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The Long Way from Complex Phenotypes to Genes: The Story of Rat Chromosome 4 and Its Behavioral Effects

World Journal of Neuroscience 2014年第3期4卷 203-215页

作者： Gabriela Ferreira de Medeiros Fernanda Junkes Corrêa maría elisa corvino Geison de Souza Izídio André Ramos Laboratório de Genética do Comportamento Departamento de Biologia Celular Embriologia e Genética Universidade Federal de Santa Catarina Florianópolis Brazil

Quantitative trait loci (QTLs) mapping has been performed during the past decades in an attempt to identify genes, gene products and mechanisms underlying numerous quantitative traits. It’s a strategy based on natural variations in genes and gene products, which facilitates translation from animal models to human clinical conditions. Our team has shown that the inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) differ with respect to several emotionality- related behaviors, one of which (inner locomotion in the open field) was strongly influenced by a QTL (Anxrr16) on rat chromosome 4. Since then, several other studies not only corroborated the initial description of Anxrr16, but also extrapolated its effects to a broader context (rats from both sexes and regardless of the estrous cycle phase) and suggested that this same region influences other emotionality-related behaviors as well as alcohol intake. Other QTLs affecting neurobiological traits were also found on rat chromosome 4 and several candidate genes have been pointed out as possibly influencing those phenotypes. Altogether, these studies suggest that rat chromosome 4 constitutes an interesting target for the study of the molecular bases of anxiety and other traits related to emotional reactivity.

关键词： Rat Chromosome 4 QTL Anxrr16 Emotionality-Related Behaviors Alcohol Consumption Stress-Response

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miniSCIDOM: a scintillator-based tomograph for volumetric dose reconstruction of single laser-driven proton bunches

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High Power Laser Science and Engineering 2024年第2期12卷 41-50页

作者： A.corvino M.Reimold E.Beyreuther F.-E.Brack F.Kroll J.Pawelke J.D.Schilz M.Schneider U.Schramm M.E.P.Umlandt K.Zeil T.Ziegler J.Metzkes-Ng Helmholtz-Zentrum Dresden–Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany OncoRay–National Center for Radiation Research in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Current affiliation:Institut Curie UniversitéPSLCNRS UMR3347OrsayFrance Current affiliation:Universitätsklinikum Freiburg FreiburgGermany

Laser plasma accelerators(LPAs)enable the generation of intense and short proton bunches on a micrometre scale,thus offering new experimental capabilities to research fields such as ultra-high dose rate radiobiology or material *** spectrally broadband,laser-accelerated proton bunches allow for tailored volumetric dose deposition in a sample via single bunches to excite or probe specific sample *** rising number of such experiments indicates a need for diagnostics providing spatially resolved characterization of dose distributions with volumes of approximately 1 cm^(3) for single proton bunches to allow for fast online *** we present the scintillator-based miniSCIDOM detector for online single-bunch tomographic reconstruction of dose distributions in volumes of up to approximately 1 cm^(3).The detector achieves a spatial resolution below 500μm and a sensitivity of 100 *** detector performance is tested at a proton therapy cyclotron and an LPA proton *** experiments’primary focus is the characterization of the scintillator’s ionization quenching behaviour.

关键词： beam monitoring detectors laser-driven proton beams scintillator-based diagnostics ultra-high dose rate

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皮瑞里大厦会堂,米兰,意大利

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世界建筑 2005年第10期 45-47页

作者： vincenzo corvino giovanni multari 科尔维诺+穆尔塔里建筑师事务所那不勒斯

随着20世纪到21世纪的过渡,一场针对所有20世纪下半叶建筑的保护运动在意大利爆发了:人们重新认识它们的价值、对它们进行修缮并恢复建筑和城市之间的各种内在联系.

关键词：意大利 20世纪下半叶会堂大厦米兰 21世纪建筑修缮

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琴托拉烟草工厂改建的欧洲新兴艺术创作中心,意大利

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世界建筑 2005年第10期 42-44页

作者： vincenzo corvino giovanni multari 科尔维诺+穆尔塔里建筑师事务所那不勒斯

琴托拉烟草销售处,皮琴蒂诺风景的工业考古学纪念碑,是蓬泰卡尼亚诺都市风格的标志.该改进项目将整个地区重新改造成一个面向都市的开阔的公共场所.

关键词：艺术创作烟草意大利欧洲改建工厂纪念碑考古学

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First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

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World Journal of Clinical Cases 2019年第21期7卷 3535-3548页

作者： maria Rosaria Iovene Vincenzo Pota Massimiliano Galdiero Giusy corvino Federica maria Di Lella Debora Stelitano maria Beatrice Passavanti maria Caterina Pace Aniello Alfieri Sveva Di Franco Caterina Aurilio Pasquale Sansone Vettakkara Kandy Muhammed Niyas marco Fiore Department of Experimental Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Medicine All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available *** SUMmarY An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk(August,1 to October,18)in patients admitted to the adult polyvalent intensive care unit of the University of Campania“Luigi Vanvitelli”located in *** episodes occurred in three patients(two patients infected,and one patient colonized).All the strains revealed the production of *** After three decades of carbapenem antibiotics use,the emergence of carbapenemresistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is *** is,to our knowledge,the first outbreak of VIM-producing Serratia marcescens in *** policies must be implemented to avoid future outbreaks.

关键词： Serratia marcescens Carbapenamase VIM Intensive care unit Outbreak Case report

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