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隔板起始位置对大型双蜗壳双吸泵径向力和压力脉动的影响

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农业工程学报 2021年第12期37卷 20-27页

作者：牛茂升朱强芦洪钟肖功槐蔡婷上海凯泉泵业(集团)有限公司上海201801

为研究双蜗壳泵内压力脉动情况,该研究以某大型双蜗壳双吸泵为研究对象,通过三维非定常计算对不同隔板起始位置对水力性能、叶轮径向力、蜗壳内各点压力脉动的影响进行研究。研究结果表明,采用双蜗壳结构后,设计点效率下降4%~5%;径向力... 详细信息

为研究双蜗壳泵内压力脉动情况,该研究以某大型双蜗壳双吸泵为研究对象,通过三维非定常计算对不同隔板起始位置对水力性能、叶轮径向力、蜗壳内各点压力脉动的影响进行研究。研究结果表明,采用双蜗壳结构后,设计点效率下降4%~5%;径向力大小在叶轮旋转过程中呈周期性变化,径向力大小受隔板起始位置影响较大,因此需要合理布置隔板起始位置;隔舌附近各点压力分布均呈现明显的周期性波动变化,隔舌后测点压力峰值、平均值及脉动值要远小于隔舌前测点,仅为隔舌前测点相应值的25%~50%,而且随着隔板起始位置后移,隔舌附近各点压力波动逐渐减弱;综合考虑水力性能及压力脉动影响,隔板起始点应布置于自隔舌点以叶轮中心为圆心向蜗壳出口方向旋转200°位置,该结构下水力效率最高,径向力最小,研究结果可以为大型双蜗壳双吸泵水力性能改进及结构优化提供一定的理论支持。

关键词：泵试验隔板位置双蜗壳泵径向力压力脉动

Applications of in-situ solid-state nuclear magnetic resonance in methanol to olefins reaction

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Science China Chemistry 2025年第1期68卷 134-151页

作者： Jing niu Shutao Xu Yingxu Wei Zhongmin Liu National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of Sciences State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The methanol-to-olefins（MTO） reaction offers an alternative pathway for the production of low-carbon olefins from non-oil feedstocks. Fundamental research has been impeded by a lack of comprehensive understanding of its underlying mechanism,despite the significant progress made in industry. In-situ solid-state nuclear magnetic resonance（ss NMR） spectroscopy has emerged as a pivotal tool, offering crucial insights into key species under real-time operando conditions. Furthermore, the host–guest interaction between zeolites or surface species residing on zeolites and the reactant/active intermediates is revealed by the combination of in-situ13C MAS NMR and 2D correlation spectroscopy. Moreover, recent technological advancements in hyperpolarization（HP） methods, including HP129Xe NMR and dynamic nuclear polarization（DNP）, have significantly improved the sensitivity of ss NMR, enabling detailed structural and kinetic analysis as well as the detection of trace species. In this feature article, we summarized recent advancements in（in-situ） ss NMR spectroscopy applied to MTO reaction processes,encompassing mechanistic investigations at various stages and the intricate host–guest interactions. These theoretical insights into the dynamic evolution of MTO reactions lay a solid foundation for the optimization of catalytic processes and the development of efficient catalysts, thereby advancing the techniques towards more sustainable and economical production route for olefins.

关键词： MTO zeolites in-situ ssNMR reactive intermediates reaction mechanism

Ubiquitin-specific protease 1 facilitates tumor immune escape from natural killer cells and predicts the prognosis in small cell lung cancer

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Oncology Research 2025年第1期33卷 213-224页

作者： SHIQIN JIANG YICHUN TANG FENG MA YUCHUN niu LEI SUN Department of Clinical Pharmacy Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen518104China Department of Pathology Zhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Radiation Oncology The First People’s Hospital of FoshanFoshan528000China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China Department of Oncology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguan523721China

Objective:Small cell lung cancer(SCLC)is commonly recognized as the most fatal lung cancer *** substantial advances in immune checkpoint blockade therapies for treating solid cancers,their benefits are limited to a minority of patients with *** the present study,novel indicators for predicting the outcomes and molecular targets for SCLC treatment were ***:We conducted bioinformatics analysis to identify the key genes associated with tumor-infiltrating lymphocytes in *** functional role of the key gene identified in SCLC was determined both in vitro and in ***:A significant correlation was observed between patient survival and CD56dim natural killer(NK)cell ***,we noted that the hub gene ubiquitin-specific protease 1(USP1)is closely correlated with both CD56dim NK cells and overall survival in *** analysis revealed that USP1 is upregulated in *** addition,gene set enrichment analysis revealed that USP1 overexpression hinders NK cell-mediated immune *** co-cultivating NK-92 cells with SCLC cells,we demonstrated that NK cell cytotoxicity against SCLC could be improved either via USP1 knock-down or pharmacological ***,using a nude-mice xenograft tumor model,we noted that USP1 inhibition effectively suppressed tumor proliferation and increased the expression of NK cell-associated ***:Our study findings highlight the importance of NK cells in regulating ***1 overexpression can inhibit NK cell-mediated immunity;therefore,USP1 may serve not only as a prognostic biomarker but also as a potential molecular target of SCLC therapy.

