检索结果-南通市图书馆

A Molecular Hepatocellular Carcinoma Prognostic Score System Precisely Predicts Overall Survival of Hepatocellular Carcinoma Patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2022年第2期10卷 273-283页

作者： Jie jia Jing tang Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:With high rates of recurrence post-treatment,hepatocellular carcinoma(HCC)is one of the most common types of cancer worldwide and the major cause of cancer *** improve the overall survival of HCC patients,identification of a reliable biomarker and precise early diagnosis of HCC remain major unsolved ***:We initially screened data from the Cancer Genome Atlas liver cancer cohort to identify potential prognosis-related ***,a metaanalysis of five international HCC cohorts was implemented to validate such ***,artificial intelligence models(random forest and neural network)were trained to predict prognosis accurately,and a log-rank test was performed for ***,the correlation between the molecular hepatocellular carcinoma prognostic score(mHPS)and the stromal and immune scoring in HCC were ***:A comprehensive list of 65 prognosis-related genes was obtained,most of which have been not extensively studied thus far.A universal HCC mHPS system depending on the expression pattern of only 23 genes was *** mHPS system had general applicability to HCC patients(log-rank p<0.05)in a platform-independent manner(RNA sequencing or microarray).The mHPS was also correlated with the stromal and immune scoring in HCC,reflecting the status of the tumor immune ***:Overall,the mHPS is an easy and cost-effective prognosis predicting system,which can disclose previously uncovered heterogeneity among patient *** mHPS system can further stratify patients who are at the same clinical stage and should be valuable for precise ***,the prognosis-related genes recog-nized in this study have potential in targeted and immune therapy.

关键词： Hepatocellular carcinoma Random forest Neural network Prog-nostic scoring system Personalized medicine

千里光通过抑制肥大细胞P2X7受体缓解炎性疼痛

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学通报 2025年第1期41卷 131-137页

作者：叶凡廖利辉唐婧玥陈佳慧成江陈功锡唐宗湘吉首大学药学院湖南吉首416000 武陵山区药用资源化学与药理湖南省高校重点实验室湖南吉首416000 南京中医药大学医学院·整合医学学院江苏南京210000

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是... 详细信息

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活引起的细胞内钙离子富集。利用全细胞膜片钳技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活后引起的内向电流。结果体内实验结果显示,千里光(3.9 g·kg^(-1))明显缓解ATP诱导的炎性疼痛(P<0.05);千里光(3.9 g·kg^(-1))明显抑制P2X7受体阳性肥大细胞的浸润(P<0.01);敲除肥大细胞可以消减千里光(3.9 g·kg^(-1))的镇痛效果(P=0.645)。体外实验结果显示,千里光明显抑制肥大细胞P2X7受体介导的钙离子内流(300 mg·L^(-1),P<0.05;1 g·L^(-1),P<0.01;3 g·L^(-1):P<0.01);千里光(1 g·L^(-1))明显抑制肥大细胞P2X7受体介导的内向电流(P<0.01)。结论千里光通过抑制肥大细胞P2X7受体功能缓解ATP诱导的炎性疼痛。

关键词：千里光疼痛肥大细胞 P2X7受体炎症 ATP

Two New Eremophilane Sesquiterpenes from Cacalia ainsliaeflora

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第7期12卷 601-602页

作者： Man Jun mao Zhong jian jia Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

Two new eremophilane sesquiterpenes 3β-angeloyloxy-8α-hydroxy-6β-methoxy eremophil-7 (11), 9 (10)-dien-8, 12-olide (1) and 3β-angeloyloxy-6β, 8α-dihydroxy-eremophi-7 (11), 9 (10)-dien-8, 12-olide (2) were isolat... 详细信息

关键词： Cacalia ainsliaeflora Compositae eremophilane sesquiterpene

The molecular mechanism of shade avoidance in crops--How data from Arabidopsis can help to identify targets for increasing yield and biomass production

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2017年第6期16卷 1244-1255页

作者： tang Yun-jia Johannes Liesche College of Life Sciences Northwest A&F University Yangling 712100 P.R.China Biomass Energy Center for Arid and Semi-arid lands Northwest A &F University Yangling 712100 P.R. China

