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Takotsubo cardiomyopathy:Pathophysiology and role of cardiac biomarkers in differential diagnosis

World Journal of Cardiology 2017年第9期9卷 723-730页

作者： Prabhakaran Gopalakrishnan Ramsha Zaidi Muhammad rizwan Sardar Division of Cardiology Department of MedicineAultman HospitalCantonOH 44710United States

Takotsubo cardiomyopathy(TC) is characterized by reversible ventricular dysfunction, not limited to the distribution of an epicardial coronary artery. A disease primarily afflicting post-menopausal women, it is frequently mistaken for acute anterior wall myocardial infarction. Alternatively called Stress Cardiomyopathy, physical or emotional triggers are identified in only three fourths of TC patients. Long considered a benign condition, recent findings suggest poor short term prognosis similar to acute coronary syndrome(ACS). Despite the widely recognized pathophysiological role of catecholamine excess, its diagnostic role is uncertain. TC is suspected based on typical wall motion abnormalities in ventriculogram or echocardiogram. Several additional electrocardiographic, laboratory and imaging parameters have been studied with the goal of clinical diagnosis of TC. While several clinical clues differentiate it from ACS, a clinical diagnosis is often elusive leading to avoidable cardiac catheterizations. Natriuretic peptides(NPs), a family of peptide hormones released primarily in response to myocardial stretch, play a significant role in pathophysiology, diagnosis as well as treatment of congestive heart failure. TC with its prominent ventricular dysfunction is associated with a significant elevation of NPs. NPs are elevated in ACS as well but the degree of elevation is typically lesser than in TC. Markers of myocardial injury such as troponin are usually elevated to a higher degree in ACS than in TC. This differential elevation of NPs and markers of myocardial injury may play a role in early clinical recognition of TC.

关键词： Takotsubo cardiomyopathy Natriuretic peptide Brain natriuretic peptide N-terminal-probrain natriuretic peptide Troponin Cardiac biomarkers Acute myocardial infarction

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Pulmonary artery catheterization in acute myocardial infarction complicated by cardiogenic shock:A review of contemporary literature

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World Journal of Cardiology 2021年第12期13卷 720-732页

作者： Shiva P Ponamgi Muhammad Haisum maqsood Pranathi R Sundaragiri Michael G DelCore Arun Kanmanthareddy Wissam A Jaber William J Nicholson Saraschandra Vallabhajosyula Division of Cardiovascular Medicine Department of MedicineCreighton University School of MedicineOmahaNE 68154United States Department of Medicine Lincoln Medical Center/Cornell UniversityBronxNY 10451United States Department of Primary Care Internal Medicine Wake Forest Baptist HealthHigh PointNC 30260United States Section of Interventional Cardiology Division of Cardiovascular MedicineDepartment of MedicineEmory University School of MedicineAtlantaGA 30322United States Section of Cardiovascular Medicine Department of MedicineWake Forest University School of MedicineHigh PointNC 27262United States

Acute myocardial infarction(AMI)with left ventricular(LV)dysfunction patients,the most common cause of cardiogenic shock(CS),have acutely deteriorating hemodynamic *** frequent use of vasopressor and inotropic pharmacologic interventions along with mechanical circulatory support(MCS)in these patients necessitates invasive hemodynamic *** the pivotal Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial failed to show a significant improvement in clinical outcomes in shock patients managed with a pulmonary artery catheter(PAC),the use of PAC has become less popular in clinical *** this review,we summarize currently available literature to summarize the indications,clinical relevance,and recommendations for use of PAC in the setting of AMI-CS.

关键词： Pulmonary artery catheter Swan-ganz catheter Acute myocardial infarction Cardiogenic shock Hemodynamic monitoring Interventional cardiology Critical care cardiology

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基于学习的故障定位方法研究

基于学习的故障定位方法研究

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作者： SYED rizwan（萨一德）哈尔滨工业大学

学位级别：硕士

故障定位是软件调试的主要任务之一。开发人员花费大量的时间和精力来人工正确定位故障。自动故障定位技术可以辅助开发者。在故障定位领域,已经提出了许多技术,输入测试套件,然后输出程序的故障实体的排序列表。可能程序不变量是发现... 详细信息

