex vivo endometrial homogenates. The TNF, TNFR1 and TNFR2 mRNAs were analyzed by real-time PCR. In control endometria, TNF, TNFR1 and sTNFR1 proteins increased during the late secretory phase. In endometriosis endometria, the protein highest level of TNFR1 was reached during the early and the mid secretory phases and of sTNFR1 concentration during the proliferative phase;however, during the late secretory phase, both TNFR1 and sTNFR1 protein levels were reduced compared to the control endometria (p sTNFR2 concentrations, and TNF and TNFR2 mRNAs were similar in control and endometriosis endometria. Although TNFR1 mRNA was highly expressed, no significant differences were found between control and endometriosis endometria. In summary, this study establishes that TNF and TNFR1 protein expressions and the sTNFR concentrations in eutopic endometria from women with and without endometriosis are dependent on the menstrual cycle. The differences on the TNFR1 and sTNFR1 protein pattern between both groups, mainly during the mid and late secretory phases may play a role in the lower implantation rates observed in women with endometriosis, and also could be related to the altered cell death, which favor the augmented cell viability facilitating the characteristic endometrial implantation and growth outside the uterus in this disease.

关键词： Endometriosis Eutopic Endometrium TNF sTNFR1 sTNFR2

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硼酸/硼硅酸盐生物活性玻璃促创面愈合进展

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硅酸盐学报 2024年第2期52卷 681-693页

作者：柳春玉王雪舒丹李帅杰张丽艳崔旭李红龙潘浩波中国科学院深圳先进技术研究院生物医药与技术研究所人体组织与器官退行性研究中心广东深圳518055 深圳市中科海世御生物科技有限公司广东深圳518120 南方科技大学广东深圳518055

随着社会老龄化的加剧,慢性创伤患者的发病率和死亡率激增。高复发率慢性创面难以得到简单有效和低成本的治疗,加重了医疗系统的负担,致使临床对高疗效、新疗法和创新产品的需求持续增长。近年来研究表明,生物活性玻璃可以通过调节免疫... 详细信息

随着社会老龄化的加剧,慢性创伤患者的发病率和死亡率激增。高复发率慢性创面难以得到简单有效和低成本的治疗,加重了医疗系统的负担,致使临床对高疗效、新疗法和创新产品的需求持续增长。近年来研究表明,生物活性玻璃可以通过调节免疫相关巨噬细胞、内皮细胞、真皮成纤维细胞和表皮细胞等,促进伤口愈合,成为一种具有临床应用前景的伤口敷料。特别是硼酸盐和硼硅酸盐组成的生物活性玻璃显示出可控的降解速率,可针对伤口愈合不同病理阶段,持续性释放功能离子并调控伤口微环境,以此诱导血管新生和加速病理伤口组织稳态恢复。本文简要概述了硼酸/硼硅酸盐生物活性玻璃结构与性能关系,重点介绍了其临床应用研究进展,并对未来生物活性玻璃创面敷料的发展进行了展望。

关键词：硼酸/硼硅酸盐生物活性玻璃伤口愈合功能离子慢性创面血管生成

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Nerve Fibres Detection in Paired Eutopic and Ectopic Endometria from Women with Endometriosis: Correlation with Nerve Growth Factor Expression

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Open Journal of Obstetrics and Gynecology 2015年第7期5卷 417-426页

作者： Sebastián Venegas Edward Parada M. angélica boric Hugo Sovino Ariel Fuentes Fernando Gabler Reinaldo González-Ramos M. Cecilia Johnson Institute of Maternal and Child Research Faculty of Medicine University of Chile Santiago Chile Medical Technology School Faculty of Medicine University of Chile Santiago Chile San Borja Arriarán Clinical Hospital Santiago Chile Department of Pathology Faculty of Medicine University of Chile Santiago Chile