In order to prevent or counteract shading,plants enact a complex set of growth and developmental adaptations when they sense a change in light quality caused by other plants in their *** shade avoidance response（SAR）typically includes increased stem elongation at the expense of plant fitness and yield,making it an undesirable trait in an agricultural *** the molecular factors involved in SAR can potentially improve productivity by increasing tolerance to higher planting ***,most of the investigations of the molecular mechanism of SAR have been carried out in Arabidopsis thaliana,and it is presently unclear in how far results of these investigations apply to crop *** this review,current data on SAR in crop plants,especially from members of the Solanaceae and Poaceae families,are integrated with data from Arabidopsis,in order to identify the most promising targets for biotechnological ***,which detect the change in light caused by neighboring plants,and early signaling components can be targeted to increase plant ***,they control various photomorphogenic processes not necessarily related to shade *** factors involved in SAR signaling could be better targets to specifically enhance or suppress *** integration from Arabidopsis and crop plants also indicates factors that could facilitate the control of specific aspects of *** are provided for the regulation of plant architecture,flowering induction and carbohydrate *** to-be-elucidated factors that control SAR-dependent changes in biotic resistance and cell wall composition are pointed *** review also includes an analysis of publicly available gene expression data for maize to augment the sparse molecular data available for this important species.

关键词： shade avoidance response phytochrome B Zea mays Solanum lycopersicum biomass carbon allocation

Characterization of Pythium chondricola associated with red rot disease of Pyropia yezoensis (Ueda)(Bangiales,Rhodophyta) from Lianyungang,China

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2019年第3期37卷 1102-1112页

作者： QIU Liping mao Yunxiang tang Lei tang Xianghai MO Zhaolan Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyKey Laboratory of Marine Genetics and Breeding (Ocean University of China)Ministry of EducationQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of MaricultureEpidemiology and BiosecurityYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China

Pyropia yezoensis(formerly Porphyra yezoensis)is an economically important red alga that is cultured extensively in *** red rot disease occurs commonly during Pyropia cultivation,causing serious economic *** incidence of red rot disease was found in a *** farm from mid-November to mid-December 2015 at Lianyungang,jiangsu Province,*** examination revealed that the naturally infected thalli were infected apparently by a pathogen,leading to red rot *** causative agent was isolated and identified as the oomycete Pythium chondricola by morphological analysis and sequence analysis of the internal transcribed spacer and cytochrome oxidase subunit 1(cox 1).In artifi cial infection experiments on the *** blades,the *** isolate was able to cause the same characteristic histopathology seen in natural *** grew well at a wide range of temperatures in the range 8-31℃,salinities at 0-45 and pH *** an orthogonal test used to determine the effects of environmental factors(temperature,salinity,and zoospore concentration)on infection,the data revealed that temperature was the most important factor to affect red rot disease development,with the optimal conditions for disease expansion being 20℃,35 salinity,and a zoospore concentration of 10^6 zoospores/*** results obtained from the present study prompted us to set up a comprehensive epidemiological study on Pyropia,which will provide support to maintain the healthy development of the Pyropia industry in China.

关键词： Pyropia yezoensis red rot identification Pythium chondricola pathogenicity disease expansion

Close-in weapon system planning based on multi-living agent theory

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2022年第7期18卷 1219-1231页

作者： tang tang Yue Wang Li-juan jia Jin Hu Cheng Ma School of Information and Electronic Beijing Institute of TechnologyBeijing100081China

The close-in weapon system(CIWS)is a combat system that faces a complex environment full of dynamic and unknown challenges,whose construction and planning require a systematic design *** agent(MLA)theory is a methodology for the combat system design,which uses the livelihood degree to evaluate the multi-dimensional long-term operational effectiveness of the system;whereas,there is still no uniform quantization framework for the livelihood degree,and the adjustment methods of livelihood degree need to be further *** this paper,we propose the uniform quantization framework for the livelihood degree and detailed discuss the methods of livelihood *** on the MLA theory,the multi-dimensional operational effectiveness of the missile-gun integrated weapon system(MGIWS)is analyzed,and the long-term combat effectiveness against the saturation attack is ***,the planning problem of the equipment deployment and configuration is *** objectives,including the overall livelihood degree and cost-effectiveness(CE),are proposed,and the optimization method based on genetic algorithm(GA)is studied for the planning problem.

