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Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： Xiaoman mao Shuang Wu Dandan Huang Chong li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy

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Nano Research 2024年第9期17卷 8192-8199页

作者： Rui-Rui liu li-Bo mao Shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials and ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

As a renewable,biocompatible,biodegradable soft material,chitin hydrogels have better advantages in stability,antibacterial activity,antifouling,cost,immunogenicity,and so on than most polymer ***,compared with other widely used polymer hydrogels with high strength and toughness,the practical applications of chitin-based hydrogels have been limited by their weak mechanical properties,such as cartilage repair and meniscus ***,we present the design and fabrication of chitin hydrogels with excellent mechanical strength and toughness by a dehydration and rehydration *** sequential dehydration and rehydration processes,the crystalline domains in the chitin hydrogels can be properly *** optimized crystallinity,the elastic modulus of the chitin hydrogels exceeds all previously reported values,and the fracture toughness is even comparable to some synthetic polymer hydrogels,while maintaining a high-water-content of about 80 wt.%.At the same water content,the mechanical properties of the chitin hydrogels are positively correlated with the hydrogel crystallinity,which proves that the change of mechanical properties of hydrogels is not simply dependent on weight *** hydrogels can be further strengthened by incorporating other biopolymers that are intrinsically weak,which makes the hydrogels promising for applications in fields such as cartilage repair and meniscus ***,the hydrogels enable loading and release of water-soluble and poorly water-soluble *** highly extendable strengthening and toughening strategy of chitin and chitin-based biopolymer hydrogels paves the way for their widely applications.

关键词： chitin hydrogel crystallinity rehydration chemical transformation strong and tough

Recent advances in stretchable triboelectric nanogenerators for use in wearable bioelectronic devices

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Bio-Design and Manufacturing 2024年第4期7卷 566-590页

作者： Yaling Wang Pengcheng Zhu Yue Sun Pan li Yanchao mao College of Science Henan Agricultural UniversityZhengzhou 450002China Key Laboratory of Materials Physics of Ministry of Education School of PhysicsZhengzhou UniversityZhengzhou 450001China

Wearable bioelectronic devices have the capacity for real-time human health monitoring,the provision of tailored services,and natural interaction with smart ***,these wearable bioelectronic devices rely on conventional rigid batteries that are frequently charged or replaced and are incompatible with the skin,leading to a discontinuity in complex therapeutic tasks related to human health monitoring and human-machine *** triboelectric nanogenerator(TENG)is a high-efficiency energy harvesting technology that converts mechanical into electrical energy,effectively powering wearable bioelectronic *** study comprehensively overviews recent advances in stretchable TENG for use in wearable bioelectronic *** working mechanism of stretchable TENG is initially explained.A comprehensive discussion presents the approaches for fabricating stretchable TENG,including the design of stretchable structures and the selection of stretchable ***,applications of wearable bioelectronic devices based on stretchable TENG in human health monitoring(body movements,pulse,and respiration)and human-machine interaction(touch panels,machine control,and virtual reality)are ***,the challenges and developmental trends regarding wearable bioelectronic devices based on stretchable TENG are elaborated.

关键词： Stretchable Triboelectric nanogenerators Structure Human health monitoring Human-machine interaction

Cucurbit[n]uril-based nanostructure construction and modification

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Chinese Chemical Letters 2024年第8期35卷 138-148页

作者： lijun mao Shuo li Xin Zhang Zhan-Ting li Da Ma School of Pharmaceutical Engineering&Institute for Advanced Studies Taizhou UniversityJiaojiang 318000China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

New fabrication method of nanostructures is of great importance for the applications of nanoscience and *** review summarizes cucurbit[n]uril(CB[n])-based nanostructure fabrication and modification *** strategies include the use of CB[n]s as building blocks and supramolecular crosslinkers to fabricate nanostructures,to surface modify nanostructures,and as gatekeepers to control the release of encapsulated *** nanostructures are used for drug delivery,bioimaging,chemical sensing,catalysis and other ***[n]s often play a vital role in the fabrication of these nanos-tructures,and the realization of the applications.

关键词： Cucurbit[n]uril Nanostructure Host-guest interaction Nanofabrication

Research progress on natural products against hepatocellular carcinoma

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BIOCELL 2024年第6期48卷 905-922页

作者： liNGli ZHANG YAN li JINGXIN mao Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System Chongqing Medical and Pharmaceutical CollegeChongqing400030China Provincial Key Laboratory of Pharmaceutical Bioactive Substances School of Life Sciences and BiopharmaceuticalsGuangdong Pharmaceutical UniversityGuangzhou510006China

Hepatocellular carcinoma(HCC)remains a prevalent and challenging malignancy globally,characterized by its numerous causal factors and generally unfavorable *** the relentless pursuit of effective treatment modalities,natural products have emerged as a promising and relatively non-toxic alternative,garnering signiﬁcant *** integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of *** review offers a comprehensive overview of the causal factors underlying HCC,and the diverse treatment options available,and highlights the advancements made by natural products in anti-HCC ***,we provide an outline of the various types of natural products,their corresponding nomenclature,target molecules,and mechanisms of action that exhibit anti-HCC *** products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer,potentially offering patients improved survival rates and an enhanced quality of life.

