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Journal of Materials Science & Technology 2021年第11期70卷 156-167页

作者： Xiaojie Zhou Yuan Yao Jian Zhang Xiaomin Chen Weiying Huang Jing Pan Haoran Wang maopeng weng Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha410114China

A high-performance Mg-4.9Gd-3.2Y-1.1Zn-0.5Zr alloy has been fabricated by multidirectional forging(MDF)after analyzing its compression behavior.The as-homogenized alloy exhibits a high activation energy Q of deformation(~285 kJ/mol).The size of DRXed grains after compression tends to decrease as the Z-H parameter(Z)increases,showing a grain size exponent m of~4.0.Lamellar LPSO phases,kinking deformation,and bimodal microstructure are detected at the relatively low compression temperature of 350 and 400℃,while sufficient DRX can be achieved at 500℃,accompanied by the dissolution of lamellar LPSO.According to the processing maps,MDF was successfully conducted under an appropriate condition.After peak-aged at 200℃for 78 h,the MDFed billet exhibits a tensile yield strength(TYS)of 331 and 305 MPa at room temperature and 200℃,respectively.The high strength mainly results from the combination of fine grains,low Schmid factor for basal slip,sufficientβ’ageing precipitates,and directionally arranged interdendritic LPSO phases,etc.This paper provides a feasible way for the fabrication of high-performance,low-RE-content,and large-scale Mg components for industrial production.

关键词： Mg-Gd-Y-Zn-Zr Deformation behavior Activation energy Forge Dynamic recrystallization Mechanical properties

Advancements in personalized stem cell models for aging-related neurodegenerative disorders

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Neural Regeneration Research 2024年第11期19卷 2333-2334页

作者： Mingxi weng Ralf Jauch School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Translational Stem Cell Biology Hong Kong Special Administrative RegionChina

Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.As a result,patients often experience a decline in mobility,sensation,memory,and cognition,which can ultimately lead to a fatal outcome.The global incidence of NDDs,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,amyotrophic lateral sclerosis(ALS),and multiple sclerosis,is increasing.

关键词： degenerative Huntington sensation

Vector Radiative Transfer in a Vertically Inhomogeneous Scattering and Emitting Atmosphere.PartⅠ:A New Discrete Ordinate Method

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Journal of Meteorological Research 2024年第2期38卷 209-224页

作者： Ziqiang ZHU Fuzhong weng Yang HAN Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081 University of Chinese Academy of Sciences Beijing 100049 CMA Earth System Modeling and Prediction Centre China Meteorological Administration(CMA)Beijing 100081 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081

The original vector discrete ordinate radiative transfer(VDISORT)model takes into account Stokes radiance vector but derives its solution assuming azimuthal symmetric surface reflective matrix and atmospheric scattering phase matrix,such as the phase matrix derived from spherical particles or randomly oriented non-spherical particles.In this study,a new VDISORT is developed for general atmospheric scattering and boundary conditions.Stokes vector is decomposed into both sinusoidal and cosinusoidal harmonic modes,and the radiance at arbitrary viewing geometry is solved directly by adding two zero-weighted points in the Gaussian quadrature scheme.The complex eigenvalues in homogeneous solutions are also taken into full consideration.The accuracy of VDISORT model is comprehensively validated by four cases:Rayleigh scattering case,the spherical particle scattering case with the Legendre expansion coefficients of 0th-13th orders of the phase matrix(hereinafter L13),L13 with a polarized source,and the randomoriented oblate particle scattering case with the Legendre expansion coefficients of 0th-11th orders of the phase matrix(hereinafter L11).In all cases,the simulated radiances agree well with the benchmarks,with absolute biases less than 0.0065,0.0006,and 0.0008 for Rayleigh,unpolarized L13,and L11,respectively.Since a polarized bidirectional reflection distribution function(pBRDF)matrix is used as the lower boundary condition,VDISORT is now able to handle fully coupled atmospheric and surface polarimetric radiative transfer processes.

关键词： radiative transfer discrete ordinate polarization Stokes vector vector discrete ordinate radiative transfer(VDISORT)

Intracellular RNA Labeling Technologies for the Analysis of RNA Biology

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Chinese Journal of Chemistry 2024年第7期42卷 790-801页

作者： Ruiqi Zhao Xin Fang Xiaocheng weng Department of Clinical Laboratory Center for Gene DiagnosisDepartment of NeurosurgeryZhongnan Hospital of Wuhan UniversityWuhanHubei 430071China College of Chemistryand Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of EducationWuhan UniversityWuhan Hubei 430072China

As a cornerstone of the central dogma of molecular biology,RNA plays vital roles in living organisms.Over the past few decades,many RNA labeling technologies have been developed to elucidate the biological function of RNA.These technologies have signifi-cantly advanced our understanding of RNA secondary structure,localization,and turnover.Additionally,taking advantage of these innovative RNA labeling approaches,plenty of tool kits have been devised for the regulation of RNA-related biological process,such as gene expression and gene editing.In this review,we primarily focus on an array of intracellular RNA labeling methods,encom-passing chemical probes-based labeling,metabolic labeling,and proximity-dependent labeling.We also provide a brief overview of their applications in the research of RNA biology.Finally,the perspectives of RNA labeling are also discussed.

