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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui mao xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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重庆药用植物新记录

中国中药杂志 2016年第12期41卷 2213-2215页

作者：张军刘翔林茂祥任明波刘正宇重庆市药物种植研究所重庆408435 重庆中药研究院重庆400065 中国中医科学院中药资源中心道地药材国家重点实验室培育基地北京100700

通过全国第四次中药资源普查重庆(试点)渝东南片区调查,发现重庆药用植物1个新记录科,即番荔枝科Annonaceae;2个新记录属,即瓜馥木属Fissistigma、鹿茸草属Monochasma;6个新记录种,即越南槐Sophora tonkinensis、凹叶瓜馥木Fissistigma ... 详细信息

通过全国第四次中药资源普查重庆(试点)渝东南片区调查,发现重庆药用植物1个新记录科,即番荔枝科Annonaceae;2个新记录属,即瓜馥木属Fissistigma、鹿茸草属Monochasma;6个新记录种,即越南槐Sophora tonkinensis、凹叶瓜馥木Fissistigma retusum、鹿茸草Monochasma sheareri、毛茛叶报春Primula ranunculoids、羽裂唇柱苣苔Chirita pinnatifida、圆扇八宝Hylotelephium sieboldii,凭证标本均存于重庆市药物种植研究所标本馆。

关键词：药用植物分布新记录重庆

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民间镇痛用药胡豆莲的资源与生态环境调查

时珍国医国药 2008年第3期19卷 627-628页

作者：邓才富章文伟林茂祥重庆市药物种植研究所重庆408435

保护民间珍稀濒危药用植物,是为了更好地挖掘和开发传统医药,更好地服务于人类。通过对民间镇痛用药胡豆莲资源和传统适生环境的调查研究,掌握其资源现状及生境条件,以便为珍稀濒危药用植物的保护和研究提供技术支持和参考。

关键词：胡豆莲生态环境金佛山保护

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang lin xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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重庆南川玄参田间杂草种类、危害及群落结构研究

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中药材 2015年第10期38卷 2042-2047页

作者：韩凤肖杰易曹厚强罗川杨天建林茂祥重庆市药物种植研究所重庆408435 重庆市中药良种选育与评价工程技术中心重庆408435

目的：明确重庆南川玄参杂草种类、危害情况和群落结构。方法：2013~2014年,采用倒置＂W＂九点取样法对南川玄参杂草进行调查。结果：南川玄参农田杂草有96种,隶属于30科75属,其中菊科最多,为18种,占整个杂草种类的18.75%;其次是禾本科... 详细信息

目的：明确重庆南川玄参杂草种类、危害情况和群落结构。方法：2013~2014年,采用倒置＂W＂九点取样法对南川玄参杂草进行调查。结果：南川玄参农田杂草有96种,隶属于30科75属,其中菊科最多,为18种,占整个杂草种类的18.75%;其次是禾本科,10种,占整个杂草种类的10.42%。所有杂草中,一年生杂草57种,占所有杂草的59.38%,越年生（两年生）及多年生杂草39种,占所有杂草的40.63%。一年蓬、马唐、窃衣、尼泊尔蓼、毛茛、繁缕、鸭跖草等在田间分布较广,是南川玄参农田的优势杂草。结论：重庆南川玄参农田杂草种类组成、群落结构的不同,主要与土壤理化性质、水分含量、种植制度、耕作方式、气候条件、作物布局、除草水平等有密切关系。

关键词：玄参杂草种类群落结构优势种重要值

A new pelagic Polyconchoecia xiang, Chen and Du, 2018(Ostracoda:Myodocopa:Halocyprididae) from the South China Sea

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Acta Oceanologica Sinica 2020年第4期39卷 73-83页

作者： Peng xiang Yu Wang Ruixiang Chen Youyin Ye Chunguang Wang Xiaoyin Chen mao lin Laboratory of Marine Biology and Ecology Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China Collaborative Innovation Center of Deep Sea Biology Hangzhou 310012China

