检索结果-南通市图书馆

Effect of ferrotitanium slag on microstructure and properties of Al_(2)O_(3)-SiC-C castables for iron runner

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第9期31卷 2122-2132页

作者： Tu Long Hua-zhi Gu Mei-jie Zhang Ao Huang Lv-ping Fu Ding Chen Wen-dong qiu mao-qi ju The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Baowu Equipment Intelligent Technology Co. Ltd.Shanghai200000China MCC Group Wuhan Research Institute of Metallurgy Construction Co.Ltd.Wuhan430081HubeiChina

Ferrotitanium slag(FS)is a waste slag produced during the smelting of ferrotitanium alloys by thermite *** alumina content is high and can be used as alumina raw *** runner castables containing different amounts of FS were prepared and *** results show that the introduction of FS is beneficial to the sintering of the castables *** the FS concentration is 11.2 wt.%,the aggregate and matrix of the castables sample have a good combination,and the mechanical strength of the Al_(2)O_(3)–SiC–C castable reaches a maximum at room ***,excessive introduction of FS generates a large amount of anorthite phase,which reduces the mechanical strength of the Al_(2)O_(3)–SiC–C castable at room *** addition,the high-melting phase CaTiO_(3)is formed in FS,which has good mechanical ***,the cracks of FS are reduced,and the combination between phases is closer,thus significantly improving the hot modulus of rupture of the *** the FS concentration is not above 33.6 wt.%,the castables show good slag *** TiO_(2)in FS is transformed into TiC by carbothermal reaction,which is enriched at the boundary and prevents further reaction of the slag.

关键词： Ferrotitanium slag Al_(2)O_(3)-SiC-C castable Hot modulus of rupture Slag resistance

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin Wang qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu mao-ju Tang Man Luo Xiao-Wu Zhong qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

在线全文

学校读者我要写书评

暂无评论

Frontiers in Energy 2016年第1期10卷 37-45页

作者： mao CHEN Yonglin ju Institute of Refrigeration and Cryogenics Shanghai Jiao TongUniversity Shanghai 200240 China

Compared with the traditional engines, the thermo-acoustic engines are relatively new and can act as the linear compressors for refrigerators. Many institutes have shown great interest in this kind of machine for its absence of moving mechanical part. In this paper, the influence of the dimensions of the main parts of the small- scale Stifling thermo-acoustic engine was numerically simulated using a computer code called DeltaEC. The resonator and the resonator cavity were found to be the most convenient and effective in improving the perfor- mance of the engine. Based on the numerical simulation, a small-scale Stifling thermo-acoustic engine were constructed and experimentally investigated. Currently, with a resonator length of only 1 m, the working frequency of the engine was decreased to 90 Hz and the onset temperature difference was decreased to 198.2 K.

关键词： thermo-acoustic Stifling engine small-scale simulation experiment

Permian integrative stratigraphy,biotas,paleogeographical and paleoclimatic evolution of the qinghai-Tibetan Plateau and its surrounding areas

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第4期67卷 1107-1151页

作者： Shuzhong SHEN Yichun ZHANG Dongxun YUAN Haipeng XU qi ju Hua ZHANG Quanfeng ZHENG mao LUO Zhangshuai HOU State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Nanjing 210049China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China

The Permian Period was a critical time interval during which various blocks of the qinghai-Tibetan Plateau have experienced profound and complex paleogeographical *** supercontinent Pangea was formed to its maximum during this interval,hampering a global east-to-west trending equatorial warm ocean ***,a semi-closed Tethys Ocean warm pool formed an eastward-opening oceanic embayment of Pangea,and became an engine fostering the evolutions of organisms and environmental changes during the Paleozoic-Mesozoic *** and preserved fossil groups have proved extremely useful in understanding such changes and the evolutionary histories of the qinghai-Tibetan *** distributed Permian deposits and fossils from various blocks of the qinghai-Tibetan Plateau exhibited varied characteristics,reflecting these blocks’different paleolatitude settings and drifting *** Himalaya Tethys Zone south to the Yarlung Zangbo suture zone,located in the northern Gondwanan margin,yields fossil assemblages characterized by cold-water organisms throughout the Permian,and was affliated to those of the *** of the exotic limestone blocks within the Yarlung Zangbo suture zone are Guadalupian(Middle Permian)to Early Triassic in *** exotic limestone blocks bear fossil assemblages that have transitional affinities between the warm Tethys and cold Gondwanan regions,suggesting that they most probably represent seamount deposits in the Neo-Tethys *** the Asselian to Sakmarian(Cisuralian,also Early Permian),the Cimmerian microcontinents in the northern part of Gondwana preserved glacio-marine deposits of Asselian to Sakmarian,and contained typical Gondwana-type cold-water *** the middle Cisuralian(~290-280 Ma),the Cimmerian microcontinents rifted off from the Gondwanaland,and drifted northward allometrically due to the active magmatism of the Panjal Traps in the northern margin of the Indian *** slices of micro

关键词： Permian Tethys Ocean qinghai-Tibetan Plateau Biotas Paleogeography

Advances in Research on Anticancer Properties of Salidroside

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2021年第2期27卷 153-160页

作者： SUN An-qi ju Xiu-lian Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan(430073)China The College of Post and Telecommunication Wuhan Institute of TechnologyWuhan(430073)China

Salidroside is a phenolic secondary metabolite present in plants of the genus Rhodiola,and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing *** review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast,ovarian,cervical,colorectal,lung,liver,gastric,bladder,renal,and skin cancer as well as gliomas and ***,it provides a reference for the further development and utilization of salidroside.

关键词： salidroside anticancer mechanism antiproliferative Chinese medicine review

Synergistic Action between Jasmonic Acid and Nitric Oxide in Inducing Matrine Accumulation of Sophora flavescens Suspension Cells

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2008年第1期50卷 92-101页

作者： mao-jun Xu ju-Fang Dong Department of Biotechnology Zhejiang Gongshang University Hangzhou 310035 China

Secondary metabolites not only play important ecological roles in plants but also are important pharmaceutical and source compounds for derivative synthesis. Production of plant secondary metabolites is believed to be controlled by the endogenous signal network of plants. However, the molecular basis is still largely unknown. Here we show that matrine production of Sophora flavescens Ait. cells treated with low levels of jasmonic acid （JA） and nitric oxide （NO） is significantly increased although treatment with low concentrations of JA or NO alone has no effects on matrine production, showing that JA and NO may act synergistically in triggering matrine production. Moreover, treatment with NO triggers lipoxygenase （LOX） activity and enhances JA levels of the cells, showing that NO may activate the endogenous JA biosynthesis of S. flavescens cells. External application of JA induces nitric oxide synthase-like activities and stimulates NO generation of S. flavescens cells, which suggests that JA may trigger NO generation of the cells. Thus, the results reveal a mutually amplifying reaction between JA and NO in S. flavescens cells. Furthermore, JA and NO inhibitors suppress not only the mutually amplifying reaction between JA and NO but also the synergistic effects of NO and JA on matrine production. Therefore, the data demonstrate that the synergistic action of JA and NO in inducing matrine production might be due to the mutually amplifying reaction between JA and NO in the cells.

关键词： jasmonic acid nitric oxide matrine Sophora flavescens cells.