关键词： Hepatocellular carcinoma Natural products Targets Research progress Drug

Theoretical Analysis on Deflection and Bearing Capacity of Prestressed Bamboo-Steel Composite Beams

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Journal of Renewable Materials 2024年第1期12卷 149-166页

作者： Qifeng Shan Ming mao Yushun li School of Civil Engineering Zhejiang Industry Polytechnic CollegeShaoxing312000China School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China College of Civil Engineering and Architecture Qingdao Agricultural UniversityQingdao266109China

A theoretical analysis of upward deflection and midspan deflection of prestressed bamboo-steel composite beams is presented in this *** deflection analysis considers the influences of interface slippage and shear ***,the calculation model for flexural capacity is proposed considering the two stages of *** theoretical results are verified with 8 specimens considering different prestressed load levels,load schemes,and prestress *** results indicate that the proposed theoretical analysis provides a feasible prediction of the deflection and bearing capacity of bamboo-steel composite *** deflection analysis,the method considering the slippage and shear deformation provides better *** theoretical method for bearing capacity matches well with the test results,and the relative errors in the serviceability limit state and ultimate limit state are 4.95%and 5.85%,respectively,which meet the accuracy requirements of the engineered application.

关键词： Bamboo scrimber composite beam prestress deflection bearing capacity

A Novel Fall Detection Framework Using Skip-DSCGAN Based on Inertial Sensor Data

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Computers, Materials & Continua 2024年第1期78卷 493-514页

作者： kun Fang Julong Pan lingyi li Ruihan Xiang College of Information Engineering China Jiliang UniversityHangzhou310018China

With the widespread use of Internet of Things(IoT)technology in daily life and the considerable safety risks of falls for elderly individuals,research on IoT-based fall detection systems has gainedmuch *** paper proposes an IoT-based spatiotemporal data processing framework based on a depthwise separable convolution generative adversarial network using skip-connection(Skip-DSCGAN)for fall *** method uses spatiotemporal data from accelerometers and gyroscopes in inertial sensors as input data.A semisupervised learning approach is adopted to train the model using only activities of daily living(ADL)data,which can avoid data imbalance ***,a quantile-based approach is employed to determine the fall threshold,which makes the fall detection frameworkmore *** proposed fall detection framework is evaluated against four other generative adversarial network(GAN)models with superior anomaly detection performance using two fall public datasets(SisFall&MobiAct).The test results show that the proposed method achieves better results,reaching 96.93% and 92.75% accuracy on the above two test datasets,*** the same time,the proposed method also achieves satisfactory results in terms ofmodel size and inference delay time,making it suitable for deployment on wearable devices with limited *** addition,this paper also compares GAN-based semisupervised learning methods with supervised learning methods commonly used in fall *** clarifies the advantages of GAN-based semisupervised learning methods in fall detection.

关键词： Fall detection skip-connection depthwise separable convolution generative adversarial networks inertial sensor

The influences of perforating phase and bedding planes on the fracture deflection in laminated shale

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Petroleum Science 2024年第2期21卷 1221-1230页

作者： Ming-Zhe Gu mao Sheng Xiao-Ying Zhuang Xin-Yi li Gen-Sheng li National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Petroleum Engineering China University of PetroleumBeijing102249China College of Civil Engineering Tongji UniversityShanghai200092China

The perforating phase leads to complex and diverse hydraulic fracture propagation behaviors in laminated shale formations. In this paper, a 2D high-speed imaging scheme which can capture the interaction between perforating phase and natural shale bedding planes was proposed. The phase field method was used to simulate the same conditions as in the experiment for verification and hydraulic fracture propagation mechanism under the competition of perforating phase and bedding planes was *** results indicate that the bedding planes appear to be no influence on fracture propagation while the perforating phase is perpendicular to the bedding planes, and the fracture propagates along the perforating phase without deflection. When the perforating phase algins with the bedding planes, the fracture initiation pressure reserves the lowest value, and no deflection occurs during fracture propagation. When the perforating phase is the angle 45°, 60°and 75°of bedding planes, the bedding planes begin to play a key role on the fracture deflection. The maximum deflection degree is reached at the perforating phase of75°. Numerical simulation provides evidence that the existence of shale bedding planes is not exactly equivalent to anisotropy for fracture propagation and the difference of mechanical properties between different shale layers is the fundamental reason for fracture deflection. The findings help to understand the intrinsic characteristics of shale and provide a theoretical basis for the optimization design of field perforation parameters.

关键词： Shale Propagation Perforating Bedding Structure

Metabolic cell death in cancer:ferroptosis,cuproptosis,disulfidptosis,and beyond

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Protein & Cell 2024年第9期15卷 642-660页

作者： Chao mao Min Wang li Zhuang Boyi Gan Department of Experimental Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Molecular and Cellular Biology Baylor College of MedicineHoustonTX 77030USA The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences HoustonTX 77030USA

Cell death resistance represents a hallmark of *** studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular *** review discusses the mechanisms of metabolic cell death—ferroptosis,cuproptosis,disulfidptosis,lysozincrosis,and alkaliptosis—and explores their potential in cancer *** review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.

关键词： cell death cancer treatment ferroptosis cuproptosis disulfidptosis