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Chinese Chemical Letters 2024年第4期35卷 382-388页

作者： Shiyu Hou maolin sun Liming Cao Chaoming Liang Jiaxin Yang Xinggui Zhou Jinxing Ye Ruihua Cheng School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Microchannels enable the fast and efficient mixing of multiphase *** this study, a millimeter-scale three-dimensional(3D) circular cyclone-type microreactor was designed for the *** flow characteristics and mixing intensity were simulated by computational fluid dynamics simulations at a flow rate range of 12–96 m L/min using a water/ethyl acetate *** the 3D variable-diameter structure,the microreactor induced paired opposite vortices and abruptly changed the local pressure to achieve a stable turbulent effect within the theoretical range of laminar *** injection simulations indicated that sufficient mixing units successfully promote fluid ***-coupling experiments showed a segregation index of X_S= 0.00,039 within a residence time of 9 *** experiments on the nbutanol/succinic acid/water system showed that the 3D circular cyclone-type microreactor achieved 100%extraction efficiency(E) in 4.25 s, and the overall volume mass transfer coefficient(K_La) reached 0.05–1.5s^(-1) in 12–96 m L/*** isolated yield of the phase transfer alkylation and oxidation reactions in the 3D circular cyclone-type microreactor achieved 99% within 36 s, which was superior to the coil microreactor and batch reactor.

关键词： Microfluidics Passive microreactor CFD simulation Extraction Liquid-liquid biphase reaction

A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate

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Chinese Chemical Letters 2024年第2期35卷 402-406页

作者： Liming Cao maolin sun Chaoming Liang Lei Yang Yueyue Ma Ruihua Cheng Yanxiong Ke Wei Yu Jinxing Ye Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Shanghai No.1 Biochemical& Pharmaceutical Co. Ltd.Shanghai 200080China

Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular *** traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable ***,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was *** acylation reaction was completed in a continuous coil reactor at 160℃ in 20 *** the high toxic solvent pyridine was replaced by ***,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer *** with the membrane phase separators,the residence time of the purification step was 30 *** isolated yield of this sequential continuous process was 92%with 99%purity.

关键词： Flow chemistry Calcium dibutyryladenosine cyclophosphate Continuous flow synthesis In-line purification 3D circular cyclone-type micromixer chip

Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor

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Chinese Chemical Letters 2024年第1期35卷 290-294页

作者： maolin sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Shanghai No.1 Biochemical&Pharmaceutical Co. Ltd.Shanghai 200080China

A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS *** constructed a telescoped two-step continuous flow *** involved a continuous tanshinone IIA sulfonation and in-line salt *** the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser *** to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal *** proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production.

关键词： Continuous flow Sodium tanshinone IIA sulfonate Cardiovascular Microreactor Green chemistry

铸膜液中水的含量对聚醚砜微滤膜结构和性能的影响

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膜科学与技术 2024年第3期44卷 67-72页

作者：孙茂林宋宗瑞何本桥李建新天津工业大学材料科学与工程学院省部共建分离膜与膜过程国家重点实验室天津300387 天津工业大学沧州研究院沧州061000

通过蒸汽诱导相分离(VIPS)耦合非溶剂诱导相分离(NIPS)制备窄孔径分布聚醚砜(PES)微滤膜。本研究以PES为成膜材料,聚乙二醇为致孔剂,以水作为添加剂制备微滤膜,探究了铸膜液中水的质量分数对VIPS阶段蒸汽暴露时间及微滤膜结构与性能的影... 详细信息

通过蒸汽诱导相分离(VIPS)耦合非溶剂诱导相分离(NIPS)制备窄孔径分布聚醚砜(PES)微滤膜。本研究以PES为成膜材料,聚乙二醇为致孔剂,以水作为添加剂制备微滤膜,探究了铸膜液中水的质量分数对VIPS阶段蒸汽暴露时间及微滤膜结构与性能的影响.结果表明,铸膜液中水的质量分数从0%增加到3%,相似孔结构的形成所需的蒸汽暴露时间从90 s降低到30 s.膜的表面由致密皮层转变为大孔结构,孔径从0.087μm增加到0.193μm,孔径分布显著变窄,水接触角从83.6°增加到113.2°,拉伸强度从1.86 MPa增加到3.85 MPa,断裂伸长率从7%增加到16%,膜的力学性能显著增强,同时膜的纯水渗透率从5840 L/(m^(2)·h·MPa)增加到42300 L/(m^(2)·h·MPa).这表明,少量水的添加显著缩短了VIPS蒸汽暴露时间,同时改善了微滤膜的结构和性能.

