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Journal of Geriatric Cardiology 2021年第3期18卷 233-237页

作者： Hang ZHU Yao LI Guang GONG mao-xiang zhao Lin LIU Si-Yu YAO Chi WANG Xin LI Yun-Dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Medical School of Chinese PLA Chinese PLA General HospitalBeijingChina Department of Vascular Surgery The No.2 People’s Hospital of YibinSichuanChina Beijing Visual 3D Medical Science and Technology Development CO.LLCBeijingChina

Deep vein thrombosis(DVT)is a manifestation of venous thromboembolism,which can result from long-term bed and lead to pulmonary embolism(PE),stroke,mesenteric artery embolis,*** after surgery without bed-off activity may prone to thrombosis,but traditional anticoagulant therapy is a contraindication for them because of high risk of postoperative *** vena cava filter(IVCF)implantation is the most effective method to intercept thrombosis from lower limb and to prevent ***,radiation and contrast agent limit its *** team have successfully performed an IVCF implantation guided by a mixed-reality(MR)system,[1]which is a chance for critically ill patients to allow the IVCF implantation exposed under no Xray and require no contrast agent.5G can help remote holographic projection images between distant range,meeting the needs of experts to guide the operation of critically ill *** describe a case of weak woman after neurosurgery who can not tolerate traditional interventional surgery to prevent DVT from falling *** performed a mixed-reality system guided IVCF implantation under remote guidance of 5G communication.

关键词： implantation mixed system

Amorphous oxide semiconductor for monolithic 3D DRAM: an enabler or passer-by?

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National Science Review 2024年第3期11卷 19-20页

作者： Shujuan mao Guilei Wang Chao zhao Beijing Superstring Academy of Memory Technology

Since dynamic random-access memory(DRAM) was invented in 1968 and put to market in the 1970s, 1 transistor plus 1 capacitor(1T1C)(Fig. 1a) cells have been used to take advantage of their structural simplicity and ease...

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Probabilistic-Ellipsoid Hybrid Reliability Multi-Material Topology Optimization Method Based on Stress Constraint

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 757-792页

作者： Zibin mao Qinghai zhao Liang Zhang College of Mechanical and Electrical Engineering Qingdao UniversityQingdao266071China National Engineering Research Center for Intelligent Electrical Vehicle Power System Qingdao UniversityQingdao266071China

This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization *** probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical *** topology optimization formula is combined with the ordered solid isotropic material with penalization(ordered-SIMP)multi-material interpolation *** stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm ***,the sequential optimization and reliability assessment(SORA)is applied to transform the original uncertainty optimization problem into an equivalent deterministic topology optimization(DTO)*** response surface and sparse grid technique are combined with SORA to get accurate information on the most probable failure point(MPP).In each cycle,the equivalent topology optimization formula is updated according to the MPP information obtained in the previous *** adjoint variable method is used for deriving the sensitivity of the stress constraint and the moving asymptote method(MMA)is used to update design ***,the validity and feasibility of the method are verified by the numerical example of L-shape beam design,T-shape structure design,steering knuckle,and 3D T-shaped beam.

关键词： Stress constraint probabilistic-ellipsoid hybrid topology optimization reliability analysis multi-material design

Stability analysis and stabilization of semi-Markov jump linear systems with unavailable sojourn-time information

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Science China(Information Sciences) 2024年第7期67卷 211-223页

作者： Xiaotai WU Yang TANG Shuai mao Ying zhao School of Mathematics and Physics Anhui Polytechnic University Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of EducationEast China University of Science and Technology

This study addresses the stability and stabilization problems of discrete-time semi-Markov jump linear systems(S-MJLSs) with unavailable sojourn-time information. The sojourn-time probability mass functions(S-TPMFs) of discrete-time semi-Markov chains are no longer confined to the geometric distribution, and it is difficult to obtain accurate and comprehensive information for S-TPMFs in practice. This is because S-TPMFs are usually deduced from the statistical characteristics according to the sampled-data, while adequate samples are often costly and time consuming. In this study, when the S-TPMFs for semi-Markov chains are assumed to be unavailable, the σ-error mean square stability is investigated for discrete-time S-MJLSs with some widely used assumptions; for semi-Markov chains, only the transition probability matrix of the embedded chain is used. In addition, the existence conditions of the effective controller are provided for closed-loop systems without using the information of S-TPMFs. Numerical examples are presented to illustrate the validity of the obtained theoretical results.

关键词： semi-Markov chain semi-Markov jump linear systems $\sigma$-error mean square stability unavailable sojourn-time information

Attractor for the Extensible Beam Equation with Nonlocal Weak Damping on Time–Dependent Space

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun xiang zhao Feng Juan MENG Institute of Applied System Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of Mathematics and Physics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-time behavior of extensible beams with nonlocal weak damping:ε(t)u_(tt)+Δ^(2)u-m(‖▽u‖^(2))Δu+‖u_(t)‖^(p_(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at *** the theory of process on time-dependent spaces,we investigate the existence of the time-dependent attractor by using the Condition(C_(t))method and more detailed *** results obtained essentially improve and complete some previous works.

