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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Optimal Allocation of Fault Current Limiter in MMC-HVDC Grid Based on Transient Energy Flow

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CSEE Journal of Power and Energy Systems 2023年第5期9卷 1786-1796页

作者： Meiqin mao Hui Lu Dejian cheng Zhuang He Research Centre for Photovoltaic System Engineering.MOE Hefei University of TechnologyHefei 230009China

Economical and reliable protection of DC-side shortcircuit faults has become a key technology for promoting the development of module multilevel converters based on the high voltage direct current grid(MMC-HVDC-Grid).The fault current limiter(FCL)can effectively suppress the rapid development of the fault current and reduce the current breaking capacity of the circuit *** this paper,a method based on transient energy flow(TEF)analysis is proposed to optimize the allocation of a resistive and inductive FCL in the *** the proposed method,the electromagnetic TEF is measured first,and then,the TEF suppression rate and suppression efficiency are defined as optimization objectives,and the installation location of the FCL and its impedance parameters as optimization *** test the proposed method,two-terminal and four-terminal bipolar MMC-HVDC-Grids with single-pole-to-ground DC faults are modeled in the PSCAD/EMTDC so that the TEF data can be *** optimal FCLs’location and parameter values are determined through investigating the evolution paradigm of TEF along with changes of the FCL position and *** results prove that the selected parameters can effectively slow down the DC fault current rising rate,thus reducing the requirements on tripping current of the DC breakers.

关键词： MMC-HVDC-Grid TEF FCL DC fault protection optimal allocation

Modelling the formation and dissolution behavior of alumina agglomerate in the cryolite

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Particuology 2024年第3期86卷 211-222页

作者： Jiaqi Wang mao Li Benjun cheng Hesong Li School of Energy Science and Engineering Central South UniversityChangsha410083China

The presence of alumina agglomerates seriously affects the current efficiency of the aluminum electrolysis *** the dynamic dissolution process of agglomerates is essential to improve the current efficiency of aluminum electrolysis.A mathematical model is proposed to describe the different phenomena from the formation until complete dissolution of *** permeation and solidification processes of cryolite,a semi-analytical mathematical model is developed to formulate the formation,melting and dissolution processes of agglomerates,and the time duration for each stage is *** and heat mass transfer of agglomerates are explored based on the packing theory and mechanism of heat mass transfer in wet porous *** approach is applied to investigate the main factors affecting the dissolution stages and porosity of *** results show that the superheat has a great influence on the formation and melting stage,the diameter of agglomerates can reach 14.93 mm for 200 particles *** density decreases with the increase of agglomerated particle number,which varies in the range of 2.27-2.28 g/cm^(3).The average dissolution rate of agglomerates is about 1.83×10^(-5)-2.95×10^(-5) kg/s within the range of alumina concentration in this study.

关键词： Mathematical model Alumina agglomerate Porous media Packing theory Heatand mass transfer

Transcription factor networks involved in cell death in the dorsal root ganglia following peripheral nerve injury

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Neural Regeneration Research 2018年第9期13卷 1622-1627页

作者： Jing Qin Jian-cheng Wu Qi-Hui Wang song-Lin Zhou Su-Su mao Chun Yao Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong University Department of Pathological Anatomy Nantong University

The peripheral nervous system has the potential to regenerate after nerve injury owing to the intrinsic regrowth ability of neurons and the permissive *** regenerative process involves numerous gene expression changes,in which transcription factors play a critical ***,we profiled dysregulated genes in dorsal root ganglion neurons at different time points（0,3 and 9 hours,and 1,4 and 7 days） after sciatic nerve injury in rats by RNA *** the present study,we investigated differentially expressed transcription factors following nerve injury,and we identified enriched molecular and cellular functions of these transcription factors by Ingenuity Pathway *** analysis revealed the dynamic changes in the expression of transcription factors involved in cell death at different time points following sciatic nerve *** addition,we constructed regulatory networks of the differentially expressed transcription factors in cell death and identified some key transcription factors（such as STAT1,JUN,MYC and IRF7）.We confirmed the changes in expression of some key transcription factors（STAT1 and IRF7） by quantitative reverse transcription-polymerase chain ***,our analyses provide a global overview of transcription factor changes in dorsal root ganglia after sciatic nerve injury and offer insight into the regulatory transcription factor networks involved in cell death.

