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Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma

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Genes & Diseases 2024年第5期11卷 81-84页

作者： Zhiyi Wang Shuang Chen Dongxiao Li Hui Xu Siyuan weng Yuyuan Zhang Yuqing Ren Chunguang Guo Xiuling Li Zaoqu Liu Xinwei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Gastroenterology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhouHenan 450004China Center of Reproductive Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100730China

Hepatocellular carcinoma(HCC)is a highly heterogeneous tumor,with dynamic equilibrium and complex interplay between its intricate tumor nature and ambient tumor immune microenvironment(TIME).1 Elegant research has indicated that cancer stem cells,a small subset of neoplastic cells confined within dedicated niches,display stem cell-like properties and interact with cells in TIME,thereby imparting an indelible impact on stemness regulation,tumor heterogeneity,and cancer cell plasticity.2 Previous taxonomies solely from the perspective of stemness or TIME may introduce some degree of bias in the comprehension of HCC carcinogenesis,3,4 and thus it is of paramount importance to systematically consider tumor stemness and TIME as a whole to truly portray the biological landscape of HCC.

关键词： thereby landscape stem

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有人/无人机智能协同:机遇与挑战

中国科学：技术科学 2024年第5期54卷 968-978页

作者：吕金虎冉茂鹏王成才王小谟北京航空航天大学自动化科学与电气工程学院北京100191 中关村实验室北京100194 中国电子科技集团有限公司电子科学研究院北京100041

随着无人机智能化水平的不断提升,人工智能驱动的有人/无人机协同有望成为未来战争新的制高点,其核心技术亟待突破.本文综述了有人/无人机智能协同面临的主要机遇与挑战,系统梳理了人工智能在有人/无人机协同体系结构、协同感知、协同... 详细信息

随着无人机智能化水平的不断提升,人工智能驱动的有人/无人机协同有望成为未来战争新的制高点,其核心技术亟待突破.本文综述了有人/无人机智能协同面临的主要机遇与挑战,系统梳理了人工智能在有人/无人机协同体系结构、协同感知、协同决策、协同控制以及评价体系等关键领域的研究现状,并重点介绍了深度学习可解释性、牵制协同控制、有限网络带宽协同控制的新进展.最后,总结了有人/无人机协同的主要发展趋势,即智能化水平更高、复杂环境适应能力更强、博弈对抗能力更强、安全性更高等.

关键词：有人/无人机协同人工智能智能协同分布式协同作战

Coupling and coordination relationship of tourism inclusive green growth system:Evidence from Shandong Province

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Chinese Journal of Population,Resources and Environment 2024年第3期22卷 334-342页

作者： Tianjun Xu Gangmin weng Wei Guo School of Economics and Management Yanshan UniversityQinhuangdao 066004China Regional Economic Development Center Yanshan UniversityQinhuangdao 066004China

Sustainable growth is a prerequisite for high-quality development,and inclusive green growth is regarded as an important way to realize sustainable *** paper constructs a tourism inclusive green growth index(IGGI)system based on the 2018 Asian Development Bank *** Shandong Province from 2017 to 2019,the entropy weight method is utilized to explore the degree of coupling and coordination among the subsystems of tourism inclusive green *** study shows that:(1)the tourism IGGI continues to grow;(2)in the tourism inclusive green growth system,the social equity subsystem shows a trend of steady improvement;and(3)in the system,there is a slight discordance between the economic growth subsystem and the environmental sustainability *** study aims to provide the scientific basis for the high-quality development of tourism and theoretical support for the field of tourism and environmental sustainability.

关键词： Tourism inclusive green growth system Coupled coordination Entropy law Tourism quality development

Thoracoscopic resection of giant left atrial appendage aneurysm: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 48-51页

作者： Jie Han Jiakan weng Jiwen Li Department of Cardiac Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Left atrial appendage aneurysm(LAAA)was first reported in the 1960s.1 LAAA is a rare condition,with just over 100 congenital or acquired cases reported to date.2 LAAA is frequently diagnosed incidentally during echocardiography or computed tomography(CT)*** patients with LAAA are asymptomatic,while a few exhibit nonspecific symptoms,such as dyspnea,palpitation,and chest *** with LAAA frequently present with atrial arrhythmias and systemic thromboembolism,such as stroke or multiorgan infarctions,due to the formation of a left atrial appendage thrombus.3 The lesion may be cured using aneurysm *** it as the potential cause of atrial arrhythmias and thromboembolism,the lesion must be identified on time and cured using a suitable treatment approach.

关键词： atrial aneurysm frequent

Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2024年第05期44卷 981-990页

作者： ZHANG Fang YAN Cuina weng Zhijun WU Luyi QI Li ZHAO Min XIN Yuhu WU Huangan LIU Huirong Key Laboratory of Acupuncture and Immunological Effects Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Cancer Hospital Fudan University