关键词： RNA Chemical probes Metabolic labeling Proximity-dependent labeling RNA structures Gene sequencing RNA recognition

Comparison of tropical cyclone thermal structures derived from ATMS and synthetic AMSU-A/MHS

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Atmospheric and Oceanic Science Letters 2024年第4期17卷 29-34页

作者： Wenyu Li Fuzhong weng Chinese Academy of Meteorological Sciences BeijingChina Center for Earth System Modeling and Prediction of CMA BeijingChina

热带气旋(TC)的暖心反映了其强度和变化.微波探测数据被广泛用于探测TC暖心,但观测到的TC暖心强度可能因仪器而异.本研究利用先进技术微波探测仪(ATMS)的过采样数据重采样至与先进微波探测仪(AMSU-A)一致的亮温,称为类AMSU数据.通过对... 详细信息

热带气旋(TC)的暖心反映了其强度和变化.微波探测数据被广泛用于探测TC暖心,但观测到的TC暖心强度可能因仪器而异.本研究利用先进技术微波探测仪(ATMS)的过采样数据重采样至与先进微波探测仪(AMSU-A)一致的亮温,称为类AMSU数据.通过对比发现,ATMS的观测更加细致,较好地刻画了TC眼区和云带.使用ATMS和类-AMSU数据反演多个TC的暖心发现,在250 hPa,使用ATMS数据反演的暖心强度比类-AMSU高约1-2K,并且其暖心结构更详细.

关键词：热带气旋暖心 ATMS AMSU-A 微波探测数据

Mass transfer in heap leaching of weathered crust elution deposited rare earth ore with Al_(2)(SO_(4))_(3) solution

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Journal of Rare Earths 2024年第6期42卷 1175-1181,I0007页

作者： Jingqun Yin Dedong Zeng Jun Tian Yaqing weng Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang330096China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang330031China

In order to increase efficiency and avoid NH^(4+)-N pollution in the leaching process of weathered crust elution-deposited rare earth ores,the mass transfer in heap leaching with Al_(2)(SO_(4))_(3) solution was simulated with column elution and experimentally optimized.The results indicate that the leaching yield is also up to 99%for leaching with aluminum sulfate instead of ammonium sulfate.The optimal flow rate is 60 mL/h,the height equivalent to a theoretical plate(HETP)is 1.29 mm correspondingly.The peak value position of RE^(3+)is 60 mL/h,Fe^(3+)is 100 mL/h,however,Al^(3+)is 150 mL/h,and the heap leaching process has kinetic separation effect.

关键词： Raree arths Mass transfer Process optimization Heapleaching Weathered crust elution-deposited rare earth ore

When Glanzmann thrombasthenia encounters antithrombin defi ciency: how do we balance the risk and benefi t of antithrombotic therapy?

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World Journal of Emergency Medicine 2024年第1期15卷 67-69页

作者： Yu Wang Zhihao Liu Haoyu weng Jianping Li Department of Endocrinology Peking University First HospitalBeijing 100034China Department of Cardiology Peking University First HospitalBeijing 100034China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100034China

Glanzmann’s thrombasthenia(GT)is an inherited autosomal recessive bleeding disorder,resulting from mutations in the ITGA2B and ITGB3 genes,that lead to a defect in the platelet membrane integrinαIIbβ3.[1]As integrinαIIbβ3 plays an important role in thrombus formation,the clinical manifestation of GT includes bleeding(mostly mucocutaneous)and purpura.For this reason,patients with GT are typically thought to be unlikely to suffer from thromboembolic incidents.Antithrombin is an anticoagulant that inhibits thrombin and is activated factor X and other serine proteases in the coagulation cascade.[2]Antithrombin deficiency is an autosomal dominant hereditary disease with an approximate prevalence of 1/500 in the overall population.[3]In contrast to the hemorrhagic tendency of GT,patients with antithrombin deficiency are at increased risk of thromboembolism,especially in the venous system.Herein,we describe a rare case of GT and antithrombin deficiency coexisting in a single patient.Rivaroxaban was used for the treatment of pulmonary embolism(PE)and deep vein thrombosis(DVT).