关键词： Time-dependent attractor extensible beams equation nonlocal weak damping

Biomimetic Gland Models with Engineered Stratagems

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Research 2024年第2期2023卷 583-612页

作者： xiang Lin Lingyu Sun Minhui Lu Yuanjin zhao Department of Rheumatology and Immunology Nanjng Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China Southeast University Shenzhen Research Institute Shenzhen 518071China

As extensively distributed tissues throughout the human body,glands play a critical role in various physiological ***,the construction of biomimetic gland models in vitro has aroused great interest in multiple *** the biological field,the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands,such as the emergence of organoid *** the perspective of biomedical engineering,the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics,to mimic the in vivo environment of glandular *** engineered stratagems endowed gland models with more biomimetic features,as well as a wide range of application *** this review,we first describe the biomimetic strategies for constructing different in vitro gland models,focusing on the role of microfluidics in promoting the structure and function development of biomimetic *** summarizing several common in vitro models of endocrine and exocrine glands,the applications of gland models in disease modelling,drug screening,regenerative medicine,and personalized medicine are ***,we conclude the current challenges and our perspective of these biomimetic gland models.

关键词： endowed constructing strata

Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

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Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei Dai zhao-Fei Zhang xiang-Yu Chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting ***,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent *** challenge has spurred the exploration of efficient activation methods to overcome this *** recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this *** the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly ***,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl ***,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

On a Flexible Loan Repayment Method Depending on Borrower's Asset with an Early Termination Clause

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 557-567页

作者： Jin LIANG Jia-qi mao zhao-ya LIU School of Mathematical Sciences Tongji UniversityShanghai 200092China

Aiming at the problem that the asset’s fluctuation influences the borrower’s repayment ability,a loan with a new and flexible repayment method is designed,which depends on the asset value of the *** repayment method can reduce the loan default probability,but it causes the uncertainty of the pay off *** the repayment term is related to the regular repayment amount in this method,a boundary for the regular repayment amount is set up in order to avoid too long repayment *** will balance the benefit of borrowers and lenders and improve the applicability of this *** establishing a mathematical model of the residual value of the loan,this model can be transformed into an initial-boundary problem of a partial differential *** analytic solution and the expected time to pay off the loan are ***,numerical analysis are shown.

关键词： flexible repayment method repayment ratio early termination clause expected pay off time

Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

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Journal of Oceanology and Limnology 2024年第3期42卷 988-1000页

作者： Xuqian zhao Wenjia mao Zijie LIN Qufei LING School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Heat stress(HS)has been shown to adversely affect fish livers and can lead to extensive *** investigate the relationship between endoplasmic reticulum(ER)stress and HS-induced apoptosis in fish livers,we isolated and cultured primary hepatocytes of largemouth bass,Micropterus salmoides by trypsin method,then established an in-vitro model of liver cells under HS(35℃).The contents of lactic dehydrogenase(LDH)and hydrogen peroxide(H2O2)were determined to evaluate the effects of HS on hepatocyte injury and oxidative ***-qPCR was performed to discover the key genes in unfolded protein response(UPR)pathways involved at different HS *** inhibitor 4-PBA and IRE1αinhibitor 4μ8C were used to further investigate the effects of HS on IRE1αapoptosis pathway in *** show that HS led to significant increases in the release of LDH,the content of H2O2,and the expressions of oxidative protein folding genes(ero1αand pdi)under HS,suggesting severe hepatocyte injury and oxidative stress happened in heat-stressed largemouth bass *** continuous activation of IRE1αpathway genes(grp78,grp94,atf6,perk,eif2a,atf4,chop,ire1α,traf2,ask1,jnk1,and jnk2)indicated that HS led significantly to ER *** particular,the mRNA expression levels of ER stress-related genes(grp78,grp94,atf6,perk,ire1α,chop,jnk1,and jnk2)in the high temperature(HT)+4-PBA group and the HT+4μ8C group were significantly down-regulated under *** 4μ8C treatment,the expression levels of apoptosis-related genes(caspase-2,caspase-3,caspase-6,caspase-7,caspase-8,caspase-9,and caspase-10)and LDH content were significantly decreased,whereas the cell survival rate was significantly increased when given 4-PBA or 4μ8C *** findings demonstrate that HS could induce liver apoptosis of largemouth bass through the IRE1αpathway,which may act as a key switch mediating liver apoptosis of largemouth bass under HS.

关键词： heat stress Micropterus salmoides endoplasmic reticulum stress apoptosis oxidative stress

Multi-scale collaborative design method for macroscopic thermal optimization and mesoscopic woven structure of hypersonic vehicle's TOCMC leading edge

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Chinese Journal of Aeronautics 2024年第4期37卷 524-541页

作者： Chenwei zhao Zecan TU Junkui mao Jian HUI Pingting CHEN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 21016China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A new thermal protection design method for hypersonic vehicle's leading edge is proposed, which can effectively reduce temperature of the leading edge without additional cooling measures. This method reduces the leading-edge's temperature by the multi-scale collaborative design of the macroscopic thermal optimization and the mesoscopic woven structures of Three-dimensional Orthogonal Woven Ceramic Matrix Composites(TOCMC). The macroscopic thermal optimization is achieved by designing different mesoscopic woven structures in different regions to create combined heat transfer channels to dredge the heat. The combined heat transfer channel is macroscopically represented by the anisotropic thermal conductivity of TOCMC. The thermal optimization multiple linear regression model is established to optimize the heat transport channel, which predicts Theoretical Optimal Thermal Conductivity Configuration(TOTCC) in different regions to achieve the lowest leading-edge temperature. The function-oriented mesostructure design method is invented to design the corresponding mesostructure of TOCMC according to the TOTCC, which consists of universal thermal conductivity prediction formulas for TOCMC. These universal formulas are firstly derived based on the thermal resistance network method, which is verified by experiments with an error of 6.25%. The results show that the collaborative design method can effectively reduce the leading edge temperature by about 12.8% without adding cooling measures.

关键词： Multi-scale collaborative design Thermal optimization Ceramic matrix composite Hypersonic vehicle Thermal protection Intelligent optimization