OBJECTIVE: To investigate the role of satellite glial cells in irritable bowel syndrome(IBS) and the effect of electroacupuncture(EA) at the Tianshu(ST25) and Shangjuxu(ST37) combination. METHODS: A model for visceral hypersensitivity in IBS was induced through colorectal distension(CRD) stimulation. Clean-grade male Sprague-Dawley(SD) rats were randomly divided into four groups: a normal group(NG), a model group(MG), an electroacupuncture group(EA), and a glial cell inhibitor group(FCA). Bilateral EA(2/100 Hz, 1 mA, 30 min) was administered at the Tianshu(ST25) and Shangjuxu(ST37) in week 6. Abdominal withdrawal reflex(AWR) scores were used to assess the behavioral response associated with visceral hyperalgesia, while hematoxylin-eosin staining was employed to evaluate pathological changes in the colon. The protein and mRNA levels of glial fibrillary acidic protein(GFAP) in the colon and colon-related dorsal root ganglion(DRG) were analyzed using immun-ofluorescence, immunohistochemistry, Western blotting, real-time polymerase chain reaction. The impact of EA on electrophysiological properties of colon-related DRG neurons was observed through whole-cell patch clamp analysis. RESULTS: EA significantly reduced the visceral pain behavior scores in rats with IBS in response to graded(20, 40, 60, 80 mm Hg) CRD stimulation. Additionally, EA downregulated the protein and mRNA expression levels of GFAP in the colon and colon-related DRG of rats with IBS. EA also regulated the resting membrane potential, rheobase and action potential of colon-related DRG neurons in rats with IBS. CONCLUSIONS: EA can regulate the excitatory properties of colon-related DRG neurons by downregulating the protein and mRNA expression of GFAP in the colon and colon-related DRG, indicating a potential neurobiological mechanism by which EA relieves visceral hypersensitivity in rats with IBS.

关键词： electroacupuncture glial fibrillary acidic proteinSupporting information irritable bowel syndrome satellite glial cell visceral hypersensitivity

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媒介与叙事:理解“经典性”的一种跨媒介视角

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浙江社会科学 2024年第5期 136-144,160,F0003页

作者：翁再红南京艺术学院艺术研究院南京210013

艺术经典作为一种特殊的历史流传物,皆由某种特定的物质材料或精神符号承载,经典建构因此在本质上也涉及文本传播问题。文本借助不同的媒介建构了差异性的文化生态,其媒介层面的表征是构成文本经典性的重要标志。以此为据,本文从“经典... 详细信息

艺术经典作为一种特殊的历史流传物,皆由某种特定的物质材料或精神符号承载,经典建构因此在本质上也涉及文本传播问题。文本借助不同的媒介建构了差异性的文化生态,其媒介层面的表征是构成文本经典性的重要标志。以此为据,本文从“经典性”概念入手,逐层梳理了其与媒介合法性、跨媒介叙事、故事世界建构之间的辩证关系。媒介之于经典的基础作用由此可以得到必要说明;经典化历程所隐含的媒介辩证法也将得到有效揭示。文本经典地位的确立,既以其在历史流传过程中不断突破原有媒介的本真性、走向高度融合的跨媒介性为关键表征,又是借助跨媒介叙事所建构的故事世界、通过叙事元素叠加和形象谱系建构而不断得到强化的。

关键词：经典经典性跨媒介性跨媒介叙事故事世界

Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zhu S.M.weng P.Li X.F.Li H.Ai H.R.Pan Z.M.Sheng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of China Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(THz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or THz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or THz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and THz spectral ranges.

关键词： laser ultrashort photon

历史记忆与文学叙事之间——论莫迪亚诺《多拉·布吕代》的记忆文化建构

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外国文学研究 2024年第2期46卷 109-123页

作者：翁冰莹深圳大学外国语学院

《多拉·布吕代》是诺贝尔文学奖法国作家帕特里克·莫迪亚诺历十年之功而写就的代表力作。莫迪亚诺以记忆的艺术手法,追述了以“他者”即多拉·布吕代这一平凡弱小的历史人物为代表的犹太人在第二次世界大战法国被占领时期的人生经历,... 详细信息

《多拉·布吕代》是诺贝尔文学奖法国作家帕特里克·莫迪亚诺历十年之功而写就的代表力作。莫迪亚诺以记忆的艺术手法,追述了以“他者”即多拉·布吕代这一平凡弱小的历史人物为代表的犹太人在第二次世界大战法国被占领时期的人生经历,从而深刻揭示了难以捉摸的人类命运和一段被模糊化的历史。莫迪亚诺《多拉·布吕代》的记忆文化建构具体呈现在历史碎片的积淀与文学创作的契机、历史文本的整合与文学文本的映射、历史记忆的呈现与文学书写的勾连之中。处在历史记忆与文学叙事的间性结构下,莫迪亚诺形成了以新历史主义式的文学创作为通路的记忆文化建构。

关键词：莫迪亚诺《多拉·布吕代》历史记忆文学叙事记忆文化建构

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应对数字经济的增值税法完善

法学家 2024年第2期 113-129,194,195页

作者：翁武耀中国政法大学民商经济法学院

我国已经进入数字经济时代,面对具有去物理化、虚拟化、移动化、碎片化、全球化等特征的数字经济交易,增值税法律制度已经面临适用上的极大挑战。总体上,为解决数字经济交易的概念界定尚不明确和周延、与传统经济交易间存在不合理的差... 详细信息

我国已经进入数字经济时代,面对具有去物理化、虚拟化、移动化、碎片化、全球化等特征的数字经济交易,增值税法律制度已经面临适用上的极大挑战。总体上,为解决数字经济交易的概念界定尚不明确和周延、与传统经济交易间存在不合理的差别待遇、消费地征税原则下实施地有待明确和细化、征管措施不健全以及国际双重征税或不征税等问题,增值税法完善应当贯彻中性原则,以实现数字经济交易征税的确定性、高效、公平和简化为目标,并与其他国家和地区应对数字经济的增值税法相协调。具体建议包括对数字经济交易统一界定并命名为销售电子化服务,统一适用6%的低税率,明确消费地征税原则并扩大适用到国内数字经济交易,对消费所在地的确定标准基于数字经济特点进行细化,对跨境数字经济交易或者取消来源地征税或者扩大适用零税率的范围,引入现代化的一站式增值税征管系统,等等。

关键词：数字经济电子化服务中性原则消费地征税征管现代化