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Acta Oceanologica Sinica 2015年第2期34卷 74-83页

作者： zhang Man mao Yong WANG jun FENG Wenrong SONG Xiaohong SU Yongquan College of Ocean and Earth Sciences Xiamen University

C-type lectins are among the most significant pattern recognition receptors（PRRs） found in invertebrate. They are a class of carbohydrate-binding proteins that can recognize specific sugar moieties on the surface of pathogens. In the present study, a novel C-type lecitn（termed Mj Lectin） from kuruma shrimp Marsupenaeus japonicus was identified. The full-length c DNA of Mj Lectin was 1 245 bp with a 1 011 bp open reading frame（ORF） that encoded a polypeptide of 336 amino acid residues. Mj Lectin consisted of two tandemly arrayed carbohydrate-recognition domains（CRDs）, unlike other reported M. japonicus C-type lectins with only one CRD. It showed a high similarity to other shrimp dual-CRD lectins. Among the Ca2＋-binding Site 2, the tripeptide motif dictating the carbohydrate binding specificity was exhibited as a rare mutant LPN（Leu134-Pro135-Asn136） in CRD1 and a traditional EPN（Glu299-Pro300-Asn301） in CRD2, respectively. Mj Lectin showed a specific expression pattern in both tissue and cellular levels, for its m RNA transcript was mainly expressed in the F-cells of the hepatopancreas. After white spot syndrome virus（WSSV） challenge（3.6×108 virions/μL）, the expression of Mj Lectin in the hepatopancreas was up-regulated significantly at 48 h（P〈0.01） compared with the control group. These results suggested that Mj Lectin might be involved in the innate immune defense against WSSV infection.

关键词： C-type lectin Marsupenaeus japonicus carbohydrate-recognition domain(CRD) gene expression white spot syndrome virus(WSSV)

Review:Phonon Engineering in Thermoelectric Materials

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Journal of Harbin Institute of Technology(New Series) 2022年第6期29卷 111-127页

作者： Asfandiyar Sichen Duan jun mao Qian zhang Institute of Materials Genome&Big Data School of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

One of the abundantly available energies that could be found in industrial power plants, running vehicles, nuclear power stations, etc. is known as thermal energy. A physical phenomenon known as thermoelectricity converts thermal energy into electrical energy and vice versa, providing a green route for power generation and a potential solution to the world energy crisis. The thermoelectric conversion efficiency is generally characterized by the temperature-dependent dimensionless figure of merit(zT), which is generally promoted by increasing the power factor and reducing the thermal conductivity. The present work reviews heat transmission in thermoelectric materials, particularly phonon engineering to reduce the lattice thermal conductivity. The two leading strategies of point defects engineering and nanostructuring for reducing thermal conductivity have been summarized. The optimized reported zTs of various thermoelectric materials in terms of reduced thermal conductivity have been presented.

关键词： phonon transport engineering defects nanostructuring thermal conductivity zT thermoelectrics

Entropy engineering in CaZn_(2)Sb_(2)-YbMg_(2)Sb_(2)Zintl alloys for enhanced thermoelectric performance

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Rare Metals 2022年第9期41卷 2998-3004页

作者： Ke-Jia Liu Zong-Wei zhang Chen Chen Li-Hua Wei Huo-Lun He jun mao Qian zhang School of Materials Science and Engineering and Institute of Materials Genome&Big DataHarbin Institute of TechnologyShenzhen518055China Department of Mechanical Engineering The University of Hong KongHong Kong999077China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin150001China

The significant atomic disorder induced by entropy engineering can effectively suppress lattice thermal conductivity and improve thermoelectric *** variety of compositions of Zintl phases offers a wide range of possibilities for entropy *** we successfully prepared a five-component solid solution(CaZn_(2)Sb_(2))_(0.5)(YbMg_(2)Sb_(2))_(0.5) with a configurational entropy of~1.40R,whereR is the gas *** a result,the room-temperature lattice thermal conductivity was only~0.68 W·m^(-1)·K^(-1),which is lower than that of all AM_(2)Sb_(2) Zintl phases.

