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Effects of epidermal growth factor receptor inhibitor on proliferative cholangitis in hepatolithiasis

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 509-515页

作者： Qin yang Yong Zhou Fu-Yu Li Hui mao Anuj Shrestha Wen-Jie Ma Nan-sheng Cheng Wei Zhang Department of Hepatobiliary Surgery West China Hospital of Sichuan University Department of Medicine The George Washington University

BACKGROUND： There is currently no effective medication to prevent stone recurrence after choledochoscopic lithotomy or to treat proliferative cholangitis（PC）, which is the pathologic basis of hepatolithiasis. This study aimed to investigate whether gefitinib, an epidermal growth factor receptor（EGFR） inhibitor, inhibited cholangio hyperplasia and lithogenesis in ***： After cholangioscopic lithotomy, indwelling catheters were placed in the diseased bile duct lumens in 94 patients with hepatolithiasis. Subsequently, 49 of the 94 patients were treated with 250 mg gefitinib solution via a catheter twice a week, and they were subjected to choledochoscopic biopsy at 6 and 12 weeks. The rest 45 hepatolithiasis patients without gefitinib treatment served as ***： The expressions of EGFR, PCNA and procollagen I were significantly reduced in the patients treated with gefitinib in 12 weeks compared with those in the control group. Patients in the gefitinib group had a much lower degree of hyperplasia of the biliary epithelium, submucosal glands and collagen fibers compared with those in the control group. Gefitinib treatment significantly decreased mucin 3 expression and β-glucuronidase ***： Postoperative gefitinib treatment could significantly inhibit PC-mediated hyperplasia and lithogenesis, which might provide a novel strategy for the prevention of biliary restenosis and stone recurrence in patients with hepatolithiasis.

关键词： hepatolithiasis proliferative cholangitis epidermal growth factor receptor blockade recurrence restenosis prevention

Enhanced Synchronization of Intercellular Calcium Oscillations by Noise Contaminated Signals

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Communications in Theoretical Physics 2008年第10期50卷 903-906页

作者： ZHANG Ji-Qian CHEN Han-Shuang WANG mao-sheng College of Physics and Electronic Information Anhui Normal University Wuhu 241000 China

We consider the dynamics of locally coupled calcium oscillation systems,each cell is subjected to extracel-lular contaminated signal,which contains common sub-threshold signal and independent Gaussian *** is found thatintermediate noise can enhance synchronized oscillations of calcium ions,where the frequency of noise-induced oscilla-tions is matched with the one of sub-threshold external *** show that synchronization is enhanced as a result ofthe entrainment of external signal Furthermore,the effect of coupling strength is *** find above-mentionedphenomenon exists only when coupling strength is very *** findings may exhibit that noise can enhance thedetection of feeble external signal through the mechanism of synchronization of intercellular calcium ions.

关键词： synchronization noise coupled oscillators random processes

Multidimensional amphibian diversity and community structure along a 2600 m elevational gradient on the eastern margin of the Qinghai-Tibetan Plateau

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Zoological Research 2022年第1期43卷 40-51页

作者： Xiao-Yi Wang mao-Jun Zhong Jian Zhang Xing-Feng Si sheng-Nan yang Jian-Ping Jiang Jun-Hua Hu Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduSichuan 610065China Zhejiang Tiantong Forest Ecosystem National Observation and Research Station School of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China University of Chinese Academy of Sciences Beijing 100049China

Mountain systems harbor an evolutionarily unique and exceptionally rich biodiversity,especially for ***,the associated elevational gradients and underlying mechanisms of amphibian diversity in most mountain systems remain poorly ***,we explored amphibian phylogenetic and functional diversity along a 2600 m elevational gradient on Mount Emei on the eastern margin of the Qinghai-Tibetan Plateau in southwestern *** also assessed the relative importance of spatial(area)and environmental factors(temperature,precipitation,solar radiation,normalized difference vegetation index,and potential evapotranspiration)in shaping amphibian distribution and community *** showed that the phylogenetic and functional diversities were unimodal with elevation,while the standardized effect size of phylogenetic and functional diversity increased linearly with *** net relatedness,nearest taxon index,and functional net relatedness index all showed a positive to negative trend with elevation,indicating a shift from clustering to overdispersion and suggesting a potential change in key processes from environmental filtering to competitive ***,our results illustrate the importance of deterministic processes in structuring amphibian communities in subtropical mountains,with the dominant role potentially switching with *** study provides insights into the underlying assembly mechanisms of mountain amphibians,integrating multidimensional diversity.

