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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

In situ decoration of nanosized metal oxide on highly conductive MXene nanosheets as efficient catalyst for li-O2 battery

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Journal of Energy Chemistry 2020年第8期29卷 272-280,I0010页

作者： Xingyu li Caiying wen Huifeng li Genban Sun Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China

Combining nanomaterials with complementary properties in a well-designed structure is an effective tactic to exploit multifunctional, high-performance materials for the energy conversion and storage. Nonprecious metal catalysts, such as cobalt oxide, with superior activity and excellent stability to other catalysts are widely desired. Nevertheless, the performance of CoO nanoparticles as an electrode material were significantly limit for its inferior conductivity, dissolution, and high cohesion. Herein, we grow ultrafine cobalt monoxide to decorate the interlayer and surface of the Ti3C2 Txnanosheets via a hydrothermal method companied by calcination. The layered MXenes act as the underlying conductive substrate,which not only increase the electron transfer rate at the interface but also greatly improve the electrochemical properties of the nanosized Co O particles by restricting the aggregation of CoO. The resulting CoO/Ti3C2 Txnanomaterial is applied as oxygen electrode for lithium-oxygen battery and achieves more than 160 cycles and first cycle capacity of 16,220 mAh g-1 at 100 mA g-1. This work paves a promising avenue for constructing a bi-functional catalyst by coupling the active component of a transition metal oxide(TMO) with the MXene materials in lithium-oxygen battery.

关键词： MXene Nanosized CoO li-O2 batteries Cathode catalyst

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

Hydraulics and swimming behavior of schizothorax prenanti in vertical slot fishways

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Journal of Hydrodynamics 2019年第1期31卷 169-176页

作者： Rui-dong An Jia li wen-min Yi Xi mao State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYaan 625014China

This paper presents a novel experiment for the correlation between the hydraulics and the swimming behavior of Schizothorax prenanti,a rare species of fish in southwest China,in passing a vertical slot *** an acoustic Doppler velocimeter,the velocities of a physical model in the equidimension fishway in the Shaping II power station are *** hydraulic parameters include the hydraulic head drop,the velocity patterns and the flow rate,and the swimming behavior includes the burst-coast,the sustained swimming and the migratory path,and they are analyzed under the test *** sustained swimming velocity is in the range from 0.65m/s to 1.09m/*** estimated hydraulic head drop of each pool is calculated and is in the range from 0.08-0.11 m,which means that 2.6% slope is *** the same slope,the maximum velocity is further reduced from 1.24 m/s to 1.14 m/s by using an L shape baffle *** above findings are used as the basis to evaluate the hydraulic performance of the fishways,where the L shape baffle structure is expected to be effective tor creating a preterencial flow for the *** the main stream of the pool,an "Ω" shape flow pattern is more fish-friendly,which can effectively extend the energy dissipation distance and avoid the bursting through a high velocity *** paper provides a useful complementary tool for practical designs.

关键词： Hydraulics swimming behavior vertical slot fishways burst-coast energy dissipation

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li Fu Tang Jingkai Zhang Yuetong Kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

Novel SrCe_(0.75)Zr_(0.20)Tm_(0.05)O_(3-δ) membrane for hydrogen separation

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Chinese Chemical Letters 2010年第3期21卷 369-372页

作者： wen Hui Yuan ling ling mao li li School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China College of Environmental Science and Engineering South China University of Technology Guangzhou 510640 China

Dense ceramic membranes with protonic and electronic conductivity have attracted considerable interest in recent *** this paper,the powders of SrCe_(0.75)Zr_(0.20)Tm_(0.05)O_(3-δ) were synthesized via the liquid citrate method,and the membranes of SrCe_(0.75)Zr_(0.20)Tm_(0.05)O_(3-δ) were prepared by pressing followed by sintering.X-ray diffraction(XRD) was used to characterize the phase structure of both the powder and sintered *** microstructure of the sintered membranes was studied by scann...

关键词： Hydrogen permeation Ceramic membrane Perovskite Mixed conductor

Significantly improved oxidation of bio-based furans into furan carboxylic acids using substrate-adapted whole cells

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Journal of Energy Chemistry 2020年第2期29卷 20-26页

作者： mao wen Xue-Ying Zhang Min-Hua Zong Ning li School of Food Science and Engineering South China University of TechnologyGuangzhou 510640GuangdongChina

Furan carboxylic acids are important building blocks in polymer and fine chemical industries. In this work, a simple substrate adaptation strategy was applied to improve the catalytic performances of Comamonas testosteroni SC1588 cells for the synthesis of various furan carboxylic acids. It was found that biocatalytic synthesis of 5-hydroxymethyl-2-furancarboxylic acid(HMFCA) was substantially promoted by adding histidine and increasing cell concentrations. HMFCA was produced in a quantitative yield from200 m M HMF in 24 h. Besides, the HMFCA yields of 71%–81% were achieved with the substrate concentrations up to 250–300 m M. It was firstly found that 4-tert-butylcatechol(TBC), as the stabilizer present in HMF, exerted a significantly detrimental effect on whole-cell catalytic synthesis of HMFCA at high substrate concentrations(more than 130 m M). In addition, a variety of furan carboxylic acids such as2-furoic acid, 5-methyl-2-furancarboxylic acid and 5-methoxymethyl-2-furancarboxylic acid were synthesized with the yields up to 98%.