关键词： alloys entropy performance

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Stationarity in the variability of arid precipitation:A case study of aridCentral Asia

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Advances in Climate Change Research 2021年第2期12卷 172-186页

作者： YAO jun-Qiang CHEN Jing zhang Tong-Wen DILINUER Tuoliewubieke mao Wei-Yi Institute of Desert Meteorology China Meteorological AdministrationUrumqi830002China

Precipitation is particularly scarce in arid Central Asia(CA),and is expected to be severely impacted by future warming,and the assessmentof the stationarity of precipitation variability is important for managing surface water resources in this *** this study,we investigated thestatistics of stationarity in the totals and extremes of precipitation in CA based on the longest observational records(1881e2006),tree-ringreconstructed records(1756e2012 and 1760e2015),and the Coupled Model Intercomparison Project 5(CMIP5)simulations,applying theautocorrelation function and testing criteria established based on the statistical definitions of *** analyzed the longest daily pre-cipitation record(Tashkent station,1881e2006)and found that the autocorrelation coefficient of the precipitation totals(PRCPTOT)and annualmaximum 1-day precipitation amount(Rx1day)were statistically insignificant for all lags,implying stationary ***,nearly allthe Global Historical Climatology Network-Daily Database(GHCN-D)observatory sites(1925e2005)indicated likely stationary *** records were also indistinguishable from a random *** the CMIP5 models,the simulated and projected PRCPTOT closelyapproximated a purely random process;however,the projected Rx1day maintained non-stationary means in most of the models under therepresentative concentration pathway(RCPs),implying that extreme events would increase in the *** mean precipitation changes(DP)can be expressed as an exponential function depending on the length of the successive mean periods(m)and variance(s2).TheDPof the nextdecade is projected to be within±14.8%of the previous decades mean annual PRCPTOT over *** higher the RCPs,the higher theDP *** results show that the detection and prediction of precipitation change will be challenging in arid CA.

关键词： Stationarity Precipitation Extreme precipitation Variance Central Asia

New Periodic Wave Solutions to Generalized Klein-Gordon and Benjamin Equations

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Communications in Theoretical Physics 2007年第5X期48卷 815-818页

作者： WU Guo-Jiang HAN Jia-Hua zhang Wen-Liang zhang Miao WANG jun-mao School of Physics and Material Science Anhui University Hefei 230039 China

By making use of extended mapping method and auxiliary equation for finding new periodic wave solu tions of nonlinear evolution equations in mathematical physics, we obtain some new periodic wave solutions for generalized Klein-Cordon equation and Benjamin equation, which cannot be found in previous work. This method also can be used to find new periodic wave solutions of other nonlinear evolution equations.

关键词： auxiliary equation method extended mapping method nonlinear evolution equations periodic wave solutions

ForkXplorer:an approach of fork summary generation

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Frontiers of Computer Science 2022年第2期16卷 1-15页

作者： zhang zhang Xinjun mao Chao zhang Yao LU Key Laboratory of Software Engineering for Complex Systems College of ComputerNational University of Defense TechnologyChangsha 410073China

Pull-based development has become an important paradigm for distributed software *** this model,each developer independently works on a copied repository(i.e.,a fork)from the central *** is essential for developers to maintain awareness of the state of other forks to improve collaboration *** this paper,we propose a method to automatically generate a summary of a *** first use the random forest method to generate the label of a fork,i.e.,feature implementation or a bug *** on the information of the fork-related commits,we then use the TextRank algorithm to generate detailed activity information of the ***,we apply a set of rules to integrate all related information to construct a complete fork *** validate the effectiveness of our method,we conduct 30 groups of manual experiment and 77 groups of case studies on *** propose Fea_(avg)to evaluate the performance of Fea_(avg)the generated fork summary,considering the content accuracy,content integrity,sentence fluency,and label extraction *** results show that the average of of the fork summary generated by this method is *** than 63%of project maintainers and the contributors believe that the fork summary can improve development efficiency.

关键词： open source software pull-based development fork summary distributed cooperative development

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： Tong zhang Martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Aerial edge computing for 6G

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The Journal of China Universities of Posts and Telecommunications 2022年第1期29卷 50-63页

作者： mao Sun zhang Yan College of Computer Science Sichuan Normal UniversityChengdu 610101China Department of Informatics University of OsloOslo 0316Norway

In the 6 th generation mobile communication system(6 G) era, a large number of delay-sensitive and computation-intensive applications impose great pressure on resource-constrained Internet of things(IoT) devices. Aerial edge computing is envisioned as a promising and cost-effective solution, especially in hostile environments without terrestrial infrastructures. Therefore, this paper focuses on integrating aerial edge computing into 6 G for providing ubiquitous computing services for IoT devices. This paper first presents the layered network architecture of aerial edge computing for 6 G. The benefits, potential applications, and design challenges are also discussed in detail. Next, several key techniques like unmanned aerial vehicle(UAV) deployment, operation mode, offloading mode, caching policy, and resource management are highlighted to present how to integrated aerial edge computing into 6 G. Then, the joint UAV deployment optimization and computation offloading method is designed to minimize the computing delay for a typical aerial edge computing network. Numerical results reveal the significant delay reduction of the proposed method compared with the other benchmark methods. Finally, several open issues for aerial edge computing in 6 G are elaborated to provide some guidance for future research.

关键词： mobile edge computing unmanned aerial vehicle the 6th generation mobile communication system