关键词： Community structure Elevational gradient Environmental filtering Functional and phylogenetic diversity Mountain systems

The current status of multivisceral transplantation

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 345-350页

作者： mao, Qi Li, You-sheng Li, Jie-Shou Nanjing Univ Sch Med Jinling Hosp Res Inst Gen Surg Nanjing 210002 Peoples R China

BACKGROUND: Multivisceral transplantation (MVTx) is concurrent transplantation of the stomach, spleen, pancreaticoduodenal complex, and intestine, with (MVTx) or without (modified MVTx) the liver. MVTx has been performed more frequently worldwide, and the survival of patients approximates that of patients who have undergone transplantation of other solid organs. This review introduces the recent development in MVTx. DATA SOURCES: Two English-language medical databases, MEDLINE and SPRINGERLINK, were searched for articles on 'multivisceral transplantation', graft procurement', 'immunosuppression,' and related topics. RESULT: MVTx has been the optimal therapy for the intestine with liver failure and/or failure of several other organs, despite many difficulties in preventing rejection and infection. CONCLUSION: Further study is needed to improve the long-term survival of recipients and reduce the complications.

关键词： multivisceral transplantation immunosuppression graft procurement abdominal wall

Is Acupressure Useful for Alleviating Hyperventilation Syndrome?

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Chinese Journal of Integrative Medicine 2019年第6期25卷 468-470页

作者： ZENG Rui-xiang CHEN mao-sheng ZHANG Min-zhou Division of Chest Pain Center Guangdong Provincial Hospital of Chinese Medicinethe 2nd Clinical College of Guangzhou University of Chinese Medicine

Case Report On April 23, 2017, a plane was flying from Hefei to Guangzhou in China. About 20 min after takeoff, a 30-year-old female passenger suddenly had on set of face redde ned all over, breathless ness, dyspnoea, palpitation and chest pain. Fortunately, two doctors came over to give help, one is Prof. Zhang, a cardiovascular specialist, the other one is Prof. Tan, a cardiovascular surgery specialist. After inquiring symptoms, two doctors believed that the woman had no organic abnormalities according to several medical examinations before, and once had a similar attack.

关键词： Acupressure Useful Alleviating Hyperventilation Case Report

International carbon markets under the Paris Agreement:Basic form and development prospects

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Advances in Climate Change Research 2019年第1期10卷 21-29页

作者： GAO Shuai LI Meng-Yu DUAN mao-sheng WANG Can State Key Joint Laboratory of Environment Simulation and Pollution Control(SKLESPC) and School of EnvironmentTsinghua UniversirBeiying100084China Institute of Energy Environment and EconomyTsinghua UniversityBeijing100084China

Article 6 of the Paris Agreement introduces two international carbon markets that receive extensive attention and are expected to play an important role in the post-2020 climate *** key elements of the two international carbon markets,including the scope,the types of tradable units and the governance,are identified,as the basis to clarify their basic *** on the key issues and their different designs identified in negotiations,this study analyzes the contributions and challenges for China to participate in international carbon *** the inherent needs of climate change mitigation,climate finance,the development of a green"Belt and Road"and the China South-South cooperation in climate change,along with the existing domestic capacities on market mechanisms,this study puts forward the short-,medium-and long-term development prospects of the two international carbon markets.

关键词： Paris Agreement International carbon markets Cooperative approaches Sustainable development mechanism Climate change

Metal-free Optical Pressure Sensor with High Sensitivity and Extensive Range

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1291-1300页

作者： mao Ji Meng Huang Haomin Lyu sheng Shi Bo Qi Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China IEEE CSEE