关键词： PES微滤膜水蒸汽诱导相分离水含量非稳态孔径分布

基于RBF神经网络的闭链下肢康复机器人自适应补偿控制

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机械传动 2024年第4期48卷 60-68页

作者：李东琦秦建军孙茂琳郑皓冉李伟北京建筑大学机电与车辆工程学院北京100044 北京市建筑安全监测工程技术研究中心北京100044 国家体育总局运动医学研究所北京100061

在下肢康复机器人的康复训练过程中,模型参数、环境干扰等不确定性因素会影响机器人轨迹跟踪的精度。针对这一问题,提出了一种基于径向基函数(Radial Basis Function,RBF)神经网络的自适应补偿控制,该控制方法能够提高机械系统轨迹跟踪... 详细信息

在下肢康复机器人的康复训练过程中,模型参数、环境干扰等不确定性因素会影响机器人轨迹跟踪的精度。针对这一问题,提出了一种基于径向基函数(Radial Basis Function,RBF)神经网络的自适应补偿控制,该控制方法能够提高机械系统轨迹跟踪的精确性。首先,设计一款具有4种工作模式、运动稳定的闭链卧式下肢康复机器人结构;然后,利用拉格朗日方法求解动力学名义模型,将康复装置的模型参数以及外界干扰等不确定性因素分离出来,并设计基于RBF神经网络的自适应补偿算法对其进行逼近控制;最后,通过Matlab/Simulink环境对其进行仿真验证,证明了该控制策略的有效性。结果显示,在人体步态曲线轨迹跟踪中,提出的基于RBF神经网络的自适应补偿算法相比传统的模糊比例-积分-微分(Proportional Integral Derivative,PID)控制的方法响应速度快、跟踪效果好,且髋关节和膝关节轨迹跟踪的角度误差峰值分别为0.08°和0.13°,远小于患者下肢在康复运动中的转动角度。设计了单腿样机试验,试验结果表明,采用的RBF补偿自适应控制器能够实现高精度的跟踪结果,也能够满足患者在康复训练中安全性的要求。

关键词：下肢康复机器人闭链结构 RBF神经网络不确定性自适应补偿控制

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铸牢中华民族共同体意识下高校体育教学的困境与突破、价值与担当

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当代体育科技 2024年第14期14卷 66-69页

作者：龙震张烈琴范江江孙茂林新疆科技学院新疆库尔勒841000

通过对当前高校体育发展的研究可知,高校体育发展所面临的主要困境有教学方法和模式的转变困难、教学过程难以监管、教学评估体系难以确定等。对此,研究得出适合高校体育发展的4点出路:改变传统的教学模式,应用课内课外“双线”教学模... 详细信息

通过对当前高校体育发展的研究可知,高校体育发展所面临的主要困境有教学方法和模式的转变困难、教学过程难以监管、教学评估体系难以确定等。对此,研究得出适合高校体育发展的4点出路:改变传统的教学模式,应用课内课外“双线”教学模式、丰富教学过程、优化教学评价体系,更注重学校体育的价值使命和责任担当;强化教学中学生的主体地位,通过多种途径,突破高校体育所面临的困境,从而促使高校体育高质量发展;教学中坚持健康第一的教育理念,培养学生的健全人格,担负起国家和社会人才培养的重任,培养学生养成终身体育锻炼的习惯,实现立德树人的总目标;学校体育作为教育的重要组成部分,具有教育价值、育人价值以及其特殊价值,担负着提高学生身体素质和促进身心健康发展的重要责任,通过学校体育教育,弘扬体育文化精神,厚植爱国主义情怀。

关键词：教学过程价值使命责任担当高校体育

Gas sensing selectivity of oxygen-regulated SnO2 films with different microstructure and texture

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Journal of Materials Science & Technology 2019年第10期35卷 2232-2237页

作者： Ruiwu Li Yanwen Zhou maolin sun Zhen Gong Yuanyuan Guo Xitao Yin Fayu Wu Wutong Ding School of Material Science and Metallurgy University of Science and Technology LiaoningAnshan114051China State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050China

The selectivity of gas sensing materials is increasingly important for their applications. The oxygenregulated SnO2 films with(110) and(101) preferred orientation were obtained through magnetron sputtering, followed by annealing treatment. Their micro-structure, surface morphology and gas response were investigated by advanced structural characterization and property measurement. The results showed that the as-prepared(110)-oriented SnO2 film was oxygen-rich and had more adsorption sites while the as-prepared(101)-oriented SnO2 film was oxygen-poor and more sensitive to de-oxidation.H2 gas sensitivity, response speed, selectivity between H2 and CO of the(110)-orientated SnO2 film was superior to that of the(101)-orientated SnO2 film. After treated at high temperature and high vacuum,the reduction of gas-sensing properties of the annealed(110) SnO2 film was much more than that of the annealed(101) SnO2 film. The lattice oxygen was responsible for the difference in gas-sensing response between(110) and(101)-oriented SnO2 films under oxygen regulation. This work indicated the gassensing selectivity of the different crystal planes in SnO2 film, providing a significant reference for design and extension of the related materials.