Halocyprid ostracods are appreciable part of ostracods floating through virtually everywhere in marine *** this study,we describe a new species of genus Polyconchoecia xiang,Chen and Du,2018,tribe Conchoeciini Chavtur and Angel,2011,family Halocyprididae Dana,1853 from the middle of the South China *** chenii *** very close to *** xiang,Chen and Du,*** it differs from *** by the distinctions of locations of major glands of carapace and the characteristics of appendages:more posteriorly situated left asymmetric gland of carapace,no right asymmetric gland;segmented frontal organ;the endopod 2 of the first antenna with a very small seta;a-and c-setae of the first antenna with long end joint have long end joint,the b-and d-setae have no end joint,spinose e-seta without end joint;the e-seta of the second antenna is present;teeth side is distinctive;the setal counts of the mandible,maxilla,fifth limb,and sixth limb are *** locations of the major glands on carapace and the characteristics of the first antenna can be the key of the new *** work is the second discovery of the genus Polyconchoecia from the world.

关键词： taxonomy Ostracoda Halocyprididae Conchoeciini Polyconchoecia chenii sp.nov. new species South China Sea

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天平山淫羊藿在重庆的分布及其群落特征

中药材 2015年第9期38卷 1825-1830页

作者：林茂祥刘正宇张军申杰韩如刚金江群重庆市药物种植研究所重庆408435

目的：明确天平山淫羊藿在重庆的分布区及其群落特征,为资源的可持续利用提供依据。方法：通过实地调查,并用GPS定位,在此基础上采用样方法,对不同生境中天平山淫羊藿分布相对集中的7个样地所有物种的多度、频度和重要值进行统计和分析... 详细信息

目的：明确天平山淫羊藿在重庆的分布区及其群落特征,为资源的可持续利用提供依据。方法：通过实地调查,并用GPS定位,在此基础上采用样方法,对不同生境中天平山淫羊藿分布相对集中的7个样地所有物种的多度、频度和重要值进行统计和分析。结果：天平山淫羊藿分布于重庆市长寿区、垫江县、忠县及丰都县,分布区海拔351~663 m,群落类型包括针叶林、阔叶林和竹林。群落植物有33科48属56种,优势种主要是乔木层的料慈竹、栎类、柏木等,灌木层的海金子、檵木、铁仔等,草本层的蝴蝶花、五节芒、长穗腹水草、披针薹草、天平山淫羊藿等。7个植物群落的物种丰富度指数D在1.1143~3.7781之间,群落中物种种数相对较少,个体数量相对较多;群落3和群落6的物种多样性指数H＇和均匀度指数E都相对较低,群落物种分布具有明显的不均匀性。乔木层的D值、H＇值和E值均低于灌木层和草本层,物种多样性较其余两层差。结论：建议将天平山淫羊藿收载入中国药典,作为正品淫羊藿药材之一。

关键词：天平山淫羊藿分布范围群落特征重庆市

大娄山山脉珍稀濒危野生药用植物资源调查研究

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时珍国医国药 2008年第10期19卷 2332-2336页

作者：林茂祥刘正宇韩凤申杰任明波重庆市药物种植研究所重庆408435

通过调查研究,大娄山山脉的珍稀濒危野生药用植物共53科80属99种,以南川、道真和武隆县分布最多,分别为99种、58种和44种。文章分别对各植物的保护级别、效用、分布海拔、生境及地理分布作了介绍,对整个山脉的珍稀药用植物资源进行了评... 详细信息

通过调查研究,大娄山山脉的珍稀濒危野生药用植物共53科80属99种,以南川、道真和武隆县分布最多,分别为99种、58种和44种。文章分别对各植物的保护级别、效用、分布海拔、生境及地理分布作了介绍,对整个山脉的珍稀药用植物资源进行了评价,并提出了一些保护建议。

关键词：药用植物资源珍稀濒危大娄山