Endometriosis, disorder characterized by the presence of endometrium outside the uterus cavity, is associated with chronic pelvic pain. Nerve growth factor (NGF) participates in development, repair and survival of neurons. We evaluated NGF and nerve fibres in eutopic and ectopic endometria from women with endometriosis and in normal endometrium from control patients without endometriosis. In endometrium collected during surgery for endometriosis (paired eutopic and ectopic endometria, proliferative n = 6 and secretory n = 7 phases) or during tubal ligation or hysterectomy for no endometrial disease (control, proliferative n = 6 and secretory n = 6 phases), NGF and neurofilament (NF) of nerve fibres were studied by immunohistochemistry measuring integrated optical density (IOD). Cytoplasmic NGF was detected in glands and stroma in all control, eutopic and ectopic endometrial samples;no statistical differences were found throughout the menstrual cycle. However, total (gland plus stroma) NGF IOD was higher in eutopic than in ectopic endometria during the secretory phase. NF was detected only in ectopic endometrium being eutopic and control endometria negative to this antibody, and no differences were observed between proliferative and secretory phases. Negative and significant correlation was found between NGF and NF expression in ectopic endometria only during the secretory phase. In conclusion, our results show a significant negative correlation between NGF and myelinated nerve fibres in secretory ectopic endometria. NGF expression was not significantly modified throughout the menstrual cycle in control and in endometriosis, even higher in eutopic than in ectopic tissues;the NGF secretion from lesions to pelvic cavity cannot be ruled out, and could explain the negative correlation observed. Although NF and NGF are not useful as diagnostic markers for endometriosis, their expression may be related to endometrial physiology and pathophysiology of the disease.

关键词： NGF Nerves Fibres Eutopic Endometrium Ectopic Endometrium Endometriosis

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Congratulatory Letter from the Center for the Promotion and Development of Belt and Road Initiative,Bosnia and Herzegovina

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International Understanding 2021年第3期 50-50页

作者： Faruk boric the Center for the Promotion and Development of Belt and Road Initiative Bosnia and Herzegovina

To:Chinese Association for International Understanding (CAFIU)CONGRATULATIONS LETTER Dear friends,I was glad to receive the news that your institution,our long-term partner,is celebrating its 40th anniversary since the founding of the *** the past few years,our two institutions as part of the non-govemmental *** jointly done several projects aimed at getting to know each other and especially on the promotion and construction of President Xi Jinping’s big Initiative,"One Belt and One Road".

关键词： jointly founding Road

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Endovascular Repair of Symptomatic （Non-ruptured） Abdominal Aortic Aneurysm in the University Hospital Centre Split

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 509-514页

作者： S. Penovic L. Cambj-Sapunar T. Batinic T. boric I. Ribicic A. Kanjer R. Opacak F. Simic D.Mestanek Clinic for Surgery University Hospital Centre Split Split 21000 Croatia Clinical Institute for Diagnostic and Interventional Radiology University Hospital Centre Split Split 21000 Croatia

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糖化血红蛋白快速诊断试纸研究

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东南大学学报（医学版） 2019年第1期38卷 181-186页

作者：昂朝满娄豆豆吉永新张宇东南大学生物科学与医学工程学院生物电子学国家重点实验室江苏省生物材料与器件重点实验室南京210096 南京东纳生物科技有限公司南京211100

目的:设计并构建两种糖化血红蛋白快速诊断试纸,比较两种不同原理的快速诊断试纸检测糖化血红蛋白(HbA_(1c))的性能。方法:设计并构建了一种侧向亲和层析试纸,根据检测线上HbA_(1c)的颜色实现半定量检测。构建了一种荧光免疫层析试纸(FI... 详细信息

目的:设计并构建两种糖化血红蛋白快速诊断试纸,比较两种不同原理的快速诊断试纸检测糖化血红蛋白(HbA_(1c))的性能。方法:设计并构建了一种侧向亲和层析试纸,根据检测线上HbA_(1c)的颜色实现半定量检测。构建了一种荧光免疫层析试纸(FICTS),利用荧光免疫定量分析仪实现HbA_(1c)定量检测。针对HbA_(1c)临床样本,对两种快速诊断试纸进行相关性能分析。结果:亲和层析试纸检测流程满足床旁诊断(POCT)的需求,但半定量的HbA_(1c)检测结果完全无法实现准确的HbA_(1c)检测。HbA_(1c)荧光免疫层析试纸保证了良好的准确度、线性度(R^2>0.99)、变异系数(CV0.95),且HbA_(1c)检测结果不受高浓度糖类和表面活性剂的影响。结论:相比于亲和层析试纸,FICTS是一种较为优秀的HbA_(1c)快速诊断试纸,这种试纸操作简便,有良好的线性度、准确度,能良好区分HbA_(1c)阴阳性样本,并且与临床高效液相色谱法(HPLC)的检测结果一致。

关键词：糖化血红蛋白亲和层析试纸荧光免疫层析试纸

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