故障定位是软件调试的主要任务之一。开发人员花费大量的时间和精力来人工正确定位故障。自动故障定位技术可以辅助开发者。在故障定位领域,已经提出了许多技术,输入测试套件,然后输出程序的故障实体的排序列表。可能程序不变量是发现和分析软件缺陷的主要方式之一,通过分析不变量特性,可以捕获和分析哪些程序代码违背了开发人员的目标。为了改进这方面的工作,本论文研究了基于不变量分析的故障定位方法,并开发了一个称为SILearning的系统,通过学习已知的缺陷信息,来定位程序中的可疑方法。该方法结合了机器学习技术“learning to rank”,程序不变量差异、以及基于程序谱的故障定位方法。将通过执行测试用例和代码覆盖率分析计算获得各方法的不变量差异和基于程序谱定位计算的可疑度值作为特征,来计算各方法导致失效的可疑度并对其进行排序。为了完成这项工作,我们将SILearning划分为五个部分:方法聚类和测试用例子集选择,可能和动态不变量检测,不变量子集选择,特征提取和模型学习以及方法排序。完成所有这些步骤后,SILearning会输出一系列按可疑度排序的方法。实验分析了从数据库“Defects4J”中提取的真实故障数据集,并将SILearning的性能与已有研究进行比较。结果表明SILearning在使用组合功能时表现更好,并且能够成功地将故障方法平均地定位在顶部1,2,3,4和5处的“76.1”,“90.4”,“108.2”,“123”,“和”“143.5”。SILearning优于ER1,ER1,ER5,ER5,ER5,GP2,GP3,GP13,GP19 and Savant。

关键词：故障定位学习排序不变量的子集选择

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The dilemma of cytomegalovirus and hepatitis B virus interaction

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Gastroenterology Report 2022年第1期10卷 108-114页

作者： Muzammil M.Khan Mukarram J.Ali Hira Hanif Muhammad H.maqsood Imama Ahmad Javier E.G.Alvarez Maria-Andreea Catana Daryl T.Y.Lau Department of Medicine Division of GastroenterologyLiver Research CenterBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Medicine North Shore Medical CenterSalemMAUSA

Hepatitis B virus(HBV)remains a global public health problem despite the availability of effective vaccine and antiviral ***(CMV),another hepatotropic virus,is also very prevalent in the general population *** HBV and CMV can persist in the host and have potential to reactivate especially with weakened host cellular *** CMV infection can lead to severe HBV *** pathogenesis of the co-infection of HBV and CMV remains poorly *** reported conflicting results regarding the inhibitory effect of CMV on HBV *** is an unmet need on the management of co-infection of HBV and CMV;research initiatives dedicated to understanding their interactions are urgently needed.

关键词： CMV HBV HBV CMV co-infection CMV reactivation HBV reactivation IgG Avidity test

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Measuring Effectiveness of COCOMO I and COCOMO II Using a Case Study

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Computer Technology and Application 2012年第10期3卷 692-698页

作者： Muhammad Munir Albakri Mohammad rizwan Jameel Qureshi Department of lnformation Technology Faculty of Computing and Information Technology King A bdulaziz University Jeddah21589 Saudi Arabia

There are several software estimation models such as Line of Code, Function Point and COnstructive COst MOdel （COCOMO）. The original COCOMO model is one of the most widely practiced and popular among the software development community because of its flexible usage. It is a suite of models i.e., COnstructive Cost MOdel I and COnstructive Cost MOdel II. in this paper, we are evaluating the both models, to find out the level of efficiency they present and how they can be tailored to the needs of modem software development projects. We are applying COCOMO models on a case study of an e-commerce application that is built using Hyper Text Markup Language （HTML） and JavaScript. We will also shed light on the different components of each model, and how their Cost Drivers effect on the accuracy of cost estimations for software development projects.

关键词： COCOMO I COCOMO II software cost estimation software cost drivers' assessment trade-off analysis componentcomposition.