关键词： thrombin throm bleeding

Cloud-Type-Dependent 1DVAR Algorithm for Retrieving Hydrometeors and Precipitation in Tropical Cyclone Nanmadol from GMI Data

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Advances in Atmospheric Sciences 2024年第3期41卷 407-419页

作者： Linjun HAN Fuzhong weng Hao HU Xiuqing HU School of the Environment China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre Beijing 100081China Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological Center(National Center for Space Weather)of CMABeijing 100081China

Understanding the structure of tropical cyclone(TC)hydrometeors is crucial for detecting the changes in the distribution and intensity of precipitation.In this study,the GMI brightness temperature and cloud-dependent 1DVAR algorithm were used to retrieve the hydrometeor profiles and surface rain rate of TC Nanmadol(2022).The Advanced Radiative Transfer Modeling System(ARMS)was used to calculate the Jacobian and degrees of freedom(△DOF)of cloud water,rainwater,and graupel for different channels of GMI in convective conditions.The retrieval results were compared with the Dual-frequency Precipitation Radar(DPR),GMI 2A,and IMERG products.It is shown that from all channels of GMI,rain water has the highest△DOF,at 1.72.According to the radiance Jacobian to atmospheric state variables,cloud water emission dominates its scattering.For rain water,the emission of channels 1–4 dominates scattering.Compared with the GMI 2A precipitation product,the 1DVAR precipitation rate has a higher correlation coefficient(0.713)with the IMERG product and can better reflect the location of TC precipitation.Near the TC eyewall,the highest radar echo top indicates strong convection.Near the melting layer where Ka-band attenuation is strong,the double frequency difference of DPR data reflects the location of the melting.The DPR drop size distribution(DSD)product shows that there is a significant increase in particle size below the melting layer in the spiral rain band.Thus,the particle size may be one of the main reasons for the smaller rain water below the melting layer retrieved from 1DVAR.

关键词： cloud-dependent 1DVAR hydrometeor precipitation GMI DPR

Wetting-drying effect on the strength and microstructure of cementphosphogypsum stabilized soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1049-1058页

作者： Lingling Zeng Xia Bian Jiaxing weng Tao Zhang College of Civil Engineering Zhejiang University of TechnologyHanzhou310014China Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou221116China Jiangsu Water Source Company Ltd.of the Eastern Route of the South-to-North Water Diversion Project Nanjing210000China Power China Zhongnan Engineering Corporation Limited Changsha410027China

Phosphogypsum has often been used as an effective and environmentally friendly binder for partial replacement of cement,improving the engineering properties of slurries with high water content.However,the influence of phosphogypsum on the physicomechnical properties of stabilized soil subjected to wettingedrying cycles is not well understood to date.In this study,the effect of phosphogypsum on the durability of stabilized soil was studied by conducting a series of laboratory experiments,illustrating the changes in mass loss,pH value and unconfined compressive strength(qu)with wettingdrying cycles.The test results showed that the presence of phosphogypsum significantly restrained the mass loss in the early stage(lower than the 4th cycle),which in turn led to a higher qu of stabilized soil than that without phosphogypsum.After the 4th cycle,a sudden increase in mass loss was observed for stabilized soil with phosphogypsum,resulting in a significant drop in qu to a value lower than those without phosphogypsum at the 6th cycle.In addition,the qu of stabilized soils correlated well with the measured soil pH irrespective of phosphogypsum content for all wettingedrying tests.According to the microstructure observation via scanning electron microscope(SEM)and X-ray diffraction(XRD)tests,the mechanisms relating the sudden loss of qu for the stabilized soils with phosphogypsum after the 4th wetting-drying cycle are summarized as follows:(i)the disappearance of ettringite weakening the cementation bonding effect,(ii)the generation of a larger extent of microcrack,and(iii)a lower pH value,in comparison with the stabilized soil without phosphogypsum.

关键词： Wetting-drying Phosphogypsum Microstructure Durability

Macrophage senescence in health and diseases

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1508-1524页

作者： Longling Wang Wenxiang Hong Hong Zhu Qiaojun He Bo Yang Jiajia Wang Qinjie weng Center for Drug Safety Evaluation and Research Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Nanhu Brain-Computer Interface Institute Hangzhou 311100China Taizhou Institute of Zhejiang University Taizhou 318000China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China

Macrophage senescence,manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype,has long been consid-ered harmful.Persistent senescence of macrophages may lead to maladaptation,immune dysfunction,and finally the development of age-related diseases,infections,autoimmune diseases,and malignancies.However,it is a ubiquitous,multi-factorial,and dynamic complex phenomenon that also plays roles in remodeled processes,including wound repair and embryogenesis.In this review,we summarize some general molecular changes and several specific biomarkers during macrophage senescence,which may bring new sight to recognize senescent macrophages in different conditions.Also,we take an in-depth look at the functional changes in senescent macrophages,including metabolism,autophagy,polarization,phagocytosis,antigen presentation,and infiltration or recruitment.Furthermore,some degenerations and diseases associated with senescent macrophages as well as the mechanisms or relevant genetic regulations of senescent macrophages are integrated,not only emphasizing the possibility of regulating macrophage senescence to benefit age-associated diseases but also has an implication on the finding of potential tar-gets ordrugs clinically.

关键词： Macrophages Senescence Molecular changes Functional alterations Aging tissues Age-associated diseases Drug treatment Genetic regulation