关键词： Multi-living agent theory Close-in weapon system Effectiveness evaluation Livelihood degree Queueing system Missile-gun integrated weapon system

库岸塔柱状危岩的压裂耦合损伤-突变失稳预测

在线全文

学校读者我要写书评

暂无评论

三峡大学学报（自然科学版） 2025年第1期47卷 28-36页

作者：唐红梅宋刚杨健毛柯洁周福川重庆交通大学岩土工程研究所重庆400074 华电金沙江上游水电开发有限公司叶巴滩分公司四川甘孜627153 重庆工程职业技术学院重庆402260

位于三峡库区巫峡段消落带的塔柱状危岩,其底部多损伤因素的耦合作用下常呈压裂诱发座溃整体失稳模式,危岩底部耦合损伤至突变机制是研究该类库岸危岩体失稳预警的关键科学问题.以三峡库区库岸巫峡段箭穿洞塔柱状危岩体为例,将危岩体简... 详细信息

位于三峡库区巫峡段消落带的塔柱状危岩,其底部多损伤因素的耦合作用下常呈压裂诱发座溃整体失稳模式,危岩底部耦合损伤至突变机制是研究该类库岸危岩体失稳预警的关键科学问题.以三峡库区库岸巫峡段箭穿洞塔柱状危岩体为例,将危岩体简化为中上部非劣化区和下部劣化区的二元地质力学模型,基于应变等价原理获得其危岩体下部劣化区的荷载效应、溶蚀效应、干湿循环弱化效应的耦合损伤本构模型和总损伤度演化方程,根据地质力学模型概化为等效弹簧模型转化为力-位移的耦合损伤本构方程;基于能量平衡原理和突变理论建立了塔柱状危岩的耦合损伤-折叠突变模型,获取了其失稳判据和临界位移的表达式.通过案例分析结果表明:该危岩体突变失稳时的系统控制变量为-0.0073,预测模型计算理论的突变起点垂向位移为42.2mm,终止点位移为60.5mm,当监测数据危岩体最大垂向累积位移为26.2mm时,小于突变起始位移时就采用及时治理措施,与危岩未失稳的状态吻合.其研究成果可为三峡库区灰岩地区库岸塔柱状压溃型危岩的监测预警与防治提供重要的理论支撑.

关键词：库岸塔柱状危岩压溃失稳型耦合损伤突变模型

On a Flexible Loan Repayment Method Depending on Borrower's Asset with an Early Termination Clause

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第2期40卷 557-567页

作者： Jin LIANG jia-qi mao Zhao-ya LIU School of Mathematical Sciences Tongji UniversityShanghai 200092China

Aiming at the problem that the asset’s fluctuation influences the borrower’s repayment ability,a loan with a new and flexible repayment method is designed,which depends on the asset value of the *** repayment method can reduce the loan default probability,but it causes the uncertainty of the pay off *** the repayment term is related to the regular repayment amount in this method,a boundary for the regular repayment amount is set up in order to avoid too long repayment *** will balance the benefit of borrowers and lenders and improve the applicability of this *** establishing a mathematical model of the residual value of the loan,this model can be transformed into an initial-boundary problem of a partial differential *** analytic solution and the expected time to pay off the loan are ***,numerical analysis are shown.

关键词： flexible repayment method repayment ratio early termination clause expected pay off time

Hydraulics and swimming behavior of schizothorax prenanti in vertical slot fishways

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2019年第1期31卷 169-176页

作者： Rui-dong An jia Li Wen-min Yi Xi mao State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYaan 625014China

This paper presents a novel experiment for the correlation between the hydraulics and the swimming behavior of Schizothorax prenanti,a rare species of fish in southwest China,in passing a vertical slot *** an acoustic Doppler velocimeter,the velocities of a physical model in the equidimension fishway in the Shaping II power station are *** hydraulic parameters include the hydraulic head drop,the velocity patterns and the flow rate,and the swimming behavior includes the burst-coast,the sustained swimming and the migratory path,and they are analyzed under the test *** sustained swimming velocity is in the range from 0.65m/s to 1.09m/*** estimated hydraulic head drop of each pool is calculated and is in the range from 0.08-0.11 m,which means that 2.6% slope is *** the same slope,the maximum velocity is further reduced from 1.24 m/s to 1.14 m/s by using an L shape baffle *** above findings are used as the basis to evaluate the hydraulic performance of the fishways,where the L shape baffle structure is expected to be effective tor creating a preterencial flow for the *** the main stream of the pool,an "Ω" shape flow pattern is more fish-friendly,which can effectively extend the energy dissipation distance and avoid the bursting through a high velocity *** paper provides a useful complementary tool for practical designs.

关键词： Hydraulics swimming behavior vertical slot fishways burst-coast energy dissipation