关键词： Gas sensor SnO2 Oxygen regulation Preferred orientation H2 selectivity

Review of the SiC LDMOS power device

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Journal of Semiconductors 2024年第8期45卷 4-17页

作者： Ziwei Hu Jiafei Yao Ang Li Qi sun Man Li Kemeng Yang Jun Zhang Jing Chen maolin Zhang Yufeng Guo College of Integrated Circuit Science and Engineering(Industry-Education Integration School) Nanjing University of Posts andT elecommunicationsNanjing 210023China National and Local Joint Engineering Laboratory of RF Integration and Micro-Assembly Technology Nanjing 210023China Nantong Institute of Nanjing University of Posts and Telecommunications Nantong 226000China

Silicon carbide(SiC),as a third-generation semiconductor material,possesses exceptional material properties that significantly enhance the performance of power *** SiC lateral double-diffused metal–oxide–semiconductor(LDMOS)power devices have undergone continuous optimization,resulting in an increase in breakdown voltage(BV)and ultra-low specific on-resistance(Ron,sp).This paper has summarized the structural optimizations and experimental progress of SiC LDMOS power devices,including the trench-gate technology,reduced surface field(RESURF)technology,doping technology,junction termination techniques and so *** paper is aimed at enhancing the understanding of the operational mechanisms and providing guidelines for the further development of SiC LDMOS power devices.

关键词： SiC LDMOS specific on-resistance breakdown voltage

手术机器人在人工全膝关节置换术中的应用及研究进展

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中国修复重建外科杂志 2021年第7期35卷 913-917页

作者：孙茂淋杨柳何锐陆军军医大学第一附属医院(西南医院)关节外科中心重庆400038

目的总结手术机器人在人工全膝关节置换术(total knee arthroplasty,TKA)中的应用及研究进展。方法查阅国内外相关文献,分析手术机器人辅助TKA(robotic-arm assisted TKA,RATKA)的优势及不足。结果TKA术中准确重建下肢力线和旋转对线、... 详细信息

目的总结手术机器人在人工全膝关节置换术(total knee arthroplasty,TKA)中的应用及研究进展。方法查阅国内外相关文献,分析手术机器人辅助TKA(robotic-arm assisted TKA,RATKA)的优势及不足。结果TKA术中准确重建下肢力线和旋转对线、精确截骨和植入假体对于提高疗效及延长假体寿命至关重要。传统TKA由于术者操作因素存在截骨偏差等问题,而RATKA在一定程度上解决了上述问题,能辅助精确截骨及植入假体、能更好地保护膝关节周围软组织。RATKA术后患者满意度高,且术者学习曲线较短、提高了手术效率,但也存在手术耗时延长、并发症增加、医疗成本提高等不足。结论初步临床应用研究显示RATKA疗效满意,但与传统TKA相比其确切优势尚待大样本随机对照研究和长期随访来验证。

关键词：手术机器人人工全膝关节置换术临床应用研究进展

3D打印导板改善人工全膝关节置换术中股骨旋转对线及髌骨轨迹的疗效研究

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中国修复重建外科杂志 2020年第3期34卷 335-340页

作者：孙茂淋杨柳何锐郝朋孙加伟陆军军医大学第一附属医院关节外科中心重庆400038

目的探讨人工全膝关节置换术(total knee arthroplasty,TKA)中采用3D打印导板辅助定位改善股骨旋转对线及髌骨轨迹的效果。方法选择2018年1月-10月60例(60膝)接受TKA治疗且符合选择标准的膝关节晚期骨关节炎患者作为研究对象,按照随机... 详细信息

目的探讨人工全膝关节置换术(total knee arthroplasty,TKA)中采用3D打印导板辅助定位改善股骨旋转对线及髌骨轨迹的效果。方法选择2018年1月-10月60例(60膝)接受TKA治疗且符合选择标准的膝关节晚期骨关节炎患者作为研究对象,按照随机数字表法分为两组,每组30例。导板组行3D打印导板辅助下TKA,对照组行传统TKA。两组患者性别、年龄、病程、侧别以及术前髋-膝-踝角(hip-knee-ankle angle,HKA)、股骨后髁角(posterior condylar angle,PCA)、髌骨横轴-股骨通髁线角(patella transverse axis-femoral transepicondylar axis angle,PFA)、美国特种医院(HSS)评分、美国膝关节协会(AKS)评分比较,差异均无统计学意义(P>0.05)。结果患者术后切口均Ⅰ期愈合,无手术相关并发症发生。两组患者均获随访,随访时间10~12个月,平均11个月。两组术后6个月HSS评分及AKS评分均较术前明显提高(P0.05)。术后X线片复查示假体位置良好,随访期间无假体松动、下沉等发生。两组术后10个月HKA、PCA、PFA均较术前明显改善(P<0.05);两组HKA比较差异无统计学意义(t=1.031,P=0.307);导板组PCA、PFA均明显小于对照组(P<0.05)。结论3D打印导板辅助TKA不仅能矫正膝关节畸形及减轻疼痛症状,还能达到股骨旋转对线准确、恢复良好髌骨轨迹的目标。

关键词： 3D打印技术导板人工全膝关节置换术下肢力线股骨旋转对线髌骨轨迹