关键词： Ubiquitin-specific protease 1(USP1) Natural killer(NK)cell Small cell lung cancer(SCLC) Prognosis Immune escape

某超超临界汽轮机高压进汽腔整圈斜置静叶的数值仿真

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中国舰船研究 2016年第3期11卷 97-101页

作者：杨建牛茂升郭栋竺晓程杜朝辉中国舰船研究设计中心上海201108 上海交通大学机械与动力工程学院上海200240

针对某超超临界汽轮机组,通过CFX数值软件模拟了汽轮机组进汽道及斜置静叶通道内部的流动情况。通过对内部流场的分析,可以得出静叶斜置后的利弊情况,通过观察进气角分布,周向各位置叶表的压力分布以及对应的速度矢量和压力分布,可以发... 详细信息

针对某超超临界汽轮机组,通过CFX数值软件模拟了汽轮机组进汽道及斜置静叶通道内部的流动情况。通过对内部流场的分析,可以得出静叶斜置后的利弊情况,通过观察进气角分布,周向各位置叶表的压力分布以及对应的速度矢量和压力分布,可以发现进汽腔体所带来的周向不对称性会对下游叶片流动产生较大的影响,使得静叶进口处的流动角差别较大,导致汽轮机偏离其工作条件。进汽腔配置斜置静叶之后,进汽腔所引起的出口处周向不均匀性在流经斜置静叶后会得到较大的改善,从而使得下游流动参数更加均匀,有益于机组的运行和转子寿命的延长。

关键词：超超临界汽轮机高压进汽腔数值模拟斜置静叶

Weak KAM theory for two classes of almost periodic Hamiltonian systems

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Science China Mathematics 2025年

作者： Xun niu Kaizhi Wang Yong Li School of Mathematics and Statistics Center for Mathematics and Interdisciplinary SciencesNortheast Normal University School of Mathematical Sciences Shanghai Frontier Science Center of Modern Analysis (CMA-Shanghai)Shanghai Jiao Tong University Institute of Mathematics Jilin University

The purpose of this paper is to investigate the dynamics of Bohr almost periodic and Levitan almost periodic Hamiltonian systems via the weak KAM theory. We obtain minimal measures and weak KAM solutions in both cases. The weak KAM solution is a weak solution to the Hamilton-Jacobi equation, which formally transforms the original Hamiltonian systems into an integrable one. Consequently, we get the existence of an invariant torus in the aforementioned weak sense.

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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui niu Xiaodong He Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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某燃气轮机舷侧进气流场数值仿真

中国舰船研究 2018年第A1期13卷 126-134页

作者：杨建朱炜何文强王艳国邹春平牛茂升中国舰船研究设计中心上海201108 海军驻沪东中华造船(集团)有限公司军事代表室上海200129

[目的]研究风向变化对燃气轮机舷侧进气流场稳定性、均匀性、流动阻力损失的影响,通过仿真研究验证该形式是否满足燃气轮机的进气要求。[方法]采用CFX对燃气轮机进气流场进行数值模拟,通过设定不同的进气角度,对比不同进气状态下其对进... 详细信息

[目的]研究风向变化对燃气轮机舷侧进气流场稳定性、均匀性、流动阻力损失的影响,通过仿真研究验证该形式是否满足燃气轮机的进气要求。[方法]采用CFX对燃气轮机进气流场进行数值模拟,通过设定不同的进气角度,对比不同进气状态下其对进气系统内流线分布、前进气百叶窗、侧进气百叶窗及进气系统出口的总压分布、前进气滤清器和侧进气滤清器截面的速度分布,研究不同进气方向下燃气轮机进气的均匀情况。[结果]仿真结果表明,进气角度的不同会导致前进气和侧进气的掺混剧烈程度不同,而在配置了该进气系统之后,前、侧进气角度不同引起的不均匀性在流经进气稳压室后会得到较大改善,从而使得下游流动更加均匀。[结论]研究结果对燃气轮机舷侧进气系统的设计具有一定的指导意义。

关键词：燃气轮机进气系统舷侧进气进气百叶窗滤清器