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Anti-Radical and Neuroprotective Potential of <i>Ficus infectoria</i>in Scopolamine Induced Memory Impairment in Mice

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Advances in Alzheimer's Disease 2018年第2期7卷 62-77页

作者： Kiran Zahid Syed Muhammad Faheem Ahmad maqsood Ahmed Farah Khan Department of Botany Lahore College for Women University Lahore Pakistan UVAS—University of Veterinary and Animal Sciences Lahore Pakistan Riphah International University Lahore Pakistan

Ficus infectoria has a wide distribution in Bangladesh, Nepal, Pakistan, Sri Lanka, Southwest China and Indochina and is an enrich source of phytochemicals thereby possess antibacterial, antifungal and hyperglycaemic activities. In this study, we attempted to examine the cognitive ability of methanolic and ethanolic extract of F. infectoria fruit extract in scopolamine induced memory impairment in mice by using preliminary phytochemical and antioxidant tests, and the cognitive ability of the methanolic and ethanolic fruit extract of F. infectoria. Fruit extract was analyzed in scopolamine amnesia mice using passive avoidance approach. Piracetam was used as a reference drug (200 mg/Kg). Further confirmation was provided by means of mice brain homogenate biochemical tests. Maximum phytochemical, antioxidant activity and nootropic ability were observed in the ethanolic fruit extract of F. infectoria. Plant extract was used at three doses i.e. 75 mg/Kg, 150 mg/Kg and 300 mg/Kg and exhibited nootropic abilities in all tests used. Enhanced SDL value i.e. (291.2 ± 0.33+++###) was observed by the administration of plant extract at all dose range in comparison to reference drug i.e. piracetam (252.8 ± 1.60###) used in the study. The plant extract utilization has showed increase in total protein (25.08 ± 0.26+++### mg/g of tissue) and reduced glutathione content (33.0 ± 0.46+++### nmoles/mg of protein) and vice versa while low malondialehyde (MDA) (9.18 ± 0.17+++### nmoles/mg of protein) and AChE activity (0.067 ± 0.009+++### M/min/g protein). However, opposite situation was observed in the scopolamine amnesia mice. Hence it was concluded the plant extract possessed neuroprotective activity in the scopolamine induced cognitive decline in mice thereby used as cost effective natural medicines in near future.

关键词： Antioxidant Malondialdehyde Reduced Glutathione Acetylcholinestrase Scopolamine Hydrobromide Neuroprotective Ficus infectoria

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Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment

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World Journal of Diabetes 2020年第1期11卷 13-25页

作者： Adebola Matthew Giwa rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad Department of Pediatrics Johns Hopkins Medical CenterBaltimoreMD 21287United States Department of Pathology Johns Hopkins Medical CenterBaltimoreMD 21205United States School of Medicine Koc UniversityIstanbul 34450Turkey Department of Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205United States

Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any *** is caused by autoreactive T cells that destroy insulin-producing beta cells in the *** studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually *** daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care *** the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this *** advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic *** this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of *** examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease *** a better understanding of this process,interventions can be developed to prevent or halt it at early stages.

关键词： Type 1 diabetes genetics Type 1 diabetes epigenetics Role of genetics in type 1 diabetes Diabetes prevention Type 1 diabetes environment Type 1 diabetes twin studies Type 1 diabetes concordance Type 1 diabetes discordance

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Improved hepatitis A and hepatitis B vaccination strategy is necessary for patients with chronic hepatitis C

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Gastroenterology Report 2020年第4期8卷 326-328,I0003页

作者： Muhammad H.maqsood Himabindu Kolli Satinder P.Kaur Karen J.Campoverde Reyes Javier Guevara Pir A.Shah Arslan Talat Daryl T.Y.Lau Division of Gastroenterology Liver Research CenterBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Introduction Hepatitis C virus(HCV)is a major cause of chronic liver *** A virus(HAV)or hepatitis B virus(HBV)infection on pre-existing hepatitis C can lead to significant morbidity and mortality[1].The Advisory Committee on Immunization Practices(ACIP)recommends HAV and HBV vaccination for patients with chronic liver diseases[2,3].Best-practice advice from the American College of Physicians and the Centers for Disease Control and Prevention(CDC)also emphasized the importance of HBV vaccination for at-risk populations[4].The hepatitis B vaccine response,however,is generally lower among patients with chronic liver diseases,especially those with cirrhosis or older age[5,6].In this study,we reported that a high proportion of patients with chronic hepatitis C remained at risk of HAV or HBV infection at their referral to our tertiary Liver Center.