关键词： 5-hydroxymethylfurfural 5-hydroxymethyl-2-furancarboxylic acid Oxidation Substrate adaptation strategy Whole-cell biocatalysis

Hollow nanostructure of sea-sponge-C/SiC@SiC/C for stable li^(+)-storage capability

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Science Bulletin 2019年第16期64卷 1152-1157页

作者： Weina li Jiaqi li Jiahao wen Ming wen Shipei Chen Qingsheng Wu Yongqing Fu School of Chemical Science and Engineering Shanghai Key Laboratory of Chemical Assessment and SustainabilityTongji UniversityShanghai 200092China School of Electrical Engineering Chongqing UniversityChongqing 400044China Faculty of Engineering and Environment Northumbria UniversityNE1 8STUK

For the purpose of stable performance in energy storage systems, a new hollow nanostructure of seasponge-C/SiC@SiC/C(SCS/SiC@SiC/C) has been successfully fabricated by the SCS/SiC nanospheres coated with SiC/C shells through an in situ reduction process. Based on SCSs and the carbon shells, the stable hollow structures of SCS/SiC@SiC/C can contain large proportion of active SiC layers, which are adhered to both SCSs and the inner surfaces of carbon shells. Such nanostructured anode enables an excellent cycling stability with a capacity of 612 mAh/g at a current density of 0.5 A/g after 1,800 cycles, achieving an excellent stable li^+-storage capability.

关键词： SiC lithium ion batteries Cycling stability Sea-sponge-C/SiC@SiC/C

MAP3K3基因过表达通过多条信号通路激活CREB促进人肺腺癌细胞增殖及上皮-间质转化

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广东医学 2022年第8期43卷 939-944页

作者：郭振辉茆文莉陈文雅梁娇侯聪艳张韧何彦丽广州中医药大学基础医学院广东广州510006

目的通过体外干预有丝分裂原活化蛋白激酶激酶激酶3(MAP3K3)基因表达研究其对人肺腺癌细胞增殖、侵袭以及上皮-间质转化(EMT)的影响,探讨MAP3K3在肺腺癌发生、发展中的作用及可能的机制。方法使用慢病毒转染构建稳定过表达MAP3K3的人肺... 详细信息

目的通过体外干预有丝分裂原活化蛋白激酶激酶激酶3(MAP3K3)基因表达研究其对人肺腺癌细胞增殖、侵袭以及上皮-间质转化(EMT)的影响,探讨MAP3K3在肺腺癌发生、发展中的作用及可能的机制。方法使用慢病毒转染构建稳定过表达MAP3K3的人肺腺癌细胞株H1299、A549,通过克隆形成实验、划痕实验及Transwell实验,检测细胞增殖、迁移及侵袭行为的变化;Western blot实验检测EMT相关蛋白波形蛋白(Vimentin)、钙黏蛋白E(E-cadherin)和钙黏蛋白N(N-cadherin)表达水平,检测MAP3K3下游信号分子AKT、mTOR、ERK1/2、JNK1/2及其磷酸化蛋白表达水平,检测过表达和敲低MAP3K3的H1299细胞p-CREB蛋白表达水平变化。结果过表达MAP3K3基因后,H1299和A549细胞的增殖、迁移及侵袭能力明显增强,细胞的上皮表型分子E-cadherin下调,间质表型分子Vimentin和N-cadherin上调,p-AKT、p-mTOR、p-ERK1/2、p-JNK1/2以及p-CREB蛋白表达上调;使用shRNA稳定敲低MAP3K3后p-CREB蛋白表达明显下调。结论人肺腺癌细胞株H1299和A549体外过表达MAP3K3基因后,可增强细胞增殖、迁移及侵袭能力,促进细胞EMT,其机制可能与MAP3K3通过激活多个下游信号通路,磷酸化激活CREB(环磷腺苷效应元件结合蛋白)有关,此研究可为基于该信号通路的新型靶向药物开发提供一些实验依据。

关键词：肺腺癌 MAP3K3 CREB 上皮-间质转化

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