Pressure monitoring of a transformer oil tank can grasp the pressure change process caused by gas production when severe internal defects occur and take timely measures to ensure the safe operation of the *** pressure sensors generally use metal encapsulation or have an air cavity structure,threatening the transformer’s insulation if it is directly used inside the *** this end,this paper proposes a method for developing a high-sensitivity,large-range,and metallizationfree optical pressure sensing device with temperature *** grating is encapsulated by fluorosilicone rubber and supplemented by an epoxy resin shielding shell on the *** the same time,a double-grating vertical arrangement is adopted to improve pressure measurement sensitivity,further avoiding the influence of temperature rise caused by a defect of the transformer on the measurement result of the *** addition,by optimizing the geometric structure of the internal sensitizing element,pre-stretching length of the fiber grating,gap distance,and other parameters,probe size can be reduced while ensuring the sensor’s *** show the proposed method can meet the requirements of sensor fabrication with different sensitivities and ranges,and to a certain extent,both high sensitivity and extensive ranges can be taken into *** sensitivity of the fabricated prototype is 15 pm/kPa,and the range is about 0.2 *** the same time,the metal-free feature of the sensor makes it suitable for use in various oil-immersed power *** records oil pressure changes caused by oil discharge breakdown,making it sensitive to small pressure changes in early failures.

关键词： Highly sensitive extensive range optical sensing no metallization pressure perception temperature compensation transformer

Unbalanced private set intersection with linear communication complexity

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Science China(Information Sciences) 2024年第3期67卷 79-93页

作者： Quanyu ZHAO Bingbing JIANG Yuan ZHANG Heng WANG Yunlong mao sheng ZHONG Department of Computer Science and Technology Nanjing University Purple Mountain Lab

The private set intersection(PSI) protocol allows two parties holding a set of integers to compute the intersection of their sets without revealing any additional information to each other. The unbalanced PSI schemes consider a specific setting where a client holds a small set of the size n and a server holds a much larger set of the size m(n ■ m). The communication overhead of state-of-the-art balanced PSI schemes is O(m + n) and the unbalanced PSI schemes are O(nlogm). In this paper, we propose a novel secure unbalanced PSI protocol based on a hash proof system. The communication complexity of our protocol grows only linearly with the size of the small set. In other words, our protocol achieves communication overhead of O(n). We test the performance on a personal computer(PC) machine with a local area network(LAN)setting for the network. The experimental results demonstrate that the client only takes 2.01 s of online computation, 4.27 MB of round trip communication to intersect 1600 pieces of 32-bit integers with 220pieces of 32-bit integers with the security parameter λ = 512. Our protocol is efficient and can be applied to resource-constrained devices, such as cell phones.

关键词： unbalanced private set intersection Hash proof system linear communication complexity small set resource-constrained devices

Extracellular magnetic labeling of biomimetic hydrogel-induced human mesenchymal stem cell spheroids with ferumoxytol for MRI tracking

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Bioactive Materials 2023年第1期19卷 418-428页

作者： Sen Yan Ke Hu Miao Zhang Jingyi sheng Xueqin Xu Shijia Tang Yan Li sheng yang Guangxiang Si Yu mao Yi Zhang Feimin Zhang Ning Gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing210009JiangsuChina Laboratory of Oral Regenerative Medicine Technology School of Biomedical Engineering and InformaticsDepartment of Biomedical EngineeringNanjing Medical UniversityNanjing211166JiangsuChina Jiangsu Key Laboratory of Oral Diseases Affiliated Hospital of StomatologyNanjing Medical UniversityNanjing210029JiangsuChina Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing100084China Department of Colorectal Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing210000JiangsuChina

Labeling of mesenchymal stem cells(MSCs)with superparamagnetic iron oxide nanoparticles(SPIONs)has emerged as a potential method for magnetic resonance imaging(MRI)tracking of transplanted cells in tissue repair studies and clinical *** of MSCs using clinically approved SPIONs(ferumoxytol)requires the use of transfection reagents or magnetic field,which largely limits their clinical *** overcome this obstacle,we established a novel and highly effective method for magnetic labeling of MSC spheroids using *** conventional methods,ferumoxytol labeling was done in the formation of a mechanically tunable biomimetic hydrogel-induced MSC ***,the labeled MSC spheroids exhibited strong MRI T2 signals and good ***,the encapsulated ferumoxytol was localized in the extracellular matrix(ECM)of the spheroids instead of the cytoplasm,minimizing the cytotoxicity of ferumoxytol and maintaining the viability and stemness properties of biomimetic hydrogel-induced MSC *** demonstrates the potential of this method for post-transplantation MRI tracking in the clinic.

关键词： Superparamagnetic iron oxide nanoparticles MSC labeling Mechanically tunable biomimetic hydrogel Spheroids MRI tracking