关键词：乙肝疫苗 diseases infection

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巴基斯坦证券交易所股票波动率研究

巴基斯坦证券交易所股票波动率研究

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作者： Ullah rizwan（李子安）北京交通大学

学位级别：硕士

本文尝试使用来自卡拉奇证券交易所(最近更名为巴基斯坦证券交易所)(KSE)的数据来模拟新兴市场的条件波动。我们采用了非对称模型,例如E-GARCH(1,1),T-GARCH(1,1)和P-GARCH(1,1)和对称模型,例如ARCH(1),GARCH(1,1)和GARCH-M(1,1),对22... 详细信息

本文尝试使用来自卡拉奇证券交易所(最近更名为巴基斯坦证券交易所)(KSE)的数据来模拟新兴市场的条件波动。我们采用了非对称模型,例如E-GARCH(1,1),T-GARCH(1,1)和P-GARCH(1,1)和对称模型,例如ARCH(1),GARCH(1,1)和GARCH-M(1,1),对22年的每日、每周及每月KSE 100指数回报系列进行了研究,以探讨波动的性质和不同的相关方面。新的经验证据表明,这三个收益序列均显示出具有高峰度和平稳性的非正态分布特性。此外,我们发现波动性很高,并且持续存在,这导致了目前所观察到的冲击的影响,对未来收益的影响持续了更长的时间。最后,事实证明,用于日收益率系列的P-GARCH(1,1)和用于每周数据的GARCH(1,1)模型与波动率建模最符合。

关键词：对称和非对称模型条件波动率卡拉奇证券交易所

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齿轮箱壳体的静力和振动阻尼研究

齿轮箱壳体的静力和振动阻尼研究

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作者： Syed rizwan Ui Haque 哈尔滨工程大学

学位级别：硕士

齿轮箱箱体由于支持着传动件而起着十分重要的作用。箱体里主要有轴、齿轮和轴承。由于整个齿轮箱要承受静态和动态的载荷,所以整个齿轮箱箱体的强度显得非常重要。同时在齿轮箱的起吊和安装过程中,齿轮箱吊耳的强度也显得十分重要。在... 详细信息

齿轮箱箱体由于支持着传动件而起着十分重要的作用。箱体里主要有轴、齿轮和轴承。由于整个齿轮箱要承受静态和动态的载荷,所以整个齿轮箱箱体的强度显得非常重要。同时在齿轮箱的起吊和安装过程中,齿轮箱吊耳的强度也显得十分重要。在整个传动装置中,振动主要是由于齿轮啮合激励和轴承处激励引起的。产生的振动能量从齿轮传动轴上,又从轴传递到轴承处,进而从轴承通过轴承座传递到齿轮箱箱体。一部分振动能量被齿轮箱中的弹性元件所吸收,而另一部分振动能量将会激励器振动。振动能量可以通过修改结构来进行控制。然而结构修改可以通过改变齿轮箱箱壁的厚度或在某些部位添加阻尼来实现。本文通过在船用齿轮箱的某些结构上添加适当的阻尼材料来减小振动能量以,并在有限元分析软件ANSYS中完成了模拟仿真。首先,根据齿轮箱的实际工作条件确定了吊耳的工作载荷及齿轮箱箱体的约束条件,对齿轮箱的吊耳进行了静力学分析。先进的子模型技术被用来获取齿轮箱某些局部或指定位置的精确应力情况。子模型技术允许从整体模型中提取一部分模型进行网格细化,以便进一步分析。此外,应用Block Lanczos法进行齿轮箱的无阻尼模态分析,并提取了齿轮箱前10阶固有频率及其振型。本文应用QR法完成了齿轮箱有阻尼模态分析。根据模态分析来分别确定阻尼材料SA-3、DFM和QZD的最佳厚度、阻尼材料的约束以及阻尼材料在齿轮箱表面的最佳粘贴位置。在整个分析中还考虑了阻尼材料的温度特性,分别计算了在25oC、30oC、40oC和50oC下每种阻尼材料对齿轮箱的减振性能。

关键词：振动阻尼阻尼材料阻尼处理方式静态分析模态分析

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