关键词： nerve regeneration cell death transcription factors dorsal root ganglia neurons peripheral nerve injury sciatic nerve ingenuitypathway analysis Cytoscape bioinformatics analysis STAT1 IRF7 neural regeneration

Experimental investigation on pressure-buildup characteristics of a water lump immerged in a molten lead pool

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Nuclear Science and Techniques 2023年第3期34卷 25-39页

作者： Zi-Jian Deng song-Bai cheng Hui cheng Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China

Motivated to understand the pressure-buildup characteristics in a circumstance of a water droplet immerged inside a heavy liquid metal pool,which is a key phenomenon during a Steam Generator Tube Rupture accident of Lead-cooled Fast Reactor,many experiments have been conducted by injecting water lumps into a molten lead pool at Sun Yat-sen *** order to deepen the understanding of the influence of melt material,this lead experiment was compared with a Lead-Bismuth-Eutectic(LBE)experiment in the *** both experiments,a steam explosion occurred in a small part of the experi-mental runs,which generally leads to strengthened pressure *** the non-explosion experimental cases,the impact of all parameters employed in lead experiments(i.e.,water lump volume,water lump shape,molten pool depth,and temperature of water and melt)on the pressure buildup is non-negligible and similar to that in our previous experiments using ***,limited pressure buildup with an increase in water lump volume was also observed.A slightly more violent pressure buildup tends to appear in the lead experiments than in the LBE experiments under the same experimental conditions,which may be due to the higher thermal conductivity of lead than of *** a few experimental runs with a relatively low melt temperature close to the melting point of lead,local solidification of liquid lead was observed,restricting pressure *** the lead and LBE experiments,the calculated melt kinetic energy conversion efficiencyηhas a relatively small value(not exceeding 1.6%),and theηvalues have an overall positive correlation with the impulse on the molten pool.

关键词： Lead-cooled fast reactor Steam generator tube rupture accident Pressure-buildup characteristics Experimental study Melt material

Electrical control goes to topological antiferromagnets

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Science China(Physics,Mechanics & Astronomy) 2020年第11期63卷 131-132页

作者： cheng song Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Ferromagnets play an important role in our daily lives,in such common devies as:compasses,electric motors and hard *** a long time,the antiferromagnetic(AFM)materials have been ignored for the *** the Nobel laureate ... 详细信息

关键词： topological magnets antiferromagnet

Grating lobes suppression method for stepped frequency GB-SAR system

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Journal of Systems Engineering and Electronics 2014年第6期25卷 987-995页

作者： Tao Zeng Cong mao cheng Hu mao Zhu Weiming Tian Jingjing Ren School of Information and Electronics Beijing Institute of Technology China Academy of Space Technology (CAST)

A grating lobes suppression method for chirp-subpulse stepped frequency（CSSF） signals is proposed, which is applied to deformation monitoring using the ground based synthetic aperture radar（GB-SAR） system. This method is based on accurate estimation and correction of the phase and amplitude error along two dimensions（range and azimuth）, i.e., the error estimation inside the subpulse（in-subpulse error） and across the stepped frequency subpulses（cross-subpulse error） of transmitted CSSF signals. Validated both with simulated data and experimental data recorded in the deformation monitoring campaign, it can be seen that the method as well as the relative conclusions can be fully and effectively applied to most of the stepped frequency systems.

关键词： chirp-subpulse stepped frequency signal(CSSF) sup-pression of grating lobes ground based synthetic aperture radar differential interferometer SAR error analysis

Moduli of Continuity of a Class of N-parameter Gaussian Processes and Their Fast Points

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Acta Mathematica Sinica,English Series 2008年第6期24卷 901-910页

作者： Zheng Yan LIN Zong mao cheng Department of Mathematics Zhejiang University Hangzhou 310028 P. R. China Institute of Applied Mathematics and Engineering Computation Hangzhou Dianzi University Hangzhou 310018 P. R. China

We study the moduli of continuity of a class of N-parameter Gaussian processes and get some results on＇the packing dimension of the set of their fast points.

关键词： N-parameter Gaussian process modulus of continuity limsup random fractal packing dimension

Achieving both high reversible and stable Zn anode by a practical glucose electrolyte additive toward highperformance Zn-ion batteries

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Rare Metals 2022年第2期41卷 356-360页

作者： Ming song cheng-Lin Zhong College Materials and Chemical Engineering Xuzhou University of TechnologyXuzhou 221018China College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China

Aqueous Zn-ion batteries(ZIBs)featuring safety,affordability and high energy density may provide a promising solution to the demand for better energy storage *** with high electrochemical performances rely on a stable and reversible Zn metal negative *** side reactions such as the hydrogen evolution reaction(HER)at the anode-electrolyte interface are responsible for the low reversibility,and uneven Zn deposition/dissolution gives rise to the instability of Zn ***,a facile and scalable method of regulating electrolytes has been proposed by Chao and his co-works through adding a lowcost,safe and environmentally-friendly electrolyte additive:*** calculations and experimental studies reveal that the glucose not only suppresses side reactions by modulating the solvated shell of Zn^(2+)but also homogenizes Zn deposition/dissolution through forming a special local absorption *** bi-functional electrolyte additive endows the Zn anode with both high reversibility and stability,which efficiently improves the performances of *** work explores a promising electrolyte strategy for realizing the large-scale application of ZIBs.

关键词： electrolyte additive anode